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All Journal JURNAL FARMASIMED (JFM) Journal Of Pharmacy
Dewi Gulyla Hari
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Evaluasi Penggunaan Obat Antihipertensi Primer Pasien Lanjut Usia Periode Januari – Juni 2022 Di Puskesmas Minas Ayu Rahmawati; Dewi Gulyla Hari; nisa, Annisa Nurul Maharani
The Journal Of Pharmacy Vol. 1 No. 1 (2023): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Hipertensi adalah keadaan seseorang yang mengalami peningkatan tekanan darah di atas normal, yaitu tekanan darah sistolik ≥ 140 mmHg dan atau tekanan darah diastolik ≥ 90 mmHg. Tujuan penelitian ini adalah untuk mengetahui ketepatan penggunaan obat antihipertensi primer dan hubungan Sosiodemografi terhadap hasil pengobatan pasien di Puskesmas Minas periode januari – juni tahun 2022. Metode yang digunakan adalah metode deskriptif dengan rancangan non ekperimental. Data penelitian diperoleh dari berkas catatan medik yang dikumpulkan dengan teknik pengumpulan secara purposive sampling dengan jumlah sampel sebanyak 110 pasien yang berusia lanjut. Pada hasil penelitian ini menunjukkan data karakteristik pasien yang paling banyak yaitu jenis kelamin perempuan sebesar 69 orang (62,7%), kelompok usia 45-59 tahun 53 orang (48,2%), pasien yang tidak bekerja 81 orang (73,6), dan golongan obat yang banyak digunakan yaitu amblodipin sebesar 107 pasien (97,2%). Pada hasil uji chi-square dengan nilai kemaknaan p value = 0,05 terhadap hubungan umur dan jenis kelamin terhadap faktor resiko didapatkan nilai umur adalah p = 0,873 sedangkan jenis kelamin memiliki nilai p = 0,000. Disimpulkan bahwa evaluasi penggunaan obat antihipertensi di Puskesmas Minas sudah 100% tepat dan menunjukkan bahwa umur dengan faktor resiko tidak memeliki hubungan, sedangkan jenis kelamin dengan faktor resiko memeliki hubungan. Untuk penelitian lebih lanjut diharapkan dapat melakukan observasi terhadap 2 tempat atau lebih sebagai pembanding untuk hasil yang lebih bervariatif.
Penetapan Kadar Flavonoid Total Ekstrak Etanol 96% Daun Gaharu (Aquilaria malaccensis Lam) dengan Spektrofotometer UV-Vis Indriani, Lusi; Dewi Gulyla Hari; Arabella Natasya; Nurdina Putri
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Gaharu leaves (Aquilaria malaccensis Lam) are a type of plant commonly used as a raw material for pharmaceuticals, cosmetics, and perfumes due to its secondary metabolic compounds such as flavonoids, alkaloids, terpenoids, steroids, and quinones. This study aims to determine the total flavonoid content of 96% ethanol extract of gaharu leaves using UV-Vis spectrophotometry. Gaharu leaves were extracted using the Microwave-Assisted Extraction (MAE) method with 96% ethanol as the solvent. The resulting extract was then qualitatively tested and the flavonoid content was measured using UV-Vis spectrophotometry with quercetin as the standard. The results of the determination of the total flavonoid content of the 96% ethanol extract of gaharu leaves were 2.539 ± 0.005% equivalent to quercetin.
Aktivitas Antidiabetes Ekstrak Daun Gaharu (Aquilaria malaccensis Lam) Dan Daun Binahong (Anredera cordifolia) Pada Mencit Jantan Lusi Indriani; Dewi Gulyla Hari; Sari Ramadhani; Nurdina Putri; Siti Niqmatun Jannah
The Journal Of Pharmacy Vol. 2 No. 2 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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The binahong plant (Anredera cordifolia) is known to contain active compounds such as alkaloids, flavonoids, saponins, tannins, and terpenoids that have the potential to lower blood glucose levels. This study aimed to evaluate the antihyperglycemic activity and determine the optimal dose of the combination of ethanol extract of agarwood (Aquilaria malaccensis) leaves and binahong leaves in male mice. The study was conducted experimentally using a Completely Randomized Design (CRD) using 25 mice divided into five treatment groups: a negative control (0.05% NaCMC) and a positive control (metformin). The other three groups were given a combination of agarwood and binahong extracts in dosage ratios of 1:1, 2:1, and 1:2. ANOVA results showed that all extract combinations significantly reduced blood glucose levels compared to the negative control. The 1:1 dose combination showed the best effectiveness, equivalent to metformin, especially on days 3 to 7.
Determination of Total Flavonoid Levels Of Cinnamon Leaf Infusion (Cinnamomum burmanni (Nees & T.Nees) Blume.) Using UV-Vis Spectrofotometry Lovena, Tri Nova; Dewi Gulyla Hari; Encik Juliansyah Arief
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/x2vajr20

