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All Journal Jurnal Ilmiah Medicamento Jurnal Ilmiah Multidisiplin Indonesia Jurnal Intelek Insan Cendikia International Journal of Contemporary Sciences (IJCS) Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian Multicore International Journal of Multidisciplinary (MIJM) International Journal of Science and Society (IJSS) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM)
Abd Rofiq
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Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Narrative Review: Efektivitas Biaya Penggunaan Antibiotik untuk Penyakit Pneumonia di Rumah Sakit Indonesia Arifin, Chandra; Roriq, Abd
Jurnal Ilmiah Medicamento Vol 9 No 2 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i2.4827

Abstract

Pneumonia is an acute inflammatory respiratory infection caused by microorganisms. This infection can occur from both toddlers to the elderly and if not properly then the acute respiratory inflammation process will continue to be able to cause various infectious complications. Until now, there are many choices of antibiotic therapy for their treatment, but they have not guaranteed their effectiveness both therapeutically and cost-effectively. The purpose of this study was to analyze the effectiveness and efficiency of pneumonia treatment costs in Indonesian Hospitals. The method used is a literature review approach, namely Systematic Review related to articles with cost-effectiveness analysis or Cost-effectiveness analysis of pneumonia treatment that have been published in the form of research articles. Search articles using three databases, namely Google Scholar, Pubmed, and Garudadekti. Then the selection stage or literature screening was carried out by reading the title, abstract, and continued with the full text of the research article obtained. The results obtained 14 research articles according to the inclusion and exclusion criteria regarding the cost-effectiveness of pneumonia treatment. From the research data, it can be concluded that the antibiotic cefotaxime is widely prescribed and the most cost-effective according to the ACER calculation. However, the ACER value is influenced by different drug administration for each patient, the effectiveness of treatment therapy, the costs incurred by the patient or direct medical costs.
Chronopharmacological Study Of Angiotensin-Converting Enzyme Inhibitor Ramipril In Hypertensive Patients In A Hospital: Analysis Of Efficacy And Tolerability Based On Administration Time Variations Fendy Prasetyawan; Faisal Akhmal Muslikh; Yuneka Saristiana; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Dewi Retno Puspitosari
Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID) Vol. 3 No. 02 (2024): Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID), July 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/esaprom.v3i02.4752

Abstract

This research investigates the chronopharmacological effects of Ramipril administration on hypertensive patients, focusing on the timing of drug intake. Studies conducted by Firli Choerun Nisa and Siti Rohmiati in 2022 provide the basis for this analysis. Using observational-analytic methods with cross-sectional designs, data were collected prospectively from 23 patients in each study. Firli Choerun Nisa's study at RSUD Singaparna Medika Citrautama, Tasikmalaya Regency, involved 14 patients in the light zeitgeber group and 9 in the dark zeitgeber group. Results indicated significant reductions in both systolic and diastolic blood pressures, with the dark zeitgeber group experiencing more substantial decreases. The SPSS analysis showed a p-value of 0.062, indicating no statistically significant difference between the groups. Siti Rohmiati's study at RSUD Dr. Soekardjo Tasikmalaya found similar results. The light zeitgeber group showed a systolic decrease of 9.9 mmHg and a diastolic decrease of 5 mmHg, while the dark zeitgeber group had decreases of 16.66 mmHg and 10.56 mmHg, respectively. The SPSS analysis also yielded a p-value of 0.062, supporting the conclusion of no significant difference in Ramipril's efficacy based on administration timing. The comprehensive analyses revealed that Ramipril effectively reduces blood pressure regardless of the administration time. Significant reductions in both the daytime and nighttime groups were noted, with trends suggesting a more pronounced effect during nighttime administration. These findings emphasize the importance of flexibility in medication timing, enhancing patient adherence without compromising therapeutic outcomes. In conclusion, the timing of Ramipril administration, whether in the morning or evening, does not significantly impact its effectiveness in managing hypertension. This flexibility offers practical benefits for clinical practice, supporting better patient adherence and optimized hypertension management. These studies contribute to the broader understanding of chronopharmacology, providing insights for improved treatment strategies in hypertensive care.
Assessment of the Effectiveness of Centella asiatica Ethanol Extract in Alleviating Diarrhea in Castor Oil-Induced White Mice: A Pharmacological Approach Yuneka Sarisitiana; Fendy Prasetyawan; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Ivan Junius Mesak
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study investigated the potential anti-diarrheal effects of ethanol extract from Centella asiatica leaves using a castor oil-induced diarrhea model in mice. The extract, obtained from Centella asiatica leaves, was administered orally to mice at various doses. Parameters including the frequency, duration, and onset of diarrhea were measured and compared with control groups. Results indicated a dose-dependent reduction in diarrhea frequency and duration in treated mice. Higher doses of Centella asiatica ethanol leaf extract demonstrated efficacy comparable to loperamide, a standard anti-diarrheal drug. Histopathological analysis further revealed protective effects on intestinal tissue integrity, suggesting a potential mechanism of action for the observed anti-diarrheal activity. These findings underscore the potential of Centella asiatica ethanol leaf extract as a natural alternative for managing diarrhea. The study contributes to the growing body of evidence supporting the traditional use of Centella asiatica in folk medicine for gastrointestinal ailments. However, further research is warranted to elucidate the underlying mechanisms of action responsible for its anti-diarrheal effects and to conduct clinical trials for human validation. In conclusion, this research highlights the significance of exploring natural remedies derived from medicinal plants like Centella asiatica for combating gastrointestinal disorders. The study underscores the potential of Centella asiatica ethanol leaf extract as a therapeutic agent for managing diarrhea and improving public health outcomes.
Patterns of Antihypertensive Medication Utilization Among Hypertensive Patients: A Review of Single-Therapy Practices in Outpatient Primary Healthcare Centers Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Chandra Arifin; Abd Rofiq; Elsa Mahardika Putri; Anis Akhwan Dhafin
Journal Health of Indonesian Vol. 2 No. 02 (2024): Journal Health of Indonesian, Edition July 2024
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/health.v2i02.115

