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All Journal Sriwijaya Journal of Surgery Sriwijaya Journal of Obstetrics and Gynecology Sriwijaya Journal of Neurology
Sonya Syarifah
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Genetic and Environmental Influences on Autism Spectrum Disorder: A Multi-Center Study Exploring Gene-Environment Interactions and Biomarkers in Indonesia Vita Amanda; Rashidah Unaib Al-Zayid; Winata Putri; Sonya Syarifah; Tiffany Gabriele; Leonardo Simanjuntak; Cinthya Callathea
Sriwijaya Journal of Neurology Vol. 1 No. 2 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.30

Abstract

Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental condition with a complex etiology involving genetic and environmental factors. This multi-center study investigated gene-environment interactions and potential biomarkers associated with ASD in the Indonesian population. Methods: Children diagnosed with ASD (n=500) and age-matched typically developing controls (n=500) were recruited across five major Indonesian cities. Whole-exome sequencing targeted genotyping, and environmental risk factor assessments were conducted. Biomarker analyses included cytokine levels, oxidative stress markers, and neurotransmitters. Results: Genetic analysis revealed both rare and common variants associated with ASD risk, including variants in CHD8, SCN2A, NRXN1, and novel genes. Prenatal exposures (maternal medication use, infections), perinatal complications (preterm birth, low birth weight), and postnatal factors (pesticide exposure, air pollution) were associated with increased ASD risk. Children with ASD exhibited elevated inflammatory markers (TNF-α, IL-6, IL-1β), increased oxidative stress (higher MDA, lower GSH), and altered neurotransmitter levels (lower serotonin and dopamine) compared to controls. Conclusion: This study provides insights into the interplay of genetic and environmental factors contributing to ASD risk in Indonesia. The identified genetic variants, environmental risk factors, and potential biomarkers may contribute to our understanding of ASD etiology and inform the development of targeted interventions and early detection strategies.
Activated Growth Factors (AGF), an Advanced Platelet-Rich Plasma (PRP) Modality, as a Novel Biological Treatment for Partial Anterior Cruciate Ligament Tears: A Case Report Hidayat, Rachmat; Kemas Abdul Mutholib Luthfi; Olivia Azalia Putri; Sony Sanjaya; Linda Purnama; Sonya Syarifah; Nadia Khoirina; Abu Bakar; Rashidah Unaib Al Zayid; Reisha Notonegoro
Sriwijaya Journal of Surgery Vol. 8 No. 1 (2025): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v8i1.114

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Introduction: Partial anterior cruciate ligament (ACL) ruptures present a complex clinical challenge. Traditional treatment options, including conservative management and surgical reconstruction, often yield unpredictable outcomes and extended recovery periods. This case report explores the potential of activated growth factors (AGF), an advanced platelet-rich plasma (PRP) modality, as a novel biological treatment strategy for partial ACL tears. Case presentation: A 39-year-old male presented with right knee pain and instability following a twisting injury sustained during exercise. Magnetic resonance imaging (MRI) confirmed a partial tear of the anteromedial bundle of the ACL. The patient was treated with a series of three intra-articular injections of AGF, administered at weekly intervals. The AGF was prepared using a proprietary protocol aimed at optimizing growth factor concentration and release. The patient's progress was meticulously monitored through clinical evaluations and functional assessments at 3 and 6 months post-treatment. Conclusion: This case suggests that AGF may offer a promising alternative for the treatment of partial ACL tears, potentially facilitating accelerated healing and improved clinical outcomes. Further research, including controlled trials, is warranted to validate these findings and establish the efficacy and safety of AGF in a larger patient population.
Assessing the Effectiveness of Telemedicine for Cervical Cancer Screening in Remote Areas of Indonesia Kristianti, Silvia; Reza Andrianto; Sonya Syarifah; Taryudi Suharyana
Sriwijaya Journal of Obstetrics and Gynecology Vol. 2 No. 1 (2024): Sriwijaya Journal of Obstetrics and Gynecology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjog.v1i2.86

Abstract

Introduction: Cervical cancer remains a significant public health issue in Indonesia, particularly in remote areas with limited access to healthcare facilities. Telemedicine offers a potential solution to overcome geographical barriers and improve cervical cancer screening rates. This study aimed to assess the effectiveness of a telemedicine-based cervical cancer screening program in remote areas of Indonesia. Methods: A cross-sectional study was conducted in five remote villages in Indonesia. Women aged 30-49 years were invited to participate in cervical cancer screening using a telemedicine platform. The program involved self-sampling for human papillomavirus (HPV) DNA testing, followed by teleconsultation with healthcare providers for result interpretation and referral for further management if required. The primary outcome was the participation rate in the telemedicine-based screening program. Secondary outcomes included the positivity rate for high-risk HPV, the rate of referral for colposcopy, and participant satisfaction with the program. Results: A total of 500 women were invited to participate in the study, of whom 380 (76%) completed the screening process. The high-risk HPV positivity rate was 12%, and 46 women (12.1%) were referred for colposcopy. Participant satisfaction with the telemedicine program was high, with 92% of women reporting that they were satisfied with the convenience and accessibility of the service. Conclusion: Telemedicine-based cervical cancer screening is a feasible and effective strategy for reaching women in remote areas of Indonesia. The program achieved a high participation rate and enabled timely referral for further management. This approach has the potential to improve cervical cancer screening coverage and reduce mortality rates in underserved populations.
Co-Authors Abu Bakar Cinthya Callathea Kemas Abdul Mutholib Luthfi Kristianti, Silvia Leonardo Simanjuntak Linda Purnama Nadia Khoirina Olivia Azalia Putri RACHMAT HIDAYAT Rashidah Unaib Al Zayid Rashidah Unaib Al-Zayid Reisha Notonegoro Reza Andrianto Sony Sanjaya Taryudi Suharyana Tiffany Gabriele Vita Amanda Winata Putri