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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Pijar MIPA
Sarie, Aldila Divana
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Mathematics Medicine & Pharmacology Physics Other

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Formulation and Evaluation of Transdermal Dissolving Microneedle Loaded with Ethanol Extract of Cocor Bebek Leaves (Kalanchoe pinnata) Balapadang, Rachel Noveriachristie; Sarie, Aldila Divana; Rosyidah, Safira; Zulqifli, Iqbal; Akifah, Muthia Nur; Zahra, Aliya Azkia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.378-385

Abstract

Background: Acne is a chronic skin inflammation caused by blockage of the sebaceous glands in the skin and hypercolonization of the acne-causing bacteria Propionibacterium acnes. Cocor bebek leaves (Kalanchoe pinnata) are known to contain various secondary metabolites, including flavonoids, with antibacterial activity. Objective: In an effort to prevent side effects from using oral and topical antibiotics to treat acne, an alternative acne treatment that is safer and more effective with a strong drug delivery system is needed: microneedle patch technology containing natural ingredients. Methods: A microneedle patch formulation of Cocor bebek leaf extract was developed using a combination of HPMC and PVP polymers. The evaluation of microneedle patches included irritation tests with rat test animals and antibacterial activity tests against Propionibacterium acnes. The results showed the formation of yellow microneedle patches with uniform needles. The evaluation results showed that the microneedle patch has an irritation index value classified as non-irritant and has antibacterial activity against Propionibacterium acnes, with the highest inhibitory diameter at an extract concentration of 30% with a moderate inhibition category. Conclusion: The microneedle patch cocor bebek leaf extract shows potential as an effective drug delivery system for the treatment of acne that is safe for use on the skin.
Bioactivity Analysis of Chalcone-Derived Compounds Based on In-Silico Molecular Docking Study Sarie, Aldila Divana; Utami, Marsah Rahmawati
Jurnal Pijar Mipa Vol. 20 No. 2 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i2.8550

Abstract

Chalcone compounds are aromatic ketones and enones that have been found to have several activities, such as antimalarial, antioxidant, anti-inflammatory, anticancer, antiviral, anti-HIV, antifungal, antihyperglycemic, and carboxygenase inhibitors. A ligand's bioactivity can be predicted through in-silico tests using molecular docking. Molecular docking studies are conducted to study the interaction between ligand and receptor and identify the receptor's active site that matches the ligand when the ligand and receptor bind in a stable complex. This study can be a preliminary test before conducting in vitro and in vivo tests. This narrative review aims to analyze information on the bioactivity of chalcone-derived compounds and their derivatives through an in silico molecular docking approach in the form of binding affinity values and amino acid residues that bind. The method used is a literature study of 13 research articles found through the Semantic Scholar and Springer Link databases. The review results showed that the new compounds derived from chalcone compounds have a good range of bioactivity, as seen from the binding affinity values, which show lower values when compared to other test ligands and referenced ligands. The functional groups that have an important role in the interaction between ligands and proteins between ligands and receptors are triazole, methoxy, amine, halogen, carbonyl, hydroxyl, and thiol groups bound to the reactive structure of the α,β unsaturated ketone aromatic ring in the structure of the chalcone compound. The compounds that show promising activity can be further investigated as new drug candidates.
Co-Authors Akifah, Muthia Nur Balapadang, Rachel Noveriachristie Marsah Rahmawati Utami Rosyidah, Safira Zahra, Aliya Azkia Zulqifli, Iqbal