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All Journal Jurnal Ilmiah RESPATI Journal of Pharmaceutical and Sciences.
Zulqifli, Iqbal
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Article Review: Formulasi dan Evaluasi Microneedle Mukoadhesif Buccal dengan Berbagai Metode Pembuatan Aini, Kania Nurul; Zahra, Aliya Azkia; Sabrina, Lina Maisa; Maulida, Verin Sakinah; Zulqifli, Iqbal; Rafifa, Muthia; Putra, Hasan Etanov
JURNAL PERTANIAN Vol 16, No 1 (2025): Jurnal Ilmiah Respati
Publisher : Universitas Respati Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/jir.v16i1.5431

Abstract

Sistem penghantaran obat menggunakan microneedle mukoadhesif buccal menawarkan teknologi inovatif untuk mengirimkan obat secara minimal invasif melalui mukosa buccal. Dalam 10 tahun terakhir, berbagai metode pembuatan, seperti ablasi laser, pencetakan 3D, dan fotolitografi, telah menghasilkan peningkatan akurasi dan efisiensi struktur microneedle. Formulasi berbahan polimer seperti HPMC dan karbopol terbukti memberikan kekuatan adhesi tinggi, mendukung retensi obat yang lebih baik pada mukosa. Polimer alami seperti asam hialuronat dan kitosan berperan dalam hidrasi mukosa serta pelepasan obat yang terkontrol. Penelitian menunjukkan ukuran microneedle yang tepat berkontribusi terhadap efisiensi penetrasi dan pelepasan obat, dengan durasi pelepasan yang dapat disesuaikan dari hitungan menit hingga beberapa hari. Selain itu, formulasi tertentu mampu menghasilkan pelepasan obat dari hitungan menit hingga beberapa hari, tergantung kebutuhan terapi. Microneedle mukoadhesif buccal sangat efektif dalam pengobatan lokal, seperti ulkus oral, dan juga dapat memberikan efek terapeutik sistemik yang signifikan. Dengan kemampuan penghantaran obat yang presisi, efisiensi tinggi, dan minim rasa sakit, sistem ini memberikan alternatif yang menjanjikan untuk meningkatkan kenyamanan pasien. Perkembangan teknologi pembuatan dan formulasi terus membuka peluang aplikasi yang lebih luas dalam berbagai kondisi klinis, menjadikan microneedle mukoadhesif buccal sebagai solusi unggulan untuk terapi obat masa depan. Kata Kunci: Buccal, Microneedle, Mukoadhesif
Interaksi Obat-Herbal dengan Agen Hormon dalam Terapi Kanker: Tinjauan Mekanisme dan Implikasi Klinis Zulqifli, Iqbal; Hikmah, Nurul; Shella, Tasya Permata; Azizah, Nabilla Faoziyyah; Apriani, Risa Dwi; Putri, Mukarromah Dita; Hilmi , Indah Laily
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1073

Abstract

Hormone therapy is the cornerstone of treatment for hormone-dependent cancers, such as breast and prostate cancer. On the other hand, the high rate of herbal medicine use as complementary treatment in cancer patients has the potential to cause herbal drug interactions (HDIs), which can affect the efficacy and safety of the primary therapy. This study aims to identify and categorize drug-herbal interactions (DHIs) in cancer hormone therapy based on pharmacokinetic mechanisms (including CYP450 enzyme and drug transporter modulation) and pharmacodynamic mechanisms (including hormone receptor and signaling pathway modulation), as well as to conclude their clinical implications. A systematic review was conducted following the PRISMA-ScR guidelines. A literature search was performed in the PubMed, Scopus, ScienceDirect, Frontiers, and Google Scholar databases for relevant in silico, in vitro, and in vivo studies published between 2015 and 2025. Analysis showed that HDI can be categorized into two main groups. First, pharmacokinetic interactions that occur through the modulation of cytochrome P450 (CYP) enzymes and drug transporters, such as the reduction in the bioavailability of tamoxifen by Hedyotis diffusa. Second, pharmacodynamic interactions at hormone receptors, such as the synergistic effect between Boswellia serrata and enzalutamide. The nature of interactions varies greatly, from antagonistic to synergistic, depending on the specific herbal-drug pair. These findings emphasize the importance of clinical vigilance, such as open communication with patients, dose adjustments, therapeutic monitoring, and interprofessional collaboration. These measures are necessary to reduce the risk of HDI and improve the efficacy of cancer therapy.
Co-Authors Aini, Kania Nurul Apriani, Risa Dwi Azizah, Nabilla Faoziyyah Hilmi , Indah Laily Maulida, Verin Sakinah Nurul Hikmah Putra, Hasan Etanov Putri, Mukarromah Dita Rafifa, Muthia Sabrina, Lina Maisa Shella, Tasya Permata Zahra, Aliya Azkia