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All Journal Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) International Journal of Health, Engineering and Technology Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Bangkit Riska Permata
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Formulation and Antibacterial Activity Test of Dragon Tail Leaf Extract Cream (Rhaphidophorapinnata (L.f) Schott) Against Staphylococcus aureus ATCC (25923) Mutia Della Citra; Bangkit Riska Permata; Kharisma Jayak Pratama
International Journal of Health Engineering and Technology Vol. 4 No. 3 (2025): IJHET SEPTEMBER 2025
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aims to formulate a cream containing Rhaphidophora pinnata (L.f) Schott leaf extract and evaluate its antibacterial activity against Staphylococcus aureus ATCC 25923. The background of this research is rooted in the potential of Indonesian medicinal plants and the increasing cases of antibiotic resistance, which drives the development of natural antibacterial agents. A quantitative experimental laboratory method was employed. The study population was the Rhaphidophora pinnata plant from Sragen, with a sample of 8 kg of fresh leaves. Antibacterial activity was tested using the disc diffusion method, and data were analyzed descriptively and inferentially using One-Way ANOVA with SPSS. The results showed that cream formulations at 10%, 30%, and 40% concentrations had physical qualities that met standards, including a safe pH (6.0–6.8) and stable viscosity. The antibacterial test demonstrated the highest activity at the 40% concentration, producing the largest inhibition zone against S. aureus. However, its efficacy was still lower than that of the positive control (gentamicin cream). In conclusion, R. pinnata leaf extract has the potential to be developed as a natural antibacterial cream, and further research is needed for stability and clinical testing.
Formulasi Sediaan Pomade dan Uji Efektivitas Ekstrak Daun Salam (Syzygium Polyanthum) terhadap Pertumbuhan Rambut Kelinci New Zealand White Putri Barlian Nur Cahyaning Tyas; Bangkit Riska Permata; Rizka Wahyu Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8332

Abstract

Bay leaves are known to contain flavonoids, tannins, saponins, and essential oils, which have been empirically proven to promote healthy hair. This study aimed to determine the potential of bay leaf extract (Syzygium polyanthum) as an active ingredient in pomade and its effectiveness on hair growth in New Zealand White rabbits. The research method used was an experimental laboratory with four variations of pomade formulations: F0 (without extract), F1 (20%), F2 (25%), and F3 (30%). Evaluations were conducted on physical quality parameters such as organoleptic properties, pH, homogeneity, spreadability, viscosity, and adhesion. Effectiveness testing was conducted on the rabbits' backs for 28 days, measuring hair growth. The results of the study showed that pomade preparations with bay leaf extract had physical qualities that met the requirements for hair growth with various extract effectiveness on the 28th day of peak testing showing Formula I (20%) 0.4 cm, formula II (25%) 0.4 cm, Formula III (30%) 1.0 cm, providing the highest hair growth results, namely Formula III compared to other formulas. The results of SPSS statistical analysis with a significance value <0.05 resulted in differences between treatments. So it can be concluded that bay leaf extract can be formulated into an effective pomade preparation in stimulating hair growth.
Formulasi Dan Uji Mutu Fisik Sediaan Bedak Padat Ekstrak Biji Bunga Matahari (Halianthus Annuus L.) Sebagai Antioksidan Ilham La Tansa; Bangkit Riska Permata; Kusumaningtyas Siwi Artini
Detector: Jurnal Inovasi Riset Ilmu Kesehatan Vol. 1 No. 4 (2023): November : Jurnal Inovasi Riset Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/detector.v1i4.2517

Abstract

Sunflower (Halianthus annuus L.) is a flower that is widely consumed by the world's people. The part that is consumed from the sunflower is the seeds of the flower. Sunflower seeds have many useful ingredients in them, such as high nutritional value, being a good source of unsaturated fat, protein, inorganic compounds, vitamin E. One of the plants that has the potential as an antioxidant is sunflower (Halianthus annuus L.). The purpose of this study was to determine whether sunflower seed extract pressed powder (Halianthus annuus L.) had good physical quality, to determine whether sunflower seed extract pressed powder (Halianthus annuus L.) had antioxidant activity, to determine what concentrations of sunflower seed extract pressed powder (Halianthus annuus L.) had strong antioxidant activity as a good compact powder. Testing the antioxidant activity using the DPPH method with a positive control, namely vitamin c. The results of this study indicate that sunflower seed extract (Halianthus annuus. L) can be made into solid powder preparations, has an extract antioxidant activity of 96.78 μg/mL and has antioxidant activity when made into pressed powder preparations of 176.20 μg/mL with a concentration of 2.5%, 143.51 μg/mL with a concentration of 5%, and 121.22 μg/mL with a concentration of 7.5%.
Uji Aktivitas Antioksidan dan Penentuan Nilai Sun Protection Factor (SPF) Sediaan Lip Balm Ekstrak Kayu Secang (Caesalpinia Sappan L.) Nugrahaeni Ayuningtyas; Niken Luthfiyanti; Bangkit Riska Permata
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 3 (2025): Desember : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i3.6755

