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All Journal Journal of Science and Technology Research for Pharmacy Jurnal Ilmiah Sultan Agung International Journal of Cell and Biomedical Science
Antari, Arini Dewi
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The Role of Mesenchymal Stem Cell in Controlling Liver Function on Liver Fibrosis Antari, Arini Dewi; Prasetio, Ardi; Nugroho, Baskoro Adi
Journal of Science and Technology Research for Pharmacy Vol 1 No 2 (2021)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/jstrp.v1i2.45699

Abstract

ABSTRACT Background: Liver fibrosis (LF) is the end-stage of liver damage characterized by the increase concentration of SGOT and SGPT. A previous study, revealed that liver transplantation as the most effective therapy for LF has limited availability and remains a major challenge. Mesenchymal stem may control inflammation and regenerate damaged tissue leading to accelerated liver function repair. Aim: The purpose of this study was to determine the optimum doze for MSC administration to recover LF. Method: The research used variations doze of MSCs administration of 1x106 and 2x106. Liver firbosis was induced by twice a week intraperitoneal injection of carbon tetrachloride (CCl4) (Sigma-Aldrich) dissolved with olive oil in 1:1 ratio for eight weeks. The concentration of SGPT SGOT was measured at day 9 post MSC administration. One Way Anova was performed to analyze statictical data. Result: This study showed that there was a significant decrease in SGOT concentration (P < 0,05). P2 group treatment showed the lowest concentration of SGOT among the treatment (Figure B). In the same time, the administration of UC-MSCs reduce SGPT concentration insignificantly (P > 0,05). Conclusion: The transplantation of MSCs ameliorated LF by reducing SGPT and SGOT concentration
PENGARUH EKSTRAK BUNGA TELANG (CLITORIA TERNATEA L.) TERHADAP NEKROSIS TUBULUS GINJAL Dewi, Lola Iva; Suprijono, Moch. Agus; Antari, Arini Dewi
Jurnal Ilmiah Penelitian Mahasiswa Vol 3, No 2 (2024): Juni 2024
Publisher : Jurnal Ilmiah Sultan Agung

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Abstract

Gagal ginjal adalah penyakit rusaknya ginjal secara irreversible yang mempunyai angka kejadian tinggi. Konsumsi MSG berlebihan menjadi salah satu penyebab terjadinya nekrosis tubulus ginjal. Ekstrak bunga telang mengandung antioksidan sehingga mencegah nekrosis tubulus ginjal. Penelitian ini bertujuan mengetahui pengaruh ekstrak bunga telang terhadap nekrosis tubulus ginjal pada tikus putih jantan galur Wistar yang diinduksi MSG. Jenis penelitian menggunakan eksperimental dengan rancangan “post test only randomized control group design” dengan sampel penelitian 25 ekor tikus putih jantan, dibagi menjadi 5 kelompok secara acak. Dosis induksi MSG adalah sebesar 3 mg/gBB/hari. Pada kelompok P1, P2, dan P3 masing masing akan diberikan ekstrak bunga telang dengan dosis 150 mg/KgBB/hari, 300 mg/kgBB/hari, dan 600 mg/kgBB/hari. Setelah perlakuan selama 21 hari dilakukan pembuatan preparat dan pengamatan. Data yang diperoleh diolah menggunakan SPSS versi 29.0 dengan uji Kruskal-Wallis dan Mann-Whitney. Rerata jumlah sel nekrosis tubulus ginjal kelompok kontrol negatif (0 sel), kelompok kontrol positif (9,72 sel), kelompok P1 (6,08 sel), kelompok P2 (1,52 sel), dan kelompok P2 (1,4 sel). Kelompok perlakuan menunjukkan hasil penurunan jumlah sel nekrosis dibanding dengan kelompok kontrol positif. Hasil uji Kruskal-Wallis menunjukkan hasil signifikan (p<0,05). Uji Mann-Whitney menunjukkan perbedaan signifikan rerata jumlah nekrosis tubulus ginjal pada semua pasangan kelompok(p<0,05) kecuali pada pasangan kelompok P2 dan P3 (p>0,05. Kesimpulan penelitian ini adalah terdapat pengaruh ekstrak bunga telang terhadap nekrosis pada tikus putih jantan galur Wistar yang diinduksi MSG. Kata kunci: monosodium glutamate, gunga telang, nekrosis tubulus ginjal
Secretome Hypoxia-Mesenchymal Stem Cells Regulate IL-10 Concentrations in STZ-induced Type 1 Diabetes Rats Sutrisman, Intan Permatasari; Antari, Arini Dewi; Putra, Agung; Irawan, Risky Chandra; Handoyo, Frigi Eko
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.18

