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All Journal Jurnal Farmasi Sains dan Komunitas JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Pengabdian Masyarakat Teknologi Pertanian Jurnal Farmasi Indonesia Jurnal Veteriner dan Biomedis AS-SHIHA: JURNAL KESEHATAN Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Journal Of Pharmacy
Indriani, Lusi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Penilaian Efektivitas Antihipertensi dan Efek Samping Obat di RSUP Fatmawati Indriani, Lusi; Rokhmah, Nisa Najwa; Shania, Nur
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.146-151.2022

Abstract

Hipertensi diartikan sebagai kondisi ketika tekanan darah mencapai atau melebihi 140/90mmHg. Dalam keputusan penggunaan obat selalu mempertimbangkan manfaat dan resikonya. Obat antihipertensi dianggap efektif jika dapat mengontrol tekanan darah. Pada penggunaan obat antihipertensi jangka panjang perlu diwaspadai kemungkinan adanya efek samping. Penelitian ini bertujuan untuk menilai efektivitas dan efek samping obat antihipertensi menggunakan data rekam medis pasien rawat inap di RSUP Fatmawati. Penelitian ini bersifat observasional (non eksperimental). Penentuan efektivitas menggunakan desain pre dan post, dan rancangan cross sectional untuk mengidentifikasi efek samping obat dengan pendekatan secara retrospektif. Pengambilan sampel ditentukan secara purposive berdasarkan kriteria tertentu. Data yang diperoleh dianalisis secara univariat dan bivariat dengan pengujian Wilcoxon, uji Spearman dan uji Fisher’s Exact. Studi ini memberikan hasil bahwa mayoritas pasien rawat inap di RSUP Fatmawati berjenis kelamin perempuan, umumnya menderita hipertensi tingkat 2, lebih banyak mendapatkan terapi gabungan. Terdapat perbedaan tekanan darah sebelum dan setelah pemberian terapi antihipertensi (p<0,05)[A1] [A2] . Kejadian efek samping obat akibat penggunaan antihipertensi ditemukan sebanyak 16%. Tidak ada hubungan yang bermakna antara jenis terapi antihipertensi dengan kejadian efek samping obat.
POTENSI ANTIPLATELET CAMPURAN EKSTRAK BINAHONG, JAHE DAN KUNYIT PADA MENCIT PUTIH JANTAN Indriani, Lusi; Moerfiah, Moerfiah; Zunnita, Oktaviana; Pradana, Faisal
Jurnal Ilmiah Manuntung Vol 7 No 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.509

Abstract

Antiplatelets can inhibit platelets aggregation and have been used in prevention and treatment the trombotic desease. Binahong leaves, ginger dan turmeric have antiplatelets activity. The mixture of these plants are expected to increase the antiplatelets potency. This study aimed to determine the optimum dose of ethanol extracts of binahong leaves, ginger dan turmeric as antiplatelets agent. The antiplatelets testing were carried out by in vivo method using parameter of bleeding and coagulation time. The testing solutions were administered orally once a day for 8 days. There were 7 treatment groups consist of positive control (Acetosal 0.29mg/20gBW), negative control (CMC-Na 0.5%), binahong 10mg/20gBW, mixture 1 of binahong:ginger:turmeric (5:0.5:1mg/20gBW), mixture 2 (10:0.5:1mg/20gBW), mixture 3 (5:1:1mg/20gBW), and mixture 4 (5:0.5:2mg/20gBW). The bleeding and coagulation time were determined at 0, 3rd, 6th and 9th day. The bleeding time was determined by injuring mice tail, the blood that comes out were absorbed with absorption paper. From the first bleeding time until stopped was calculated as bleeding time. The coagulation time was determined by observing the formation of fibrin thread in the broken capillary pipe. The blood from the end tail were absorbed with capillary pipe, and then was broken every 15 seconds. The antiplatelets activity in mice with bleeding time parameter showed that mixture 3 was more effective at 3rd day with an increased of 16.60%, than the positive control group (3.92%). The coagulation time parameter showed that the binahong group was more effective at 9th day with an increased of 203.55%, than the positive control group (89.71%). The mixture of binahong, ginger, and turmeric were the most effective in increasing bleeding time, whereas binahong was the most effective in increasing coagulation time.
Penetapan Kadar Flavonoid Total Ekstrak Etanol 96% Daun Gaharu (Aquilaria malaccensis Lam) dengan Spektrofotometer UV-Vis Indriani, Lusi; Dewi Gulyla Hari; Arabella Natasya; Nurdina Putri
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Gaharu leaves (Aquilaria malaccensis Lam) are a type of plant commonly used as a raw material for pharmaceuticals, cosmetics, and perfumes due to its secondary metabolic compounds such as flavonoids, alkaloids, terpenoids, steroids, and quinones. This study aims to determine the total flavonoid content of 96% ethanol extract of gaharu leaves using UV-Vis spectrophotometry. Gaharu leaves were extracted using the Microwave-Assisted Extraction (MAE) method with 96% ethanol as the solvent. The resulting extract was then qualitatively tested and the flavonoid content was measured using UV-Vis spectrophotometry with quercetin as the standard. The results of the determination of the total flavonoid content of the 96% ethanol extract of gaharu leaves were 2.539 ± 0.005% equivalent to quercetin.
Evaluation of the Level of Knowledge, Attitudes, and Behavior of High School Students in the City of Pekanbaru in the Use of Antibiotics Lubis, Nursyafni; Rahmawati, Ayu; Indriani, Lusi; Afandi, Ayu Indah Lestari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007268