Abstract

Hypertension, often referred to as "The Silent Disease," presents a significant global health challenge due to its asymptomatic nature and association with severe cardiovascular complications. Effective management of hypertension primarily relies on the administration of antihypertensive drugs, either as monotherapy or combination therapy. This study investigates the utilization patterns of single antihypertensive drugs among hypertensive patients in the outpatient setting of Puskesmas "X" in Solo City. Utilizing a retrospective approach, data from patient medical records were analyzed to examine drug usage patterns and patient responses to therapy. Results revealed a noteworthy preference for combination therapy, with approximately 64.18% of patients opting for this approach. Combination therapy strategies were favored due to their additive and synergistic effects, potential for reducing side effects, and enhanced blood pressure control. Specifically, amlodipine from the calcium channel blocker (CCB) group emerged as the most commonly prescribed single antihypertensive drug, while the combination of amlodipine with candesartan from the angiotensin receptor blocker (ARB) group was the predominant combination therapy. These findings align with previous research, emphasizing the significance of combination therapies in hypertension management..
Cost-Effectiveness Analysis of Immunosuppressant Drug Methylprednisolone at Gembleb Farma Trenggalek Pharmacy Service Fendy Prasetyawan; Yuneka Saristiana; Tsamrotul Ilmi; Widhi Astutik; Chandra Arifin; Abd Rofiq; Eka Hayati Rhomah
International Journal of Science and Society (IJSS) Vol. 1 No. 2 (2025): December
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/v9v9ke75