Abstract

Sappan wood (Caesalpinia sappan L.) is known to contain various bioactive compounds such as saponins, tannins, flavonoids, phenols, brazilin, and gallic acid. These compounds play an important role as antioxidants that can ward off free radicals and absorb UVA and UVB radiation that are harmful to the skin. Ultraviolet radiation is known to accelerate premature aging and cause tissue damage, so a topical formulation is needed that can provide protection while maintaining skin health. This study aims to determine the antioxidant activity and sunscreen ability of sappan wood extract in the form of lip balm with varying extract concentrations. Antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method, while the Sun Protection Factor (SPF) value was determined by the Mansyur method using UV-Vis spectrophotometry. Sappan wood extract was formulated into four lip balm preparations, namely F0 (control without extract), F1 (5%), F2 (10%), and F3 (15%). Physical tests including homogeneity, pH, spreadability, adhesiveness, and organoleptic were conducted to ensure the quality of the preparation. The results showed that sappanwood extract had an IC50 value of 23.62 ppm which was categorized as very strong antioxidant activity. In the lip balm formulation, the IC50 values ​​obtained were F0 = 246.76 ppm (very weak), F1 = 92.68 ppm (strong), F2 = 78.03 ppm (strong), and F3 = 63.58 ppm (strong). The SPF test showed a protection value of F0 = 2.11 (minimum), F1 = 13.64 (maximum), F2 = 14.25 (maximum), and F3 = 18.28 (ultra). Thus, lip balm made from sappanwood extract has the potential as a cosmetic preparation that not only meets physical criteria, but also provides high antioxidant activity and effective sunscreen protection.
Preparation Formulation Clay Mask From Butterfly Pea Flower Pollen (Clitoria Ternatea l.) And Yam Powder (Pachyrhizus Erosus l.) As a Natural Antioxidant Dian Nur Aisyah; Rahmat Hidayat; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.559

Abstract

Antioxidants play an important role in preventing cell damage, primarily through free radical scavenging mechanisms. This study aimed to formulate clay masks based on butterfly pea (Clitoria ternatea L.) and jicama (Pachyrhizus erosus L.) flower powder and to evaluate their physical characteristics. Butterfly pea flowers were used for their anthocyanin and flavonoid content, which act as antioxidants, while jicama was chosen for its vitamin C and flavonoid content. Clay mask formulations were made with varying concentrations of butterfly pea and jicama flower powder. These were then tested for organoleptic properties, homogeneity, pH, drying time, and antioxidant activity. The clay mask results showed good physical properties: a semi-solid texture, and a pH value within the skin-friendly range of 4.5-8.0, indicating no irritation. The homogeneity test confirmed that all formulations were uniform, without lumps or unmixed particles. The drying time of the clay masks ranged from 15.19 to 15.26 minutes, meeting the optimal range of 15-20 minutes. Antioxidant activity, formula 0 has an IC50 of 102.75 µg/mL (moderate activity), formula 1 (10% butterfly pea flowers, 10% jicama) shows strong antioxidant activity with an IC50 of 62.15 µg/mL. Formula 2 (12% butterfly pea flowers, 8% jicama) shows strong antioxidant activity with an IC50 of 53.70 µg/mL. Formula 3 (8% butterfly pea flowers, 12% jicama), with an IC50 of 41.20 µg/mL, so it is classified as very strong.
Antibacterial Activity Test Of Extracts And Fractionsn-Hexane, Ethyl Acetate, And Pineapple Peel Water (Ananas Comosus(L.) Merr.) Against Bacteria Propionibacterium Acnes ATCC 6919 Dian Fatimatus Salwa; Tatiana Siska Wardani; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.655

Abstract

Acne vulgaris is a common dermatological problem in adolescents in Indonesia's tropical climate related to the activity of Propionibacterium acnes bacteria. Long-term use of antibiotics risks causing resistance, so natural antibacterial alternatives are needed. This study aims to evaluate the antibacterial activity of ethanol extract and fractions of n-Hexane, ethyl acetate, and pineapple peel water against Propionibacterium acnes ATCC 6919, and to determine the most active fraction and MIC and MBC values. This study is a quantitative experimental study. The study population was the bacterial culture of P. acnes ATCC 6919, with samples in the form of pineapple peel extract and fraction. The research instruments included disc diffusion and liquid and solid dilution methods, while data analysis used the Shapiro-Wilk, Levene, and Kruskal-Wallis tests. The results showed that the ethanol extract had moderate to strong antibacterial activity, the ethyl acetate fraction showed the highest activity compared to other fractions, while the n-hexane fraction showed no activity. MIC and MBC values ​​were obtained at a concentration of 20 percent. The conclusion of this study is that pineapple peel has the potential as a natural antibacterial source against P. acnes and the ethyl acetate fraction is the most active fraction.
Antioxidant Body Lotion Formulation From Yakon Leaf Extract (Smallanthus Sonchifolius) Khaisya Sabila; Bangkit Riska Permata; Siwi Hastuti
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.659

