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All Journal Jurnal Ilmiah Wahana Pendidikan Journal of Pharmaceutical and Sciences.
Akifah, Muthia Nur
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Perbandingan Efektivitas Antibiotik Terhadap Durasi Terapi Demam Tifoid Sholih, Mally Ghinan; Mulki, Munir Alinu; Nurhadis, Nurhadis; Akifah, Muthia Nur; Aprillia, Cantika; Maharani, Puteri Rahma; Subekti, Firli Reisya; Affandhy, Adhwa'a Kaylla
Jurnal Ilmiah Wahana Pendidikan Vol 11 No 1.D (2025): Jurnal Ilmiah Wahana Pendidikan 
Publisher : Peneliti.net

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Abstract

Demam tifoid merupakan penyakit yang sering terjadi di Indonesia, disebabkan oleh bakteri Salmonella typhi yang menyebar melalui jalur fecal-oral. Prevalensi demam tifoid di Indonesia mencapai 1,60%, dengan prevalensi tertinggi pada anak-anak berusia 5 hingga 14 tahun karena kebiasaan jajan sembarangandan kurangnya perhatian terhadap kebersihan diri . Pengobatan demam tifoid melibatkan pemberian antibiotik yang tepat dan perawatan suportif. Studi ini bertujuan untuk menganalisisefektivitas antibiotik dalam mengurangi durasi terapidemam tifoid, dengan fokus pada antibiotik seperticeftriaxone, cefotaxime, azithromycin, ciprofloxacin, kloramfenikol, dan tiamfenikol. Metode yang digunakan dalam penelitian initermasuk dalam jenis penelitian systematics literature review. Penelitian menunjukkan bahwa ceftriaxone lebih efektif dari pada kloramfenikol dalam mengatasi demam tifoid, dan kombinasi antibiotik seperti tiamfenikol dan ceftriaxone dapat mengurangi lama rawat inap. Azitromisin juga efektif untuk kasus tanpa komplikasi. Penggunaanantibiotik yang tepat penting untuk mengurangi case fatality rate. Terapi kombinasi dapat memperluas spektrumaktivitas antimikroba dan mencegah resistensi. Studi ini memberikan wawasan tentang pengobatan demam tifoiddengan antibiotik yang efektif, seperti ceftriaxone, azithromycin, dan kombinasi antibiotik tertentu. Pentingnya edukasi tentang kebersihan pribadi dan lingkungan juga disorot untuk mencegah penyebaran infeksi lebih lanjut. Dengan pemahaman yang lebih baiktentang efektivitas antibiotik dalam pengobatan demam tifoid, diharapkan dapat meningkatkan penanganan kasusdemam tifoid dan mengurangi dampak negatifnya.Kata kunci: Demam tifoid, Lama pengobatan, Terapi antibiotik, Efikasi obat, dan Efektivitas perbandingan
Literature Review : Perbandingan Aktivitas Senyawa Kimia Yang Berpotensi Sebagai Kandidat Obat Kanker Payudara Oral Menggunakan Metode In Silico Akifah, Muthia Nur; Damara , Dandy Satria; Putri , Indah Syah; Utami , Marshah Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.679

Abstract

Breast cancer is a type of cancer with a high prevalence rate, especially in women, which contributes significantly to the global death rate from cancer. This disease is characterized by abnormal cell growth that attacks body tissues and is often difficult to treat due to the limitations of effective treatment and minimal side effects. Although treatments such as chemotherapy, surgery, and radiation therapy are available, significant side effects, including impaired patients' quality of life, remain a major challenge. Therefore, a new approach is needed to find drug candidates with high efficacy and lower side effects.  This study aims to compare the activity of chemical compounds that have the potential to be used as a breast cancer drug using the in silico method. The method involves computer simulations to evaluate molecular interactions with cancer receptors, such as ER-α and HER-2, as well as verify their pharmacokinetic feasibility through compliance with Lipinski's rules. This review literature draws on eight relevant recent studies, showing that some compounds have significant activity against cancer receptors and meet pharmacokinetic criteria for oral administration. The results of the analysis revealed that Longipinocarvone compounds had the best affinity for ER-α receptors (-8.20 kcal/mol), while Galagin showed the best affinity for HER-2 (-7.79 kcal/mol). Both also meet Lipinski's rule, indicating the potential to be developed into an oral drug. This in silico simulation provides efficient and cost-effective initial insight into the drug discovery process. The study concluded that both compounds have the potential to be promising breast cancer drug candidates, although further validation through in vitro and in vivo trials is needed to support these results.
Co-Authors Affandhy, Adhwa'a Kaylla Aprillia, Cantika Damara , Dandy Satria Maharani, Puteri Rahma Munir Alinu Mulki Nurhadis, Nurhadis Putri , Indah Syah Sholih, Mally Ghinan Subekti, Firli Reisya Utami , Marshah Rahmawati