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All Journal Media Farmasi Indonesia International Journal of Medicine and Health Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) International Journal of Health, Engineering and Technology Jurnal Pengabdian Masyarakat dan Riset Pendidikan
Niken Luthfiyanti
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary Other

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Relationship Between Appropriateness Of Medicine Selection And Therapy Outcome In Outpatients Of Hypertension At Dr. Moewardi Surakarta Hospital Shela Novita Devi; Niken Luthfiyanti; Kharisma Jayak Pratama; Tiara Ajeng L
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.280

Abstract

Hypertension is a degenerative disease characterized by blood pressure that exceeds the standard limit of >140/90 mmHg, which can cause diseases such as heart, eyes, kidneys, brain and blood vessels. Drug selection is one of the factors that is very important because it can help the success of therapy. The purpose of this study was to determine the relationship between the accuracy of drug selection and therapeutic outcomes in outpatient hypertension patients at Dr Moewardi Surakarta Hospital using 100 medical record data with retrospective study and using data analysis techniques in the form of univariate test methods, bivariate tests and chi-square tests . The results showed that patients who received treatment with the suitable indication, right drug, correct dose and proper patient criteria were Ninety-two patients (92%). The relationship between the accuracy of drug selection and therapeutic outcomes in outpatient hypertension patients at RSUD Dr Moewardi Surakarta shows a p-value of 0.030 (p <0.05), so Ho is rejected, meaning that there is a significant relationship in the accuracy of antihypertensive drug selection with therapeutic outcomes in the form of achieving blood pressure targets based on JNC VIII in 2014.
Relationship of Medication Adherence to Clinical Outcome in Patients Type 2 Diabetes with Modified Morisky Adherence Scale 8 (MMAS 8) Niken Luthfiyanti; Ardi Setyawan; Kharisma Jayak Pratama
International Journal of Medicine and Health Vol. 3 No. 4 (2024): Desember : International Journal of Medicine and Health (IJMH)
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v3i4.4547

Abstract

Diabetes melitus is a chronic condition desease that requires continued use of medication. High adherence to treatment will produce good clinical results and play a role in improving the quality of life of diabetes melitus sufferers. The following research aims to assess the relationship between adherence to medication use and clinical outcomes for patients with type 2 diabetes mellitus at RSUD DR. Moewardi Surakarta which was conducted in the period April – June 2024. This research used a cross sectional method with a total of 98 patients as respondents who met the inclusion and exclusion criteria. Adherence data was assessed using the Modified Morisky Adherence Scale 8 (MMAS 8) questionnaire, and clinical outcomes were assessed from fasting or fasting blood glucose values ​​and %HbA1C from medical record data. Analysis of the relationship between adherence and clinical outcomes using chi-square. The results of the level of treatment compliance can be divided into 3 categories, namely: high treatment compliance has a percentage of 24.5%, moderate treatment compliance has a percentage of 46.9%, and low treatment compliance has a percentage of 28.6%. Clinical outcomes were achieved by 38.8% and not achieved by 62.2%. There is a relationship between adherence medication and therapeutic outcomes in type 2 diabetes melitus patients with a Pearson chi square value of 0.011. Based on these data, pharmacist professionals need to place greater emphasis on adherence with medication use in type 2 diabetes mellitus patients to obtain good clinical outcomes.
Uji Aktivitas Antioksidan Ekstrak Metanol dan Fraksi Kulit Buah Markisa Konyal (Passiflora Ligularis Juss) dengan Metoda DPPH: Penelitian Meli Oktavia; Kharisma Jayak Pratama; Niken Luthfiyanti
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 3 No. 4 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 3 Nomor 4 (April 2025
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v3i4.845

