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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Strada Journal of Pharmacy Indonesian Journal of Health Research Innovation Journal Health of Indonesian
Ivan Junius Mesak
Progam Studi Sarjana Farmasi Institut Ilmu Kesehatan STRADA Indonesia Kediri
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Uji Efektivitas Penyembuhan Luka Bakar dari Sediaan Gel Ekstrak Daun Jarak Pagar (Jatropha Curcas L) pada Tikus Putih Jantan (Rattus Norvegicus) Mesak, Ivan; Christina, Odilia Dea; T.I., Angelina
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p172-178

Abstract

The occurrence of burns on the skin is a type of injury that requires fast and appropriate treatment in order to achieve an optimal level of healing. Handling burns using medicinal plants can be done. One of the plants that can be used is Jatropha leaves. Jatropha leaves contain active substances such as saponins, tannins, alkaloids, and flavonoids that are efficacious as antibacterial, antioxidant, anticancer and antiinflammatory. The purpose of this study was to determine the effectiveness of Jatropha curcas leaf extract gel preparations with concentrations of 10%, 15%, 20% on burn wound healing. This study is an experimental study by comparing the effectiveness of burn wound healing in rats in each test group, namely negative control given gel base, positive control given Bioplacenton gel, and three test control groups with each given Jatropha leaf extract gel concentrations of 10%, 15% and 20%. The test results show that the most effective Jatropha leaf extract gel preparation heals rat burns, namely the 20% concentration compared to the positive control with a P>0.914 value (P>0.05).
Testing The Effectiveness Of Burns Healing Of Gel Preparations Jatropagar ( Jatropha Curcas L) Leaf Extract On Male White Rats ( Rattus Norvegicus) Angelina Tamo Inya; Ivan Junius Mesak
Strada Journal of Pharmacy Vol. 6 No. 1 (2024): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i1.110

Abstract

Indonesia has a variety of traditional medicinal plants for treating burns. One of them is Jatropha leaves which contain active substances such as saponins, tannins, alkaloids and flavonoids which have antibacterial, antioxidant, anticancer and anti-inflammatory properties. The aim of this research was to determine the effectiveness of Jatropha leaf preparations with extract concentrations of 10%, 15%, 20% on healing burns. This research stage includes plant determination, simplicia making, extract making, phytochemical screening testing, physical quality testing of gel preparations and animal testing. The research was experimental by comparing the effectiveness of healing burns in grouped mice and Jatropha leaf extract gel preparations and the most effective formula for healing burn wounds was Jatropha leaf extract gel preparations at concentrations of 10%, 15%, 20%. Statistical test results showed that there was a difference in the duration of healing of burn wounds in male white rats between Jatropha curcas (Jatropha curcas L) leaf gel preparations with concentrations of 10%, 15%, 20%, bioplaceton gel and gel base.
TESTING THE ACTIVITY OF THE N-HEXANE FRACTION OF THE ETHANOL EXTRACT OF BETTER BETTER LEAVES (Momordica Charantia L.) WITH VASELINE CARRIER ON THE HEALING OF CUT WOUNDS IN WHITE RATS (Rattus Norvegicus) Lucky Andriani; Ivan Junius Mesak
Strada Journal of Pharmacy Vol. 2 No. 1 (2020): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v2i1.135

Abstract

Wound are a form of damage to anatomical structure and function. When a wound occurs, the integrity of the epithelial structure of the skin is lost and dysfungtion occours in the skin. Therefore, normalization of integrity is required as soon as possible. Bitter melon leaves have benefits for wound healingand repairing skin granulation tissue. to understand the most optimal concentration level of N-Hexane Fraction of Bitter melon leaf ethanol extract in healing white rat incision wound using vaselin carrier and to understand the healing activity of N-Hexane fraction of Bitter melon leaf extract on white rat incision wound healing. The research conducted was an experimental type with the test animal, namely 18 white male rats. The white rats were grouped into 6 groups, where the standard control was group I, the positive control was group II with (injuring and giving sagestam cream) treatment, the negative control was group III with (injuring and giving it vaseline base) treatment, the last group IV, V, and VI were treated (injuring and giving it n-hexane fraction of bitter melon leaves at concentration levels of 1,5%, 3%, 6% and the base was vaseline).Then induced an incisions wound 2.0 cm deep and 0.2 cm long, but before shaving the rat’s back first and then anesthetizing using lidocaine injection. The observation process is carried out for 2 weeks and data collection is every 2 days. Furthermore, conduct statistical test when the data has been collected. Based on the results of observations and testing of the N-hexane fraction of bitter melon leaf ethanolextract, it has activity in healing cuts in white rats and the most optimal concentration in healing cuts is a concentration of 6%. The N-Hexane fraction of ethanol extract of bitter gourd leaves has activity in healing cuts in white rats and the most optimal concentration in healing cuts is 6%.
Formulation And Evaluation Quality Physique Preparation Lip Tint Extract Sweet Potato ( Ipomoea batatas (L.) Lamb) with Extract Dragon Fruit ( Hylocereus polyrhizus ) As a Natural Lip Pigment Poppy Martha Lowra; Devita Riafinola Andaririt; Sri Rahayu Dwi P; Ivan Junius Mesak
Strada Journal of Pharmacy Vol. 6 No. 2 (2024): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i2.147

