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All Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI ALCHEMY Jurnal Penelitian Kimia Jurnal Pendidikan Kimia (JPKim) Sains Natural: Journal of Biology and Chemistry Molekul: Jurnal Ilmiah Kimia
Ricson Pemimpin Hutagaol
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Nusa Bangsa University, Bogor 16166|Nusa Bangsa University|Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Engineering Environmental Science Materials Science & Nanotechnology

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Crystal guava (Psidium guajava L. “Crystal”) treated with gibberelic acid (GA3) : Evaluation of in vitro antioxidant capacities Fajar Sumi Lestari; Ricson Pemimpin Hutagaol; Srikandi Srikandi
Jurnal Pendidikan Kimia (JPKIM) Vol 15, No 2 (2023): August
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v15i2.41780

Abstract

Free radicals can cause many diseases, such as cancer. Antioxidant is a compound that could scavenge free radicals. One of the natural source antioxidants is guava. The application of gibberellic acid (GA3) is known to affect the physicochemical properties and antioxidant content of the fruit. The goals of this research were to investigate the antioxidant activity of skin, flesh and fruit of crystal guava were given additional GA3 treatment with concentration 0; 60; 120; 180; 240; and 300 ppm by determining the value of the Antioxidant Activity Index (AAI) using DPPH; evaluate the total phenolic content (TPC), ferric reducing antioxidant power (FRAP) and physicochemical properties; analyse the correlation between the TPC with AAI DPPH by Pearson’s method. Extraction was performed by the maceration method using acetone 50% mixed with a magnetic stirrer for 1 h. Determination of AAI DPPH, FRAP and the TPC was performed by UV-Visible spectrophotometry. TPC in the flesh and fruit fractions tended to increase and FRAP values in all fractions decreased with GA3 application. The highest TPC and FRAP was given by the G3 treatment on the skin fraction and G0 treatment on the skin fraction. The highest AAI in all fractions was given by the G3 treatment. The TPC was significantly positively correlated with the AAI DPPH of the flesh and fruit fraction extracts (0.250 ≤ r ≤ 0.880), and the skin fraction extracts showed a strong negative correlation between TPC and AAI DPPH (-0.813 < r < -0.973).Keywords: Antioxidant activity; DPPH; FRAP; Gibberellic acid; Psidium guajava
A Cycloartane Triterpenoid and Steroid from The Leaves of Aglaia shawiana Merr. (Meliaceae) Ricson Pemimpin Hutagaol; Tjandrawati Mozef; Sofa Fajriah; Gian Primahana; Muhammad Eka Prasetya; Miskah Yumna; Heriansyah Rangkuti
Jurnal Kimia Sains dan Aplikasi Vol 27, No 7 (2024): Volume 27 Issue 7 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.7.307-315

Abstract

Natural products and their structural analogs are the main sources of pharmacotherapy. Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties. This research focuses on isolating the terpenoid group from Aglaia shawiana, to provide a basis for further research to identify lead compounds for drug development. The hexane extract of Aglaia shawiana leaves was isolated using vacuum liquid chromatography and gravity column chromatography, employing solvents with varying polarities. The isolation process yielded two compounds: compound 1 and compound 2. A total of 15 mg of a pure isolate was obtained for compound 1, and 4.5 mg for compound 2. Their structures were characterized using 1D NMR (¹H, 13C, DEPT 135) and 2D NMR (HMQC, HMBC, 1H-1H COSY) and by comparing them with previously reported spectral data. It was concluded that compound 1 has the molecular formula C30H50O3, is a triterpenoid type cycloartane, and is named cycloartan-3β,29-diol-24-one, while compound 2 has the molecular formula C30H52O, is a steroid compound, and is named 23a-homostigmast-5en-3β-ol. These compounds were discovered for the first time in this species.
Cholestan Steroids from The Stem Bark of Aglaia angustifolia Miq and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines Hutagaol, Ricson Pemimpin; Mozef, Tjandrawati; Fajriah, Sofa; Primahana, Gian; Supratman, Unang; Harneti, Desi; Hidayat, Ace Tatang; Awang, Khalijah; Shiono, Yoshihito
Molekul Vol 18 No 2 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.2.6205