Abstract

Free radicals due to UV exposure, pollution, and the environment damage the skin and accelerate premature aging, so natural antioxidants are needed. This study aims to formulate and evaluate antioxidant body lotion from ethanol extract of yacon leaves (Smallanthus sonchifolius). Semi-quantitative laboratory experimental research used old yacon leaves from Wonosobo as a purposive sample (1,897 g of dried simplicia). Instruments include a UV-Vis spectrophotometer for DPPH (515 nm) test, a Brookfield viscometer, and a pH meter. Data analysis used IC₅₀ regression and physical quality standards (SNI). The results showed that the IC₅₀ of the extract was 28.08 ppm (very strong, <50 ppm), positive phytochemical screening (phenolics, flavonoids), and all lotion formulas (F0-F3: 0-10% extract) met physical standards (pH 4.6-6.2, viscosity 2,187-9,230 cps, O/W emulsion). Formula F1 (2.5%) was optimal overall. The conclusion is that yacon leaf extract has strong potential for the development of a stable body lotion.
Formulation And Antioxidant Activity Testing Of Ethanol Extract Moisturizing Gel From Kesum Leaves (Polygonum Minus Huds.) Using The DPPH (2,2-Diphenyl-1-Picrylhydrazyl) Method Windy Marcella; Bangkit Riska Permata; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.684

Abstract

Free radicals are unstable molecules that can cause cell damage and play a role in premature aging and various skin disorders. One way to inhibit the effects of free radicals is through the use of topical preparations containing antioxidants. Kesum leaves (Polygonum minus Huds) are known to contain bioactive compounds, particularly flavonoids and phenolics, which have the potential to act as natural antioxidants. This study aims to formulate kesum leaf ethanol extract into a moisturizing gel preparation and evaluate its physical quality and antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. This study was an experimental study with variations in the concentration of kesum leaf ethanol extract, namely F1 (1%), F2 (2%), and F3 (3%). The evaluation of the physical quality of the gel included organoleptic testing, homogeneity, pH, Viscosity and spreadability. Antioxidant activity was expressed as the IC₅₀ value. The results showed that all gel formulations met the physical quality requirements for preparations. The IC₅₀ values of the gel preparations in F1, F2, and F3 were 169.556 ppm, 150.759 ppm, and 125.396 ppm, respectively, while the positive control showed an IC₅₀ value of 44.792 ppm. An increase in the concentration of kesum leaf ethanol extract in the gel formulation showed a tendency to increase antioxidant activity. Formula F3 had the best antioxidant activity among the gel formulations tested. Thus, kesum leaf ethanol extract has potential as an antioxidant agent.
Predictors Of Antihypertensive Drug (AHD) Therapy Failure Among Elderly Patients At Sangkrah Public Health Center, Surakarta. Aditya Raka Fahri; Siwi Hastuti; Bangkit Riska Permata
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.686

Abstract

Hypertension is the most common non-communicable disease in Indonesia with a prevalence of 34.1% in adults aged 18 years and above, with the elderly at high risk due to physiological changes such as decreased kidney function and arterial stiffness. This study aims to identify predictors of antihypertensive drug (ADH) therapy failure and dominant factors in elderly patients at the Sangkrah Surakarta Community Health Center. A quantitative analytical observational study with a cross-sectional design involved 96 elderly respondents (≥60 years) with ADH therapy for at least 3 months, selected the Lemeshow formula and total sampling. Medical record data and questionnaires covering demographics, knowledge, adherence (MMAS-8), lifestyle, were analyzed univariately, bivariately (Chi-Square), multivariate (logistic regression) using SPSS. The results showed 72.9% were male, 71.9% had good knowledge, 80.2% were compliant; Age (p=0.629), gender (p=0.622), and education (p=0.559) were not significant, but knowledge significantly influenced adherence (p=0.011). Low knowledge was the main predictor of therapy failure (BP ≥140/90 mmHg). Intensive education is recommended to improve adherence.
Co-Authors Aditya Raka Fahri Dian Fatimatus Salwa Dian Nur Aisyah Ilham La Tansa Khaisya Sabila Kharisma Jayak Pratama Kusumaningtyas Siwi Artini Mutia Della Citra Niken Luthfiyanti Nugrahaeni Ayuningtyas Putri Barlian Nur Cahyaning Tyas Rahmat Hidayat Rahmatillah, Annie Rizka Wahyu Syahputra Siwi Hastuti Wardani, Tatiana Siska Windy Marcella