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Journal : JURNAL ILMIAH SIMANTEK

PERBANDINGAN EFEKTIVITAS JUS BUAH TOMAT (LYCOPERSICUM ESCULANTUM MILL.) DENGAN JUS BUAH JAMBU BIJI MERAH (PSIDIUM GUAJAVA L.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL PADA TIKUS PUTIH JANTAN YANG DIINDUKSI KUNING TELUR MUHAMMAD AULIA RAHMAN; IRFAN HAMDANI; ISRA THRISTY; MUHAMMAD JALALUDDIN ASSUYUTHI CHALIL
JURNAL ILMIAH SIMANTEK Vol 3 No 3 (2019): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Communities have an unhealthy lifestyle that leads to an increase in total cholesterol levels. Tomato juice (Lycopersacum esculentum M.) and red guava (Psidium guajava L.) contain lycopene which is high enough of antioxidant that can lower blood cholesterol levels. Methods: This study was experimental using pretest posttest with control group design. White rat (Rattus norvegicus L.) male 24 wistar strain induced egg yolk 6.25gr / kgBW, grouped into 4, negative controls were given distilled water, positive control was given egg yolk, one treatment was given tomato juice 3 cc and two treatment was administered 3 cc red guava fruit juice for 2 weeks then blood was taking for 3 times, pretest, intervention and posttest. Result: the average of total cholesterol level posttest negative control group, positive control, one treatment and two treatment respectively 64,82 mg / dl, 78,48 mg / dl, 61,24 mg / dl, 41,81 mg / dl . ANOVA test results showed that there was a significant difference between posttest intervention of treatment group one and treatment group two with p = 0,021 and 0,000 (p <0,05). Conclusion: The provision of tomato juice and red guava juice can reduce total cholesterol levels of rats. Red Guava juice is more effective to lower total cholesterol of rats.
PERBANDINGAN EFEKTIVITAS EKSTRAK ETANOL DAUN AFRIKA (VERNONIA AMYGDALINA DEL.) DENGAN SIMVASTATIN TERHADAP KADAR HDL PADA TIKUS JANTAN GALUR WISTAR YANG DIINDUKSI KUNING TELUR YUFI YUWARDITRA; ISRA THRISTY
JURNAL ILMIAH SIMANTEK Vol 5 No 1 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Egg yolk is a food that contains a lot of lipids so that it can cause dyslipidemia which is characterized by a decrease in HighDensity Lipoprotein (HDL). In overcoming this, simvastatin are often used therapies. Indonesian people are starting to worryabout the side effects of treatment using chemicals. Using many traditional medicinal herbs. One type of plant used is Africanleaves (Vernonia amygdalina Del.). To study the interaction of African leaf ethanol extract (Vernonia amygdalina Del.) withsimvastatin on HDL levels in wistar strain male rats induced by egg yolk. This study was an experimental study with thePosttest method with a control group design. This study uses test animals male white rats Wistar (Rattus novergicus) whichwill be divided into 5 groups and using Oneway ANOVA test data analysis. From the results of data analysis, the averagevalue of HDL extract of African leaf ethanol obtained was 72.6; simvastatin 75,8 and a combination of ethanol extract ofAfrican leaves with simvastatin 81,6. Oneway ANOVA analysis showed (p <0.05). Giving ethanol extract of African leaves,simvastatin and Combination of extracts Ethanol leaves of Africa with simvastatin did not differ in increasing HDL levels ofmice.
KARAKTERISTIK PADA ANAK DOWN SINDROM DI SLB NEGRI PEMBINA MEDAN ADINDA .; ISRA THRISTY
JURNAL ILMIAH SIMANTEK Vol 5 No 4 (2021): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Down syndrome is a genetic disorder caused by chromosomal abrasion which causes the baby to have an excess of 1chromosome on chromosome 21, can be recognized by specific physical signs, IQ intelligence level is below normal andbelongs to the group of mental retardation. This type of research is quantitative descriptive with a cross sectional design,data collection is taken once, to determine the characteristics of children with Down syndrome at SLB E Negri PembinaMedan. The highest proportion of Down Syndrome children based on the sociodemography of Down Syndrome childrenaged 6-10 years (63%), based on male sex 11 people (40.7%), based on education level 27 elementary school students(100%), based on Most children diagnosed with Down syndrome were after birth as many as 25 people (92.6%), based onfamily ancestry without previous Down syndrome as many as 24 people (88.9%), Clinical symptoms that often appear inchildren with Down syndrome are slanted eyes, ears small and low position, short neck, short fingers and toes, 2 finger littlefinger, wide thumb and forefinger distance of 27 people (100%). Children with down syndrome are mostly affected by themale sex. male, aged 6-10 years, with elementary school education, many children with Down syndrome are diagnosed afterbirth, and do not have children in the family.