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All Journal Universa Medicina Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Jurnal Lentera: Penelitian dan Pengabdian Masyarakat
Jaya Edy, Hosea
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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STANDARISASI EKSTRAK MANGROVE Sonneratia ovata Backer. DARI DESA TONGKAINA, BUNAKEN, SULAWESI UTARA SEBAGAI BAHAN BAKU OBAT TOPIKAL Jaya Edy, Hosea; Parwanto, edy; Sudewi, Sri; Hariyanto, Yuanita Amalia
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i2.59468

Abstract

Mangrove merupakan tanaman yang tumbuh pada area pantai atau daerah pesisir, hingga membentuk ekosistem hutan mangrove. Mangrove memiliki kandungan metabolit sekunder yang sangat beragam dan sangat berpotensi sebagai bahan baku obat-obatan. Penelitian ini bertujuan melakukan identifikasi dan standarisasi ekstrak daun mangrove Sonneratia ovata Backer. yang dikoleksi dari desa Tongkaina, Sulawesi Utara. Metode standarisasi ekstrak dengan melakukan pengujian parameter spesifik dan parameter non-spesifik ekstrak serta pengujian sterilitas ekstrak etanol daun mangrove Sonneratia ovata Backer. dari desa Tongkaina. Nilai kadar sari ekstrak etanol terlarut air adalah 18,78 % dan nilai kadar sari ekstrak larut etanol adalah 25,44%. Nilai susut pengeringan dari ekstrak etanol daun S. ovata adalah 0,187 % dan nilai kadar air dalam ekstrak adalah 7,254 %. Nilai kadar abu ekstrak daun S. ovata adalah 3,940 % dan nilai kadar abu tidak larut asam adalah 0,410 %. Ekstrak etanol daun S. ovata bebas kontaminan mikroorganisme dan dapat dimanfaatkan sebagai bahan baku zat aktif sediaan topikal berbasis bahan alami.
Edukasi Pemilihan Pangan Lokal Bergizi Pencegah Stunting di Paniki Atas, Minahasa Utara Jaya Edy, Hosea; Mansauda, Karlah Lifie Riani; Tasiam , Ezrani
Jurnal Lentera: Penelitian dan Pengabdian Masyarakat Vol. 6 No. 2 (2025): Jurnal Lentera: Penelitian dan Pengabdian Masyarakat
Publisher : Yayasan Bina Lentera Insan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57207/xkwas041

Abstract

Stunting remains a chronic nutritional problem faced by communities in Indonesia, including those in Paniki Atas, North Minahasa Regency. This community service activity aimed to enhance public understanding of stunting prevention through the utilization of nutritious local food resources. The method employed was counseling and interactive discussion involving pregnant women, breastfeeding mothers, and community health cadres, with materials covering the introduction of local nutritious foods, balanced menu planning, and healthy food processing practices. The results indicated high participant enthusiasm and a significant increase in knowledge, with the average score improving from 50% before the session to 90% after the counseling. This program contributes to raising nutritional awareness and fostering community self-reliance in utilizing local food resources as a sustainable effort to prevent stunting in the Paniki Atas area.
Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats Tjahyadi, David; Parwanto, Edy; Sisca, Sisca; Xavierees, Endrico; Jaya Edy, Hosea; Digambiro, Reza Aditya; Oladimeji, Ashaolu Victoria; Tjahyadi, Joey Joshua Vidova; Gabrielle, Laurentia
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

Abstract

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.
Co-Authors David Tjahyadi Gabrielle, Laurentia Hariyanto, Yuanita Amalia Karlah L. R. Mansauda Oladimeji, Ashaolu Victoria Parwanto, Edy Reza Aditya Digambiro Sisca Sisca, Sisca Sri Sudewi, Sri Tasiam , Ezrani Tjahyadi, Joey Joshua Vidova Xavierees, Endrico