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All Journal Majalah Kedokteran Bandung Global Medical and Health Communication Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Kesehatan Panrita Husada JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Jurnal Implementa Husada Jurnal Ilmiah Wahana Pendidikan Muhammadiyah Medical Journal Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Jurnal Pandu Husada

Isra Thristy

Universitas Muhammadiyah Sumatera Utara

Author-ID : 806229

Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Prostat Spesifik Antingen Isra Thristy
Buletin Farmatera Vol 1, No 1 (2016)
Publisher : Universitas Muhammadiyah Sumatera Utara

PendahuluanKelenjar prostat merupakan salah satu organ yang hanya terdapat pada pria. Salah satu gangguan pada kelenjar prostat adalah keganasan kelanjar prostat dan penyebab kanker kelenjar prostat belum diketahui secara pasti. Faktor resikonya meningkat dengan bertambahnya usia (biasanya terjadi pada usia 50 tahun keatas). Selain itu, faktor resiko lain adalah adanya riwayat penyakit keluarga. Salah satu cara untuk mendeteksi adanya keganasan adalah dengan pemeriksaan Prostat Spesifik Antigen (PSA) yaitu suatu molekul glikoprotein yang dihasilkan di kelenjar prostat.

Efektivitas Ekstrak Etanol Daun Afrika (Vernonia Amygdalina Del.) sebagai Obat Antikolesterol pada Tikus Jantan Galur Wistar yang Diinduksi Kuning Telur Nuryani Nuryani; Yufi Yuwarditra; Sigit Kurniawan; Isra Thristy
Buletin Farmatera Vol 3, No 3 (2018)
Publisher : Universitas Muhammadiyah Sumatera Utara

Abstrak: Daun Afrika mengandung senyawa berupa senyawa flavonoid, saponin dan tannin untuk menurunkan kadar kolesterol. Daun Afrika banyak digunakan sebagai pengobatan alternatif hiperkolesterolemia. Daun Afrika diharapkan dapat menurunkan kadar kolesterol secara efektif sehingga dapat mencegah terjadinya penyakit jantung koroner. Tujuan penelitian untuk membandingkan efektivitas ekstrak etanol daun Afrika (Vernonia amygdalina Del.) dengan simvastatin pada tikus jantan galur wistar yang diinduksi kuning telur. Penelitian ini menggunakan metode eksperimental dengan rancangan Pre and Post Test Controlled Group Design, yaitu jenis penelitian yang melakukan pengamatan pada dua kelompok (kontrol dan perlakuan) yang dilakukan sebelum dan sesudah tindakan. Penelitian ini menggunakan tikus putih (Rattus novergicus) sebanyak 30 tikus yang dibagi menjadi 5 kelompok. Setiap kelompok terdiri dari 5 tikus, dengan 1 cadangan tikus masing-masing kelompok. Penelitian ini menggunakan 500 lembar daun Afrika dan kuning telur. Data yang diperoleh akan diuji menggunakan analisis data uji Oneway ANOVA dan uji Post Hoc. Uji Oneway ANOVA (Analysis of Variant) digunakan untuk membandingkan rata-rata lebih dari 2 kelompok, sedangkan uji Post Hoc digunakan untuk membandingkan rata-rata antara 2 kelompok. Hasil uji ANOVA, ada jumlah yang signifikan antara kelompok perlakuan satu, dua dan tiga kelompok perlakuan dengan p= ,002 (P<0,05). Simpulan, ekstrak etanol Vernonia amygdalina, simvastatin dan kombinasi simvastatin dengan ekstrak etanol Vernonia amygdalina dapat menurunkan kadar kolesterol total pada tikus.Kata kunci: Vernonia amygdalina, kolesterol total, simvastatin

HUBUNGAN POLIMORFISME GEN ANGIOTENSIN CONVERTING ENZYME DENGAN PERBAIKAN FRAKSI EJEKSI VENTRIKEL KIRI PADA PASIEN GAGAL JANTUNG KRONIK Handayani, Ahmad; Thristy, Isra; Andina, Meizly
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5549

Angiotensin-converting enzyme (ACE) is a circulating and membrane-bound enzyme in the renin-angiotensin system. Polymorphism is the presence of two or more alleles at a locus in a population. In patients with heart failure with impaired systolic function, the RAA system is activated. One of the main therapies in heart failure is the administration of angiotensin-converting enzyme blockers. This study aims to examine the relationship between angiotensin-converting enzyme gene polymorphisms with improvement in left ventricular ejection fraction (FEVK).This research is a prospective observational study using a convenient sampling technique, carried out at Mitra Medika Hospital Bandar Klippa, Deli Serdang. The number of samples in the study was 37 people. Each patient was examined for initial echocardiography and at least 1 month after treatment when clinical improvement was seen. All patients received treatment according to the standard guidelines for the management of chronic heart failure according to the European Society of Cardiology (ESC)/Indonesian Cardiovascular Specialist Doctors Association (PERKI). The majority of research subjects were male as much as 81% and the average age of the patients was 56 years. ACE gene polymorphism was dominated by gene II as much as 57%. The average FEVK value in the first measurement was 25.8% and in the second measurement, it increased to 34.4%. There was a significant change between FEVK I measurements by an average of 25% to 34% in the next measurement (p 0.05). In the analysis of the relationship, it was seen that the ACE gene polymorphism did not affect the improvement of the FEVK value.Treatment of chronic heart failure with a decrease in ejection fraction was seen to have a significant effect in increasing FEVK. There is no relationship between angiotensin-converting enzyme gene polymorphisms on response to therapy in patients with chronic heart failure in this study.