Abstract

The high use of antibiotics in the community will lead to resistance. According to the results of studies in Indonesia, the problem of antibiotic resistance is very complex and will continue to increase every year. Infectious diseases account for more than 13 million deaths per year in developing countries. Wise and rational use of antibiotics can reduce the disease burden, especially infectious diseases. Conversely, the widespread use of antibiotics that do not match the indications significantly increases antibiotic resistance. Students must know the proper use of antibiotics so as not to develop antibiotic resistance. They do not know much or fully understand antibiotics during the transition from childhood to adulthood. This study aims to determine the relationship between knowledge, attitudes, and behavior of SMAN Se-Kota Pekanbaru students in the use of antibiotics. This research uses a descriptive survey method with 360 respondents. Data analysis was done using a chi-square test with a significance level of p 0.05. The results of this study showed that there were students with good knowledge (67%), with some who showed a positive attitude (75%), and less behavior in the use of antibiotics (74%). The chi-square test showed a significant relationship between attitudes and antibiotic use behavior with a p-value of 0.001 (p 0.005). While the level of knowledge and attitude had a p-value of 0.605 (p 0.05) and the level of knowledge and behavior had a p-value of 0.118 (p 0.05), indicating there was no significant relationship. From the results of this study, it can be concluded that there is no significant relationship between students' knowledge with attitudes and behavior in the use of antibiotics, and there is a significant relationship between attitudes and student behavior in the use of antibiotics.
Treatment Duration and Drug Regimen Correlation with Side Effects Incidence in Drug-Resistant Tuberculosis (DR-TB) Patients at Pulmonary Hospital Indriani, Lusi; Renitia, Gita Iftitah; Setiani, Lusi Agus
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.320-326.2023

Abstract

The bacteria Mycobacterium tuberculosis causes Drug-Resistant Tuberculosis (DR-TB). Excessive use of drugs canresult in drug resistance with various side effects. This study aimed to analyze the correlation between the treatment duration and drug regimen with the side effects incidence in DR-TB Patients at Pulmonary Hospital Dr. M. Goenawan Partoidigdo (RSPG) Bogor. This is an observational study with a cross-sectional design. Subjects were selected with purposive sampling methods based on inclusion and exclusion criteria. The research showed that DR-TB patients were mostly male (50.2%) with productive age (46.1%). The most common DR-TB treatment experienced by patients in the advanced phase, generally for 9-24 months (75.3%), and the type of drug side effect most experienced was gastrointestinal disorders, that is nausea (55.1%). The use of standard conventional drug regimens mostly in Z, E, Eto, Km, Lfx, Cs (Pyrazinamide, Ethambutol, Ethionamide, Kanamycin, Levofloxacin, Cycloserine) of 51.4%. The chi-square analysis showed no significant correlation between the treatment duration and the incidence of side effects. At the same time, there was a meaningful correlation between the drug regimen (short-term, long-term, and conventional standard regimen) and the side effects incidence. The suspected drugs causing gastrointestinal side effects were pyrazinamide, ethambutol, ethionamide, and levofloxacin. The side effects of arthritic arthralgia were suspected to be caused by pyrazinamide, ethionamide, and levofloxacin.
Pengaruh Edukasi melalui Leaflet terhadap Kepatuhan Pasien Hipertensi di Puskesmas Leuwiliang Nhestricia, Nhadira; Indriani, Lusi; Sulistio, Eko Nugraha
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.89