Abstract

Antioxidants are compounds that can absorb or neutralize free radicals so that they can ward pff disease. Free radicals are foreign compounds that enter the body and damage the body’s immune system. Konyal passion fruit seeds (Passiflora ligularis Juss) have been widely used as passion fruit juice. Konyal passion fruit skin is a waste that can be used as a natural medicine. This study aims to determine the antioxidant activity of methanol extract and passion fruit skin fraction (Passiflora ligularis Juss) with the DPPH method using UV-VIS spectrophotometry at a maximum absorption wavelength of 517 nm with vitamin C as a comparator. The antioxidant activity test obtained IC50 Vitamin C : 3,054 µg/mL, IC50 methanol extract : 222,5 µg/mL, IC50 n-hexane fraction : 93,71 µg/mL, IC50 ethyl acetate fraction : 205,29 µg/mL and IC50 water fraction 124,76 µg/mL. Based on the IC50 value, it can be concluded that the antioxidant activity of the methanol extract is in the weak category, the n-heksan fraction is in te strong category, the ethyl acetate fraction is in the weak category and the water fraction is in the medium category.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Lulur Body Scrub Ekstrak Daun Kelor (Moringa oleifera) dengan Metode DPPH: Pengabdian Silvia Mawardani; Tiara Ajeng Listyani; Niken Luthfiyanti
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 4 No. 1 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 4 Nomor 1 (Juli 2025 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v4i1.2824

Abstract

Moringa leaves (Moringa oleifera) are rich in various components of active substances, namely tannins, steroids, triterpenoids, flavonoids, saponins, anthraquinones, and alkaloids. Moringa leaves also contain minerals, essential amino acids, antioxidants, and vitamins. The content of the moringa plant that is efficacious as an antioxidant was found in the leaves, namely the content of vitamin E. Antioxidants are substances that are able to prevent or delay free radical reactions that occur in the lipid oxidation process. This study aimed to determine whether moringa leaf ethanol extract could be made into body scrub preparations that met physical quality standards, to determine the antioxidant activity of moringa leaf extract body scrub preparations, and to determine the concentration of body scrub preparations that were best used as antioxidants. In this study, the DPPH method (1,1-diphenyl-1-picrylhydrazyl) was used, and the extraction method was carried out using the maceration method. The extract was formulated with concentrations of 15%, 25%, and 35%, respectively. The evaluations used in this study included organoleptic test, homogeneity test, pH test, dispersion test, irritation test, and hedonic test. The results of this study showed that the best formulation of moringa leaf extract body scrub (Moringa oleifera) was the 35% formula with an IC₅₀ value of 62.120 μg/ml, categorized as having strong antioxidant activity.
Analysis of Phenolic Content, Flavonoids, and α-Amylase Enzyme Inhibition Activity of Ethanol Extracts and Clove Stem Fractions (Syzygium aromaticum L.) Oktafia Nur Fatimah; Niken Luthfiyanti; Danang Raharjo
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from impaired insulin secretion, insulin action, or both. The condition is associated with severe long-term complications, including cardiovascular disease, nephropathy, neuropathy, and retinopathy, making effective management strategies crucial. One therapeutic approach is the inhibition of the α-amylase enzyme, which plays a key role in the hydrolysis of complex carbohydrates into glucose, thereby controlling postprandial blood sugar levels. Natural products containing bioactive compounds such as phenolics and flavonoids are increasingly being investigated as safer alternatives to synthetic drugs. Clove stalks (Syzygium aromaticum L.), an underutilized byproduct of the clove plant, are known to be rich in these compounds and may serve as a potential natural enzyme inhibitor. This study aimed to analyze the phenolic and flavonoid content as well as α-amylase inhibitory activity of ethanol extract and its fractions (n-hexane, ethyl acetate, and water) obtained from clove stalks. Extraction was carried out using maceration with 70% ethanol, followed by fractionation and analysis with UV-Vis spectrophotometry. The ethanol extract exhibited the highest phenolic and flavonoid levels (44.581 mg GAE/g and 50.491 mg QE/g, respectively), while the ethyl acetate fraction demonstrated the strongest α-amylase inhibitory activity with an IC₅₀ value of 26.303 µg/mL. These findings suggest that the ethyl acetate fraction of clove stalks has promising potential as a natural antidiabetic agent, supporting its development as an alternative functional ingredient in diabetes management.
Uji Efek Tonikum Ekstrak Etanol Kombinasi Temu Putih (Curcuma zedoaria) dan Temu Hitam (Curcuma aeruginosa) terhadap Mencit Putih Jantan (Mus musculus) Afina Rachmalia Artha Aryasuta; Niken Luthfiyanti; Kharisma Jayak Pratama
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6738