Relationship between Polymorphism of Angiotensin Converting Enzyme Gene with Symptoms of Depression in Schizophrenic Patients Nuralita, Nanda Sari; Thristy, Isra; Lubis, Debby Mirani
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.9483

In schizophrenic patients, symptoms of depression are often found which can lead to adverse effects on the treatment process, such as increasing the length of treatment, increasing the possibility of relapse, non-adherence in taking medication, and can also lead to suicide in schizophrenic patients. In schizophrenic patients, the activity of the central angiotensin converting enzyme (ACE) gene is altered and angiotensin II interacts with central dopamine, thereby contributing to the pathophysiology of schizophrenia. In addition, it is likely that the ACE gene variant is also involved in the development of depressive symptoms in schizophrenic patients. This research is a categorical analytic study with a cross sectional method, the sampling method is non-probability sampling with consecutive sampling type, with a total sample of 42 people. There was no significant difference between depression symptoms and ACE gene polymorphisms with P value = 0.746. There was no significant difference between depression symptoms and ACE gene polymorphisms.

The Relationship Between Anthropometric Measurements and Low-Density Lipoprotein (LDL) Levels in Women Aged 30-50 Years Harahap, Shofiah Rahmah; Thristy, Isra
Buletin Farmatera Vol 10, No 1 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i1.24413

Abstract: Nutritional status is known to influence low-density lipoprotein (LDL) levels. It can be assessed by measuring body mass index (BMI), waist circumference (WC), and mid-upper arm circumference (MUAC). Individuals with obesity are at greater risk of having elevated LDL levels compared to those with normal nutritional status. In women, hormonal changes, particularly during menopause, can affect lipid metabolism and contribute to higher LDL levels. This study aimed to examine the correlation between BMI, WC, and MUAC with LDL levels in women aged 30-50 years. This descriptive-analytical study used a cross-sectional design involving 38 females’ subjects aged 30-50 years old. Anthropometric measurements and LDL levels were recorded. Pearson’s correlation test was used for data analysis. The results showed a weak but statistically significant positive correlation between BMI and LDL (p = 0,034, r = 0,344), WC and LDL (p= 0,035, r=0,344), and MUAC and LDL (p = 0,046, r = 0,326). This study found a correlation between BMI, WC, and MUAC on LDL levels.

Perbandingan Penggunaan Antipsikotik Atipikal Tunggal Dan Antipsikotik Atipikal Kombinasi Terhadap Kadar Ldl Pada Pasien Skizofrenia Toniara, Safriwan; thristy, Isra; Nuralita, Nanda Sari
Buletin Farmatera Vol 11, No 3 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v11i3.28213

Abstract: Schizophrenia is a collection of psychotic disorders with irregularities in the thought process, which have the feeling that they are controlled by external forces, delusions, perceptual disorders and abnormal effects integrated with real situations or reality. The use of antipsychotics in schizophrenic patients is the treatment of this disease, especially the most commonly used atypical antipsychotic users. This study aims to compare LDL (low-density lipoprotein) levels in schizophrenia patients who use single atypical antipsychotics and combination atypical antipsychotics at Madani Hospital Medan, North Sumatra. This type of research is descriptive analytical using a cross-sectional method that takes data on variable-free bound variables at one time, which is housed at the Upt Health Laboratory. North Sumatra Provincial Health Office. The results of the Independent T-Test of the use of single antipsychotics and a combination of atypical antipsychotics on LDL levels in schizophrenia patients were p=0.001 (P≤0.05). There was a significant difference between the administration of a single atypical antipsychotic and a combination of atypical antipsychotics to LDL levels in patients with schizophrenia.

Co-Authors ADINDA . Ahmad Handayani Amelia Eka Damayanti Amelia Eka Damayanty Ance Roslina Andi Ipaljri ANDRE PRAMUDIA KRISNA Br. Sembiring, Tiara Amanda Cut Mourisa Cut Mutia Mampatdi Damanik, Syifa Akbar DESI ELISA FLOWER Dorando, Raja Mahendra Putra Eka Damayanty, Amelia ELMEIDA EFFENDY ELVIANI . Fathinia Masyulani Harahap, Shofiah Rahmah Hasibuan, Hijriyah Putri Tarmizi Hutagaol, Nadya Utami IRFAN HAMDANI Koto, Ulfa Lubis, Debby Mirani Lubis, Eva Sahnita Meizly Andina, Meizly MUHAMMAD AULIA RAHMAN Muhammad Edy Syahputra Nasution Muhammad Fajar Muhammad Jalaluddin Assuyuthi Chalil Muhammad Zulfikar Karim Chan Noval, Wildana Luthfi Nuralita, Nanda Sari Nurfadly, Nurfadly Nuryani Nuryani Nuryani Yani Oche Axena Yulhan Octaliana Sihaloho POPI LATIFAH BAWEAN Pratiwi, Annisa Nola Prayoko, Herdianto PUTRI NADIA Putri, Humairani Putri, Maduri Yaner Rahmi Sibagariang Rina Sari Mardia Rita Zahara, Rita ROJU LUBIS Saleha, Imamah Maratu Sari, Ria Wilan Permata Sigit Kurniawan TARISA ANANDASMARA Toniara, Safriwan Tria Tiurma Lestari Yahwardiah Siregar Yenita . Yenita Yenita Yufi Yuwarditra YUFI YUWARDITRA

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