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Sifat Fisik Air Minum Di Desa Sukasari, Pulosari, Pandeglang, Banten (Program Tahun 2022) Edy Parwanto; David Tjahyadi; Sisca Sisca
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 8 : September (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Aims of this Pengabdian Kepada Masyarakat (PKM) to determine the physical properties of drinking water in Sukasari Village, Pulosari, Pandeglang, Banten in 2022. Furthermore, the characteristics of the drinking water are informed to residents who consume it. Knowing to the physical properties of drinking water sourced from local springs in Sukasari Village, Pulosari, Pandegalang, Banten, the public can know and implemented it to the health of the drinking water they consume. The method used is to measure the physical properties of drinking water in the form of temperature, pH, total dissolved solid (TDS), smell and color. The result of this PKM are: temperature of drinking water ranges from 26.2 - 29.4 oC, pH ranges from 5.2-5.5, and the TDS is 11 ppm. In conclusion, the physical properties of drinking water (temperature, pH, TDS, smell, and color) in Sukasari Village, Pulosari, Pandeglang, Banten can still be consumed, provided that the pH of the drinking water is slightly acidic (not neutral). Based on the physical properties of drinking water which include temperature, pH, TDS, smell, and color has a positive significance to the health of the population who consume it. The positive implication of this PKM is to clarify the factors that can change the physical properties of drinking water from drinking water sources to people's homes. The existence of drinking water reservoirs has a positive impact on the physical properties of drinking water, especially on pH stability and TDS.

Pemberdayaan Masyarakat Untuk Meningkatkan Kewaspadaan Terhadap Infeksi Strongyloides Stercoralis Di Desa Sukasari, Pulosari, Pandeglang, Banten David Tjahyadi; Edy Parwanto; Sisca Sisca
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 8 : September (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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The purpose of this PKM is to examine the rhabditiform larvae of Strongyloides stercoralis from soil samples in the yard of the residents of Sukasari, Pulosari, Pandeglang, Banten in 2022. The results of the examination which include the presence of rhabditiform larvae are used to explain to the residents. That is, so that residents understand the meaning of environmental cleanliness for their family members. Information about these rhabditiform larvae need to be known and understood that they can cause infectious diseases for their family members. The spread of rhabditiform larvae is related to habits that can cause autoinfection. Method of examination of soil samples to determine whether or not rhabditiform larvae of S. stercoralis. The result of this PKM showed that average length of S. stercoralis rhabditiform larvae is 81.13 μm. Ninety-five percent of the total samples contained S. stercoralis rhabditiform larvae. This means that the residents' yards, which are mostly soil, can be found with S. stercoralis rhabditiform larvae. The follow-up that needs to be done is to determine the prevalence of Strongyloidiasis, especially in elementary school age children and junior high school students.

Pemeriksaan Kadar Zat Pada Sumber Air Minum Di Desa Sukasari, Pulosari, Pandeglang, Banten Edy Parwanto; David Tjahyadi; Sisca Sisca
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 8 : September (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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The villages of Sukasari, Pulosari, Pandeglang, Banten are agricultural areas. Most of the residents of Sukasari Village grow rice in the rice fields, while others are traders, employees and so on. In general, residential areas are located in villages. Most people's houses are permanent, made of brick walls. In general, the village in Sukasari Village at the foot of Mount Karang has a moderate population density (not too dense). The houses in Sukasari Village generally have a yard. The working area of Sukasari Village consists of 3 hamlets, 8 RWs, 26 RTs with a population of 4,239 people. In the work area of Sukasari Village itself, there are only health facilities in the form of 1 midwife practice and 6 posyandu. Pulosari District is one of the sub-districts in Pandeglang Regency. This sub-district has an area of 27.62 km2 and has a population of 28,885 people. Pulosari District consists of 9 (nine) villages, namely Banjarnegara, Kaduhejo, Koranji, Sanghiangdedek, Cilentung, Karyawangi, Sukasari, and Sukaraja. Sukasari Village itself has an area of 4.20 km2. An unbalanced ratio between population and existing health facilities can cause health problems, because if health problems are resolved then the success of an area's development can be said to be successful. Even though we are facing the COVID-19 pandemic, we must not ignore other health problems. Therefore, we will implement a PKM program to check the quality of drinking water for residents in the Sukasari, Pulosari, Pandeglang, Banten Village areas. "We do not yet have the courage to invite residents, even for medical purposes." In connection with this, we need to convey that our PKM officers will only have 2 people to take drinking water samples from sources in RW 04 and 05 (± 20 houses). We will check the quality of the drinking water, and the results can provide input for the health of the population. Drinking water quality checks include levels of Cl, Mn, nitrate, detergent, dissolved solids, pH, organoleptics and coliform bacteria.

Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca Sisca; Edy Parwanto; Monica Dwi Hartanti; David Tjahyadi
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia

Tingkat Pengetahuan Kecacingan Di Desa Sukasari Pandeglang Tjahyadi, David; Parwanto, Edy; Ganeca Widyatama, Haryo; Sisca, Sisca; Aditya Digambiro, Reza; Pakpahan, Alfred
AMMA : Jurnal Pengabdian Masyarakat Vol. 3 No. 6 : Juli (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Worm disease still a serious problem and is second health problem in Indonesia come after malnutrition. Cumulative worms in human body can cause loss of substances that are useful for growth. The Filariasis and Worm Worms Sub-Directorate of P2PL stated that the prevalence of worm diseases in Pandeglang Regency was 58.3%. Various worm larvae were found when examining soil samples taken at the homes of residents of Sukasari, Pulosari, Pandeglang villages. The aim of this community service (PKM) is to increase knowledge about worm diseases. This Community Service Method (PKM) uses the counseling or lecture method by the presenter. Before and after counseling, residents were given a questionnaire to measure their level of knowledge about worm diseases. Residents' knowledge increased after being given counseling and it is hoped that this can help the community to prevent the emergence of worm diseases in the future.

Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca Sisca; Edy Parwanto; Monica Dwi Hartanti; David Tjahyadi
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia

Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats Tjahyadi, David; Parwanto, Edy; Sisca, Sisca; Xavierees, Endrico; Jaya Edy, Hosea; Digambiro, Reza Aditya; Oladimeji, Ashaolu Victoria; Tjahyadi, Joey Joshua Vidova; Gabrielle, Laurentia
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.

Role of sex steroid hormone on hand grip strength and cognitive function in the elderly Parwanto, Edy; Tjahyadi, David; Amalia, Husnun; Hairunisa, Nany; Edy, Hosea Jaya; Oladimeji, Ashaolu Victoria; Djebli, Noureddine
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.329-345

The aging process is associated with changes in hormone levels. There is a noticeable change in estrogen levels in women, while in men, there is a change in testosterone levels. In the elderly, as a result of the aging process, changes in these hormone levels affect handgrip strength, and cognitive function. In both women and men, the function of several organs is influenced by sex steroid hormones, namely Oestrogen and androgens. There are two theories of steroid action mechanism on target cells, namely steroid hormone action mechanism genomically and non-genomically. The function and action mechanism of steroid hormone is important because it is the basis of the hormonal aspect for muscle mass, handgrip strength, and cognitive function. Due to the aging process, hormonal changes in the elderly are different compared to the previous period. This has consequences for changes in metabolic processes that affect the body’s condition, including changes in the composition of bones, muscles, and other tissues, such as the brain. In the aging process, it is important to pay attention to nutritional factors because they contribute to hormone levels that help maintain muscle mass, body mass index, hand grip strength, and cognitive function. In the brain, the sex steroid hormone has activating and organizational effects mediated by intracellular or transmembrane G-protein-coupled receptors. Articles published in English in the last 9 years (from 2014 to 2023) were retrieved from Science Direct, PubMed, Springer link, Oxford and Nature using relevant searching terms. The fact that testosterone bioavailability is predominated in the brain in relation to its activity and significant positive association with processing speed, sustained attention, and working memory in older men. To obtain a better quality of life for the elderly, nutritional factors must be considered to maintain optimal sex steroid hormone levels, hand grip strength, and cognitive function.

Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca, Sisca; Parwanto, Edy; Hartanti, Monica Dwi; Tjahyadi, David
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia

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