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All Journal JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Prosiding Seminar Nasional COSMIC Kedokteran Medicosphere
Tedjaprasadja, Leonardo
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Humanities Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Medicosphere

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The Role of One Health Framework to Neglected Tropical Diseases in South East Asia: A Literature Review Tedjaprasadja, Leonardo
Journal of Diverse Medical Research: Medicosphere Vol. 2 No. 5 (2025): J Divers Med Res 2025
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v2i5.179

Abstract

Neglected tropical diseases (NTDs) remain a significant public health challenge in Southeast Asia, disproportionately affecting marginalized communities and exacerbating cycles of poverty and poor health. These diseases often arise at the interface of human, animal, and environmental health, necessitating a transdisciplinary approach. The One Health framework, which integrates human, animal, and environmental health strategies, offers a holistic and sustainable solution to combat NTDs in the region. This article explores the application of One Health in addressing NTDs such as dengue, leptospirosis, schistosomiasis, and rabies across Southeast Asia. It highlights current regional initiatives, identifies challenges including fragmented surveillance systems and limited intersectoral coordination and underscores the importance of cross-border collaboration, community engagement, and policy integration. Emphasizing the need for sustained investment and capacity building, the article advocates for strengthening One Health systems as a pathway toward effective NTD control and elimination in Southeast Asia.
Early Warning System for Disaster Preparedness in Local Flood Management: A Literature Review Tedjaprasadja, Leonardo
Journal of Diverse Medical Research: Medicosphere Vol. 2 No. 6 (2025): J Divers Med Res 2025
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v2i6.187

Abstract

Background: Flooding remains one of the most recurrent and devastating natural hazards, disproportionately impacting low-lying and poorly drained areas, particularly in developing countries. Exacerbated by rapid urbanization, climate change, and inadequate infrastructure, flood-related disasters increasingly affect socioeconomically vulnerable populations. Despite the predictable nature of such events, local-level disaster preparedness remains insufficient, largely due to the absence or inefficiency of Early Warning Systems (EWS). Methods: This paper investigates the role of EWS in strengthening community-based flood preparedness by applying the United Nations Office for Disaster Risk Reduction (UNDRR) four-component framework: risk knowledge, monitoring and warning service, dissemination and communication, and response capability. Using a qualitative, framework-based methodology, the study assesses each component through case study analysis, technological review, and institutional mapping. Result and Discussions: Findings indicate that while EWS provides a robust conceptual tool for flood risk mitigation, their implementation is frequently hindered by technical, institutional, social, and financial barriers. These include unreliable monitoring infrastructure, fragmented governance, inequitable communication access, and unsustainable funding mechanisms. Moreover, the study reveals that the success of EWS hinges not merely on technological sophistication, but on their alignment with local contexts, community participation, and cross-sectoral coordination. Conclusion: This concludes that for EWS to be effective and equitable, they must be embedded within broader resilience strategies that emphasize localized governance, long-term capacity building, and inclusive risk communication. By reorienting EWS toward community-driven models, stakeholders can enhance flood preparedness and reduce disaster vulnerability amid escalating climate threats. Keywords: EWS, Disaster Preparedness, Flood Management, Local Context
The Correlation of Landslide Disaster with Increased Cases of Atopic Dermatitis in Disaster Victims : A Literature Review Carissa Aulia Ramadhani Sutopo; Seliana, Irma; Durry, Fara Disa; Tedjaprasadja, Leonardo; Verawaty, Liana
Journal of Diverse Medical Research: Medicosphere Vol. 2 No. 7 (2025): J Divers Med Res 2025
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

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Abstract

Background landslides not only bring physical damage, but also trigger various health problems, including an increase in cases of atopic dermatitis. The post-landslide environment conditions that are humid, dusty, and limited access to clean water in evacuation centers worsen the skin health of the survivors. Exposure to allergens from soil, mold, and disaster stress further increases the risk of skin inflammation. Purpose from this literature is to analyze the relationship between landslide disasters and the increase in atopic dermatitis cases through environmental factors and explore the effect of limited sanitation and allergen exposure on the increase in atopic dermatitis cases after landslide disasters. Method this study uses Literature Review with data obtained from the databases Science Direct, Elsevier, Open Exploration, Research Gate, Pubmed, Taylor and Francis, Proquest, and SINTA with a total of 10 national journal articles, 20 international journal articles, and 5 theses. Result some studies show that landslides can increase cases of atopic dermatitis due to exposure to dust, mold, poor sanitation, and stress in evacuation camps. Changes in microbiota and the immune system are also implicated in aggravating symptoms, and microbiota manipulation is a suggested therapeutic strategy. Other studies have shown that such an impact does not necessarily take place, especially where quality emergency sanitation and adequate access to health care services exist. Conclusion environmental, sanitation, and microbiota factors play a role in the severity of atopic dermatitis, especially in areas affected by landslides. Exposure to dust, mold, and limited clean water in evacuation camps can worsen skin conditions, while post-disaster stress also weakens the immune system, so health, hygiene, and environmental management education is needed for more effective prevention. However, some studies argue that not all landslide events increase atopic dermatitis, especially in regions with adequate emergency sanitation and health services.
Wastewater Surveillance of SARS-CoV-2 as Monitoring Tool for COVID-19: A Literature Review Satyafebrianti, Kendra Callista; Tedjaprasadja, Leonardo; Durry, Fara Disa; Seliana, Irma
Journal of Diverse Medical Research: Medicosphere Vol. 2 No. 8 (2025): J Divers Med Res 2025
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