Abstract

Leaflet merupakan salah satu media yang dapat digunakan dalam edukasi untuk meningkatkan pemahaman dan kepatuhan pasien dalam minum obat terutama bagi pasien yang memiliki regimen terapi yang kompleks, seperti hipertensi. Penelitian yang dilakukan di Puskesmas Leuwiliang bertujuan untuk menganalisis pengaruh pemberian edukasi melalui media leaflet terhadap peningkatan kepatuhan minum obat pasien hipertensi. Penelitian ini menggunakan metode quasi-eksperimental dengan rancangan Pretest-Posttest Design. Sejumlah 47 responden yang memenuhi kriteria bersedia mengikuti penelitian, berusia lebih dari 18 tahun, dan yang menjalani kontrol perawatan rutin hipertensi selama 3 bulan terakhir diwawancara untuk diukur kepatuhannya dalam minum obat, kemudian diberikan edukasi melalui leaflet. Setelah 1 bulan kepatuhan responden dalam minum obat kembali diukur. Data yang diperoleh dianalisis menggunakan uji wilcoxon dan menunjukkan bahwa pemberian edukasi melalui leaflet memberikan pengaruh sangat nyata terhadap peningkatan kepatuhan minum obat (p<0,020). Terdapat hubungan yang signifikan antara tingkat kepatuhan dengan tekanan darah sesudah diberikan intervensi pemberian informasi menggunakan media leaflet (p<0,003). Terdapat hubungan yang signifikan antara tingkat kepatuhan dengan kontrol tekanan darah (p=0,000). Penelitian ini menunjukkan bahwa edukasi melalui media leaflet berpengaruh sangat nyata dalam meningkatkan kepatuhan minum obat pasien hipertensi di Puskesmas Leuwiliang.
Anti-inflammatory activity of An Ethanol Extract of Pucuk Merah (Syzigium myrtifolium Walp.) in vivo Nursyafni, Nursyafni; Rahmawati, Ayu; Indriani, Lusi; Ashari, Dicki Hamed
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.286-292.2023

Abstract

Compared with classical Utilization of medicinal plants with anti-inflammatory properties, it needs to be done to find alternative treatments with relatively more minor side effects, such as Syzygium myrtifolium walp. This study aims to determine the effective dose of ethanol extract of pucuk merah as an anti-inflammatory in 30 male white rats of the Wistar strain. Testing the extract's anti-inflammatory effect was measured by measuring the edema volume on the soles of the rats' feet after being induced with 1% carrageenan with a pletismometer. The test animals were divided into six treatment groups, namely group 1 negative control (Na CMC 1%), group 2 positive control (Na Diclofenac 50 mg/KgBW), group 3 (dose of pucuk merah leaves extract 75 mg/KgBW), group 4 (quantity of pucuk merah leaves extract 100 mg/kgBW), and group 5 (amount of pucuk merah leaves extract 125 mg/kg BW), with observation times of 30, 60, 90, 120, 150, and 180 minutes. The results showed that rats in group 5 with a dose of pucuk merah (125 mg/kgBW) had the best anti-inflammatory effect, with an anti-inflammatory potential of 97% compared to diclofenac sodium.
Antibacterial activities of three species of mangrove leaves extract against Staphylococcus aureus and Escherichia coli Rahmawati, Ayu; Nursyafni, Nursyafni; Herly, Moh. Azhari Herly Azhari; Indriani, Lusi; Lovena, Tri Nova; Khairiah, Kinanti Bahy; Aprilia, Indri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.300-306.2023

Abstract

The increasing incidence of infections and drug resistance has led scientists to seek approaches towards medicinal plants that are potentially effective against many microorganisms. Therefore, this study was planned to assess the antibacterial activity of 3 mangrove species (Scyphipora hydrophylaceae C.F.Gaertn., Lumnitzera littorea (Jack) Voigt and Avicennia alba Blume) against Staphylococcus aureus and Escherichia coli bacteria. This study used the disc diffusion method to measure the diameter of inhibition at several concentrations of mangrove leaf ethanol extracts, namely 15%, 10%, 5%, 2.5%, 1.25% and 0.625% b/v as well as positive control cefadroxil for bacteria and DMSO as negative control. The test results showed that ethanol extracts of mangosteen leave Scyphipora hydrophylaceae C.F.Gaertn and Lumnitzera littorea (Jack) Voigt had a solid response to Escherichia coli bacteria and moderate potential against S. Aureus bacteria—no antibacterial activity against both test bacteria for Avicennia alba mangrove. This study concludes that Scyphipora hydrophylaceae C.F.Gaertn and Lumnitzera littorea (Jack) Voigt have potent antibacterial activity against Escherichia coli, but Avicennia alba has no antibacterial activity.
MENINGKATKAN KREATIVITAS MASYARAKAT MELALUI PENGOLAHAN JAGUNG PULUT (Zea Mays Ceratina) MENJADI PRODUK YANG INOVATIF SERTA PEMANFAATAN MEDIA SOSIAL SEBAGAI MEDIA PROMOSI DI DESA ILOPONU KECAMATAN TIBAWA KABUPATEN GORONTALO Saleh, Yanti; Indriani, Ria; Mustafa, Ramlan; Bobihu, Ijhan; Cahyani, Nisa Dwi; Rahim, Nur Cindi; Mahmud, Sri Anggita; Lasena, Nurhayati; Pontoh, Moh Fais; Indriani, Lusi
Jurnal Pengabdian Masyarakat Teknologi Pertanian Vol 2, No 1 (2023)
Publisher : Universitas Negeri Gorontalo

