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All Journal Pharmasipha Jurnal Delima Harapan Jurnal Farmasi Indonesia PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Jurnal Kesehatan Tambusai Jurnal Ilmiah Wahana Pendidikan Proceedings of the International Conference on Nursing and Health Sciences JURNAL JAMU KUSUMA Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional Jurnal Ilmiah Kesehatan Jurnal Medika Nusantara Parapemikir Jurnal Ilmiah Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Sains dan Kesehatan Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) Science and Community Pharmacy Journal Jurnal Ilmiah Farmasi Indonesia (JIFIN)
Listyani, Tiara Ajeng
Universitas Duta Bangsa Surakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Analisis Docking Molekuler Senyawa Derivat Phthalimide sebagai Inhibitor Non-Nukleosida HIV-1 Reverse Transcriptase Tiara Ajeng Listyani; Rina Herowati
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.258 KB) | DOI: 10.31001/jfi.v15i2.445

Abstract

Phthalimide derivate compounds was reported as a new class of nonnucleoside reverse tranckriptase inhibitors. Docking molekuler analysis in phthalimide derivative compounds against reverse transcriptase enzym necessary to determine the affinity and interaction patterns between the above compounds with reverse transcriptase enzym. Derived compounds phthalimide geometry optimized using VegaZZ software then performed by way of target preparation, ligand preparation, docking method validation, and analysis of docking using PyRx-Python0.8 - AutoDock vina so we get to the target ligand interactions, free energy bonding, hydrogen bonding, and interaction patterns. Interaction pattern seen in thirty-three phthalimide derivatives with reverse transcriptase enzym showed hydrogen bonding with amino acids Lys101 where the interaction is similar to the interaction of TIBO R 86183 compounds which are the original ligands of the target protein.
In Silico Adme and Toxicity Studies of Derivative Phthalimide Compounds as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Tiara Ajeng Listyani; Fazlin Fauzi; Ariyanti Ariyanti; Tatiana Siska Wardani
Proceedings of the International Conference on Nursing and Health Sciences Vol 3 No 1 (2022): May 2022
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v3i1.1109

Abstract

Phthalimide derivate compounds was reported as a new class of nonnucleoside reverse tranckriptase inhibitors. The aim of this research is to determine the prediction of absorption, distribution, metabolism, and excretion (ADME) as well as the toxicity test of phthalimide-derived compounds which have the best potential as HIV-1 reverse transcriptase enzyme inhibitors. This study used an in silico approach to predict oral bioavailability and toxicity. The prediction of the ADME in this study using SwissADME which is run online where thirty-three phthalimide derivate compounds have molecular weight, hydrogen donor and acceptor bond, and log P ​​that meet the criteria of Lipinski Rules. Prediction of toxicity ​​in this study using in silico method with Toxtree v1.60 and it is known that phthalimide derivate compounds are not carcinogenic and mutagenic.
In Silico Adme and Toxicity Studies of Derivative Phthalimide Compounds as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor Tiara Ajeng Listyani; Fazlin Fauzi; Ariyanti Ariyanti; Tatiana Siska Wardani
Proceedings of the International Conference on Nursing and Health Sciences Vol 3 No 1 (2022): January-June 2022
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v3i1.1109

Abstract

Phthalimide derivate compounds was reported as a new class of nonnucleoside reverse tranckriptase inhibitors. The aim of this research is to determine the prediction of absorption, distribution, metabolism, and excretion (ADME) as well as the toxicity test of phthalimide-derived compounds which have the best potential as HIV-1 reverse transcriptase enzyme inhibitors. This study used an in silico approach to predict oral bioavailability and toxicity. The prediction of the ADME in this study using SwissADME which is run online where thirty-three phthalimide derivate compounds have molecular weight, hydrogen donor and acceptor bond, and log P ​​that meet the criteria of Lipinski Rules. Prediction of toxicity ​​in this study using in silico method with Toxtree v1.60 and it is known that phthalimide derivate compounds are not carcinogenic and mutagenic.
UJI AKTIVITAS ANTIBAKTERI FRAKSI n-HEKSAN, FRAKSI ETIL ASETAT DAN FRAKSI AIR BIJI PEPAYA (Carica papaya L.) TERHADAP BAKTERI Salmonella typhi ATCC 13311 Khilda Hilyatul 'Ulya; Tiara Ajeng Listyani; Tatiana Siska Wardani
Jurnal Jamu Kusuma Vol. 2 No. 2 (2022): JURNAL JAMU KUSUMA
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.441 KB) | DOI: 10.37341/jurnaljamukusuma.v2i2.36

