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All Journal Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Ananda, Luthfiah
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Computer Science & IT Education Environmental Science Medicine & Pharmacology Social Sciences Other

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THE OPTIMATION OF FERMENTATION FOR METABOLITE PRODUCTION BY SYMBIONT Penicillium nalgiovense FROM THE SPONGE Gelliodes fibulata Rusmalina, Siska; Mahfur, Mahfur; Ermawati, Nur; Maliah, Nabilatun; Ananda, Luthfiah; Bintang Pratama, Kevin; Evi Ulfiani , Riska; Abdul Aziz, Danang; Husain, Khafidz; Ilma Faza, Febi; Hidayatullah, Adib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1682

Abstract

The fungi are sponge symbionts.  The fungus Penicillium nalgiovense acc MK087096  is a symbiont of the sponge Gelliodes fibulata. This symbiont has antibacterial activity, which supports the development of sponge-based drugs that are as effective as antibiotics. However, the primary challenge in developing marine resource-based medicine is the availability and sustainability of sponge raw materials. Fermentation biotechnology using sponge symbiont fumgi is an effective solution to address these challenges, as it allows the production of bioactive secondary metabolite compounds in large quantities, which can be used as raw materials for pharmaceutical preparation. The aim of this study was to determine the optimal medium and fermentation duration for producing secondary metabolites with antibiotic properties from the symbiotic fungus Penicillium nalgiovense, isolated from the sponge Gelliodes fibulata. This study was conducted naturally. The symbiotic fungus from the sponge Gelliodes fibulata was cultivated to facilitate growth. Fermentation was conducted with variations in secondary metabolite harvesting times of 2, 4, 6, 8, 10, and 12 days.  Secondary metabolites were obstained using liquid-liquid extraction with ethyl acetate. The optimal medium and fermentation time were determined based on the yield percentage for each medium across the six time variations. The fermentation biotechnology of the symbiotic fungus Penicillium nalgiovense acc MK087096 from the spone Gelliodes fibulata was carried out on SDB, PDB, also coconut flake-enriched PDB media.  The results showed the growth of the fungus and the production of bioactive secondary metabolites with antibiotic properties ...
THE OPTIMATION OF FERMENTATION FOR METABOLITE PRODUCTION BY SYMBIONT Penicillium nalgiovense FROM THE SPONGE Gelliodes fibulata Rusmalina, Siska; Mahfur, Mahfur; Ermawati, Nur; Maliah, Nabilatun; Ananda, Luthfiah; Bintang Pratama, Kevin; Evi Ulfiani , Riska; Abdul Aziz, Danang; Husain, Khafidz; Ilma Faza, Febi; Hidayatullah, Adib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1682

Abstract

The fungi are sponge symbionts.  The fungus Penicillium nalgiovense acc MK087096  is a symbiont of the sponge Gelliodes fibulata. This symbiont has antibacterial activity, which supports the development of sponge-based drugs that are as effective as antibiotics. However, the primary challenge in developing marine resource-based medicine is the availability and sustainability of sponge raw materials. Fermentation biotechnology using sponge symbiont fumgi is an effective solution to address these challenges, as it allows the production of bioactive secondary metabolite compounds in large quantities, which can be used as raw materials for pharmaceutical preparation. The aim of this study was to determine the optimal medium and fermentation duration for producing secondary metabolites with antibiotic properties from the symbiotic fungus Penicillium nalgiovense, isolated from the sponge Gelliodes fibulata. This study was conducted naturally. The symbiotic fungus from the sponge Gelliodes fibulata was cultivated to facilitate growth. Fermentation was conducted with variations in secondary metabolite harvesting times of 2, 4, 6, 8, 10, and 12 days.  Secondary metabolites were obstained using liquid-liquid extraction with ethyl acetate. The optimal medium and fermentation time were determined based on the yield percentage for each medium across the six time variations. The fermentation biotechnology of the symbiotic fungus Penicillium nalgiovense acc MK087096 from the spone Gelliodes fibulata was carried out on SDB, PDB, also coconut flake-enriched PDB media.  The results showed the growth of the fungus and the production of bioactive secondary metabolites with antibiotic properties ...
PENGENALAN BAHAYA DAN PENANGANAN PENYAKIT DEGENERATIF  PADA USIA MUDA Fatkhiya, Musa Fitri; Jeff, Jamaludin Al; Faza, Febi Ilma; Ananda, Luthfiah; Chelsea, Najwa
BESIRU : Jurnal Pengabdian Masyarakat Vol. 1 No. 6 (2024): BESIRU : Jurnal Pengabdian Masyarakat, Juni 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/169waj73

Abstract

Penyakit degenerative adalah penyakit jangka panjang yang bersifat progresif. Penyakit degenerative yang paling umum diketahui adalah penyakit kardiovaskuler atau penyakit yang berhubungan dengan jantung dan pembuluh darah dan penyakit neurodegenerative atau penyakit jangka panjang yang menyerang system neuron atau saraf. Penyakit degenerative tidak dapat disembuhkan dan hanya dapat dikontrol gejalanya menggunakan obat-obatan. Penggunaan obat yang tidak patuh dapat menyebabkan perburukan kondisi pasien, dapat menimbulkan komplikasi penyakit lain bahkan kematian. Salah satu factor resiko dari timbulnya penyakit kardiovaskuler adalah gaya hidup yang tidak baik dan benar. Untuk mencegah terjadinya penyakit kardiovaskuler, maka diperlukan pemahaman dan pengetahuan yang cukup dalam menjaga pola hidup yang baik yang dimulai sejak sedini mungkin. Kegiatan yang akan dilaksanakan yaitu penyuluhan Pengenalan Bahaya Dan Penanganan Penyakit Degeneratif Pada Usia Muda yang akan dilaksanakan di Smk Nusantara Comal. Hasil kegiatan kepada masyarakat ini menunjukkan perbedaan pada sebelum dan setelah diberikan penyuluhan yang diharapkan kegiatan penyuluhan dapat rutin dilakukan dan dapat membantu anak-anak usia muda mencegah terjadinya komplikasi dan gangguan kardiovaskuler
Co-Authors Abdul Aziz, Danang Bintang Pratama, Kevin Chelsea, Najwa Evi Ulfiani , Riska Fatkhiya, Musa Fitri Faza, Febi Ilma Hidayatullah, Adib Husain, Khafidz Ilma Faza, Febi Jeff, Jamaludin Al Mahfur, Mahfur Maliah, Nabilatun Nur Ermawati, Nur Siska Rusmalina