Abstract

With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties. This research objective was to find secondary metabolites that have activity as anti-breast cancer compounds from endemic Indonesian Aglaia, such as Aglaia angustifolia Miq. Two cholestan type steroids, stigmast-5en-3α-acetat (1), as a new steroid with α-sterochemistry of acetyl moiety at C-3 and 23a-homostigmast-5en-3β-ol (2), with unusual side chain were isolated for the first time from the stem bark of Aglaia angustifolia Miq or known as segara tree in Kalimantan. The chemical structures of two steroids were identified with spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, NOESY, 1H-1H COSY) and HRTOF-MS, as well as by comparing with previously reported spectral data. These two steroids were isolated for the first time from this genus. Steroids 1 and 2 were evaluated for cytotoxic activity against MCF-7 breast cancer cells and showed weak activity with IC50 values of 829.0 and 903.0 µg/mL, respectively.
Dammarane-Type Triterpenoids from Twigs of Aglaia Foveolata and Their Antibacterial Activity Hutagaol, Ricson Pemimpin; Mozef, Tjandrawati; Nurilmala, Febi; Primahana, Gian; Fajriah, Sofa; Prastya, Muhammad Eka; Hidayatullah, Sigit; Satyaningsih, Desy
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.16241

Abstract

ABSTRACT. The Aglaia species, which contains triterpenoids, is the most numerous in the Meliaceae family. Aglaia foveolata (A. foveolata) is a type of plant that has many benefits, as medicinal ingredients. The potential of this plant is inseparable from the content of various bioactive compounds. This study aims to isolate, characterize the active compound from the twigs of A. foveolata and test its activity as an antibacterial. Three dammarane-type triterpenoids were isolated from the A. foveolata twigs which is, namely dammar-24-en-3β,20-diol (1), an epimeric mixture of shoreic and eichlerianic acid (2, 3). Their chemical structures were determined based on spectroscopic data using infrared, high-resolution mass spectrometry, and including one and two-dimensional NMR techniques, as well as through data comparison of the reported compound. Compound 1 was reported for the first time to be successfully isolated from this species. All these substances were tested for the first time for their antibacterial activity against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and two Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, through this study. Compound 1 was inactive, the epimeric mixture of 2 and 3 showed moderate antibacterial activity with a minimum inhibitory concentration (MIC) value ranging from 31.7 to 126.6 ppm, particularly against S. aureus with a MIC value of 31.7 ppm. Keywords: Aglaia, Elucidation, Isolation, Spectroscopy, Bacterial
Campuran Senyawa β-Sitosterol dan Stigmasterol dari Ekstrak Metanol Daun Aglaia shawiana serta Aktivitas Sitotoksiknya terhadap Sel Kanker MCF-7 Ricson Pemimpin Hutagaol; Syifa Dwi Juwairriyyah; Tjandrawati Mozef; Sofa Fajriah; Gian Primahana
ALCHEMY Jurnal Penelitian Kimia Vol 21, No 2 (2025): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.21.2.101051.424-431