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Abstract

Pulut corn is one of the food commodities that has economic value and has the potential to be developed. Iloponu village has considerable pulut corn producing potential. The harvest of pulut corn is only sold in wet and dry form, there is no processing to become a new product that can add creativity to the community and can add economic value to the people of Iloponu village. Based on the existing problems, it is necessary to have innovative product innovations as an effort to take advantage of the potential of superior commodities in Iloponu village. The purpose of this activity is to increase community creativity in producing processed pulut corn commodities that have high selling power and increase public interest in denying family income. This counseling and training was carried out at the Iloponu Village Hall in stages and involved villagers and members of MSMEs assisted by Iloponu village. The method used is the commodity development model, which is an approach that involves the community directly as a subject and object in the implementation of counseling and training activities for making products from pulut corn. The results obtained during this activity the community understands the great benefits of the pulut corn commodity and increases people's creativity in product processing and the importance of entrepreneurship.
Ekstrak Herba Seledri (Apium Graveolens L.) (Microwave-Assisted Extraction) Sebagai Antipiretik Pada Mencit Jantan Yang Diinduksi Demam Dengan Vaksin Dpt-Hb-Hib Rahminiwati, Min; Indriani, Lusi; Hidayanti, Tiyan
Jurnal Veteriner dan Biomedis Vol. 2 No. 1 (2024): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.2.1.48-55.

Abstract

Seledri (Apium graveolens L) mengandung flavonoid, suatu senyawa yang dilaporkan mempunyai efek antiinflamasi melalui mekanisme inhibisi terhadap cyclo oxidase yakni suatu enzim yang berperan penting dalam proses demam terkait peradangan. Flavonoid mempunyai kelarutan yang baik dalam pelarut polar seperti alkohol. Dengan mempertimbangkan Microwave-Assisted Extraction merupakan salah satu cara penarikan flavonoid yang lebih baik dibandingkan dengan maserasi konvensional, penelitian ini dilakukan untuk menetapkan efektivitas ekstrak etanol 70% herba seledri hasil dari MAE sebagai antipiretik pada mencit yang diinduksi vaksin DPT-HB-HIB. Penelitian dilakukan pada 25 ekor mencit yang dibagi menjadi lima kelompok perlakuan yakni kelompok yang diberi CMC Na 0,5 % sebagai kontrol negatif, paracetamol 1,82 mg/20 g BB sebagai kontrol positif dan ekstrak herba seledri dosis 2, 4, dan 6 mg/20 g BB sebagai kelompok perlakuan. Sediaan diberikan peroral pada mencit yang mengalami demam setelah divaksin dengan DPT. Pengukuran suhu tubuh dilakukan sebelum dan sesudah di vaksin DPT dan setiap 15 menit sekali selama perlakuan. Hasil penelitian menunjukan bahwa ekstrak herba seledri dapat menurunkan suhu tubuh mencit. Efek terbaik terjadi pada dosis 6 mg/20 g BB dan efeknya setara dengan kontrol positif. Sedangkan onset paling cepat terjadi pada menit ke-30 pada dosis 4 mg/20 gBB. Dengan demikian ekstrak herba seledri hasil MAE potensial sebagai antipiretik.
Co-Authors Afandi, Ayu Indah Lestari Arabella Natasya Ashari, Dicki Hamed AYU RAHMAWATI Bobihu, Ijhan Cahyani, Nisa Dwi Dewi Gulyla Hari Gulyla Hari, Dewi Hendri Sandi, Nofri Herly, Moh. Azhari Herly Azhari Hidayanti, Tiyan Indri Aprilia, Indri Khairiah, Kinanti Bahy Lasena, Nurhayati Lovena, Tri Nova Lubis, Nursyafni Mahmud, Sri Anggita MOERFIAH . Muhammad Arif Najwa Rokhmah, Nisa Nhestricia, Nhadira Noveri Rahmawati Nurbaiti Nurdina Putri Nursyafni Nursyafni, Nursyafni Pontoh, Moh Fais Pradana, Faisal Rahim, Nur Cindi Rahminiwati, Min Ramlan Mustafa Renitia, Gita Iftitah Ria Indriani Shania, Nur Sulistio, Eko Nugraha Yanti Saleh Zunnita, Oktaviana