Abstract

Demam tifoid ialah penyakit infeksi akut yang sampai kini yang disebabkan oleh bakteri Salmonella typhi. Obat antibiotik yang digunakan terus menerus untuk mengobati penyakit ini dapat mengakibatkan resistensi. Obat Tradisional yang dapat berfungsi sebagai antibakteri adalah tanaman pepaya (Carica papaya L.) karena kandungan dari alkaloid karpain biji pepaya mempunyai efek antibakteri. Tujuan penelitian untuk mengamati potensi aktivitas antibakteri fraksi n-heksan, fraksi etil.asetat dan fraksi air biji pepaya (Carica papaya L.) terhadap.bakteri Salmonella typhi ATCC 13311. Tahapan ekstraksi dan fraksinasi dengan metode cair-cair. Pengujian aktivitas.antibakteri fraksi n-heksan, fraksi etil asetat dan fraksi air biji pepaya (Carica papaya L.) dilakukan pada konsentrasi 10%, 25%, 50%, dan 75% dengan tiga kali replikasi. Metode pengujian dengan difusi cakram. Kontrol positif dengan  Ciproflaxacin 5 ppm dan kontrol negatif yang dipakai yaitu pelarut DMSO 1%. Hasil penelitian ini yaitu fraksi biji pepaya (Carica papaya L.) mempunyai aktivitas.antibakteri terhadap bakteri Salmonella typhi ATCC 13311. Fraksi n-Heksan, fraksi etil asetat dan fraksi air biji pepaya (Carica papaya L.) memiliki aktifitas antibakteri terhadap pertumbuhan bakteri Salmonella typhi ATCC 13311 dan zona hambat teraktif biji pepaya terdapat pada fraksi etil asetat dengan konsentrasi 10% sebesar 8,1 mm, 25% sebesar 9,46 mm, 50% sebesasr 10,6 mm dan 75% sebesar 12,23 mm. Hasil uji Oneway ANNOVA dengan Post hoc Tuckey data terdistribusi normal nilai (P<0,05).   Kata kunci: antibakteri, biji pepaya, Salmonella typhi
Ethanol Extract Guava Leaves (Psidium Guajava) Give Antidiabetic Effect On Male Mice With Alloxan Induction Tiara Ajeng Listyani; Aisyah Rabitha Alisi; Tatiana Siska Wardani
Proceeding of International Conference on Science, Health, And Technology Proceeding of the 3rd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.511 KB) | DOI: 10.47701/icohetech.v3i1.2190

Abstract

Diabetes mellitus is a chronic condition caused by increasing glucose level in blood. Long term use of antidiabetic drugs can cause various unwanted side effects, which makes people with diabetes try to use natural materials to control blood glucose levels. The aim of this study was to determine the antidiabetic activity of ethanol extract guava leaves (Psidium guajava) on male mice with alloxan induction. Mice were induced intravenously by alloxan dose of 160 mg/kg bw. After 7 days, mice were diabetic (blood glucose levels > 175 mg/dL) and were divided into 5 groups: negative control group (only treated with CMC-Na) ,positive control group (glibenclamide 0.65 mg/kg bw) and the 3 other groups were given ethanol extract guava leaves (Psidium guajava) at doses of 150 ,300 and 600 mg/kg bw. Dosage administered for 15 days and blood glucose levels was checked every 3 days using a glucotest. Data were analyzed by LSD (Least Significant Difference). Ethanol extract guava leaves (Psidium guajava) at doses of 150 ,300 and 600 mg/kg bw can lower blood sugar levels from day 3 to day 15 and was significantly different compared to the negative control group (p<0,05). Ethanol extract guava leaves (Psidium guajava) at doses of 150 ,300 and 600 mg/kg bw showed antidiabetic activity on male mice with alloxan induction.
RASIONALITAS PENGGUNAAN OBAT ANTIDIABETES PADA PASIEN DM TIPE 2 PASIEN RAWAT JALAN DI RSUD Dr. MOEWARDI SURAKARTA Kusumaningtyas Siwi Artini; Tiara Ajeng Listyani; Galuh Puspitasari
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 12 No 1 (2023): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v12i1.160

