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Journal : SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL

EVALUASI FUNGSI GINJAL BERDASARKAN FARMAKOKINETIK EKSKRESI PADA PASIEN HIPERTENSI DI INSTALASI RAWAT INAP RSUD CILINCING JAKARTA UTARA Octaviani, Egy; Amirulah, Fajar; Sari, Dini Permata; Astiani, Rangki
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.8932

Abstract

Hypertension is a major risk factor for impaired renal function, which may progress to chronic kidney disease (CKD). This study aimed to evaluate renal function based on excretory pharmacokinetic parameters (urea, creatinine, and creatinine clearance) in hypertensive inpatients, and to assess the impact of patient characteristics and types of antihypertensive drugs on renal function decline. This observational analytic study with a cross-sectional design utilized secondary data from 100 medical records of hypertensive inpatients at RSUD Cilincing, North Jakarta, collected during March–April 2025. Most patients were classified in CKD stages 2–3a. The most frequently prescribed therapies were calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs). Chi-Square analysis revealed significant associations between renal function and gender, age, and CCB use (p < 0.05), while diuretic use was not significantly associated (p = 0.134). These findings highlight the importance of appropriate antihypertensive drug selection and regular renal monitoring to prevent CKD progression in hypertensive patients.
STUDI DRUG UTILIZATION REVIEW (DUR) TERHADAP PENGGUNAAN ANTIBIOTIK PADA INFEKSI SALURAN PERNAPASAN ATAS Amirulah, Fajar
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9411

Abstract

Upper respiratory tract infection (URTI) is a condition characterized by irritation and swelling of the upper respiratory tract without pneumonia, usually accompanied by a cough. According to the Indonesian Ministry of Health, the use of medication can be categorized as rational when the medication given meets the patient's needs. Treatment can only be considered rational if it meets several criteria, namely: the right patient, the right indication, the right drug, the right dose, the right interval of administration, the right duration of administration, and others. The objective of this study is to examine the use of antibiotics for ARI in pediatric patients at Jawilan Health Center. The research method employed is a descriptive method with a cross-sectional design to determine the pattern of antibiotic use for ARI in pediatric patients. Data collection was conducted retrospectively using secondary data obtained from medical records and prescriptions of patients with ARI during the period of May 2024–April 2025 at Puskesmas Jawilan, Serang Regency, Banten. The number of patients was 261 patients aged 1-17 years, diagnosed with ARI and given antibiotics. The most commonly used class of antibiotics was amoxicillin, with 253 administrations (96.9%), followed by cotrimoxazole with 8 administrations (3.1%). The results of the treatment rationality are as follows: correct patient 100%, correct indication 77%, correct drug 100%, correct dosage 86.6%, correct interval of antibiotic administration 100%, and correct duration of antibiotic administration 97.7%. From this research data, it can be concluded that there are still irrational drug administrations below 100% that have long-term effects on the patient's body.