Abstract

Tonic is a preparation thats can stqrengsthen the body and improve stamina. Curcuma zedoaria and Curcuma aeruginosa are known to have phytochemical compunds such as flavonoids, alkaloids, saponins, tannin, triterpenoids, curcuminoid and polyphenols that can function as stimulant and tonics. This studiy aimed to investigate tonic effects of ethanolic extracts of Curcuma zedoaria, ethanolic extract of Curcuma aeruginosa, and their combinations on male white mice (Mus musculus). Curcuma zedoaria rhizome and Curcuma aeruginosa rhizome were extracted using the maceration method for 3 days using 70% ethanol solvent which was then thickened in a waterbath. A total of 35 male mice were divided into 7 groups with different treatments, including negative control (aquadest), positive control (caffeine 100 mg/kgBB), ethanolic exctract of Curcuma zedoaria (600 mg/kgBB), ethanolic extract of Curcuma aeruginosa (600 mg/kgBB), and combination ethanolic extract of Curcuma zedoaria and Curcuma aeruginosa at dosage of 150:450 mg/kgBB, 300:300 mg/kgBB, and 450:150 mg/kgBB. Tonic effect were evaluated using natatory exhaustion and rotarod tests. The natatory exhaustion test is carried out by observing how long the mice swim, while the rotarod test is carried out by observing how long the mice stay on the rotarod apparatus. The data analyzed using ANOVA and Tukey’s test. The results of One Way Anova showed a there were significansts differensce in each groups (p<0,05) with combination of Curcuma zedoaria : Curcuma aeruginosa (150:450 mg/kgBB) yielding the best tonic effect. From the result of Tukey’s followsup test, it showed that the highers the dosae of Curcuma aeruginosa rhizome extracts the better the tonics effects giiven. This suggest that Curcuma aeruginosa has a dominant role in enhancing phsycal endurance in male white mice.
Uji Aktivitas Antioksidan dan Penentuan Nilai Sun Protection Factor (SPF) Sediaan Lip Balm Ekstrak Kayu Secang (Caesalpinia Sappan L.) Nugrahaeni Ayuningtyas; Niken Luthfiyanti; Bangkit Riska Permata
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6755

Abstract

Sappan wood (Caesalpinia sappan L.) is known to contain various bioactive compounds such as saponins, tannins, flavonoids, phenols, brazilin, and gallic acid. These compounds play an important role as antioxidants that can ward off free radicals and absorb UVA and UVB radiation that are harmful to the skin. Ultraviolet radiation is known to accelerate premature aging and cause tissue damage, so a topical formulation is needed that can provide protection while maintaining skin health. This study aims to determine the antioxidant activity and sunscreen ability of sappan wood extract in the form of lip balm with varying extract concentrations. Antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method, while the Sun Protection Factor (SPF) value was determined by the Mansyur method using UV-Vis spectrophotometry. Sappan wood extract was formulated into four lip balm preparations, namely F0 (control without extract), F1 (5%), F2 (10%), and F3 (15%). Physical tests including homogeneity, pH, spreadability, adhesiveness, and organoleptic were conducted to ensure the quality of the preparation. The results showed that sappanwood extract had an IC50 value of 23.62 ppm which was categorized as very strong antioxidant activity. In the lip balm formulation, the IC50 values ​​obtained were F0 = 246.76 ppm (very weak), F1 = 92.68 ppm (strong), F2 = 78.03 ppm (strong), and F3 = 63.58 ppm (strong). The SPF test showed a protection value of F0 = 2.11 (minimum), F1 = 13.64 (maximum), F2 = 14.25 (maximum), and F3 = 18.28 (ultra). Thus, lip balm made from sappanwood extract has the potential as a cosmetic preparation that not only meets physical criteria, but also provides high antioxidant activity and effective sunscreen protection.
Co-Authors Afina Rachmalia Artha Aryasuta Ardi Setyawan Bangkit Riska Permata Danang Raharjo Kharisma Jayak Pratama Listyani, Tiara Ajeng Meli Oktavia Nugrahaeni Ayuningtyas Oktafia Nur Fatimah Shela Novita Devi Silvia Mawardani Tiara Ajeng L