Abstract

ABSTRACT Introduction: Lip Tint is one of the stock cosmetics that have role in give role decorative on lip pigment coloring . The rise of use dye synthesis in preparation dangerous liptint​ for lips so use material Sweet Potato Nature ( Ipomoea batatas) (L.) Lamb) which is combined Dragon Fruit ( Hylocereus polyrhizus ) can replace dye synthesis in the preparation. Purpose : to know difference concentration extract sweet potato jalar ( ipomoea Batatas (l.) lamb) combination extract fruit dragon ( hylocereus polyrhizus ) against evaluation quality physical . Method: research experimental formulation stock lip tint with using sweet potatoes concentrations of 10%, 20% and 30% combined fruit dragon 6%. Substance color natural contained in sweet potatoes are keratinoids and in fruit dragon that is anthocyanin . Results: In the study This show that stock lip tint sweet potato concentrations of 10, 20 and 30% combined fruit dragon 6%. Yield liptint that has texture , color , aroma, and Power stickiness , power spread , good viscosity . The pH of the preparation is at a value of 8 but No cause irritation to the skin . The results of the data analysis were obtained No there is significant difference in power test spread , power test adhesion and viscosity test and occurs significant differences in pH and FIII were most preferred by respondents . Conclusion: Research This own conclusion concentration sweet potato extract and extract fruit dragon influence results testing quality physique preparation . Quality test results physique show that stock lip tint with sweet potato concentration of 30% (F III) provides results best .
Antibacterial Activity Test of Combination of Chitosan and Ethanol Extract of Cocoa Leaves (Theobroma Cacao L.) Against Salmonella Typhi Bacteria Saifullah Al Fahmi; Luluk Aniqoh Meliana Putri; Ivan Junius Mesak; Juvita Herdianty
Strada Journal of Pharmacy Vol. 6 No. 2 (2024): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i2.148

Abstract

Introduction:Typhoid fever is a systemic infectious disease caused by the bacterium Salmonella typhi. The increasing antibiotic resistance of Salmonella typhi has spurred interest in natural antibacterial agents. This study examines the antibacterial activity of a combination of chitosan and ethanol extract of cocoa leaves (Theobroma cacao L.) against Salmonella typhi. Methods: The research involved extracting cocoa leaves using ethanol and combining the extract with chitosan. The antibacterial activity was evaluated using the well diffusion method on Salmonella typhi. The combination of chitosan and cocoa leaf extract was tested at various concentrations, and chloramphenicol was used as a positive control. Results: The combination of chitosan and cocoa leaf extract showed significant antibacterial activity, with the best results obtained at higher concentrations. The zone of inhibition for the combination at 600 ppm was comparable to that of the positive control of chloramphenicol. Conclusion: The study suggests that the combination of chitosan and cocoa leaf extract has the potential to be developed as an alternative treatment for typhoid fever, particularly against antibiotic-resistant strains of Salmonella typhi.
ANALISIS EFEKTIVITAS SISTEM INFORMASI PENGELOLAAN OBAT DENGAN METODE HOT-FIT DI APOTEK K24 KECAMATAN BANYUMANIK KOTA SEMARANG Shafira Septiana Haryanti; Ferika Indrasari; Sri Suwarni; Ivan Junius Mesak; Yunita Diyah Safitri
Indonesian Journal of Health Research Innovation Vol. 1 No. 1 (2024): Indonesian Journal of Health Research Innovation
Publisher : Yayasan Menawan Cerdas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64094/p75az822

