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Sembiring, Mahral Effendi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Public Health Veterinary

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Identifikasi Komponen Minyak Atsiri Daun Salam (Syzygium polyanthum (Wight Walp.) dengan GC-MS dan Potensinya Sebagai Antibakteri Sihotang, Santyria; Simanjuntak, Helen Anjelina; Purba, Hermawan; Iksen, Iksen; Sembiring, Mahral Effendi
Herbal Medicine Journal Vol 8 No 1 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i1.137

Abstract

Essential oils, known as volatile oils or essential oils, are oils produced from plants and have the property of easily evaporating at room temperature without undergoing decomposition. The bay leaf plant (Syzygium polyanthum (Wight.) Walp.) is one of the plants that is very often used as an alternative medicine. There is evidence that bay leaves, which contain compounds such as niacin, fiber, tannin, and vitamin C, have the ability to lower serum triglyceride levels. This research aims to determine the essential oil content in bay leaves using the steam distillation method and its potential as an antibacterial. The results of the research show that bay leaves contain essential oils which have antibacterial properties against the bacteria Helicobater pylori and Bacillus cereus. Bay leaf essential oil (Syzygium polyanthum (Wight.) Walp) with varying concentrations of 10%, 30%, 50%, 70% and 100% showed the highest inhibitory zone diameter for Helicobater pylori bacteria, namely at a concentration of 100% with a diameter of 5, 25 mm and in Bacillus cereus bacteria with a diameter of 7.95 mm.
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Ranti (Solanum nigrum L.) dengan Metode DPPH Sembiring, Mahral Effendi; Nainggolan, Tumpak V
Herbal Medicine Journal Vol 7 No 2 (2024): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v7i2.139

Abstract

Ranti (Solanum nigrum L.) leaf is a solanaceae plant. This ranti leaf contains alkaloid, saponin, flavonoid and tannin compounds. Flavonoids in the human body function as antioxidants so it is very good for preventing anti-cancer diseases. This study aims to determine the antioxidant activity of ethanol extract of ranti leaves, Vitamin C and calculate the IC50 value of ethanol extract of ranti leaves and vitamin C using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results of measuring antioxidant activity in the DPPH method showed that the ethanol extract of ranti leaves had very weak antioxidant activity with an IC50 value of 245.128 ppm, while the measurement results of vitamin C had very strong antioxidant activity with an IC50 value of 16.9235 ppm.
Uji Aktivitas Antibakteri Krim Ekstrak Etanol Daun Kitolod (Isotoma longiflora)(L).C.Presl Terhadap Staphylococcus epidermidis dan Pseudomonas aeruginosa Simanjuntak, Helen Anjelina; Nahampun, Laura Yunita; Purba, Hermawan; Simanjuntak, Herlina; Sinaga, Suharni Pintamas; Sembiring, Mahral Effendi; Rahmiati, Rahmiati; Situmorang, Toberni S
Herbal Medicine Journal Vol 8 No 2 (2025): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v8i2.186

Abstract

Kitolod plants are used to treat various types of diseases, such as eye pain, wound healing, asthma, bronchitis, rheumatism and others. This study aims to determine the antibacterial activity test of kitolod leaf ethanol extract cream (Isotoma longiflora) (L).C.Presl against Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. This research stage includes determination, preparation of simplicia, extraction, phytochemical screening, cream formulation F0 (0%), F1 (4%), F2 (6%) F3 (8%), and antibacterial test. The results of the phytochemical screening showed that alkaloids, flavonoids, tannins, saponins and steroids were obtained. The results of the antibacterial activity test of the formula against Staphylococcus epidermidis in sequence F0 (0%), F1 (4%), F2 (6%) and F3 (8%) were 11.315 mm; 15.205 mm; 18.843 mm; 23.698 mm. Meanwhile, against Pseudomonas aeruginosa bacteria, the measurements were 6.04 mm, 8.19 mm, 12.46 mm, and 17.24 mm, respectively. In conclusion, all variations of the cream formula showed antibacterial activity in inhibiting the growth of Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria. The cream formulation was more sensitive to Staphylococcus epidermidis bacteria than Pseudomonas aeruginosa bacteria.
Effectiveness Test of Ethanol Extract of Red Betel Leaves (Piper Crocatum Ruiz & Pav) Against Histopathological Features of The Pancreas and Blood Sugar Levels of Alloxan-Induced Male Mice (Mus Musculus L) Sembiring, Mahral Effendi; Nasution, Ali Napiah; Chiuman, Linda
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes Mellitus induces hyperglycemia. Low insulin production causes insulin resistance and altered protein, fat, and carbohydrate metabolism. Much research has shown that traditional herbal treatments can treat diabetes. Diabetes increases free radical production. Secondary metabolic plants include antioxidants that treat extreme illnesses like diabetes. This study examines the efficacy of ethanol extract from red betel leaves (EERBL) in lowering blood glucose levels in vivo, the optimal dose, secondary metabolite content based on phytochemical screening, and alloxan-induced pancreatic hyperglycemia histopathology. Mouse. Six 20-30 gram groups of mice were treated. Group III got 0.65 mg/kgBW glibenclamide, and Groups IV, V, and VI received oral gavage EERBL 100, 300, and 500 mg/kgBW. Group I was in standard control without alloxan, and Group II was in alloxan control. Hyperglycemic mice received 150 mg/kg BW intraperitoneal alloxan. Red betel is 96% ethanol-macerated. Oral red betel leaf extract was given for 21 days to monitor blood glucose and pancreatic function. Splitting red betel leaves to male mice significantly altered blood glucose and pancreatic histology. Red betel goes low cuts close and pancreatic histology by 58.4%. Blood glucose readings were Kruskal-Wallis significant at 0.004 or 0.05. Red betel leaf extract reduced blood glucose and enhanced pancreatic histology in male mice.
Co-Authors Chiuman, Linda Helen Anjelina Simanjuntak Iksen, Iksen Nahampun, Laura Yunita Nainggolan, Tumpak V Nasution, Ali Napiah Purba, Hermawan Rahmiati Rahmiati Sihotang, Santyria Simanjuntak, Herlina Sinaga, Suharni Pintamas Toberni S Situmorang