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All Journal Journal of Health Sciences Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Physical Therapy Journal of Indonesia
Astini, Dewa Ayu Agung Alit Suka
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Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Hematology Profiles in Colorectal Cancer Patients in Bali Kurniawati, Ida; Dewi, Anak Agung Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Witari, Ni Putu Diah; Adyasputri, A A I Ayesa Febrinia; Sueta, Made Agus Dwianthara; Sumadewi, Komang Trisna; Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka
Jurnal Ilmiah Kesehatan Vol 18 No 01 (2025): Jurnal Ilmiah Kesehatan (Journal of Health Science) 
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v18i01.6936

Abstract

Colorectal cancer is a leading cause of cancer-related deaths worldwide. This study explores blood profile and cancer staging in colorectal cancer patients in Bali. It was a descriptive-analytical study that collected demographic and clinical data from medical records of colorectal cancer patients at Prof. Dr. I.G.N.G. Ngoerah Hospital. The results of the study showed the basic characteristics and hematology profiles of 100 colorectal cancer patients. The average age of patients was 55.6 ± 11.4 years, with 54% of the total sample being male. The average body mass index (BMI) was 21.1 ± 3.6 kg/m², with an average height of 161.9 ± 6.1 cm and an average weight of 55.3 ± 10.0 kg. Laboratory tests revealed an average hemoglobin (Hb) level of 11.0 ± 3.6 g/dL, red blood cell count of 4.0 ± 0.9 million/μL, white blood cell count of 11.2 ± 7.3 thousand/μL, and platelet count of 302.8 ± 154.8 thousand/μL. The average hematocrit (HCT) level was 33.7 ± 6.6 L/L. Liver function parameters indicated average aspartate aminotransferase (AST/SGOT) levels of 45.6 ± 63.6 U/L and alanine aminotransferase (ALT/SGPT) levels of 24.6 ± 29.4 U/L. Renal function was described by an average blood urea nitrogen (BUN) level of 21.8 ± 21.0 mg/dL, urea levels of 21.9 ± 21.2 mg/dL, and creatinine levels of 2.3 ± 11.5 mg/dL. Our study highlights the importance of hematology profiles in colorectal cancer patients as part of cancer screening examination. Further study with a larger number of samples and more diverse populations is needed to analyze the relation between variables.
Female gender and time from injury to surgery as risk factors for decreased knee functions in ACL injury survivors Kurniawati, Ida; Witari, Ni Putu Diah; Dewi, Anak Agung Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Sumadewi, Komang Trisna; Astini, Dewa Ayu Agung Alit Suka; Evayanti, Luh Gde
Physical Therapy Journal of Indonesia Vol. 6 No. 1 (2025): January-June 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i1.247

Abstract

Background: Anterior cruciate ligament (ACL) injuries are serious orthopedic conditions that require long-term recovery and significant costs. This study aimed to assess the risk of decreased knee function among ACL injury survivors in the Indonesian ACL community. Methods: This study used a prospective observational cohort design with a population of all members of the Indonesian ACL community who experienced ACL injury. The primary outcome of this study was a decrease in knee function was measured using the Lysholm knee score. We calculated univariate and multivariate analyses using logistic regression for each variable. Results: The results showed that female gender and time from injury to surgery were significant factors that influenced poor knee function after ACL reconstruction. Women had a significantly higher risk (odd ratio (OR) = 15.28; adjusted OR (AOR) = 23.47; p-value < 0.010). In addition, the time between injury and surgery significantly affected postoperative knee function (AOR = 1.05; p-value = 0.049). Other factors such as age and body mass index did not show significant associations in either univariate or multivariate analyses. Conclusion: This study confirmed that female gender and time from injury to surgery were important factors influencing poor knee function after ACL reconstruction. Timely intervention and focused rehabilitation programs are key steps to improve patient functional outcomes.
The Role of Antioxidant Therapy in the Management of Type 2 Diabetes Mellitus: A Literature Review Astini, Dewa Ayu Agung Alit Suka; Yasa, I Wayan Putu Sutirta; Jawi, I Made; Wande, I Nyoman
Review of Primary Care Practice and Education Vol 8, No 1 (2025): January
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.104276

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease and has become a global problem due to the rapid increase in the number of cases. This disease is characterized by chronic hyperglycemia caused by insulin resistance and pancreatic beta cell dysfunction. The occurrence of oxidative stress is known to play a central role in the development of T2DM complications, through increased reactive oxygen species (ROS) that worsen insulin resistance, worsen beta cell function, and trigger complications such as cardiovascular complications, nephropathy, and neuropathy. Objectives: This literature review aims to evaluate the scientific evidence supporting the use of antioxidant therapy as an additional approach in the management of T2DM, focusing on the effectiveness and mechanism of action of antioxidant compounds on glycemic parameters, oxidative stress, and diabetes complications. Methods: A literature search was conducted through databases on ScienceDirect, PubMed, and Google Scholar, with the keywords "antioxidant therapy", "type 2 diabetes mellitus", "oxidative stress", and "diabetes management". The selected articles included in vitro, in vivo studies, and clinical trials published in the period 2013-2023. Literature review focused on the biochemical mechanisms of antioxidant compounds and clinical outcomes related to glycemic parameters and diabetes complications. The literature extraction process was carried out from January to March 2024. Results: Supplementation of vitamin D, vitamin E, vitamin C, polyphenols, saponins, and flavonoids has been proven to reduce blood glucose levels and increase insulin sensitivity in type 2 diabetes mellitus. The mechanism involves increasing antioxidant activity, regulating glucose homeostasis, as well as modulating signaling pathways such as AMPK, PPAR, and GLUT4. Conclusions: This bioactive compound has potential as an adjunct therapy in the management of type 2 diabetes mellitus by targeting oxidative stress and insulin resistance. Further research is needed to determine optimal dosage and long-term effectiveness.
Co-Authors A A I Ayesa Febrinia Adyasputri Dewi, Anak Agung Ayu Asri Prima I Made Jawi I Nyoman Wande I Wayan Putu Sutirta Yasa Ida Kurniawati, Ida Kerans, Fransiscus Fiano Anthony Luh Gde Evayanti Sueta, Made Agus Dwianthara Sumadewi, Komang Trisna Witari, Ni Putu Diah