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All Journal Jurnal Cakrawala Ilmiah Jurnal Sains Farmasi dan Kesehatan
Hendri Anugrah Wibowo
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Humanities Economics, Econometrics & Finance Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Formulasi Sediaan Tablet Dan Evaluasi Dari Jenis Zat Aktif Dengan Metode Granulasi Basah Jaida Rahma; Alya Puspita Dewi; Septia Miranti; Hendri Anugrah Wibowo; Nabila Syifa Firdaus
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1791

Abstract

This study aims to understand how the wet granulation technique can affect the physical quality and the effectiveness of active ingredient release in tablets. In this review, various types of active ingredients will be analyzed to evaluate how their chemical and physical properties, such as solubility, compressibility, and stability, influence the resulting tablet formulation. Wet granulation was chosen due to its ability to improve the flow, compressibility, and stability of the mixture of active ingredients and excipients, resulting in tablets with better quality. To achieve this objective, the study uses a Systematic Literature Review (SLR) approach, which gathers and analyzes relevant literature related to tablet formulations with active ingredients using wet granulation. The results of the review show that wet granulation is effective in improving the physical quality of tablet and granule preparations. Wet granulation can enhance flow, compressibility, and active ingredient release control, although it has drawbacks, such as high costs and multiple stages that require validation. Increasing the concentration of gelatin in the tablet formulation of Eugenia polyantha extract improved the physical strength and dissolution rate of the tablets. Similarly, research on acetaminophen demonstrated that wet granulation produces tablets with physical qualities that meet the required standards for tablet physical testing. Finally, this study shows that Tectona grandis leaf extract can be formulated into granules with optimal quality that meets the physical evaluation criteria. Overall, wet granulation has proven to be effective in improving the quality and release of active ingredients in tablets and granules, with the selection of appropriate materials and concentrations greatly affecting the final formulation results.
REVIEW METODE UJI AKTIVITAS ANTIDIABETIK DARI EKSTRAK TANAMAN ALAM SECARA IN VIVO DAN IN VITRO Muhammad Arif Akbar; Muhammad Zairullah; Laila Sonia Agustina; Fitria Noor Hafifah; Sindy Maulida; Muhammad Faqih Madhani; Muhammad Lukmannul Hakim; Hendri Anugrah Wibowo
Jurnal Cakrawala Ilmiah Vol. 4 No. 11: Juli 2025
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes melitus merupakan penyakit metabolik kronis yang prevalensinya terus meningkat secara global dan nasional, serta berdampak signifikan terhadap aspek kesehatan dan ekonomi. Keterbatasan terapi konvensional, seperti efek samping jangka panjang dan tingginya biaya pengobatan, mendorong pengembangan alternatif terapi yang lebih aman dan terjangkau berbasis bahan alam. Artikel ini menyajikan kajian pustaka sistematis mengenai metode uji aktivitas antidiabetik secara in vitro dan in vivo terhadap ekstrak tanaman Syzygium polyanthum (daun salam) dan Carica papaya (daun pepaya). Metode kajian dilakukan melalui telaah literatur dari jurnal ilmiah terindeks dan dokumen relevan lainnya. Uji in vitro mencakup penghambatan enzim α-glukosidase dan α-amilase sebagai indikator awal aktivitas hipoglikemik, sedangkan uji in vivo menggunakan model hewan yang diinduksi streptozotosin atau aloksan untuk mengevaluasi parameter biologis secara sistemik. Hasil telaah menunjukkan bahwa kedua tanaman mengandung senyawa bioaktif seperti flavonoid, tanin, dan alkaloid yang berkontribusi terhadap penurunan kadar glukosa darah, peningkatan ekspresi protein IRS-1/Akt, serta perbaikan profil lipid. Sinergisme antarsenyawa dalam ekstrak turut memperkuat efek farmakologis. Kesimpulannya, integrasi pendekatan in vitro dan in vivo penting untuk memperoleh validasi ilmiah yang komprehensif dalam pengembangan fitofarmaka antidiabetik berbasis tanaman lokal.
Co-Authors Alya Puspita Dewi Fitria Noor Hafifah Jaida Rahma Laila Sonia Agustina Muhammad Arif Akbar Muhammad Faqih Madhani Muhammad Lukmannul Hakim Muhammad Zairullah Nabila Syifa Firdaus Septia Miranti Sindy Maulida