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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Science Midwifery JOURNAL LA MEDIHEALTICO
Saputra, I Gede Agus Rio
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Humanities Dentistry Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Pemberian Gel Chitosan Dari Ekstrak Kulit Udang Vannamei (Litopenaeus Vannamei) Terhadap Angiogenesis Pada Tikus Jantan (Rattus Norvegicus) Pramana, Anak Agung Ngurah Gede Anggra; Rahadianto, Rahadianto; Biutifasari, Verna; Saputra, I Gede Agus Rio
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i1.56203

Abstract

Luka merupakan keadaan hilang atau rusaknya sebagian jaringan tubuh yang dapat disebabkan oleh trauma benda tajam atau tumpul, perubahan suhu, zat kimia, ledakan, sengatan listrik, atau gigitan serangga. Menurut WHO pada tahun 2018, Luka bakar adalah masalah kesehatan masyarakat global, yang menyebabkan sekitar 180.000 kematian setiap tahunnya. Kulit udang vannamei diketahui mengandung chitosan yang berpotensi dapat meningkatkan penyembuhan luka bakar. Tujuan penelitian ini untuk mengetahui pengaruh pemberian gel chitosan dari ekstrak kulit udang selama 7 hari secara topikal terhadap angiogenesis pada tikus jantan galur Wistar dengan luka bakar derajat II. Desain penelitian ini yang dilakukan di Laboratorium Biokimia Fakultas Kedokteran Universitas Hang Tuah Surabaya. rancangan penelitian ini adalah Post Test Only Control Group Design. Sampel yang digunakan adalah 18 ekor tikus jantan galur Wistar yang dibagi menjadi dua kelompok ; kelompok pertama, luka hanya dibiarkan sebagai kelompok kontrol. Kelompok kedua diberi gel chitosan dari ekstrak kulit udang secara topikal sebagai kelompok perlakuan, kemudian hari ke-8 tikus diambil jaringan kulitnya kemudian dibuat preparat histopatologi di Universitas Hang Tuah Surabaya. Tahap terakhir penelitian, dilakukan perhitungan jumlah angiogenesis. Data yang diperoleh dianalisis menggunakan uji statistik t dua sampel bebas. Hasil rerata jumlah angiogenesis pada kelompok kontrol sebanyak 3,83, pada kelompok perlakuan 6,72. Uji statistika uji t dua sampel bebas didapatkan hasil sebesar 0.001 (<0.05). Penelitian menunjukan bahwa terdapat pengaruh pemberian gel chitosan dari ekstrak kulit udang vannamei (litopenaeus vannamei) terhadap angiogenesis pada tikus jantan (rattus norvegicus) galur wistar dengan luka bakar derajat II.
Research trends and clinical evidence: A comparison of surgical vs. conservative approaches for chronic pelvic pain syndrome – a systematic review and bibliometric analysis Saputra, I Gede Agus Rio; Pramana, Anak Agung Ngurah Gede Anggra; Marta, Kadek Fajar
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1945

Abstract

Chronic Pelvic Pain Syndrome (CPPS) is a complex medical condition that affects patients' physical, emotional, and social quality of life. Its management involves two main approaches: surgical and conservative. However, there are significant differences in the effectiveness, risks, and long-term impacts of each approach. This study aims to evaluate the effectiveness of surgical and conservative approaches in managing CPPS through a systematic review and bibliometric analysis, focusing on pain reduction, improvement in quality of life, and risk of complications. This research employs the Systematic Literature Review (SLR) method, following the PRISMA guidelines to search, screen, and evaluate relevant literature from databases such as PubMed, Scopus, and the Cochrane Library. The quality of the relevant studies is assessed using standardized appraisal tools. Quantitative data are analyzed through bibliometric analysis to identify differences in effectiveness between surgical and conservative approaches. The results indicate that the surgical approach is more effective in reducing severe and refractory pain compared to conservative therapy, but it is associated with a higher risk of complications. Conversely, the conservative approach provides benefits for mild to moderate symptoms with minimal risk and lower cost. In the context of Indonesia, the conservative approach is more suitable to be implemented as the first-line treatment for CPPS, with surgical options considered for cases that do not respond to initial therapy.
Acute Lupus Pneumotitis as a Complication of Pregnancy: A Case Report Saputra, I Gede Agus Rio; Putra, I Putu Bagus Darma; Putra, I Wayan Artana
Journal La Medihealtico Vol. 6 No. 5 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i5.2556

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that is chronic in nature and has considerable clinical heterogeneity. Acute Lupus Pneumonitis (ALP) is one of its many presentations. We report the case of a 29-year-old, primigravida patient at 30 weeks of gestation presenting with progressive dyspnoea, phlegmatic cough lasting three weeks and morning fever. On physical examination, there was a stabilized alert patient with normal vital signs. Examination by auscultation of thorax revealed slight subcostal retraction and other rhonchi and wheezing. Cephalic foetal presentation was present in the abdomen and abdominal ultrasound was reported normal. Investigations in the laboratory showed thrombocytopenia, over iron-deficiency anaemia, and systemic inflammatory factors. The presence of demonstrable anti-SSA and anti-SSB antibodies provided support to the diagnosis of pregnancy-related suspicious SLE bronchopneumonia. A restrictive diet was established, which included ceftriaxone once per day, Methylprednisolone between two times per day, Nebulised salbutamol between three times per day, N-Acetyl cysteine between three times per day, hydroquinone once per day, aspartilet once a day, and vitamin D once a day. The patient was discharged four days after therapy after clinical improvement was noted. After two months, she gave birth to clinically healthy infant via caesarean section, due to breech presentation and placenta previa as well as the persistence of SLE with the risk of lupus flare. ALP is a dangerous pulmonary SLE process. Here, the positive anti-SSA and anti-SSB were especially worrying considering that such antibodies are linked to very severe maternal and foetal complications.
Co-Authors Biutifasari, Verna Marta, Kadek Fajar Pramana, Anak Agung Ngurah Gede Anggra Putra, I Putu Bagus Darma Putra, I Wayan Artana Rahadianto, Rahadianto