Abstract

Diabetes mellitus adalah penyakit degeneratif yang terjadi karena adanya gangguan produksi insulin sehingga terjadi peningkatan kadar insulin. Prevalensi kejadian Diabetes mellitus terus meningkat karena gaya hidup yang kurang baik. Pasien dengan penyakit diabetes mellitus harus menjalani pengobatan seumur hidup dan membutuhkan obat yang tepat dan rasional agar tujuan terapi tercapai. Tujuan dari penelitian ini adalah untuk mengetahui profil penggunaan antidiabetes dan rasionalitas penggunaan obat antidiabetes melitus pada pasien diabetes melitus tipe 2 yang menjalani rawat jalan di RSUD Dr. Moewardi Surakarta. Penelitian ini dilaksanakan dengan menggunakan metode cross sectional dan pengambilan data dilaksanakan dengan cara retrospektif. Hasil dari penelitian ini adalah obat antidiabetes diberikan secara kombinasi dengan antiabetes oral atapun dengan insulin. Rasionalitas tepat penggunaan obat didapatkan hasil tepat diagnosis sebesar 100%, tepat indikasi 100%, tepat obat 100%, tepat dosis 100%, dan tepat interval waktu pemberian 100%. Kata kunci: antidiabetes, diabetes mellitus tipe 2, rasional, rsud dr. moewardi ABSTRACT Diabetes mellitus is a degenerative disease that occurs due to impaired insulin production resulting in increased insulin levels. The prevalence of diabetes mellitus continues to increase due to unfavorable lifestyles. Patients with diabetes mellitus must undergo lifelong treatment and need appropriate and rational drugs so that therapeutic goals are achieved. The purpose of this study was to determine the profile of antidiabetic use and the rationality of antidiabetic drug use in type 2 diabetes mellitus patients undergoing outpatient care at RSUD Dr. Moewardi Surakarta. This research was conducted using the method cross sectional and data collection was carried out retrospectively. The results of this study are anti-diabetic drugs given in combination with oral anti-diabetics or with insulin. Rationality for the right drug use results in the right diagnosis of 100%, the right indication 100%, the right drug 100%, the right dose 100%, and the right time interval for giving 100%. Keywords: antidiabetic, diabetes mellitus type 2, rational, rsud dr. moewardi
- Antioksidan Ekstrak Etanol dan Fraksi Akar Rhyzopora stylosa Metode ABTS dan FRAP: Antioksidan Ekstrak Etanol dan Fraksi Akar Rhyzopora stylosa Metode ABTS dan FRAP Danang Raharjo; Tiara Ajeng Listyani; Dwi Bagus Pambudi
Jurnal Ilmiah Kesehatan Vol. 15 No. 2 (2022): Jurnal Ilmiah Kesehatan
Publisher : Universitas Muhammadiyah Pekajangan Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48144/jiks.v15i2.1148

