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All Journal HAYATI Journal of Biosciences Jurnal Sumberdaya Hayati
Ghoza, Muhammad Radian
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Immunology & microbiology

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Potensi Waste Organic Product (WOP) FST 1310 terhadap Pertumbuhan Candida albicans Penyebab Kandidiasis: Potential of the Waste Organic Product (WOP) FST 1310 on the Growth of the Fungi Candida albicans Causes Candidiasis Ramadhan, Firdaus; Ghoza, Muhammad Radian; Haribowo, Dinda Rama; Sholeha, Dania Refia Riska; Kartika; Lestari, Anggita Rana Sasmita; Fikriwansyah, Aswir; Putri, Lily Surayya Eka; Ramadhani, Lidia Anggita; Sugoro, Irawan
Jurnal Sumberdaya Hayati Vol. 11 No. 1 (2025): 2025
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.11.1.8-15

Abstract

Candida albicans is an agent that causes candidiasis which can cause health problems in human’s organs. This study aims to determine the antifungal activity and inhibition zone diameter of Waste Organic Product (WOP) FST 1310 against Candida albicans. This type of research is experimental, using the Kirby-Bauer agar diffusion method with 6 treatments: P1: 100%, P2: 80%, P3: 60%, and P4: 40%, along with 2 controls, P5: nystatin (positive control) and P6: distilled water (negative control). The results showed that the WOP FST 1310 from orange peel had a larger inhibition zone diameter compared to the vegetable-derived. For the vegetable-derived eco-enzyme, the highest inhibition zone diameter was at a 100% concentration with an average of 3.7 mm. Meanwhile, for the orange peel eco-enzyme, the highest inhibition zone diameter was at a 40% concentration with an average of 5.3 mm.
Preparation and Characterization of P(3HB-co-HHX)/Silk Fibroin Nanofiber for Chondrogenic Differentiation on Human Adipose Mesenchymal Stem Cell Pramono, Andri Pramesyanti; Yulianti, Retno; Razi, Muhamad Alif; Karina; Ang, Shaik Ling; Sudesh, Kumar; Hanan; Endarwati, Yuni Cahya; Ghoza, Muhammad Radian
HAYATI Journal of Biosciences Vol. 33 No. 3 (2026): May 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.3.617-633

Abstract

This study explored the proliferative and chondrogenic differentiation capacities of nanofiber containing silk fibroin hybrid Bombyx mori silkworm cocoons (Japan-China SP-01 variant from Indonesia) and PHA P(3HB-co-3HHx) on human adipose mesenchymal stem cells. First, the scaffolds were prepared for electrospinning by combining two distinct biomaterials, consisting of silk fibroin derived from hybrid Bombyx mori silkworm cocoons, with a combination of 3-hydroxybutyrate (3HB) and 3-hydroxyhexanoate (3HHx). The effects of various ratios of P(3HB-co-3HHx)/Silk Fibroin nanofiber mixture on proliferative and differentiation capacity were then investigated. Following that, the morphology, chemical compositions, contact angle, tensile strength, roughness, cell viability, and human adipose mesenchymal stem cell differentiation of the nanofiber were investigated by collagen type 2 gene expression. The results of scanning electron microscopy showed the mean diameter of the nanofiber ranged from 370-600  nm. Following that, 16,000 volts was prominent for nanofiber manufacture in all ratios. It was also demonstrated that the nanofiber has significant mechanical properties, acceptable hydrophilicity and smoothness, and appropriate cell viability (up to 99.1% compared to the control on silk fibroin nanofiber). Although PHA increased tensile strength, silk fibroin administration to the mixture predominantly enhanced chondrogenic differentiation, as evidenced by modulation of chondrogenic collagen type 2 (up to 8.718-fold) gene markers. Furthermore, the physicochemical characteristics of the nanofiber mixture significantly influenced the proliferation and differentiation of human adipose mesenchymal stem cells. The results of the tests showed that silk fibroin administration into a nanofiber mixture has improved chondrogenesis and showed great potential as a cartilage tissue scaffold.
Co-Authors Andri Pramesyanti Pramono Ang, Shaik Ling Endarwati, Yuni Cahya Fikriwansyah, Aswir Firdaus Ramadhan Hanan Irawan Sugoro Karina Kartika Lestari, Anggita Rana Sasmita Lily Surayya Eka Putri, Lily Surayya Eka Ramadhani, Lidia Anggita Razi, Muhamad Alif Retno Yulianti Sholeha, Dania Refia Riska Sudesh, Kumar