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All Journal Pharmaciana: Jurnal Kefarmasian MPI (Media Pharmaceutica Indonesiana)
Herdianti, Nita
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Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Hubungan Penggunaan Kombinasi Antihipertensi Dengan Luaran Neonatal pada Pasien Preeklamsia Awaludin, Adila; Nurzaman, Mochamad Herdi; Annisa; Herdianti, Nita
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.6072

Abstract

Hipertensi selama kehamilan meningkatkan risiko terjadinya komplikasi maternal. Preeklamsia merupakan komplikasi yang umumnya paling sering terjadi selama masa kehamilan. Komplikasi pada masa kehamilan berdampak pada pemburukan luaran neonatal. Manajemen terapi yang tepat pada pasien preeklamsia dihubungkan dengan luaran neonatal yang lebih baik. Tujuan dari penelitian ini adalah untuk menggambarkan penggunaan antihipertensi pada pasien preeklamsia pada fasilitas kesehatan sekunder di Tasikmalaya dan menilai hubungan antara pemberian kombinasi antihipertensi dengan luaran neonatal yang dihasilkan. Penelitian ini merupakan studi multisenter menggunakan desain potong lintang secara retrospektif dari Juli 2018-Juni 2023. Selama periode penelitian didapat 88 pasien bersalin dengan diagnosa preeklamsia yang memenuhi kriteria inklusi dan eksklusi. Metildopa, nifedipin, dan amlodipin merupakan antihipertensi yang digunakan pada populasi studi dimana kombinasi antihipertensi yang digunakan diantaranya adalah kombinasi amlodipin dengan metildopa atau nifedipin dengan metildopa. Pada populasi studi, metildopa merupakan antihipertensi yang paling sering digunakan. Hasil analisis menunjukkan bahwa tidak terdapat hubungan antara penggunaan kombinasi antihipertensi dengan luaran neonatal. Namun, pasien dengan terapi kombinasi antihipertensi memiliki prevalensi lebih tinggi untuk luaran neonatal yang tidak diinginkan. Hypertension during pregnancy increases the risk of maternal complications. Preeclampsia is the most common complication that appears during pregnancy. Complications during pregnancy had a poor impact on neonatal outcomes. Appropriate therapy management in preeclampsia patients is suggested to improve neonatal outcomes. This study aimed to describe the use of antihypertensives in preeclampsia in Tasikmalaya and assess the association between the combination of antihypertensives with neonatal outcomes. This was a multi-center study with a cross-sectional design retrospectively from July 2018 to June 2023. In the study period, 88 maternal deliveries with preeclampsia met the inclusion and exclusion criteria. Methyldopa, nifedipine, and amlodipine were used in the study population whereas amlodipine with metildopa or nifedipine with metildopa were the option of antihypertensive combination. In the study population, metildopa was the most frequently used antihypertensive. The analysis results showed there was no association between using a combination of antihypertensives and neonatal outcomes. However, patients treated with combination antihypertensive had a higher prevalence of unfavorable neonatal outcomes.
Ethanol solvent and pH effect on antioxidant activity of purple sweet potato (Ipomoea batatas L.) Nurzaman, Mochamad Herdi; Adlina, Salsabila; Herdianti, Nita; Amin, Saeful
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.30406

Abstract

Air pollution induces the production of reactive oxygen species (ROS), which can cause tissue damage when excessive. Antioxidants help counteract this damage, and purple sweet potatoes, rich in anthocyanins, are a promising natural antioxidant source. This study aimed to determine the effect of solvent acidity variations on the antioxidant activity of purple sweet potato (PSP) tuber extract and identify the optimal pH condition. Using the DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging assay, ethanol solvents at different pH levels (non-acidified ethanol, pH 2.5, pH 2, and pH 1.5) were tested. The results showed that higher acidity enhanced antioxidant activity, with the strongest activity observed at pH 1.5, yielding an IC50 value of 9.74±0.23 ppm. Although less potent than Vitamin C (IC50 1.22±0.04 ppm), the extract demonstrated significant potential as a natural antioxidant source. Further studies on anthocyanin content are recommended to better understand its contribution to antioxidant activity.
Co-Authors Adila Awaludin Annisa Mochamad Herdi Nurzaman Saeful Amin, Saeful Salsabila Adlina