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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Sheridan, Sabilla
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Analysis of Handgrip Strength with Insulin Resistance in Male and Female Indonesian Adults Kurniawan, Liong Boy; Sheridan, Sabilla; Syafaat, Andi Wali; Surur, Andi Ainun Zulkiah; Nadhifah, Naurah; Afandi, Ichlas Nanang; Ariyandy, Andi; Basri, Muhammad Iqbal; Aminuddin, Aminuddin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2345

Abstract

Insulin resistance, a precursor to diabetes mellitus and metabolic syndrome, has increased in prevalence in recent decades. Grip strength reflects muscle strength and is thought to provide an overview of the condition of insulin sensitivity. The purpose of this study was to evaluate the association between insulin resistance and handgrip strength in male and female Indonesian adults. This cross-sectional study recruited 169 adult participants, 71 of the subjects were males and 98 of the subjects were females. Handgrip strength, insulin, fasting glucose, HOMA-IR, and OGTT were measured, then the association between handgrip strength and insulin resistance was assessed. Linear regression analysis showed that in male subjects, relative handgrip strength was negatively associated with log HOMA-IR (univariate: B= -0.703, beta= -0.323, p=0.006; multivariate: B= -0.687, beta= -0.316, p=0.012) while no association was found in female subjects (univariate: B= -0.192, beta= -0.136, p=0.183; multivariate: B= -0.172, beta= -0.121, p=0.262). The optimal cut-off value of relative handgrip strength to assess insulin resistance is 0.45 (sensitivity 73.3%, specificity 73.1%) in the male group and 0.34 (sensitivity 68.4%, specificity 61.0%) in the female group. The weaker the handgrip strength in males, the higher the HOMA-IR value. In females, no significant correlation showed between handgrip strength and insulin resistance.
Analysis of Urine Synaptopodin Levels in Non-Diabetic Adults with Obesity and without Obesity Sheridan, Sabilla; Samad , Raehana; Kurniawan, Liong Boy
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2293

Abstract

Obesity correlates strongly with insulin resistance and diabetes mellitus and ultimately becomes a major risk factor for kidney disease. Podocytes play a crucial role in maintaining glomerular filtration balance. Synaptopodin is a proline-rich protein closely associated with the actin microfilaments in podocyte foot processes. This study aims to compare urinary synaptopodin levels in non-diabetic obese subjects with non-obese subjects. A cross-sectional study was conducted on males and females without diabetes mellitus who met inclusion and exclusion criteria. Urinary synaptopodin levels were assessed using an ELISA method. The study included 70 participants, comprising 35 males and 35 females. There were 36 obese subjects and 34 non-obese subjects. No significant difference was found in urinary synaptopodin levels between non-obese and obese subjects (0.51±0.43 vs. 0.49±0.37 ng/dL, p=0.672). No correlation was found between urinary synaptopodin levels and body mass index (r = -0.060, p=0.623). Urinary synaptopodin levels did not differ significantly between non-obese and obese subjects.
Co-Authors Afandi, Ichlas Nanang Aminuddin Aminuddin Ariyandy, Andi Basri, Muhammad Iqbal Liong Boy Kurniawan, Liong Boy Nadhifah, Naurah Samad , Raehana Surur, Andi Ainun Zulkiah Syafaat, Andi Wali