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All Journal JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASIMED (JFM) AS-SHIHA: JURNAL KESEHATAN
Lovena, Tri Nova
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Antibacterial activities of three species of mangrove leaves extract against Staphylococcus aureus and Escherichia coli Rahmawati, Ayu; Nursyafni, Nursyafni; Herly, Moh. Azhari Herly Azhari; Indriani, Lusi; Lovena, Tri Nova; Khairiah, Kinanti Bahy; Aprilia, Indri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 3 (2023): J Sains Farm Klin 10(3), Desember 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.3.300-306.2023

Abstract

The increasing incidence of infections and drug resistance has led scientists to seek approaches towards medicinal plants that are potentially effective against many microorganisms. Therefore, this study was planned to assess the antibacterial activity of 3 mangrove species (Scyphipora hydrophylaceae C.F.Gaertn., Lumnitzera littorea (Jack) Voigt and Avicennia alba Blume) against Staphylococcus aureus and Escherichia coli bacteria. This study used the disc diffusion method to measure the diameter of inhibition at several concentrations of mangrove leaf ethanol extracts, namely 15%, 10%, 5%, 2.5%, 1.25% and 0.625% b/v as well as positive control cefadroxil for bacteria and DMSO as negative control. The test results showed that ethanol extracts of mangosteen leave Scyphipora hydrophylaceae C.F.Gaertn and Lumnitzera littorea (Jack) Voigt had a solid response to Escherichia coli bacteria and moderate potential against S. Aureus bacteria—no antibacterial activity against both test bacteria for Avicennia alba mangrove. This study concludes that Scyphipora hydrophylaceae C.F.Gaertn and Lumnitzera littorea (Jack) Voigt have potent antibacterial activity against Escherichia coli, but Avicennia alba has no antibacterial activity.
Determination of Total Flavonoid Levels Of Cinnamon Leaf Infusion (Cinnamomum burmanni (Nees & T.Nees) Blume.) Using UV-Vis Spectrofotometry Lovena, Tri Nova; Dewi Gulyla Hari; Encik Juliansyah Arief
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/x2vajr20

Abstract

Background: Cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.) are natural plants used as traditional medicine because they have secondary metabolite compounds, namely flavonoids, tannins, saponins, alkaloids, and triterpenoids. Objective: This study aims to determine the total flavonoid compound levels found in cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.). Methods:The extraction method used is the infusa method using aquadest solvent. Qualitative analysis used phytochemical screening and quantitative analysis used is by UV Vis Spectrophotometry with standard comparison using quercetin. Results: For parametric data analysis using One Way Annova analysis. The results of phytochemical screening examination of cinnamon leaves (Cinnamomum burmanni (Nees & T.Nees) Blume.) are positive for flavonoid compounds with the total flavonoid compound content using the UV-Vis Spectrophotometry method is 0.5691 mgQE/g, and the results of parametric data analysis using One Way Annova analysis show a significant value of flavonoid content of 1.000> 0.05. This indicates that the flavonoid levels in the sample are relatively stable and homogeneous, so the treatments applied did not result in significant variation. This may suggest that the treatment factors in the study did not significantly affect the amount of flavonoids contained in the cinnamon leaf extract. Thus, the detected flavonoid content is likely more influenced by the natural characteristics of the plant rather than by the treatments tested. Conclusion: The cinnamon leaf (Cinnamomum burmanii) showed a positive result for the presence of flavonoid compounds.
Uji Aktivitas Antiinflamasi Ekstrak Etil Asetat Daun Tumbuhan Akar Kaik-Kaik (Uncaria cordata (Lour.) Merr) pada Tikus Putih (Rattus norvegicus) Jantan Noveri Rahmawati; Gulyla Hari, Dewi; Nurbaiti; Rahmawati, Ayu; Nursyafni; Indriani, Lusi; Lovena, Tri Nova; Arif, Muhammad; Hendri Sandi, Nofri
As-Shiha: Jurnal Kesehatan Vol. 3 No. 1 (2023): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

Antiinflammatory activity of ethyl acetate extracts of the leaves of plant Akar Kaik-kaik Uncaria cordata (Lour.) Merr on white male rats. This research examined the quality of crude drugs and extracts ethyl acetate. It is intended to obtain raw materials which can ultimately ensure uniform pharmacologic effect. Antiinflammatory activity of the ethyl acetate extract were tested using the method of paw edema against white male rats. The research were 15 rats mile which divided into 5 groups. Negative control (Na CMC 1%), positive control (Na diklofenak dose 4,5 mg/kgBB) and extract group ethyl acetat with the dose 100, 200 and 400 mg/kgBB given orally. The volume measurement after subcutaneous injection caragen 1% performed with one hour interval for 5 hours assessing with pletysmometer and calculated the inhibition persen. The result of this study showed that the quality of crude drugs and extract ethyl acetate meet the specified requirements Indonesian Herbal Pharmacopoeia. Ethyl acetate extract has significant anti-inflammatory effects to the negative control at doses of 200 and 400 mg/kgBB while against the positive control did not differ significantly white male rats.
Uji Aktivitas Ekstrak Etanol Daun Mimba (Azadirachta Indica A. Juss) Terhadap Bakteri Staphylococcus Aureus Lovena, Tri Nova; Gulyla Hari, Dewi
As-Shiha: Jurnal Kesehatan Vol. 3 No. 2 (2023): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

Infectious disease is a disease caused by microorganisms which is the body's response due to immune stimulation. One of the herbal ingredients used as a therapeutic agent is neem (Azadirachta indica A.Juss). This study aims to determine the content of secondary metabolites, minimum inhibitory concentration (MIC) and antibacterial activity found in n-hexane and ethanol extracts of neem leaves to Staphylococcus aureus bacteria. The extraction method used is the maceration method, the MIC method used is the liquid dilution method and the antibacterial activity test uses the disc diffusion method. The results of the phytochemical screening showed that the simplicia, n-hexane and ethanol extract of neem leaves positively contained flavonoids, saponins, tannins, steroids/triterpenoids. The MIC test results on the ethanol extract was obtained at a concentration of 6.25%. The ethanol extract with a concentration of 7% has weak activity at a concentration of 14% and 21% has moderate activity.
Co-Authors AYU RAHMAWATI Dewi Gulyla Hari Encik Juliansyah Arief Gulyla Hari, Dewi Hendri Sandi, Nofri Herly, Moh. Azhari Herly Azhari Indri Aprilia, Indri Indriani, Lusi Khairiah, Kinanti Bahy Muhammad Arif Noveri Rahmawati Nurbaiti Nursyafni Nursyafni, Nursyafni