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Torg ratios based on cervical lateral plain films in normal subjects Tjahjadi, David; Onibala, MZ
Universa Medicina Vol 29, No 1 (2010)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2010.v29.8-13

Stenosis of the spinal canal can be caused by trauma, degenerative processes, and tumors, causing a neurological deficit. If the neurological deficit could be detected or diagnosed earlier, the late complications such as quadriparesis could be prevented. The Torg ratio can be used to find evidence of cervical canal stenosis on lateral plain film, as it has the advantage of not being affected by magnification. The purpose of this study was to determine the Torg ratio for normal subjects using lateral plain films of cervical vertebrae. This cross-sectional study was done at the Department of Radiology FKUI/RSUPN-CM Jakarta, starting from September 16 â€“ 20, 2008. The study included 98 subjects, aged 20 â€“ 40 years, were the mean age of the subjects was 27.4 years (SD Â± 5.4). All participants were subjected to measurement of the Torg ratio by cervical lateral plain film. The mean Torg ratio of normal subjects was 0.99 for males and 1.06 for females. The mean Torg ratio of several ethnicities were 1.04 for Javanese, 1.02 for Sundanese, 1.01 for Betawi, and 0.99 for other ethnicities. The mean Torg ratio of our subjects is different from that of other people, such as Pakistanis, Singaporeans, and Koreans. The mean Torg ratios of ethnicities are not significantly different from one another. Therefore, the Torg ratio can be relied upon to predict narrowing of the cervical spinal canal in the sagittal plane.

Evaluation of the oral toxicity of formaldehyde in rats David, David; Arkerman, Hanslavina
Universa Medicina Vol 27, No 3 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.106-112

Formaldehyde is used in the production of plywood, particleboard, a wide variety of molded or extruded plastic items, and for preserving cadavers. Experimental posttest only control group design was used to determine the histopathological changes of rat stomach tissue exposed to formaldehyde for 12 weeks in thirty adult female Sprague-Dawley rats weighing 150â€“200 g. The animals were randomized into three groups, namely the control group, the treatment group given 4 mg/L of formaldehyde, and the group treated with 6 mg/L of formaldehyde. The results showed that there was a significant difference in the thickness of the mucous layer of the gastric fundus between the control group and the group treated with 6 mg/L (p = 0.011), and also a significant difference in the thickness of the mucous layer of the gastric fundus between both treatment groups (4 mg/L vs. 6 mg/L) (p = 0.003), indicating that there was necrosis of the superficial layers of the gastric mucosa due to high concentrations of formaldehyde. In histopathology sections from all groups, similar changes were observed in both treatment groups, in the form of vacuolar (hydropic) degeneration of gastric fundus glands. In conclusion, administration of formaldehyde in drinking-water for 12 weeks caused histopathologic effects on the gastric mucosa in rats.

Low testosterone level increases fasting blood glucose level in adult males Suweino Suweino; ML Eddy Parwanto; David Tjahjadi
Universa Medicina Vol. 31 No. 3 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.200-207

BACKGROUND Total testosterone (TT) levels in males decrease with age. There has been a vigorous debate on the extent to which low testosterone causally contributes to diabetes and its complications. The aim of the present study was to determine the relationship between sex hormones and blood glucose levels in adult males. METHODS A cross-sectional study involving 259 males aged 41 - 70 years was conducted at Cilandak Subdistrict, South Jakarta. Sex hormone binding globulin (SHBG) and testosterone levels were measured by means of electro–chemiluminescent immunoassay (ECLIA), while blood glucose levels were measured enzymatically using a spectrophotometer. Free testosterone index (FTI) and body massa index (BMI) were calculated. Inter-variable relationships were tested by Pearson correlation analysis, followed by multiple linear regression analysis to determine the most influential factor on fasting blood glucose levels. RESULTS BMI was positively correlated with fasting blood glucose, but the correlation was statistically not significant (r=0.105; p=0.106). In contrast, total testosterone (TT) (r=-0.258; p=0.000) and SHBG (r=-0.193; p=0.02) had a significant negative correlation with fasting blood glucose level. Multiple linear regression showed that TT was the most influential factor on fasting blood glucose level (â=-0.044; p=0.008). CONCLUSIONS Low total testosterone level may increase fasting blood glucose level in adult males. SHBG levels did not predict fasting blood glucose levels.Assessment of testosterone in middle-aged men may allow early intervention for diabetes mellitus.

