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All Journal Journal Syifa Sciences and Clinical Research (JSSCR) Journal of Pharmacology and Natural Products
Andy Suryadi, A. Mu'thi
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology

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Analisis Cemaran Logam Berat Merkuri (Hg), Timbal (Pb), dan Tembaga (Cu) pada Sungai Provinsi Gorontalo H. Hutuba, Ariani; Maku, Mohamad Aditya; Taupik, Muhammad; Adam Mustapa, Mohamad; Andy Suryadi, A. Mu'thi
Journal Syifa Sciences and Clinical Research Vol 7, No 1 (2025): Volume 7 Edisi 1 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i1.29865

Abstract

Heavy metals are a group of elements with high density (5 g/cm³) and unique chemical properties. They can be toxic and hazardous to the environment and human health. Heavy metal contamination in river waters is commonly caused by mercury (Hg), lead (Pb), and copper (Cu). This study aims to analyze the concentration of these metals in several rivers in Gorontalo Province using Atomic Absorption Spectrophotometry (AAS). Water samples were collected from four different rivers at a depth of 0.5 meters. The results showed that Hg concentration in the Bulango River exceeded the established quality standards, while Pb and Cu levels in the Bone River were within safe limits. The Limboto and Hulawa Rivers also met the quality standards.
Uji Aktivitas Antihiperglikemik Ekstrak Etanol 70% Daun Hulotua (Commelina longifolia L.) Secara In Vivo Menggunakan Mencit Andy Suryadi, A. Mu'thi; Ramadhani, Fika Nuzul; Makkulawu, Andi; Uno, Wiwit Zuriati; Manno, Mohamad Reski; Maku, Diva Julyar Cahyani
Journal of Pharmacology and Natural Products Vol. 2 No. 1 (2025): Volume 2, Nomor 1, Tahun 2025
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jpnp.v2i1.126

Abstract

Tanaman Hulotua (Commelina longifolia L.) merupakan tanaman yang berasal dari family commelinaceae yang dapat dijadikan sebagai sumber tanaman yang berkhasiat sebagai obat. Dipercaya tanaman yang masuk kedalam genus commelina memiliki kandungan senyawa yang dapat berpotensi sebagai antihiperglikemik. Penelitian ini bertujuan untuk mengetahui efek antihiperglikemik ekstrak etanol 70% daun hulotua (Commelina longifolia L.) menggunakan mencit. Metode penelitian yang digunakan yaitu metode eksperimental model pre and post test randomize control group design dengan mengukur pengaruh ekstrak etanol daun hulotua terhadap kadar glukosa darah pada mencit. Penelitian ini menggunakan mencit yang terbagi menjadi 5 kelompok dan terdiri dari 5 kelompok perlakuan diantaranya kelompok kontrol negatif (Na-CMC), kelompok kontrol positif (Glibenklamid), kelompok uji I (dosis 5,6 mg/20 g BB mencit), kelompok uji II (dosis 11,2 mg/20 g BB mencit) dan kelompok uji III (22,4 mg/20 g BB mencit). Hasil penelitian menunjukkan bahwa daun hulotua (Commelina longifolia L.) yang diekstraksi menggunakan metode maserasi didapatkan hasil persen rendemen sebesar 21,67%, dan diantara kelompok uji I, kelompok uji II, dan kelompok uji III menunjukkan ketiga dosis ini dapat menurunkan kadar glukosa darah mencit, dengan dosis yang memiliki efektiftas paling baik sebagai antihiperglikemik pada mencit jantan terdapat pada dosis 22,4 mg/20 g BB mencit dengan penurunan kadar glukosa darah dari 70,04 mg/dL ke 132,2 mg/dL.
Major Sesquiterpenes of Patchouli Leaf Essential Oil (Pogostemon cablin Benth.): A GC-MS Study Taupik, Muhammad; Adam Mustapa, Mohamad; Radjak, Fahmi As; Andy Suryadi, A. Mu'thi; Aprianto Paneo, Mohamad
Journal of Pharmacology and Natural Products Vol. 2 No. 2 (2025): Volume 2, Nomor 2, Tahun 2025
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jpnp.v2i2.224

Abstract

Patchouli (Pogostemon cablin Benth.) is a tropical plant widely recognised as the main source of patchouli oil, an essential oil with high economic and pharmaceutical value. This study aimed to identify the chemical constituents of patchouli leaf essential oil and determine its major compounds. Extraction was performed using solvents of different polarities, followed by analysis with Gas Chromatography–Mass Spectrometry (GC-MS). The results revealed five dominant compounds: Bicyclo[5.3.0]decane, 2-methylene-5-(1-methylvinyl)-8-methyl (19.99%), Aromandendrene (12.04%), Naphthalene, decahydro-4a-methyl-1-methylene-7 (9.20%), Caryophyllene (7.29%), and Valerena-4,7(11)-diene (6.87%). These compounds play an important role in both the aroma and biological activities of patchouli oil. Methanol, as a polar solvent, produced the highest yield (10%), while n-hexane yielded the lowest (2%). The findings confirm the potential of patchouli essential oil as a natural source for pharmaceutical, cosmetic, and aromatherapy applications.
Co-Authors Aprianto Paneo, Mohamad Ariani H. Hutuba Fika Nuzul Ramadhani Makkulawu, Andi Maku, Diva Julyar Cahyani Maku, Mohamad Aditya Manno, Mohamad Reski Mohamad Adam Mustapa Muhammad Taupik Radjak, Fahmi As Wiwit Zuriati Uno