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All Journal Jurnal Pengabdian Magister Pendidikan IPA eJournal Kedokteran Indonesia
Dwisaraswati, Salma Aulia
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Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Optimalisasi Edukasi Nutrisi 1000 Hari Pertama Kehidupan untuk Mencegah Stunting di Desa Arjasa Kecamatan Arjasa Amini, Stefia Aisyah; Wahyukundari, Melok Aris; Syahirah, Diva Rana; Putri, Dhiani Eka; Adriana, Putu Julio; Dwisaraswati, Salma Aulia; Fitri, Amira Qanitah; Wijaya, Clarissa; Ramadhan, Takbir Sabda Akhiru; Hayati, Chairy; Arzani, Tiara Putri
Jurnal Pengabdian Magister Pendidikan IPA Vol 7 No 4 (2024): Oktober-Desember 2024
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v7i4.9615

Abstract

The prevalence of stunting in Jember remains high, with Arjasa being one of the areas with significant incidence rates. The 2019 nutritional status estimate report for toddlers showed that one of village in Jember namely Arjasa had a high prevalence of stunting, at 44.1% of 663 children. Existing research indicates that Arjasa has a family stunting risk level based on maternal factors of 85.90%. These maternal factors include low maternal knowledge about nutrition and the ability to provide nutritious food during the first 1000 days of life. Therefore, this community service aims to educate mothers and prospective mothers in Arjasa on the importance of optimizing nutrition during the first 1000 days of life. The methods used include educating young women on healthy mother preparation, socializing stunting and its detection to Arjasa's posyandu cadres, socializing healthy 1000 HPK nutrition to pregnant women's communities, and developing local MSMEs. All activities went smoothly with each target event being attended. Post-test results showed an increase in knowledge and understanding of target subjects after providing the material. The activity received positive responses from village officials and Arjasa's posyandu, and was well-received by the local community. The community's knowledge related to stunting and improving 1000 HPK nutrition began to increase, but in practice, it still needed to cover all branch posyandu in Arjasa. In the future, it is expected that there will be more adequate facilities and infrastructure to cover more target subjects.
Effect of Low-Dose Chlorpyrifos on Hepatocyte Necrosis and Serum Albumin Levels in Wistar Rats Abrori, Cholis; Dwisaraswati, Salma Aulia; Wahyudi, Septa Surya; Rumastika, Nindya Shinta; Rachmania, Sheilla; Wisudanti, Desie Dwi; Sakinah, Elly Nurus; Komariah, Cicih; Supangat, Supangat
eJournal Kedokteran Indonesia Vol. 13 No. 2 (2025): Vol 13, No. 2 - Agustus 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1003.1

Abstract

Chlorpyrifos is a broad-spectrum organophosphate pesticide that also causes various health problems. The active metabolite of chlorpyrifos can increase free radicals in the body, especially in the liver and kidneys. The continuous increase in free radicals will cause an imbalance between free radicals and oxidants, triggering oxidative stress. Oxidative stress stimulates mitochondrial dysfunction, resulting in changes in the hepatocyte shape and serum albumin levels. This study aimed to determine the effect of chlorpyrifos on the hepatic histopathology scores and serum albumin levels of Wistar rats. Experimental research was conducted at the Faculty of Medicine, University of Jember in May-December 2024. A total of 12 male Wistar rats were divided into two groups. The control group was given normal saline (+5% Tween 20), and the chlorpyrifos group was given chlorpyrifos + normal saline (+5% Tween 20) orally for 7 days. On the 8th day, all animals were euthanized with ketamine-xylazine, hepatic organs, and blood were taken intracardiac. Preparations were made using HE staining, and serum albumin levels were checked using a photometer. The results showed that hepatic histopathology scores assessed by the Manja Roenigk method and serum albumin levels had significant differences between the groups metabolized. Seven days of chlorpyrifos exposure can increase hepatocyte necrosis and decrease serum albumin levels.
Co-Authors Adriana, Putu Julio Amini, Stefia Aisyah Arzani, Tiara Putri Cholis Abrori, Cholis Cicih Komariah Desie Dwi Wisudanti Elly Nurus Sakinah, Elly Nurus Fitri, Amira Qanitah Hayati, Chairy Melok Aris Wahyukundari, Melok Aris Putri, Dhiani Eka Ramadhan, Takbir Sabda Akhiru Rumastika, Nindya Shinta septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Supangat Supangat Syahirah, Diva Rana Wijaya, Clarissa