Abstract

Aglaia merupakan salah satu genus terbesar dari famili tanaman Meliaceae (tanaman mahoni). Sejak tahun 1960-an, genus ini banyak diteliti untuk mengetahui kandungan fitokimia dan sifat biologisnya. Tujuan penelitian ini adalah untuk menemukan metabolit sekunder dari Aglaia Aglaia shawiana, yang memiliki aktivitas sebagai senyawa anti kanker payudara. Isolasi dan identifikasi struktur senyawa kimia telah dilakukan dari ekstrak metanol daun A. shawiana. Ekstrak metanol daun A. shawiana telah diisolasi, difraksinasi menghasilkan sebuah isolat dengan berbagai metode kromatografi kolom gravitasi. Penentuan struktur senyawa isolat dilakukan dengan metode spektroskopi resonansi magnetik inti 1 dimensi (1H-NMR, 13C-NMR dan DEPT-1350) dan perbandingan dengan referensi terdahulu. Isolat yang telah berhasil diisolasi dalam studi ini merupakan campuran senyawa β-sitosterol dan stigmasterol, dimana β-sitosterol lebih dominan jumlahnya dibandingkan stigmasterol. Isolat telah diuji aktivitas sitotoksiknya terhadap lini sel kanker payudara MCF-7 dengan metoda dimetiltiazol difeniltetrazolium bromid (MTT) dan diperoleh nilai IC50 sebesar 135,9 µg/mL.Mixture of β-Sitosterol and Stigmasterol Compounds from Methanol Extract of Aglaia shawiana Leaves and Its Cytotoxic Activity Against MCF-7 Cancer Cell. Aglaia is one of the largest genera of the Meliaceae plant family (mahogany plants). Since the 1960s, this genus has been widely studied for its phytochemical content and biological properties. This study aimed to find secondary metabolites from Aglaia shawiana that have activity as anti-breast cancer compounds. Isolation and identification of the structure of chemical compounds have been carried out from the methanol extract of A. shawiana leaves. The methanol extract of A. shawiana leaves has been isolated and fractionated, resulting in an isolate by various gravity column chromatography methods. Determination of the structure of pure isolate compounds was carried out by 1-dimensional nuclear magnetic resonance spectroscopy (1H-NMR, 13C-NMR, and DEPT-1350) and comparison with previous references. The isolated fraction successfully isolated in this study is a mixture of β-sitosterol and stigmasterol compounds, where β-sitosterol is more dominant than stigmasterol. The isolate was tested for its cytotoxic activity against the MCF-7 breast cancer cell line using the dimethylthiazole diphenyltetrazolium bromide (MTT) method and obtained an IC50 value of 135.9 µg/mL. 
Triterpenoids from Aglaia shawiana with their Cytotoxicity against MDA-MB468 and MCF-7 Cancer Cell Lines Ricson Pemimpin Hutagaol; Tjandrawati Mozef; Gian Primahana; Sofa Fajriah; Nuralih Nuralih; Fitri Nur Aini; Desy Setyaningsih
Molekul Vol 21 No 2 (2026)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2026.21.2.18839

Abstract

Triterpenoids are secondary metabolite compounds that are predominantly found in plants of the genus Aglaia. Since the 1960s, various triterpenoid structures from Aglaia species have been successfully isolated, and many are known to have interesting biological activities. This study aims to find triterpenoid compounds from Aglaia shawiana, which will then be tested for their activity against two breast cancer cell lines, MCF-7 and MDA MB 468. This research is expected to be used as a basis for further study in the development of cancer drug substances from Aglaia triterpenoids. Two triterpenoids were isolated from n-hexane extract of Aglaia shawiana leaves and twigs which is, namely cycloartan-3β,29-diol-24-ones (1), and 3-epi-cabraleahydroxylactone (2). Their chemical structures were determined based on spectroscopic data using infrared, high-resolution mass spectrometry, and including one and two-dimensional NMR techniques. Comparative data analysis was also carried out with appropriate reference journals and through a biosynthesis approach of the triterpene compounds. Both compounds were evaluated for their cytotoxic effects on MCF-7 and MDA MB-468 breast cancer cells. Compound 1 showed cytotoxicity with IC50 values of 118,2668 and 3,6505 µg/ml, meanwhile compound 2 values of 115,1065 μg/ml and 14,5274µg/ml, respectively. Doxorubicin used as a positive control with IC50 values of 3,2724 and 0,0303 µg/ml, respectively.
Co-Authors Ace Tatang Hidayat Agus Taufik Agus Taufiq Alvera Raisa Desi Harneti Putri Huspa Desy Setyaningsih Fajar Sumi Lestari Febi Nurilmala Fitri Nur Aini Gian Primahana Gian Primahana Gian Primahana Heriansyah Rangkuti Hidayatullah, Sigit I Gusti Ayu Manik Widhyastini Ihsan Rahadian Jessica Analy Khalijah Awang Khalijah Awang Lany Nurhayati Lilis Sugiarti Mamay Maslahat Miskah Yumna Muhammad Eka Prasetya Nasrudin Nasrudin Niken Niken Nina Maria Santi Nuralih Nuralih Prastya, Muhammad Eka Primahana, Gian Satyaningsih, Desy Shanti Lestari Shiono, Yoshihito Sofa Fajriah Sofa Fajriah Sofa Fajriah Sofa Fajriah Srikandi Srikandi Srikandi, Srikandi Syifa Dwi Juwairriyyah Tb Achyadi Tjandrawati Mozef Tjandrawati Mozef Tjandrawati Mozef Tjandrawati Mozef Ujang Pramono Unang Supratman Yoshihito shiono