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All Journal Sriwijaya Journal of Internal Medicine Sriwijaya Journal of Neurology Crown: Journal of Dentistry and Health Research Sriwijaya Journal of Otorhinolaryngology
Aisyah Andina Rasyid
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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A Comparative Study of Intranasal Corticosteroids versus Antihistamines in the Management of Persistent Allergic Rhinitis in Indonesia Mariana Alifah; Abhimanyu Putra; Zainal Abidin Hasan; Aisyah Andina Rasyid; Sari Sulistyoningsih
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.92

Abstract

Introduction: Allergic rhinitis (AR) is a prevalent chronic inflammatory disease in Indonesia. Intranasal corticosteroids (INCS) and antihistamines are commonly prescribed treatments, but their comparative effectiveness in the Indonesian context remains unclear. This study aimed to compare the efficacy and safety of INCS versus antihistamines in managing persistent AR in Indonesia. Methods: A randomized controlled trial was conducted involving 120 patients diagnosed with persistent AR according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Participants were randomly assigned to receive either INCS (fluticasone propionate) or oral antihistamines (cetirizine) for eight weeks. The primary outcome was the change in the Total Nasal Symptom Score (TNSS), and secondary outcomes included the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score and adverse events. Results: Both INCS and antihistamines significantly improved TNSS and RQLQ scores from baseline. However, the INCS group demonstrated a significantly greater reduction in TNSS scores compared to the antihistamine group (p<0.05) at weeks 4 and 8. No significant difference was found between the two groups in terms of RQLQ score improvement. Both treatments were well-tolerated, with mild and transient adverse events reported in both groups. Conclusion: INCS are more effective than antihistamines in controlling nasal symptoms in patients with persistent AR in Indonesia. Both treatments improve quality of life, with comparable safety profiles. These findings support the preferential use of INCS as first-line therapy for persistent AR in the Indonesian population.
Transcranial Magnetic Stimulation for the Treatment of Chronic Dizziness: A Randomized Controlled Trial in Bandung, Indonesia Zahra Amir; Nabila Saraswati; Made Swastika; Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Bernadette Wilson
Sriwijaya Journal of Neurology Vol. 2 No. 1 (2024): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i2.90

Abstract

Introduction: Chronic dizziness is a debilitating condition with limited treatment options. Transcranial magnetic stimulation (TMS) has shown promise in treating various neurological conditions. This randomized controlled trial investigated the efficacy and safety of TMS in treating chronic dizziness in Bandung, Indonesia. Methods: Participants with chronic dizziness (≥ 3 months) were randomly assigned to receive either active TMS or sham TMS for 10 sessions over two weeks. The active TMS group received 1 Hz stimulation over the right dorsolateral prefrontal cortex (DLPFC), while the sham group received placebo stimulation. The primary outcome was the change in Dizziness Handicap Inventory (DHI) score from baseline to four weeks post-intervention. Secondary outcomes included changes in Vertigo Symptom Scale (VSS) scores, Hospital Anxiety and Depression Scale (HADS) scores, and quality of life measures. Safety was assessed through monitoring of adverse events. Results: A total of 60 participants completed the study (30 in each group). The active TMS group showed a significantly greater improvement in DHI scores compared to the sham group (p < 0.001). Significant improvements were also observed in VSS, HADS, and quality of life measures in the active TMS group. No serious adverse events were reported. Conclusion: This study provides evidence for the efficacy and safety of TMS in treating chronic dizziness in the Indonesian population. TMS may be a valuable therapeutic option for patients with chronic dizziness who have not responded to conventional therapies.
Accuracy and Efficiency of Artificial Intelligence-Driven Treatment Planning in Clear Aligner Therapy: A Comparative Study with Conventional Methods in Bandung, Indonesia Dea Albertina; Akmal Hasan; Tiffany Gabriele; Aisyah Andina Rasyid
Crown: Journal of Dentistry and Health Research Vol. 1 No. 1 (2023): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v1i1.55

Abstract

Introduction: Clear aligner therapy (CAT) has gained popularity as an esthetic alternative to traditional braces. Artificial intelligence (AI) is increasingly being integrated into CAT treatment planning, promising improved accuracy and efficiency. This study aimed to compare the accuracy and efficiency of AI-driven treatment planning with conventional methods in Bandung, Indonesia. Methods: A retrospective study was conducted involving 100 patients treated with CAT in Bandung. Fifty patients were treated using conventional methods (CM) by experienced orthodontists, while the other 50 were planned with AI-driven software. Accuracy was assessed by comparing the planned tooth movement with the actual outcome using Little's Irregularity Index (LII) and Peer Assessment Rating (PAR) scores at the end of treatment. Efficiency was evaluated by comparing the time required for treatment planning and the number of refinements needed. Results: The AI-driven group demonstrated significantly lower LII scores (p<0.05) and higher PAR scores (p<0.05) compared to the CM group, indicating greater accuracy in achieving the planned tooth movement. Additionally, the AI-driven group showed a significant reduction in treatment planning time (p<0.05) and fewer refinement aligners required (p<0.05) compared to the CM group. Conclusion: AI-driven treatment planning in CAT demonstrated superior accuracy and efficiency compared to conventional methods in Bandung, Indonesia. AI has the potential to optimize treatment outcomes and reduce treatment time, offering a valuable tool for orthodontists.
The Impact of Uncontrolled Type 2 Diabetes Mellitus on Chronic Rhinosinusitis Severity and Treatment Outcomes: A Prospective Cohort Study in Bandung, Indonesia Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Alexander Mulya; Pham Uyen; Maria Rodriguez
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.176