Abstract

Semakin berkembangnya zaman, membuat apotek membutuhkan suatu teknologi informasi yang digunakan untuk mengumpulkan, menyimpan, dan memproses dari data dan menghasilkan informasi yang membantu apotek tersebut melakukan pelayanan kefarmasian. Semakin baik sistem informasi manajemen pengelolaan persediaan obat pada suatu apotek, maka semakin baik dan efektif pula pelayanan di apotek tersebut. Efektivitas merupakan cara bagaimana suatu perusahaan dapat memperkecil penggunaan harta atau persediaan perusahaan dengan tepat dan benar tanpa terganggunya tujuan utama. Metode yang digunakan adalah HOT-Fit yang memiliki empat aspek penting yakni manusia, organisasi, teknologi serta keseimbangan hubungan tiap aspeknya. Metode HOT FIT memiliki komponen yang tidak hanya berfokus pada sistem tetapi berfokus juga pada lingkungan pendukung. Penelitian ini bertujuan untuk mengetahui analisis efektivitas sistem informasi pengelolaan persediaan obat dengan metode HOT-Fit di Apotek K24 Kecamatan Banyumanik Kota Semarang. Jenis penelitian ini adalah deskriptif menggunakan alat ukur kuisioner yang dikembangkan dari metode HOT-Fit. Sampel pada penelitian ini adalah Tenaga Kefarmasian Apotek K24 Kecamatan Banyumanik Kota Semarang yang dapat menggunakan sistem informasi di Apotek. Berdasarkan hasil data penelitian yang diperoleh dari Apotek K24 Kecamatan Banyumanik Kota Semarang dapat disimpulkan bahwa penerapan sistem pengelolaan obat sudah efektif dan sesuai dengan komponen-komponen Hot-Fit. Untuk komponen Human memiliki persentase 80%, komponen Organization 90%, komponen Technology 90% dan komponen Net-Benefit dengan persentase 90%.
Antimicrobial Activity Testing of Ethyl Acetate Fraction from Mikania micrantha Leaves Against Escherichia coli and Staphylococcus aureus Ivan Junius Mesak; Mariana Kristiani
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.173

Abstract

Bacterial infections remain a major global health issue, worsened by rising antibiotic resistance. This study evaluated the antimicrobial activity of the ethyl acetate fraction of Mikania micrantha leaves against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) using the disc diffusion method. Phytochemical screening identified flavonoids, tannins, saponins, and steroid/triterpenoids in the fraction. The antimicrobial test showed that this fraction inhibited the growth of both bacteria, with larger inhibition zones observed at higher extract concentrations. At 5% concentration, E. coli showed an inhibition zone of 8.43 mm, while at 15%, the zone increased to 12.26 mm. For S. aureus, the 15% concentration produced a 20.43 mm inhibition zone. Statistical analysis confirmed significant differences between concentrations (p < 0.05). These results suggest that the ethyl acetate fraction of Mikania micrantha leaves has potential as an antibacterial agent, especially effective against Escherichia. coli at 15%.
Assessment of the Effectiveness of Centella asiatica Ethanol Extract in Alleviating Diarrhea in Castor Oil-Induced White Mice: A Pharmacological Approach Yuneka Sarisitiana; Fendy Prasetyawan; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Ivan Junius Mesak
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Journal Health of Indonesian

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study investigated the potential anti-diarrheal effects of ethanol extract from Centella asiatica leaves using a castor oil-induced diarrhea model in mice. The extract, obtained from Centella asiatica leaves, was administered orally to mice at various doses. Parameters including the frequency, duration, and onset of diarrhea were measured and compared with control groups. Results indicated a dose-dependent reduction in diarrhea frequency and duration in treated mice. Higher doses of Centella asiatica ethanol leaf extract demonstrated efficacy comparable to loperamide, a standard anti-diarrheal drug. Histopathological analysis further revealed protective effects on intestinal tissue integrity, suggesting a potential mechanism of action for the observed anti-diarrheal activity. These findings underscore the potential of Centella asiatica ethanol leaf extract as a natural alternative for managing diarrhea. The study contributes to the growing body of evidence supporting the traditional use of Centella asiatica in folk medicine for gastrointestinal ailments. However, further research is warranted to elucidate the underlying mechanisms of action responsible for its anti-diarrheal effects and to conduct clinical trials for human validation. In conclusion, this research highlights the significance of exploring natural remedies derived from medicinal plants like Centella asiatica for combating gastrointestinal disorders. The study underscores the potential of Centella asiatica ethanol leaf extract as a therapeutic agent for managing diarrhea and improving public health outcomes.
Co-Authors Abd Rofiq Angelina Tamo Inya Chandra Arifin Devita Riafinola Faisal Akhmal Muslikh Fendy Prasetyawan Ferika Indrasari Juvita Herdianty Lucky Andriani Mariana Kristiani Odilia Dea Christina Poppy Martha Lowra Putri, Luluk Aniqoh Meliana Ratna Mildawati Safitri, Yunita Diyah Saifullah Al Fahmi Shafira Septiana Haryanti Sri Rahayu Dwi P Sri Suwarni T.I., Angelina Yuneka Sarisitiana