Garuda - Garba Rujukan Digital

ANALISIS KOMPARATIF ATROFI SEREBRAL PADA GANGGUAN KOGNITIF NON-ALZHEIMER DAN PENYAKIT ALZHEIMER DI INDONESIA Digambiro, Reza Aditya; Marsiati, Himmi; Hadi, Restu Syamsul; Hastuty, Dewi; Parwanto, Edy
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.245

Abstrak Penelitian ini menganalisis pola atrofi serebral pada pasien gangguan kognitif non-Alzheimer dan penyakit Alzheimer (AD) di Indonesia. Atrofi otak terjadi lebih cepat pada pasien AD dibandingkan penuaan normal, dan percepatan atrofi hipokampus ditemukan pada subjek dengan gangguan kognitif ringan (MCI) yang berkembang menjadi AD. Data diperoleh dari 710 subjek yang menjalani MRI di Rumah Sakit Cipto Mangunkusumo dan Rumah Sakit Hasan Sadikin. Analisis laju atrofi otak keseluruhan, hipokampus, dan pembesaran ventrikel menunjukkan perbedaan signifikan antara kelompok kontrol, MCI, dan AD. Rata-rata percepatan atrofi hipokampus pada subjek MCI mencapai 0,44% per tahun kuadrat (p < 0,05). Temuan ini menggarisbawahi pentingnya deteksi dini dan intervensi terapeutik pada tahap MCI. Penelitian ini juga menunjukkan bahwa pola atrofi serebral di Indonesia serupa dengan temuan global, meskipun terdapat perbedaan faktor risiko lokal. Penelitian lanjutan perlu mencakup analisis longitudinal jangka panjang untuk pemahaman yang lebih baik tentang progresi AD di Indonesia. Kata Kunci: Atrofi serebral, Alzheimer, gangguan kognitif ringan, Indonesia, hipokampus, MRI Abstract This study analyzes cerebral atrophy patterns in patients with non-Alzheimer cognitive impairment and Alzheimer's disease (AD) in Indonesia. Brain atrophy progresses faster in AD patients compared to normal aging, with accelerated hippocampal atrophy observed in mild cognitive impairment (MCI) subjects who progress to AD. Data were obtained from 710 subjects who underwent MRI at Cipto Mangunkusumo Hospital and Hasan Sadikin Hospital. Analysis of overall brain atrophy rates, hippocampal atrophy, and ventricular enlargement revealed significant differences between control, MCI, and AD groups. The average acceleration of hippocampal atrophy in MCI subjects was 0.44% per year squared (p < 0.05). These findings emphasize the importance of early detection and therapeutic intervention at the MCI stage. This study also indicates that cerebral atrophy patterns in Indonesia are similar to global findings, despite local risk factor variations. Further research should include long-term longitudinal analysis to gain a better understanding of AD progression in Indonesia. Keywords: Cerebral atrophy, Alzheimer’s disease, mild cognitive impairment, Indonesia, hippocampus, MRI

STANDARISASI EKSTRAK MANGROVE Sonneratia ovata Backer. DARI DESA TONGKAINA, BUNAKEN, SULAWESI UTARA SEBAGAI BAHAN BAKU OBAT TOPIKAL Jaya Edy, Hosea; Parwanto, edy; Sudewi, Sri; Hariyanto, Yuanita Amalia
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i2.59468

Mangrove merupakan tanaman yang tumbuh pada area pantai atau daerah pesisir, hingga membentuk ekosistem hutan mangrove. Mangrove memiliki kandungan metabolit sekunder yang sangat beragam dan sangat berpotensi sebagai bahan baku obat-obatan. Penelitian ini bertujuan melakukan identifikasi dan standarisasi ekstrak daun mangrove Sonneratia ovata Backer. yang dikoleksi dari desa Tongkaina, Sulawesi Utara. Metode standarisasi ekstrak dengan melakukan pengujian parameter spesifik dan parameter non-spesifik ekstrak serta pengujian sterilitas ekstrak etanol daun mangrove Sonneratia ovata Backer. dari desa Tongkaina. Nilai kadar sari ekstrak etanol terlarut air adalah 18,78 % dan nilai kadar sari ekstrak larut etanol adalah 25,44%. Nilai susut pengeringan dari ekstrak etanol daun S. ovata adalah 0,187 % dan nilai kadar air dalam ekstrak adalah 7,254 %. Nilai kadar abu ekstrak daun S. ovata adalah 3,940 % dan nilai kadar abu tidak larut asam adalah 0,410 %. Ekstrak etanol daun S. ovata bebas kontaminan mikroorganisme dan dapat dimanfaatkan sebagai bahan baku zat aktif sediaan topikal berbasis bahan alami.

