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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Ilmiah Kesehatan Cermin Dunia Kedokteran
Sini, Kieran Pasha Ivan
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Health Professions Medicine & Pharmacology Public Health

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The Age as a Risk Factor for Advanced Stage in Cervical Cancer Patients at RSUPN Cipto Mangunkusumo 2019-2022: A Retrospective Multivariate Study Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Purwoto, Gatot; Wulandari, Anisa Saphira; Soloan, Garry; Sini, Kieran Pasha Ivan; Utami, Tofan Widya; Anggaraeni, Tricia Dewi; Putra, Andi Darma; Nuryanto, Kartiwa Hadi; Winarto, Hariyono
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2366

Abstract

Abstract Introduction: In 2020, cervical cancer ranked as the fourth most common cancer in women globally, with an incidence of 604,000 cases. In Indonesia, cervical cancer holds the second position among the most prevalent cancers in women. This study aims to evaluate the relationship between age and the occurrence of advanced-stage cervical cancer as a step towards effective prevention, early detection, and management. Methods: This research adopts a retrospective study design based on the Cancer Registration database of RSUPN Cipto Mangunkusumo, focusing on cervical cancer patients from 2019 to 2022. Multivariate analysis was conducted with age as the primary independent variable, considering parity and employment status in the analysis. The FIGO classification of cervical cancer stages was used to categorize patients into early and advanced stages. Results: Out of 512 cervical cancer cases, 492 were included in this study. The distribution of cervical cancer stages and the age distribution of patients is depicted in Figure 1 and Figure 2. The analysis of the relationship between cervical cancer stage, age, parity, and employment status is presented in Table 2. The association between age and cervical cancer stage is statistically significant (p<0.05) with an odds ratio of 2.13, particularly in individuals aged >54 years. Conclusion: Age over 54 years is a significant risk factor for advanced-stage cervical cancer. Although there is no significant association with parity and employment history, these findings support preventive and early detection efforts in the older population. Increased screening programs and education are expected to reduce cases of advanced-stage cervical cancer in the future.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN TINGKAT KEHAMILAN PASIEN HIPERPLASIA DAN KANKER ENDOMETRIUM: TINJAUAN SISTEMATIS DAN META-ANALISIS Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Wulandari, Anisa Saphira; Binathara, Geraldus Sigap Gung; Soloan, Garry; Sini, Kieran Pasha Ivan; Purwoto, Gatot; Utami, Tofan Widya; Anggaraeni, Tricia Dewi; Putra, Andi Darma; Nuryanto, Kartiwa Hadi; Winarto, Hariyono
Jurnal Ilmiah Kesehatan Vol 23 No 03 (2024): Jurnal Ilmiah Kesehatan terbitan Desember Volume 23 Nomor 03 Tahun 2024
Publisher : UIMA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jikes.v23i03.3405

Abstract

Hiperplasia endometrium dan kanker endometrium adalah kondisi yang memengaruhi kesuburan wanita. Tujuan dari tinjauan sistematis dan meta-analisis ini adalah untuk mengevaluasi faktor-faktor yang berhubungan dengan tingkat kehamilan pada pasien dengan kondisi tersebut. Pencarian dilakukan di lima database utama: PubMed, Science Direct, Scopus, Embase, dan Cochrane Library. Dari 2.742 studi yang awalnya ditemukan, 7 studi memenuhi kriteria inklusi dan dianalisis lebih lanjut. Meta-analisis dilakukan untuk mengevaluasi efek terapi kombinasi Levonorgestrel-Releasing Intrauterine System (LNG-IUS) dengan progestin dan pengaruh indeks massa tubuh (BMI) terhadap tingkat kehamilan. Analisis gabungan dari dua studi yang membandingkan kombinasi LNG-IUS dengan progestin terhadap LNG-IUS saja menghasilkan Odds Ratio (OR) sebesar 1,54 [95% CI: 0,74–3,24], tanpa signifikansi statistik (p = 0,25). Untuk BMI, gabungan dua studi memberikan Risk Ratio (RR) sebesar 1,40 [95% CI: 0,93–2,10], juga tidak signifikan (p = 0,11). Heterogenitas yang rendah (I² = 0%) pada analisis terapi dan sedang (I² = 53%) pada analisis BMI menunjukkan konsistensi antarstudi. Meskipun ada tren peningkatan angka kehamilan dengan terapi kombinasi LNG-IUS dan progestin serta BMI ≥ 25, hasil meta-analisis ini belum menunjukkan signifikansi statistik. Penelitian lebih lanjut diperlukan untuk memperjelas faktor-faktor yang berhubungan dengan kehamilan pada pasien dengan hiperplasia dan kanker endometrium.
Hubungan antara Bersepeda dan Infertilitas Pria: Tinjauan Sistematis dari Penelitian Saat Ini: Analisis Suryoadji, Kemal Akbar; Ridwan, Alifaturrasyid Syafaatullah; Fauzi, Ahmad; Sini, Kieran Pasha Ivan; Taher, Akmal
Cermin Dunia Kedokteran Vol 52 No 5 (2025): Kardiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i5.1241

Abstract

Introduction: Cycling is a popular sport and also has various health benefits. However, cycling carries health risks, including fertility problems. This research aims to explore the association between cycling and infertility in men. Methods: This systematic review was conducted according to a PROSPERO protocol (ID: CRD42024509255) and PRISMA guidelines using the PubMed, Cochrane, and ScienceDirect databases. Keywords “(Bicycle) AND (Infertility)” are used. The risk of bias was assessed based on the Cochrane risk of bias tool for cohort studies. Results: The final two cohort studies were included with a total of 487 cyclists. Regular cycling of more than 1.5 hours/week was associated with 34% (95% CI 4-55%) lower sperm concentration compared to control. Regular cycling of more than 5 hours/week was associated with lower sperm concentration (OR 1.92, 95% CI 1.03-3.56) and lower total sperm motility (OR 2.05, 95% CI 1.19-3.56) compared to the control group. Conclusion: There is a relationship between cycling and male infertility; a decrease in sperm concentration in men who cycle at least 1.5 hours/week and lower sperm motility in men who cycle for at least 5 hours/week. The direct efect of cycling on the incidence of infertility as a consequence needs to be explored further.
Co-Authors Akmal Taher Andi Darma Putra Anggaraeni, Tricia Dewi Binathara, Geraldus Sigap Gung Fauzi Ahmad Muda Fitriyadi Kusuma Gatot Purwoto Hariyono Winarto Kartiwa Hadi Nuryanto Ridwan, Alifaturrasyid Syafaatullah Soloan, Garry Suryoadji, Kemal Akbar Utami, Tofan Widya Wulandari, Anisa Saphira