Abstract

Background: Type 1 Diabetic Mellitus (T1DM) is a well-known autoimmune disease that is characterized by a specific adaptative immunity against β-cell antigens. Mesenchymal stem cells (MSC) have emerged as potential immunomodulators in a paracrine manner via their bioactive soluble molecules that involve inflammation-related diseases, including T1DM. Objective: This study aims to investigate the effect of S-HMSC on regulating IL-10 concentrations in STZ-induced T1DM rats. Materials and Methods: This study uses a post-only control group design and randomized system. To induce T1DM rats, an intraperitoneal injection (65 mg/kg BW) of streptozotocin (STZ) was inducted. 20 Wistar rats were subdivided into the following groups: T1DM, DM with 0,5cc S-HMSC (Low-dose), and DM with 1cc S-HMSC (High-dose). The animals received an intraperitoneal injection of S-HMSC once a week for up to 4 weeks. On day 28, the animals were terminated and IL-10 concentrations were measured by ELISA. Results: After S-HMSC administration, the concentration of IL-10 in the treated group was increased in either low-dose or high-dose groups compared with the T1DM group. Conclusion: Administration of secretome-hypoxia MSC may regulate IL-10 concentrations in STZ-induced Type 1 Diabetes Rats.
Regulatory Effect of Secretome-Hypoxia Preconditioned Mesenchymal Stem Cells on TNF-α Level in Streptozotocin-induced Rats Amellia, Nazzala Luthfin; Antari, Arini Dewi; Nazar, Mohammad Ariq; Husain, Sofian Azalia; Arifin, Naufal Ardjivani
International Journal of Cell and Biomedical Science Vol 1 No 3 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i3.23

Abstract

Background: Type 1 Diabetic Mellitus (T1DM) is a well-known autoimmune disease characterized by a specific adaptative immunity against β-cell antigens. Mesenchymal stem cells (MSC) have emerged as potential immunomodulators in a paracrine manner via their bioactive soluble molecules that involve inflammation-related diseases, including T1DM. Objective: This study aims to investigate the effect of SHMSCs on regulating TNF-α concentrations in STZ-induced rats. Materials and Methods: This study uses a post-only control group design and randomized system that was conducted from December 2022 until January 2023. To induce T1DM-like rats, an intraperitoneal injection (65 mg/kg BW) of streptozotocin (STZ) was inducted. 15 male Wistar rats were subdivided into the following groups: STZ, STZ with 0.5 cc SHMSCs (Low-dose), and STZ with 1 cc SHMSCs (High-dose). The animals received an intraperitoneal injection of SHMSCs once a week for up to 4 weeks. On day 28, the animals were terminated and ELISA measured TNF-α concentrations. Results: After SHMSCs administration, the level of TNF-α in the treated group was decreased in either low-dose or high-dose groups compared with the STZ group. Conclusion: Administration of secretome-hypoxia MSCs may regulate TNF-α concentrations in STZ-induced Rats.
The Effect of X-Ray Radiation to IL-10 Levels in Secretome Mesenchymal Stem Cells Cosmeceutical Product Antari, Arini Dewi; Ghaissani, Shabrina Syifa; Prawitasari, Salindri; Haryono, Erlina; Adityani, Resanti
International Journal of Cell and Biomedical Science Vol 2 No 4 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i4.27

Abstract

Background: X-ray radiation has been widely used in the pharmaceutical industry because it regenerates and repairs damaged tissues. Objective: In this study, we evaluate the effect of X-ray radiation on the secretome cosmeutical product. Methods: We conducted interleukin 10 (IL-10) analysis by ELISA in each product sample after exposure to X-ray radiation. Results: The levels of IL-10 in each sample were significantly lower than those in the control samples. Moreover, the level of IL-10 in the product samples was significantly higher than that of the control sample. Conclusion: In conclusion, exposure to radiation during shipping or storage of skin care products can potentially damage the proteins in the products by inducing the production of reactive oxygen species (ROS) and decreasing the treatment effectiveness.
Co-Authors Adityani, Resanti Agung Putra Amellia, Nazzala Luthfin Arifin, Naufal Ardjivani Dewi, Lola Iva Ghaissani, Shabrina Syifa Handoyo, Frigi Eko Haryono, Erlina Husain, Sofian Azalia Irawan, Risky Chandra Moch. Agus Suprijono Nazar, Mohammad Ariq Nugroho, Baskoro Adi Prasetio, Ardi Prawitasari, Salindri Sutrisman, Intan Permatasari