PROFIL TINGKAT TEKANAN DARAH DAN PREVALENSI PENYAKIT DI DESA SUKASARI, KECAMATAN PULOSARI, PANDEGLANG David David; ML Edy Parwanto; Haryo Ganeca Widyatama; Sisca Sisca
JUARA: Jurnal Wahana Abdimas Sejahtera Volume 1, Nomor 2, Juli 2020
Publisher : Universitas Trisakti

Darah tinggi adalah kondisi kronis dimana tekanan pada arteri meningkat secara persisten. Prevalensi hipertensi di Provinsi Banten sebanyak 27,6%. Hipertensi merupakan penyebab kematian nomor tiga di Indonesia. Desa Sukasari memiliki jumlah penduduk sebanyak 4.239 orang. Fasilitas kesehatan yang terdapat di desa ini masih kurang. Dengan perbandingan tidak seimbang antara jumlah penduduk dan fasilitas kesehatan yang ada dapat sebabkan suatu masalah kesehatan. Tujuan kegiatan ini adalah untuk mengetahui profil tingkat tekanan darah dan prevalensi penyakit di Desa Sukasari sebagai gambaran kepada pihak terkait untuk dilakukan intervensi berikutnya dalam rangka membangun desa sehat. Metode pada PKM ini berupa pengobatan gratis. Dari hasil pemeriksaan oleh dokter umum didapatkan diagnosis suatu penyakit yang digunakan sebagai gambaran tingkat tekanan darah dan prevalensi tekanan darah di Desa Sukasari. Khalayak yang disasar adalah masyarakat umum di wilayah kerja Desa Sukasari yang datang. Tingkat tekanan darah pada tingkat normal yang paling banyak ditemukan. Prevalensi penyakit terbanyak adalah arthritis, dyspepsia, dan hipertensi grade II. Mayoritas tingkat tekanan darah pada tingkat normal. Jumlah penyakit terbanyak di Desa Sukasari adalah hipertensi grade II, dyspepsia, dan arthritis dengan jumlah 4 kasus. Dengan mengetahui profil tingkat tekanan darah dan prevalensi penyakit terbanyak di desa Sukasari, dapat dilakukan suatu intervensi yang terarah.

Sifat Fisik Air Minum Di Desa Sukasari, Pulosari, Pandeglang, Banten (Program Tahun 2022) Edy Parwanto; David Tjahyadi; Sisca Sisca
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 8 : September (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Aims of this Pengabdian Kepada Masyarakat (PKM) to determine the physical properties of drinking water in Sukasari Village, Pulosari, Pandeglang, Banten in 2022. Furthermore, the characteristics of the drinking water are informed to residents who consume it. Knowing to the physical properties of drinking water sourced from local springs in Sukasari Village, Pulosari, Pandegalang, Banten, the public can know and implemented it to the health of the drinking water they consume. The method used is to measure the physical properties of drinking water in the form of temperature, pH, total dissolved solid (TDS), smell and color. The result of this PKM are: temperature of drinking water ranges from 26.2 - 29.4 oC, pH ranges from 5.2-5.5, and the TDS is 11 ppm. In conclusion, the physical properties of drinking water (temperature, pH, TDS, smell, and color) in Sukasari Village, Pulosari, Pandeglang, Banten can still be consumed, provided that the pH of the drinking water is slightly acidic (not neutral). Based on the physical properties of drinking water which include temperature, pH, TDS, smell, and color has a positive significance to the health of the population who consume it. The positive implication of this PKM is to clarify the factors that can change the physical properties of drinking water from drinking water sources to people's homes. The existence of drinking water reservoirs has a positive impact on the physical properties of drinking water, especially on pH stability and TDS.