Abstract

Introduction: Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition, and type 2 diabetes mellitus (T2DM) is a known comorbidity that can exacerbate inflammatory processes. This study aimed to investigate the impact of uncontrolled T2DM on CRS severity and treatment outcomes in a cohort of patients in Bandung, Indonesia. Methods: A prospective cohort study was conducted at a private hospital in Bandung, Indonesia, from January 2020 to December 2022. Adult patients diagnosed with CRS (with or without nasal polyps) were enrolled and categorized into two groups: controlled T2DM (HbA1c ≤ 7%) and uncontrolled T2DM (HbA1c > 7%). CRS severity was assessed using the Sino-Nasal Outcome Test-22 (SNOT-22) and Lund-Mackay CT scoring. Treatment outcomes were evaluated at 3, 6, and 12 months post-initial treatment (medical and/or surgical) based on SNOT-22 scores, endoscopic findings, and the need for revision surgery. Results: A total of 240 patients were included (120 with controlled T2DM, 120 with uncontrolled T2DM). At baseline, the uncontrolled T2DM group had significantly higher mean SNOT-22 scores (58.5 ± 12.3 vs. 45.2 ± 10.1, p < 0.001) and Lund-Mackay CT scores (11.8 ± 3.5 vs. 8.2 ± 2.8, p < 0.001) compared to the controlled T2DM group. At 12 months, the uncontrolled T2DM group showed significantly less improvement in SNOT-22 scores (mean change: -15.4 ± 8.7 vs. -28.3 ± 9.2, p < 0.001) and a higher rate of revision surgery (18.3% vs. 5.8%, p = 0.002). Multivariate analysis revealed that uncontrolled T2DM (HbA1c > 7%) was an independent predictor of poorer treatment outcomes (OR: 3.45, 95% CI: 1.98-6.01, p < 0.001). Conclusion: Uncontrolled T2DM is associated with increased CRS severity and significantly poorer treatment outcomes in patients in Bandung, Indonesia. Effective glycemic control should be a crucial component of CRS management in patients with T2DM.
A Simplified Scoring System for Diagnosing Allergic Rhinitis in Indonesian Primary Care Settings: A Cross-Sectional Study Comparing Accuracy to Specialist Diagnosis Febria Suryani; Irna Nettles; Aisyah Andina Rasyid; Fifia Ardinanti
Sriwijaya Journal of Otorhinolaryngology Vol. 3 No. 1 (2025): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v2i2.183

Abstract

Introduction: Allergic rhinitis (AR) is a prevalent condition in Indonesia, yet often underdiagnosed and undertreated in primary care settings. Access to specialist otorhinolaryngologists is limited, particularly in rural areas. A simplified, accurate diagnostic tool for primary care physicians (PCPs) could significantly improve early diagnosis and management. This study aimed to develop and validate a simplified scoring system for AR diagnosis in Indonesian primary care, comparing its accuracy to the gold standard of specialist diagnosis. Methods: A cross-sectional study was conducted in five major Indonesian cities (Medan, Palembang, Jakarta, Surabaya, and Makassar) across various primary care clinics. Patients presenting with nasal symptoms suggestive of AR were recruited. Each patient was assessed by a PCP using the newly developed "Indonesian Allergic Rhinitis Score" (IARS) and subsequently by a board-certified otorhinolaryngologist. The IARS included key symptoms and history elements weighted based on existing literature and expert consensus. The otorhinolaryngologist's diagnosis, based on a comprehensive history, physical examination (including nasal endoscopy when indicated), and allergy testing (skin prick test or specific IgE), served as the reference standard. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and1 area under the receiver operating characteristic curve (AUC)2 were calculated to evaluate the IARS's diagnostic accuracy. Results: A total of 1500 patients were included in the study (300 from each city). The mean age was 32.4 years (SD = 10.2), with a slight female predominance (58%). The IARS demonstrated a sensitivity of 85.3% (95% CI: 83.1-87.3%), specificity of 79.6% (95% CI: 76.8-82.2%), PPV of 82.5% (95% CI: 80.2-84.6%), and NPV of 83.0% (95% CI: 80.3-85.4%) for diagnosing AR. The AUC was 0.89 (95% CI: 0.87-0.91), indicating good diagnostic accuracy. The most common symptoms reported were nasal congestion (92%), rhinorrhea (88%), sneezing (85%), and itchy nose (79%). Conclusion: The IARS provides a simple, accurate, and readily implementable tool for diagnosing AR in Indonesian primary care settings. Its high sensitivity and acceptable specificity suggest it can effectively identify individuals who require further evaluation and management for AR, improving access to care and potentially reducing the burden of undiagnosed allergic disease.
Co-Authors Abhimanyu Putra Akmal Hasan Alexander Mulya Bernadette Wilson Dea Albertina Febria Suryani Fifia Ardinanti Hasrita Soleiman Irna Nettles Made Swastika Maria Rodriguez Mariana Alifah Nabila Saraswati Pham Uyen Sari Sulistyoningsih Tiffany Gabriele Zahra Amir Zainal Abidin Hasan