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All Journal International Journal of Cell and Biomedical Science Mammiri: Jurnal Pengabdian Masyarakat
Bhirau Wilaksono
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Social Sciences Other

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Hypoxia Precondition Enhance the Therapeutic Effects of Mesenchymal Stem Cells via regulating TGF-β1 and IL-10 serial expression in Skin Excision Rat Models Kustyah, Azizah Retno; Fatimah, Nandiah; Rizkiyani, Elytia Mutia; Ramadhanti, Olifiarsy Wiet; Istiqomah, Dyah Ayu Fitri; Hidayah, Nurul; Bhirau Wilaksono
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.9

Abstract

Background: The skin excisional wound healing process involves an intricate-regulated series of cellular responses to reverse the formation of skin tissue integrity. This process requires paracrine communication involving anti-inflammatory cytokines and growth factors, especially interleukin 10 (IL-10) and TGF-β. On the other hand, hypoxic preconditioned mesenchymal stem cells (Hypoxia-MSCs) have been acknowledged to enrich IL-10 and TGF- β secretion contributing to accelerated wound healing compared to normal preconditioned mesenchymal stem cells (Normoxia-MSCs). Objective: This study aimed to compare Hypoxia-MSCs and Normoxia-MSCs in integrating the serial expression of IL-10 and TGF-β associated with improved collagen density in animal models of excision wounds. Methods: Thirty-six male Wistar rats with excision wounds were made as animal models using the 6 mm biopsy method. The rats were randomly divided into four groups consisting of four treatment groups: N-MSCs 1x106, H-MSCs 1x106, Control (PBS treatment), and Sham (untreated or healthy mice). The treatments were administered 2 times intraperitoneally on day 0. Skin tissue was collected on days 12, 18, and 24 post-injections. IL-10 dan TGF-β expressions were examined by qPCR. Results: This study showed that there was a significant increase in IL-10 and TGF-β after Hypoxia-MSCs and Normoxia-MSCs treatment compared to the Control group. Conclusion: Hypoxia-MSCs can improve the serial expression of IL-10 which leads to wound repair of the mouse model of excision wound. These results suggest that a hypoxic environment can enhance the therapeutic effect of MSCs.
Edukasi Bahaya Rokok dan Vape: Mengubah Persepsi Remaja dari Gaya Hidup Menjadi Ancaman Kesehatan di SMAN 1 Parepare Nurussyariah Hammado; Paramita, Diah Astini; Nurul Mutiah Aminuddin; Rayhani Ichsan; Bhirau Wilaksono
MAMMIRI: JURNAL PENGABDIAN MASYARAKAT Vol. 2 No. 3 (2025): Oktober 2025
Publisher : Education and Talent Development Center Indonesia

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Abstract

The prevalence of smoking and vaping among Indonesian adolescents continues to increase, driven by the misconception that these products represent a modern lifestyle rather than a serious health risk. School-based health education interventions are essential to address this issue. This community service program aimed to increase students' knowledge and awareness regarding the dangers of smoking and vaping at SMAN 1 Parepare. A participatory health education approach was implemented involving 43 participants. The intervention utilized poster media, peer education with university students as presenters, interactive discussions, and gamified quizzes. Evaluation was conducted through participant observation, active participation assessment, and post-education quiz. The retention rate reached 100% with no participant dropout. All participants engaged in the quiz session, and three students actively raised critical questions regarding smoking prevention strategies at school. The combination of peer education, visual media, and gamification effectively maintained participant engagement and facilitated knowledge transfer regarding smoking and vaping risks among adolescents.
Co-Authors Fatimah, Nandiah Hammado, Nurussyariah Istiqomah, Dyah Ayu Fitri Kustyah, Azizah Retno NURUL HIDAYAH Nurul Mutiah Aminuddin Paramita, Diah Astini Ramadhanti, Olifiarsy Wiet Rayhani Ichsan Rizkiyani, Elytia Mutia