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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmiah Kesehatan Indonesian Journal of Cancer
Wulandari, Anisa Saphira
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Age as a Risk Factor for Advanced Stage in Cervical Cancer Patients at RSUPN Cipto Mangunkusumo 2019-2022: A Retrospective Multivariate Study Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Purwoto, Gatot; Wulandari, Anisa Saphira; Soloan, Garry; Sini, Kieran Pasha Ivan; Utami, Tofan Widya; Anggaraeni, Tricia Dewi; Putra, Andi Darma; Nuryanto, Kartiwa Hadi; Winarto, Hariyono
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2366

Abstract

Abstract Introduction: In 2020, cervical cancer ranked as the fourth most common cancer in women globally, with an incidence of 604,000 cases. In Indonesia, cervical cancer holds the second position among the most prevalent cancers in women. This study aims to evaluate the relationship between age and the occurrence of advanced-stage cervical cancer as a step towards effective prevention, early detection, and management. Methods: This research adopts a retrospective study design based on the Cancer Registration database of RSUPN Cipto Mangunkusumo, focusing on cervical cancer patients from 2019 to 2022. Multivariate analysis was conducted with age as the primary independent variable, considering parity and employment status in the analysis. The FIGO classification of cervical cancer stages was used to categorize patients into early and advanced stages. Results: Out of 512 cervical cancer cases, 492 were included in this study. The distribution of cervical cancer stages and the age distribution of patients is depicted in Figure 1 and Figure 2. The analysis of the relationship between cervical cancer stage, age, parity, and employment status is presented in Table 2. The association between age and cervical cancer stage is statistically significant (p<0.05) with an odds ratio of 2.13, particularly in individuals aged >54 years. Conclusion: Age over 54 years is a significant risk factor for advanced-stage cervical cancer. Although there is no significant association with parity and employment history, these findings support preventive and early detection efforts in the older population. Increased screening programs and education are expected to reduce cases of advanced-stage cervical cancer in the future.
Exploring the Molecular and Cellular Aspects of Hydatidiform Mole: a Narrative Review Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; As’syifa, Salsa Billa; Metasyah, Namira; Binathara, Geraldus Sigap Gung; Putra, Abdul Hafiidh Surya; Wulandari, Anisa Saphira
Indonesian Journal of Cancer Vol 19, No 3 (2025): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i3.1304

Abstract

Background: Hydatidiform mole, a type of gestational trophoblastic disease, arises from abnormal placental tissue and has the potential for malignant transformation. The condition’s incidence varies globally, with notable prevalence in Indonesia. Advanced maternal age, dietary factors, and a history of previous moles contribute to recurrence risks. Understanding the molecular and cellular mechanisms is critical for effective management.Methods: This narrative review synthesizes findings from primary studies and reviews exploring the molecular and cellular characteristics of hydatidiform mole. Data were sourced from Google Scholar, PubMed, and ScienceDirect using keywords like “hydatidiform mole,” “molecular mechanisms,” and “cell signaling pathways.”Results: The pathogenesis involves chromosomal abnormalities, particularly in complete moles characterized by a diploid genome lacking maternal DNA. P57KIP2 expression serves as a diagnostic marker, distinguishing complete from partial moles. Molecular genotyping, including short tandem repeat (STR) analysis, aids in accurate diagnosis and risk stratification for malignancy. Genetic factors, including mutations in NLRP7 and KHDC3L, are associated with recurrence in familial cases.Conclusion: The cellular and molecular insights into hydatidiform moles enhance understanding of their pathophysiology and inform diagnostic strategies. Recognizing genetic predispositions enables better patient management, emphasizing the need for continued research into the condition’s underlying mechanisms to improve clinical outcomes and therapeutic approaches.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN TINGKAT KEHAMILAN PASIEN HIPERPLASIA DAN KANKER ENDOMETRIUM: TINJAUAN SISTEMATIS DAN META-ANALISIS Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Wulandari, Anisa Saphira; Binathara, Geraldus Sigap Gung; Soloan, Garry; Sini, Kieran Pasha Ivan; Purwoto, Gatot; Utami, Tofan Widya; Anggaraeni, Tricia Dewi; Putra, Andi Darma; Nuryanto, Kartiwa Hadi; Winarto, Hariyono
Jurnal Ilmiah Kesehatan Vol 23 No 03 (2024): Jurnal Ilmiah Kesehatan terbitan Desember Volume 23 Nomor 03 Tahun 2024
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikes.v23i03.3405

Abstract

Hiperplasia endometrium dan kanker endometrium adalah kondisi yang memengaruhi kesuburan wanita. Tujuan dari tinjauan sistematis dan meta-analisis ini adalah untuk mengevaluasi faktor-faktor yang berhubungan dengan tingkat kehamilan pada pasien dengan kondisi tersebut. Pencarian dilakukan di lima database utama: PubMed, Science Direct, Scopus, Embase, dan Cochrane Library. Dari 2.742 studi yang awalnya ditemukan, 7 studi memenuhi kriteria inklusi dan dianalisis lebih lanjut. Meta-analisis dilakukan untuk mengevaluasi efek terapi kombinasi Levonorgestrel-Releasing Intrauterine System (LNG-IUS) dengan progestin dan pengaruh indeks massa tubuh (BMI) terhadap tingkat kehamilan. Analisis gabungan dari dua studi yang membandingkan kombinasi LNG-IUS dengan progestin terhadap LNG-IUS saja menghasilkan Odds Ratio (OR) sebesar 1,54 [95% CI: 0,74–3,24], tanpa signifikansi statistik (p = 0,25). Untuk BMI, gabungan dua studi memberikan Risk Ratio (RR) sebesar 1,40 [95% CI: 0,93–2,10], juga tidak signifikan (p = 0,11). Heterogenitas yang rendah (I² = 0%) pada analisis terapi dan sedang (I² = 53%) pada analisis BMI menunjukkan konsistensi antarstudi. Meskipun ada tren peningkatan angka kehamilan dengan terapi kombinasi LNG-IUS dan progestin serta BMI ≥ 25, hasil meta-analisis ini belum menunjukkan signifikansi statistik. Penelitian lebih lanjut diperlukan untuk memperjelas faktor-faktor yang berhubungan dengan kehamilan pada pasien dengan hiperplasia dan kanker endometrium.
Co-Authors Andi Darma Putra Anggaraeni, Tricia Dewi As’syifa, Salsa Billa Binathara, Geraldus Sigap Gung Fitriyadi Kusuma Gatot Purwoto Hariyono Winarto Kartiwa Hadi Nuryanto Metasyah, Namira Putra, Abdul Hafiidh Surya Sini, Kieran Pasha Ivan Soloan, Garry Suryoadji, Kemal Akbar Utami, Tofan Widya