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All Journal Sriwijaya Journal of Internal Medicine Sriwijaya Journal of Neurology Sriwijaya Journal of Otorhinolaryngology
Hasrita Soleiman
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Characterizing the Biofilm-Forming Capacity of Bacterial Isolates from Chronic Suppurative Otitis Media in Bhutan Tan Kiew Lee; Hasrita Soleiman
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.79

Abstract

Introduction: Chronic suppurative otitis media (CSOM) is a persistent middle ear infection characterized by recurrent ear discharge and hearing loss, significantly impacting the quality of life. Biofilm formation by bacteria plays a crucial role in the chronicity and recalcitrance of CSOM to conventional antibiotic treatments. This study aimed to characterize the biofilm-forming capacity of bacterial isolates from CSOM patients in Bhutan and assess their antibiotic susceptibility. Methods: Ear swab samples were collected from 100 patients diagnosed with CSOM at a tertiary hospital in Bhutan. Bacterial isolates were identified using standard microbiological techniques, including Gram staining, culture on selective media, and biochemical tests. Biofilm formation was quantitatively assessed using the crystal violet assay, and the biofilm architecture was visualized using confocal laser scanning microscopy (CLSM). The antibiotic susceptibility of biofilm-forming isolates was determined using the minimum biofilm eradication concentration (MBEC) assay. Results: The most prevalent bacterial isolates were Pseudomonas aeruginosa (35%), Staphylococcus aureus (25%), and Escherichia coli (15%). A significant proportion of these isolates (70%) exhibited strong biofilm-forming capacity. CLSM revealed a complex three-dimensional structure of the biofilms with channels and water passages, facilitating nutrient transport and waste removal. Biofilm-forming isolates demonstrated significantly higher MBEC values compared to their planktonic counterparts, indicating enhanced antibiotic resistance. Conclusion: This study highlights the significant prevalence of biofilm-forming bacteria in CSOM cases in Bhutan. The enhanced antibiotic resistance of these biofilms emphasizes the urgent need for alternative treatment strategies, such as biofilm-disrupting agents or targeted drug delivery systems, to effectively manage CSOM and prevent associated complications like hearing loss and intracranial infections.
Transcranial Magnetic Stimulation for the Treatment of Chronic Dizziness: A Randomized Controlled Trial in Bandung, Indonesia Zahra Amir; Nabila Saraswati; Made Swastika; Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Bernadette Wilson
Sriwijaya Journal of Neurology Vol. 2 No. 1 (2024): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i2.90

Abstract

Introduction: Chronic dizziness is a debilitating condition with limited treatment options. Transcranial magnetic stimulation (TMS) has shown promise in treating various neurological conditions. This randomized controlled trial investigated the efficacy and safety of TMS in treating chronic dizziness in Bandung, Indonesia. Methods: Participants with chronic dizziness (≥ 3 months) were randomly assigned to receive either active TMS or sham TMS for 10 sessions over two weeks. The active TMS group received 1 Hz stimulation over the right dorsolateral prefrontal cortex (DLPFC), while the sham group received placebo stimulation. The primary outcome was the change in Dizziness Handicap Inventory (DHI) score from baseline to four weeks post-intervention. Secondary outcomes included changes in Vertigo Symptom Scale (VSS) scores, Hospital Anxiety and Depression Scale (HADS) scores, and quality of life measures. Safety was assessed through monitoring of adverse events. Results: A total of 60 participants completed the study (30 in each group). The active TMS group showed a significantly greater improvement in DHI scores compared to the sham group (p < 0.001). Significant improvements were also observed in VSS, HADS, and quality of life measures in the active TMS group. No serious adverse events were reported. Conclusion: This study provides evidence for the efficacy and safety of TMS in treating chronic dizziness in the Indonesian population. TMS may be a valuable therapeutic option for patients with chronic dizziness who have not responded to conventional therapies.
The Impact of Uncontrolled Type 2 Diabetes Mellitus on Chronic Rhinosinusitis Severity and Treatment Outcomes: A Prospective Cohort Study in Bandung, Indonesia Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Alexander Mulya; Pham Uyen; Maria Rodriguez
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.176