Abstract

This study aims to evaluate the cost-effectiveness of the immunosuppressant drug methylprednisolone at Gembleb Farma Pharmacy in Trenggalek, East Java, Indonesia. The research was conducted on May 30, 2025, using a descriptive quantitative approach supported by interviews with the responsible pharmacist. Data collection involved daily sales records of methylprednisolone and clinical response outcomes among patients. Each patient typically received five tablets per treatment, and the pharmacy recorded an average daily sale of 250 tablets. Therefore, it was estimated that approximately 50 patients were served per day. From those, 45 patients—equivalent to 90%—experienced favorable clinical responses to methylprednisolone therapy. The cost per tablet was IDR 500, resulting in a total daily cost of IDR 125,000. The calculated Cost-Effectiveness Ratio (CER) per day was IDR 2,777.78 per effectively treated patient. This value remained consistent when scaled to monthly (IDR 3,750,000 for 1,350 effective patients) and annual estimates (IDR 45,625,000 for 16,425 effective patients), yielding the same CER value of IDR 2,777.78. The findings indicate that methylprednisolone provides a stable and predictable cost-effectiveness profile in outpatient pharmacy settings. These results may support decision-making in therapeutic planning, particularly in community pharmacies that aim to deliver effective yet affordable immunosuppressive therapies. Additionally, this cost-efficiency aligns with the goals of rational drug use and sustainable pharmaceutical services at the primary healthcare level. 
Interactive Discussion Related to the Preparation of Pharmacy Professional Work Practice at the Health Center and Health Office Saristiana, Yuneka; Prasetyawan, Fendy; Mildawati, Ratna; Marhenta, Yogi Bhakti; Kadir, Mujtahid Bin Abd; Arifin, Chandra; Rofiq, Abd; Astutik, Widhi; Rohmah, Eka Hayati
Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) Vol. 1 No. 1 (2025): Maret
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mjpmm.v1.i1.3

Abstract

The Professional Pharmacy Practice Experience (PKPA) at Community Health Centers and Health Offices plays a crucial role in developing the professional competence of pharmacy students before they enter the actual workforce. To facilitate this preparation, an interactive discussion activity has been conducted as a means of training and collective reflection among students, supervising lecturers, and resource persons from the Health Office and community health centers. This discussion aims to enhance students' understanding of the roles and responsibilities of pharmacists within primary healthcare facilities (FKTP), while also identifying the challenges and solutions involved in the implementation of PKPA. The execution of the discussion demonstrated a high level of enthusiasm among students in exploring both the technical and non-technical aspects of the pharmacy profession, including the integration of clinical and managerial roles. The evaluation of the questionnaire reveals that over 85% of participants believe this activity significantly aids in preparing them to confront the PKPA with greater confidence. Group discussions highlight the significance of interpersonal communication skills, professional ethics, and teamwork collaboration as essential factors for the success of practice. A representative from the Health Department assessed that this activity is effective in aligning the perspectives between educational institutions and practical venues, thereby fostering ongoing synergy.
Prediction of Sinensetin from Kumis Kucing (Orthosiphon aristatus) as Aspulvinone Dimethylallyltransferase Inhibitor for Anticancer Agent Prasetyawan, Fendy; Arifin, Chandra; Astutik, Widhi; Rohmah, Eka Hayati; Kadir, Mujtahid Bin Abd; Ariawan, M Wahyu; Marhenta, Yogi Bhakti; Mildawati, Ratna; Saristiana, Yuneka; Rofiq, Abd
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.3

Abstract

Sinensetin, a polymethoxylated flavone found in Orthosiphon aristatus (commonly known as Kumis Kucing), was evaluated in silico for its potential inhibitory activity against Aspulvinone Dimethylallyltransferase, an enzyme implicated in cancer-related biosynthetic pathways. The SMILES structure of sinensetin was retrieved from PubChem and analyzed using the PASS online prediction tool (www.way2drug.com). The results showed a high probability of activity (Pa = 0.865) and a very low probability of inactivity (Pi = 0.016), indicating that sinensetin is likely to act as a potent inhibitor of the enzyme. These findings suggest that sinensetin could be a promising anticancer agent candidate by targeting Aspulvinone Dimethylallyltransferase. Further studies are recommended to validate this prediction through molecular docking and biological assays.
The Comparative Effectiveness of Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors in Outpatient Hypertensive Patients at Community Health Centers Prasetyawan, Fendy; Yuneka Saristiana; Faisal Akhmal Muslikh; Wisnu Haryo Widyoko; Chandra Arifin; Abd Rofiq
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 3 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v2i1.8346