Abstract

Rhyzopora stylosa atau sering disebut bakau kecil oleh masyarakat pesisir sering digunakan untuk mengobati berbagai macaam penyakit diantaranya diabetes, ulkus, diare analgetik, radang, nyeri dan mempercepat penyembuhan luka. Penelitian ini bertujuan untuk meneliti kadar senyawa flavonoid dalam ekstrak etanol akar Rhyzopora stylosa dengan metode komplek AlCl3 dan aktivitas antioksidan dengan metode ABTS (2,2 azinobis (3-etilbenzotiazolin)-6-asam sulfonat) dan FRAP (Ferric Reducing Antioxidant Power) terhadap ekstrak etanol dan 3 fraksi akar Rhyzopora stylosa. Ekstraksi dilakukan dengan metode maserasi dengan etanol 96% sebagai pelarut. Fraksinasi dilakukan dengan partisi cair-cair dengan pelarut etanol, n-heksane dan etil asetat. Penetapan kadar flavonoid diukur dengan komplek AlCl3 dengan kuersetin sebagai baku pembanding. Aktivitas antioksidan ditentukan dengan metode ABTS dan FRAP. Dari pengujian kadar flavonoid didapatkan hasil kadar flavonoid dalam ektrak etanol akar Rhyzopora stylosa sebesar 18.803 ± 0.198 QE. Aktivitas antioksidan dengan metode ABTS dan FRAP didapatkan fraksi etil asetat memiliki aktivitas antioksidan tertinggi dengan nilai masing-masing 18,553 ± 1,440 ppm dan 24.636 ± 0.128 mgAAE/g. Berdasarkan tabel aktivitas antioksidan fraksi etil asetat termasuk dalam kategori antioksidan yang sangat kuat karena kurang dari 50 ppm
Formulasi Sediaan Gel Ekstrak Daun Alpukat (Persea americana Mill.) Sebagai Terapi Pengobatan Luka Bakar Terhadap Kelinci New Zeland White Aprilia Rika Alvita; Tatiana Siska Wardani; Tiara Ajeng Listyani
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.628

Abstract

Researched on burn wounds healing activity of extract of avocado leaft (Persea americana Mill.) in gel preparation forms were tested on rabbits New Zeland White. This study aimed to determine variations effect of concentration in gel extract of avocado leaft for the treatment of burn wounds in rabbits which had been wounded using hot metal. In this study, avocado leaft extract was obtained through maceration method and formulated into gel preparations with concentration of 1%, 2% and 5%. Gel base was used as a negativ control, namely carbomer 940 and Bioplacenton® gel was used as a positive control, applied to burns on the back of New Zeland White rabbits with a diameter of 1,5 cm. The avocado leaft extract gel activity test was carried out on 3 rabbit, each formulation was replicated 3 times and wound diameter measurements were taken on each day. Data on the percentage of burn wound healing was statistically analyzed using One Way ANOVA method. The result of the data analysis at a concentration of 5% obtained a sig value <0,05. Based on One Way ANOVA analysis of the five treatments, the most effective was avocado leaft extract gel with a concentration of 5%.
PENETAPAN KADAR TOTAL FLAVONOID DAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BATANG DAN DAUN TURI PUTIH (Sesbania grandiflora L) DENGAN METODE ABTS Silvia Devi; Desy Ayu Irma Permatasari; Tiara Ajeng Listyani
Parapemikir : Jurnal Ilmiah Farmasi Vol 11, No 3 (2022): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v11i3.4176

Abstract

Turi putih (Sesbania grandiflora L) merupakan tanaman yang termasuk dalam famili Fabaceae. Turi putih (Sesbania grandiflora L) mengandung banyak senyawa metabolit sekunder meliputi alkaloid, saponin, tanin, steroid, triterpenoid, fenolik dan flavonoid (Nista et al., 2010). Namun dalam kalangan masyarakat pemanfaatan turi putih (Sesbania grandiflora L) digunakan sebagai tanaman hias dan bunga turi putih (Sesbania grandiflora L) sebagai bahan makanan, turi putih (Sesbania grandiflora L) juga memiliki manfaat lain yaitu sebagai antioksidan. Tujuan penelitian ini yaitu untuk mengetahui kadar flavonoid dan aktivitas antioksidan batang dan daun turi putih (Sesbania grandiflora L) yang diekstraksi dengan menggunakan pelarut etanol 95%. Penetapan kadar flavonoid dengan menggunakan metode kolorimetri dengan kontrol positif yaitu kuersetin. Pengujian aktivitas antioksidan dengan menggunakan metode ABTS. Hasil penelitian menunjukkan bahwa kadar flavonoid total ekstrak etanol batang turi putih (Sesbania grandiflora L) sebesar 12,08 mg/L dan kadar flavonoid total ekstrak etanol daun turi putih (Sesbania grandiflora L) sebesar 11,28 mg/L. Serta ekstrak etanol batang, daun dan kombinasi ekstrak etanol batang dan daun turi putih (Sesbania grandiflora L) memiliki aktivitas antioksidan dengan nilai IC50 berturut-turutsebesar 36,519 mg/L, 37,438 mg/L, dan 40,860 mg/L. 
Perbandingan Aktivitas Antibiofilm Ekstrak Biji Kopi Hijau dan Sangrai Kopi Robusta terhadap Staphylococcus aureus Sri Khanti Urip; Tatiana Siska Wardani; Tiara Ajeng Listyani
Publikasi Penelitian Terapan dan Kebijakan Vol 6 No 2 (2023): Publikasi Penelitian Terapan dan Kebijakan
Publisher : Badan Penelitian dan Pengembangan Daerah Provinsi Sumatera Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46774/pptk.v6i2.547