Abstract

Introduction: Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition, and type 2 diabetes mellitus (T2DM) is a known comorbidity that can exacerbate inflammatory processes. This study aimed to investigate the impact of uncontrolled T2DM on CRS severity and treatment outcomes in a cohort of patients in Bandung, Indonesia. Methods: A prospective cohort study was conducted at a private hospital in Bandung, Indonesia, from January 2020 to December 2022. Adult patients diagnosed with CRS (with or without nasal polyps) were enrolled and categorized into two groups: controlled T2DM (HbA1c ≤ 7%) and uncontrolled T2DM (HbA1c > 7%). CRS severity was assessed using the Sino-Nasal Outcome Test-22 (SNOT-22) and Lund-Mackay CT scoring. Treatment outcomes were evaluated at 3, 6, and 12 months post-initial treatment (medical and/or surgical) based on SNOT-22 scores, endoscopic findings, and the need for revision surgery. Results: A total of 240 patients were included (120 with controlled T2DM, 120 with uncontrolled T2DM). At baseline, the uncontrolled T2DM group had significantly higher mean SNOT-22 scores (58.5 ± 12.3 vs. 45.2 ± 10.1, p < 0.001) and Lund-Mackay CT scores (11.8 ± 3.5 vs. 8.2 ± 2.8, p < 0.001) compared to the controlled T2DM group. At 12 months, the uncontrolled T2DM group showed significantly less improvement in SNOT-22 scores (mean change: -15.4 ± 8.7 vs. -28.3 ± 9.2, p < 0.001) and a higher rate of revision surgery (18.3% vs. 5.8%, p = 0.002). Multivariate analysis revealed that uncontrolled T2DM (HbA1c > 7%) was an independent predictor of poorer treatment outcomes (OR: 3.45, 95% CI: 1.98-6.01, p < 0.001). Conclusion: Uncontrolled T2DM is associated with increased CRS severity and significantly poorer treatment outcomes in patients in Bandung, Indonesia. Effective glycemic control should be a crucial component of CRS management in patients with T2DM.
Development and Validation of the Indonesian Voice Handicap Index Adapted for Javanese and Sundanese Speakers (I-VHI-JS) Hasrita Soleiman; Andhika Kurnianta Kusuma; Eduardo Michael Perez
Sriwijaya Journal of Otorhinolaryngology Vol. 3 No. 1 (2025): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v2i2.186

Abstract

Introduction: Voice disorders significantly impact quality of life. The Voice Handicap Index (VHI) is a widely used patient-reported outcome measure, but its applicability is limited by linguistic and cultural factors. Indonesia, with its diverse languages, requires culturally adapted versions. This study aimed to develop and validate the Indonesian Voice Handicap Index adapted for Javanese and Sundanese speakers (I-VHI-JS). Methods: The original English VHI was translated into Indonesian, Javanese, and Sundanese using a rigorous forward-backward translation process. A cross-sectional study was conducted involving three groups: (1) individuals with voice disorders (n=150; Javanese speakers = 75, Sundanese speakers = 75), (2) age- and gender-matched vocally healthy controls (n=150; Javanese speakers = 75, Sundanese speakers = 75), and (3) a test-retest reliability group (n=50; Javanese speakers = 25, Sundanese speakers = 25) from the voice disorder group. Participants completed the appropriate I-VHI-JS version. Otolaryngological examination and acoustic voice analysis (jitter, shimmer, noise-to-harmonics ratio) were performed. Internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coefficient - ICC), construct validity (known-groups comparison), concurrent validity (correlation with acoustic parameters), and discriminant validity (receiver operating characteristic - ROC curve analysis) were assessed. Results: The I-VHI-JS demonstrated excellent internal consistency (Cronbach's alpha > 0.90 for all versions) and test-retest reliability (ICC > 0.85 for all versions). Significant differences in I-VHI-JS scores were found between the voice disorder and control groups (p < 0.001) for all language versions, confirming construct validity. Moderate correlations were observed between I-VHI-JS scores and some acoustic parameters (e.g., jitter, r = 0.45, p < 0.01; shimmer, r = 0.40, p < 0.01). ROC curve analysis showed excellent discriminant ability (area under the curve - AUC > 0.80 for all versions). Conclusion: The I-VHI-JS is a reliable and valid instrument for assessing voice-related handicaps in Indonesian, Javanese, and Sundanese speakers. It can be used in clinical practice and research to evaluate the impact of voice disorders and monitor treatment outcomes.
Co-Authors Aisyah Andina Rasyid Alexander Mulya Andhika Kurnianta Kusuma Bernadette Wilson Eduardo Michael Perez Made Swastika Maria Rodriguez Nabila Saraswati Pham Uyen Tan Kiew Lee Zahra Amir Zainal Abidin Hasan