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Abstract

Background: The COVID-19 pandemic, caused by SARS-CoV-2, has significantly impacted global health, requiring effective surveillance methods. Wastewater surveillance has emerged as a cost-effective and non-invasive tool to detect viral RNA from both symptomatic and asymptomatic individuals, allowing early detection of outbreaks. Objective: This study analyzes the effectiveness of wastewater surveillance in detecting SARS-CoV-2 RNA in untreated wastewater, comparing it with clinical surveillance and evaluating its role in public health monitoring. Method: A literature review was conducted using PubMed, Google Scholar, and Scopus, focusing on studies published between 2015–2025. Articles were selected based on relevance, availability, and originality, applying the PICO strategy to refine the search. From ten initially identified studies, two were selected for in-depth analysis. Result: The findings demonstrate that wastewater surveillance effectively tracks SARS-CoV-2 trends in communities. A study in Brazil showed a strong correlation between viral loads in wastewater and clinical case trends, proving its potential as an early warning system. Meanwhile, research in Australia confirmed the presence of SARS-CoV-2 in wastewater and estimated infection prevalence using Monte Carlo simulation, aligning with reported clinical cases. These studies highlight wastewater surveillance as a reliable tool for population-wide monitoring. Conclusion: Wastewater surveillance is a proven method for detecting SARS-CoV-2, complementing clinical surveillance by enabling early detection, wider coverage, and cost efficiency. Challenges such as RNA degradation and detection standardization require further research, but integrating RT-qPCR and genomic sequencing enhances its accuracy for future epidemiological monitoring.
Early Detection and Treatment of Pediatric Amblyopia: A Cost-Benefit Analysis in the Indonesia: A Literature Review Tedjaprasadja, Leonardo
Journal of Diverse Medical Research: Medicosphere Vol. 2 No. 8 (2025): J Divers Med Res 2025
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

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Abstract

Background: Amblyopia is a leading cause of preventable visual impairment in children. Despite effective treatment, delayed diagnosis limits visual recovery and may reduce lifetime productivity. In Indonesia, where pediatric vision screening is not yet universal, undiagnosed amblyopia may lead to lifelong productivity losses. This study evaluates the cost-effectiveness of early screening and intervention for amblyopia from a societal perspective. Methods: A Markov model simulated a cohort of 100,000 children aged 3 over a 70-year period. Two strategies were compared: (1) early vision screening and treatment through primary care (e.g., Puskesmas), and (2) no structured screening. Costs, utilities, productivity losses, benefit-cost ratio were estimated using local data where available and adjusted using purchasing power parity (PPP) and Indonesian-specific parameters from WHO-CHOICE, BPJS Kesehatan reimbursement rates, and labor market data. Results: The findings affirm that nationwide early screening and treatment for amblyopia in Indonesia are not only clinically effective but also economically justified. The estimated lifetime productivity gain per successfully treated child was USD 4,130, yielding a total indirect savings of over USD 11.3 million. The benefit-cost ratio was 7.8:1, The calculated ICER was USD 183.54 per QALY gained Conclusion: Universal amblyopia screening in Indonesia is cost benefit and highly cost-effective. Integration into school-based health programs and the Puskesmas system could optimize early detection, reduce visual disability burden, and improve long-term national productivity.
Atopic Dermatitis: Relationship Of Risk Factors On Children With Atopic Dermatitis.: A Literature Review Athirah, Fatin Nisrina; Tedjaprasadja, Leonardo
Journal of Diverse Medical Research: Medicosphere Vol. 1 No. 1 (2024): J Divers Med Res 2024
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v1i1.45

Abstract

AbstractBackground: Atopic dermatitis (AD) is a persistent and recurring inflammatory skin condition, marked by acute eczema or chronic lichenified lesions, with a diverse range of presentations. This skin disease affects almost 10-20% of people worldwide. The progression of atopic dermatitis is characterized by chronic relapses, which can greatly impact patients' quality of life. Biomarkers have long played an essential role in various medical applications, particularly for diagnostic purposes. However, identifying appropriate biomarkers for atopic dermatitis remains challenging, primarily due to difficulties in obtaining samples. Objective: To find out the antiderm mobile-based application, discussing the knowledge of atopic dermatitis. Method: Literature review is taken from databases such as PubMed and Google Scholar published in the last 5 years, namely from 2018-2022. Then find out about the ANTIDERM mobile-based application. Results: Based on the literature, there are several biomarkers that can be used for patients with atopic dermatitis including TARC or CCL17, CCL27, phytosphingosine CD300a, Interleukin-1 family (IL-18, IL1?, CXCL8), adipokines, FABP5, filaggrin. In addition, the mobileantiderm-based application facilitates communication between doctors and patients, and contains some information about the symptoms of dermatitis so that the public can know the symptoms of dermatitis and how to avoid this dangerous disease. Conclusion: From this literature, it was found that there are several current methods for patients with atopic dermatitis that can be used to help the community in preventing atopic dermatitis. Keywords: Biomarker Atopic Dermatitis, Atopic Dermatitis Diagnosis, Mobile Health Applications Atopic Dermatitis
Co-Authors Agustina, Putri Noviana Arbani, Rafi Auliya Athirah, Fatin Nisrina Carissa Aulia Ramadhani Sutopo Fara Disa Durry Satyafebrianti, Kendra Callista Seliana, Irma Verawaty, Liana Zahira, Alya Shofiyah