Pemberdayaan Masyarakat Untuk Meningkatkan Kewaspadaan Terhadap Infeksi Strongyloides Stercoralis Di Desa Sukasari, Pulosari, Pandeglang, Banten David Tjahyadi; Edy Parwanto; Sisca Sisca
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 8 : September (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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The purpose of this PKM is to examine the rhabditiform larvae of Strongyloides stercoralis from soil samples in the yard of the residents of Sukasari, Pulosari, Pandeglang, Banten in 2022. The results of the examination which include the presence of rhabditiform larvae are used to explain to the residents. That is, so that residents understand the meaning of environmental cleanliness for their family members. Information about these rhabditiform larvae need to be known and understood that they can cause infectious diseases for their family members. The spread of rhabditiform larvae is related to habits that can cause autoinfection. Method of examination of soil samples to determine whether or not rhabditiform larvae of S. stercoralis. The result of this PKM showed that average length of S. stercoralis rhabditiform larvae is 81.13 μm. Ninety-five percent of the total samples contained S. stercoralis rhabditiform larvae. This means that the residents' yards, which are mostly soil, can be found with S. stercoralis rhabditiform larvae. The follow-up that needs to be done is to determine the prevalence of Strongyloidiasis, especially in elementary school age children and junior high school students.

Pemeriksaan Kadar Zat Pada Sumber Air Minum Di Desa Sukasari, Pulosari, Pandeglang, Banten Edy Parwanto; David Tjahyadi; Sisca Sisca
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 8 : September (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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The villages of Sukasari, Pulosari, Pandeglang, Banten are agricultural areas. Most of the residents of Sukasari Village grow rice in the rice fields, while others are traders, employees and so on. In general, residential areas are located in villages. Most people's houses are permanent, made of brick walls. In general, the village in Sukasari Village at the foot of Mount Karang has a moderate population density (not too dense). The houses in Sukasari Village generally have a yard. The working area of Sukasari Village consists of 3 hamlets, 8 RWs, 26 RTs with a population of 4,239 people. In the work area of Sukasari Village itself, there are only health facilities in the form of 1 midwife practice and 6 posyandu. Pulosari District is one of the sub-districts in Pandeglang Regency. This sub-district has an area of 27.62 km2 and has a population of 28,885 people. Pulosari District consists of 9 (nine) villages, namely Banjarnegara, Kaduhejo, Koranji, Sanghiangdedek, Cilentung, Karyawangi, Sukasari, and Sukaraja. Sukasari Village itself has an area of 4.20 km2. An unbalanced ratio between population and existing health facilities can cause health problems, because if health problems are resolved then the success of an area's development can be said to be successful. Even though we are facing the COVID-19 pandemic, we must not ignore other health problems. Therefore, we will implement a PKM program to check the quality of drinking water for residents in the Sukasari, Pulosari, Pandeglang, Banten Village areas. "We do not yet have the courage to invite residents, even for medical purposes." In connection with this, we need to convey that our PKM officers will only have 2 people to take drinking water samples from sources in RW 04 and 05 (± 20 houses). We will check the quality of the drinking water, and the results can provide input for the health of the population. Drinking water quality checks include levels of Cl, Mn, nitrate, detergent, dissolved solids, pH, organoleptics and coliform bacteria.

Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca Sisca; Edy Parwanto; Monica Dwi Hartanti; David Tjahyadi
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia

Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca Sisca; Edy Parwanto; Monica Dwi Hartanti; David Tjahyadi
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia

Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats Tjahyadi, David; Parwanto, Edy; Sisca, Sisca; Xavierees, Endrico; Jaya Edy, Hosea; Digambiro, Reza Aditya; Oladimeji, Ashaolu Victoria; Tjahyadi, Joey Joshua Vidova; Gabrielle, Laurentia
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.

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