Abstract

Green Coffee Beans (Coffea canephora P.) and Roasted Robusta Coffee (Coffea canephora L.) contain compounds including caffeine, polyphenols, flavonoids, chlorogenic acid. Chlorogenic acid is a phenolic compound contained in coffee beans which functions as an antifungal and antibacterial. Some infectious diseases caused by Staphylococcus aureus are boils, acne and wound infections and have the ability to inhibit biofilm. Biofilms are aggregates of microorganisms covered by an extracellular polymer matrix produced by microorganisms. This study aims to test the antibiofilm inhibition and destruction of green coffee bean extract (Coffea canephora P.) and roasted robusta coffee (Coffea canephora L.) against Staphylococcus aureus ATCC 25923. The antibiofilm activity test consists of a biofilm formation test, a biofilm inhibition test, and a destruction of biofilm using the Microtitter Plate Biofilm Assay method on extract samples macerated with 96% ethanol. The antibiofilm activity test used concentrations of 2, 4.8, 16 mg/mL. The results of testing the antibiofilm activity of green coffee bean extract and roasted robusta coffee had inhibitory activity with calculated IC50 values of 4.14 mg/mL and 2.13 mg/mL. The results of the crushing activity of green coffee bean extract and roasted robusta coffee with calculated EC50 values were 10.18 mg/mL and 19.32 mg/mL.
Co-Authors Achsantya, Raden Roro Karyna Cindy Addawiyyah, Muniroh Agung Eru Wibowo Aini, Riszki Nur Aisyah Rabitha Alisi Anna Fitriawati Aprilia Rika Alvita Apriliawan, Hidayah Ariyanti Ariyanti Artini, Kusumaningtyas Siwi Danang Raharjo Desy Ayu Irma Permatasari Diza Aulia Ramadhani Dwi Bagus Pambudi Ekarani, Meisyah Litang Endang Suciati Fazlin Fauzi Galuh Puspitasari Guterres, Agostinha Hafalika, Aviv Ifalahma, Darah Kharisma, Putri Nur Khilda Hilyatul 'Ulya Kusumaningtyas Siwi Artini Kusumasedya, Willyana Pratiwi Luthfiyanti, Niken Muniroh Addawiyyah Nabillah Sirli Okta Maharani Niken Luthfiyanti ningsih, endang wahyu Nugraha, Novanda Satria Nur Azmi, Tasya Nabila Pang Jyh Chyang Pratama, Kharisma Jayak Puspitasari, Rara Ayu Rafidah Hanifah Rahmasari, Ikrima Rahmat Hidayat Rahmat Hidayat Ratna Safitri Rohmana, Vivin Marwiyati Sari, Cantyka Eka Viemala Sejati, Siti Laila Utari Septian Maulid Wicahyo Septiarini, Anita Dwi Silvia Devi Silvia Mawardani Sri Khanti Urip Suwardi, Nisa Aura Rizky Tanoyo, William Tatiana Siska Wardani Tatiana Siska Wardani Tatiana, Siska Wardani Wahyu Budi Utomo Wardani, Tatiana Siska Wargani, Rizki Nugraha Weri Veranita Yoga Pratama Yuliana, Ana Yuliana, Silvia Zanjabila, Chanida Zavitra, Mei Nanda