Abstract

Hypertension, often termed "The Silent Disease" due to its asymptomatic nature, remains a global health concern. This study investigates the comparative effectiveness of Angiotensin II Receptor Blockers (ARBs) and Angiotensin-Converting Enzyme Inhibitors (ACEIs) in managing hypertension, focusing on Valsartan and Candesartan (ARBs) and Ramipril and Captopril (ACEIs). Analyzing retrospective data from Community Health Centers in Solo City, the research aims to provide nuanced insights into outpatient care scenarios. The meticulous statistical analysis, utilizing SPSS and t-tests, uncovers notable differences, particularly favoring Valsartan and Ramipril within their respective drug classes. These findings carry substantial implications for healthcare practitioners, aiding in the development of precise treatment guidelines. Understanding the comparative clinical effectiveness, safety profiles, and tolerability of ARBs and ACEIs ensures a more personalized approach to hypertension management
Frekuensi Penggunaan Obat Antivirus Pada Pasien SARS-CoV-2 dengan Penyakit Ginjal Kronis di Instalasi Farmasi Rawat Inap Rumah Sakit Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq
Jurnal Intelek Insan Cendikia Vol. 1 No. 1 (2024): Maret 2024
Publisher : PT. Intelek Cendikiawan Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pandemi COVID-19 telah menimbulkan tantangan global yang signifikan sejak munculnya virus SARS-CoV-2 pada tahun 2020. Pengendalian penyakit ini menjadi prioritas kesehatan utama mengingat dampaknya yang luas. Indonesia juga terpengaruh dengan laporan kasus pertama COVID-19 pada Maret 2020, membutuhkan perhatian serius dalam penanganannya. Salah satu komorbiditas yang sering terjadi pada pasien COVID-19 adalah penyakit ginjal kronis (CKD), yang meningkatkan risiko komplikasi medis. Pemahaman yang lebih mendalam tentang penggunaan obat antivirus pada pasien CKD yang terinfeksi COVID-19 menjadi penting, mengingat potensi toksisitas obat dan interaksi yang mungkin terjadi. Meskipun obat antivirus seperti favipiravir dan remdesivir telah menjadi strategi penting dalam penanganan COVID-19, perhatian khusus diperlukan saat memberikannya kepada pasien CKD karena risiko akumulasi dan toksisitas yang lebih tinggi. Studi potong lintang yang dilakukan di RSUD Dr. Soedomo Trenggalek bertujuan untuk mengevaluasi penggunaan obat antivirus pada pasien COVID-19 dengan CKD. Hasilnya menunjukkan bahwa mayoritas pasien menerima favipiravir (64%) dibandingkan dengan remdesivir (36%). Namun, penggunaannya perlu disesuaikan dengan fungsi ginjal pasien untuk menghindari toksisitas. Penelitian lebih lanjut diperlukan untuk memahami perbandingan efektivitas antara kedua jenis obat antivirus ini pada pasien CKD, sehingga dapat memberikan pedoman pengobatan yang lebih tepat bagi populasi pasien yang rentan ini
Pharmacokinetic Prediction Of Apigenin From Celer (Apium Graveolens L.) Using Pkcsm Lusiana Aprillia; Fendy Prasetyawan; Yuneka Saristiana; Ratna Mildawati; Chandra Arifin; Abd Rofiq
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 1 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i1.3

Abstract

Celery (Apium graveolensL.) is a plant that has various pharmacological activities. One of the main bioactive compounds in celery is apigenin. Understanding the pharmacokinetic properties of apigenin is very important in evaluating its effectiveness and safety as a drug candidate. This study aims to predict the pharmacokinetic properties of apigenin using the pkCSM computational approach. The prediction results show that apigenin has good intestinal absorption, but low water solubility. Distribution ability is moderate, with limited penetration into the central nervous system. Apigenin is not a major substrate of CYP2D6 and CYP3A4 enzymes, but can inhibit CYP1A2 and CYP3A4. The elimination rate is moderate. Apigenin is not mutagenic, not hepatotoxic, and does not cause cardiotoxic effects. Apigenin has low toxicity toT. pyriformisand safe in acute doses with an LD50 of 2,432 log mM.
Co-Authors Anis Akhwan Dhafin Astutik, Widhi Chandra Arifin Dewi Retno Puspitosari Eka Hayati Rhomah Elsa Mahardika Putri Faisal Akhmal Muslikh Fendy Prasetyawan Ivan Junius Mesak Kadir, Mujtahid Bin Abd Lusiana Aprillia M. Wahyu Ariawan Marhenta, Yogi Bhakti Mildawati, Ratna Ratna Mildawati Rohmah, Eka Hayati Tsamrotul Ilmi Widhi Astutik Wisnu Haryo Widyoko Yuneka Sarisitiana Yuneka Saristiana