Abstract

Background: Cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.) are natural plants used as traditional medicine because they have secondary metabolite compounds, namely flavonoids, tannins, saponins, alkaloids, and triterpenoids. Objective: This study aims to determine the total flavonoid compound levels found in cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.). Methods:The extraction method used is the infusa method using aquadest solvent. Qualitative analysis used phytochemical screening and quantitative analysis used is by UV Vis Spectrophotometry with standard comparison using quercetin. Results: For parametric data analysis using One Way Annova analysis. The results of phytochemical screening examination of cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.) are positive for flavonoid compounds with the total flavonoid compound content using the UV-Vis Spectrophotometry method is 0.5691 mgQE/g, and the results of parametric data analysis using One Way Annova analysis show a significant value of flavonoid content of 1.000> 0.05. This indicates that the flavonoid levels in the sample are relatively stable and homogeneous, so the treatments applied did not result in significant variation. This may suggest that the treatment factors in the study did not significantly affect the amount of flavonoids contained in the cinnamon leaf extract. Thus, the detected flavonoid content is likely more influenced by the natural characteristics of the plant rather than by the treatments tested. Conclusion: The cinnamon leaf (Cinnamomum burmanii) showed a positive result for the presence of flavonoid compounds.
Determination of Flavonoid Content of Ethanol Extract of Yellow Pumpkin Leaves (Cucurbita moschata Dulchesne ) Using Uv-Vis Spectrophotometry Dewi Gulyla Hari; Tri Nova Lovena; Ummul Khairiah
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/3rps7m67

Abstract

Background: Flavonoids are one of the most abundant groups of secondary metabolite compounds found in plant tissues. Pumpkin leaves (Cucurbita moschata Dulchesne ) can generally be used as antidiabetic, analgesic, nephroprotective and anticancer for stomach pain, jaundice, skin infections, lowering cholesterol, and blood sugar levels, and contain flavonoid compounds. Purpose: to determine the levels of flavonoid compounds contained in 70% ethanol extract of pumpkin leaves (Cucurbita moschata Dulchesne ). Methods: using the UV-Vis spectrophotometry method and to determine the flavonoid content from the results of phytochemical screening in the ethanol extract of pumpkin leaves. Pumpkin leaf extract was obtained through maceration techniques with 70% ethanol as the solvent. Results: The study showed that there was flavonoid content in pumpkin leaves, which was orange in color and the results of the study determined the flavonoid levels using UV-Vis spectrophotometry at a wavelength of 428 nm. om the resultsobtained from the measurement of the standard curve of quarcetin, it can be concluded that the higher the concentration used, the higher the absorbance value obtained and it can be seen that the results obtained total flavonoid content in the 70% ethanol extract sample of pumpkin leaves is 7.2672 mgQE/g.  Conclusion: There is a flavonoid compound content contained in pumpkin leaves.
Co-Authors Arabella Natasya Ayu Rahmawati Encik Juliansyah Arief Indriani, Lusi Lovena, Tri Nova Lusi Indriani nisa, Annisa Nurul Maharani Nurdina Putri Sari Ramadhani Siti Niqmatun Jannah Tri Nova Lovena Ummul Khairiah