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All Journal Medula Jurnal Ilmu Kedokteran dan Kesehatan
Syarif, Muhammad Reza
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Uji Daya Hambat Ekstrak Daun Bakau Lindur (Bruguiera gymnorrhiza) Terhadap Pertumbuhan Bakteri Pseudomonas aeruginosa Syarif, Muhammad Reza; Kurniawaty, Evi Kurniawaty; Busman, Hendri; Rahmanisa, Soraya Rahmanisa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.18963

Abstract

Pseudomonas aeruginosa adalah bakteri Gram-negatif oportunistik yang menyebabkan infeksi nosokomial berat. Virulensinya didukung oleh pembentukan biofilm dan resistansi antibiotik, sehingga diperlukan terapi alternatif. Bruguiera gymnorrhiza (bakau lindur) diketahui memiliki senyawa bioaktif dengan sifat antibakteri. Penelitian ini menggunakan ekstrak etanol daun bakau untuk menguji aktivitas antibakteri terhadap Pseudomonas aeruginosa. Ekstraksi dilakukan dengan metode maserasi, dan uji fitokimia dilakukan untuk mengidentifikasi senyawa aktif. Aktivitas antibakteri dianalisis melalui uji zona hambat dan evaluasi statistik. Ekstrak menunjukkan efek antibakteri bergantung konsentrasi dengan zona hambat 12,82 mm; 14,18 mm; dan 15,34 mm masing-masing untuk konsentrasi 50%, 75%, dan 100%. Senyawa aktif seperti flavonoid dan saponin merusak membran sel bakteri dan metabolisme, berkontribusi pada hasil yang diamati. Meski efektif, ekstrak menunjukkan daya hambat lebih rendah dibandingkan antibiotik standar karena perbedaan dalam kemurnian dan konsentrasi. Temuan ini menegaskan potensi ekstrak bakau sebagai agen antibakteri alami yang membutuhkan optimalisasi lebih lanjut. Ekstrak etanol daun Bruguiera gymnorrhiza menunjukkan aktivitas antibakteri signifikan terhadap Pseudomonas aeruginosa, memberikan dasar untuk pengembangan terapi berbasis tanaman.
Resistensi Antibiotik terhadap Pseudomonas aeruginosa: Literature Review Syarif, Muhammad Reza; Kurniawaty, Evi; Rahmanisa, Soraya
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1324

Abstract

Pseudomonas aeruginosa is a gram-negative aerobic bacterium. This bacterium often causes infections in immunocompetent and immunocompromised hosts. This bacterium usually causes opportunistic infections and plays an important role in nosocomial infections. Treatment and eradication of Pseudomonas aeruginosa are very difficult because the mutation of this bacterium occurs rapidly and this bacterium is easily adaptable, causing high rates of antibiotic resistance in this bacterium. Pseudomonas aeruginosa is one of the bacteria included in the MDR ESKAPE pathogen group by WHO. This article is a literature review that examines several literatures to be made into a discussion and conclusion. Pseudomonas aeruginosa is resistant to various types of antibiotics through 3 mechanisms, namely intrinsic, acquired, and adaptive. This bacterium has minimal nutritional needs and can tolerate various temperatures, this is one of the strengthening factors for antibiotic resistance to this bacterium. WHO includes this bacterium in the critical list because of its resistance to carbapenem antibiotics. Research shows high resistance of P. aeruginosa to carbapenems, quinolones, and aztreonam. While piperacillin and tazobactam are the most effective antibiotics for this bacteria. Many classes of antibiotics have become resistant to this bacteria, so that renewal is needed in the line of treatment for infections by P. aeruginosa. Therefore, wise and rational use of antibiotics is needed so that the number of antibiotic resistance, especially to this bacteria, does not increase.
Co-Authors Hendri Busman Kurniawaty, Evi Kurniawaty, Evi Kurniawaty Rahmanisa, Soraya Rahmanisa Soraya Rahmanisa