The Impact of High Dose Ozone Therapy on Hematological and Biochemical Profiles : An Observational Study Digambiro, Reza Aditya; Parwanto, Edy; Lestari, Indah Widya; Chendrasari, Julian; Setyaningrum, Dyah Ayu Woro; Ilona, Florinda
The Avicenna Medical Journal Vol 5, No 1 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i1.34859

Background: Ozone therapy, namely High Dose Ozone Therapy (HDO), has become a versatile medical treatment in several clinical settings. Although it is becoming more well acknowledged, there is still a lack of extensive evidence about the impact of this on hematological and biochemical indicators. This study seeks to address this void by examining the consequences of this phenomenon in a clinical environment.Method: An observational study was done, which followed a structured approach, comprising a total of 100 patients who were selected from the SMC Clinic. Hematological and biochemical indices were evaluated before and after ozone therapy sessions to analyze blood parameters. Two blood samples were obtained at two specific time points: prior to the commencement of the ozone therapy (T0) and after the therapy was finished (T1).Results: Substantial alterations were noted in both hematological and biochemical parameters after the therapy. The hematological changes observed in this study showed a substantial rise in the red blood cell count (p=0.009), hemoglobin levels (p=0.004), and hematocrit (p=0.039), along with a decrease in erythrocyte sedimentation rate (ESR) (p=0.020). Notable biochemical changes were observed, including significant modifications in total plasma protein (TPP) (p=0.008) and lactate levels (p=0.001). Furthermore, there was a noteworthy decrease (p<0.05) in the levels of malondialdehyde (MDA), which is a marker for oxidative stress.Conclusion: HDO exerts a regulatory influence on crucial hematological, biochemical, and oxidative stress factors. These findings indicate that HDO may have therapeutic benefits for treating chronic disorders and cancer. It can improve blood parameters and reduce oxidative stress. The decrease in markers of oxidative stress, such as MDA, suggests a potential reduction in the likelihood of problems associated with oxidative damage in chronic diseases. Nevertheless, additional research is required to validate these findings, investigate their wider therapeutic implications, and comprehend the long-term consequences and safety of HDO therapy.

The Impact of High Dose Ozone Therapy on Hematological and Biochemical Profiles : An Observational Study Digambiro, Reza Aditya; Parwanto, Edy; Lestari, Indah Widya; Chendrasari, Julian; Setyaningrum, Dyah Ayu Woro; Ilona, Florinda
The Avicenna Medical Journal Vol. 5 No. 1 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i1.34859

Background: Ozone therapy, namely High Dose Ozone Therapy (HDO), has become a versatile medical treatment in several clinical settings. Although it is becoming more well acknowledged, there is still a lack of extensive evidence about the impact of this on hematological and biochemical indicators. This study seeks to address this void by examining the consequences of this phenomenon in a clinical environment.Method: An observational study was done, which followed a structured approach, comprising a total of 100 patients who were selected from the SMC Clinic. Hematological and biochemical indices were evaluated before and after ozone therapy sessions to analyze blood parameters. Two blood samples were obtained at two specific time points: prior to the commencement of the ozone therapy (T0) and after the therapy was finished (T1).Results: Substantial alterations were noted in both hematological and biochemical parameters after the therapy. The hematological changes observed in this study showed a substantial rise in the red blood cell count (p=0.009), hemoglobin levels (p=0.004), and hematocrit (p=0.039), along with a decrease in erythrocyte sedimentation rate (ESR) (p=0.020). Notable biochemical changes were observed, including significant modifications in total plasma protein (TPP) (p=0.008) and lactate levels (p=0.001). Furthermore, there was a noteworthy decrease (p<0.05) in the levels of malondialdehyde (MDA), which is a marker for oxidative stress.Conclusion: HDO exerts a regulatory influence on crucial hematological, biochemical, and oxidative stress factors. These findings indicate that HDO may have therapeutic benefits for treating chronic disorders and cancer. It can improve blood parameters and reduce oxidative stress. The decrease in markers of oxidative stress, such as MDA, suggests a potential reduction in the likelihood of problems associated with oxidative damage in chronic diseases. Nevertheless, additional research is required to validate these findings, investigate their wider therapeutic implications, and comprehend the long-term consequences and safety of HDO therapy.

Meckel's Diverticulum-Induced Intussusception Coinciding with Diabetes Mellitus in a Young Adult Male: A Rare Case Study Digambiro, Reza Aditya; Parwanto, Edy; Setianingrum, Dyah Ayu Woro; Ilona, Florinda; Lestari, Indah Widya; Chendrasari, Julian
Jurnal Kedokteran Meditek Vol 31 No 1 (2025): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i1.3084

Introduction: Intussusception in adults, especially when caused by Meckel's Diverticulum, is a rare occurrence, often presenting with nonspecific symptoms such as abdominal pain and nausea, making it challenging to diagnose. When concurrent with conditions like diabetes mellitus, the situation need particular care. Case Illustration: A 27-year-old male with a medical history of diabetes presented with severe right abdominal pain, nausea, and a reduced appetite. Initial symptomatic treatment did not alleviate the condition. Subsequent CT scans revealed an ileo-ileal intussusception triggered by Meckel's Diverticulum and partial high obstruction ileus, leading to surgical intervention. Discussion: Ileo-ileal resection (end to end anastomosis) and adhesiolysis surgery were successfully performed, followed by vigilant postoperative monitoring for complications, effective pain management, maintenance of drain patency, and careful glucose level monitoring. The patient's significant postoperative improvement underscores the importance of early diagnosis and timely surgical intervention in managing Meckel's Diverticulum-induced intussusception in adults. Conclusion: The clinical course also highlighted the importance of tailoring postoperative care considering the patient's comorbidities, in this case, diabetes mellitus. This case served as a reminder for clinicians to consider Meckel's Diverticulum as a potential cause of intussusception in adults presenting with abdominal pain.

Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats Tjahyadi, David; Parwanto, Edy; Sisca, Sisca; Xavierees, Endrico; Jaya Edy, Hosea; Digambiro, Reza Aditya; Oladimeji, Ashaolu Victoria; Tjahyadi, Joey Joshua Vidova; Gabrielle, Laurentia
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly Parwanto, Edy; Tjahyadi, David; Amalia, Husnun; Hairunisa, Nany; Edy, Hosea Jaya; Oladimeji, Ashaolu Victoria; Djebli, Noureddine
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.329-345

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.

Analysis of Pulmonary Function between E-Cigarette Users and Non-Smokers Aged 20–30 Years in Jakarta Digambiro, Reza Aditya; Parwanto, Edy; Tjahjadi, David; Ditriana, Ditriana
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.791

Background: This study aimed to compare pulmonary function between e-cigarette users and non-smokers aged 20–30 years in Jakarta. Methods: A cross-sectional study was carried out between May 2023 and May 2024 at SMC Clinic Jakarta, Ibnusina Hospital Jakarta, and Naura Medika Clinic Depok. The sample consisted of 65 individuals who used e-cigarettes and 63 individuals who did not smoke. Spirometry was employed to evaluate pulmonary function by measuring forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. The data were analyzed using independent t-tests using IBM SPSS software version 25.0. Results: The study revealed substantial disparities in pulmonary function between individuals who use e-cigarettes and those who do not smoke. Individuals who use e-cigarettes had significantly reduced FEV1 at 3.02±0.50 L and FVC at 4.00±0.47 L, in comparison to non-smokers (FEV1=3.51±0.57 L; FVC=4.57±0.50 L). E-cigarette users exhibited a considerably lower FEV1/FVC ratio (74.86±5.55) compared to non-smokers (79.29±5.11), suggesting a higher occurrence of obstructive airway diseases. Conclusion: Young adults aged 20-30 years in Jakarta who use e-cigarettes experience a decrease in pulmonary function. The results emphasize the possible respiratory hazards associated with the use of e-cigarettes and emphasize the necessity for greater awareness and regulatory actions to tackle these hazards.

D-dimer sebagai Biomarker Diagnostik Tuberkulosis Paru pada Efusi Pleura: Tinjauan Pustaka Digambiro, Reza Aditya; Ilona, Florinda; Chendrasari, Julian; Lestari, Indah Widya; Parwanto, Edy
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1242

Background: Tuberculosis (TB) remains a major health threat, especially in developing countries. Although the lungs are the most affected organ, systemic manifestations are quite significant. D-dimer, as one of the fibrin degradation products and also an indicator of coagulation activity, has been extensively researched for its predictive and diagnostic value in various diseases. This study aims to assess the effectiveness of D-dimer as a diagnostic biomarker for pulmonary tuberculosis (TB) in patients with pleural effusion compared to those with non-TB pleural effusion. Methods: The study was conducted as an observational case-control on 64 patients with pulmonary TB with pleural effusion were compared to 64 non-TB subjects with pleural effusion. Result: In the TB patient group, 62.5% of patients were smokers, 46.9% of patients had been exposed to TB. Patients were assessed based on the TB symptom scale and with radiological lung examinations, either x-rays or CT scans. D-dimer levels were correlated with the TB severity. D-dimer levels above the threshold value were significantly higher in patients with severe TB symptoms. Conclusion: A direct correlation was observed between the size of radiological lung lesions and D-dimer levels. The average D-dimer level in the control group was 220 ± 60 ng/mL, which increased to 450 ± 90 ng/mL in TB patients with severe lesions.

Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca, Sisca; Parwanto, Edy; Hartanti, Monica Dwi; Tjahyadi, David
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia

Title

Found 11 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 11 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 11 Documents
Search