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All Journal Journal of Scientific Research, Education, and Technology Jurnal Ilmiah Multidisiplin Indonesia Jurnal Media Akademik (JMA) Assoeltan: Indonesian Journal of Community Research and Engagement Jurnal Intelek Insan Cendikia Jurnal Pengabdian Kepada Masyarakat Al-Amin Jurnal Informatika dan Kesehatan Amaluna: Jurnal Pengabdian Masyarakat Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian Jurnal Kajian dan Inovasi Ilmu (JKII) Journal Abdimas Paspama Service
Ratna Mildawati
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The Effectiveness of Aloevera Compress on Changes in Breast Swelling of Breastfeeding Women in the Working Area of the Srengat Health Center Fransiska Septiana; Dwi Lukmawati; Neta Ayu Andera; Ratna Mildawati
Journal of Scientific Research, Education, and Technology (JSRET) Vol. 1 No. 2 (2022): Vol. 1 No. 2 2022
Publisher : Kirana Publisher (KNPub)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58526/jsret.v1i2.298

Abstract

Breast swelling occurs in mothers who have given birth for the first time. Significant breast care can affect the smoothness of breast milk. Breast swelling pain that is not followed up can lead to further complications. Aloevera has many ingredients that are believed to reduce pain and swelling in the breast because it contains aloin and emodin. The purpose of the study was to determine the effectiveness of aloevera compresses against breast swelling of breastfeeding mothers in the work area of the Srengat Health Center. This research method is a pre-experiment with a one group pretest-postest design approach. The population in this study was all postpartum mothers in the working area of the Srengat Health Center. The sampling technique is by taking a large number of samples, which is as many as 22 people. Based on the results of the study, it shows that the value of p = 0.000 (p< 0.05) means that the administration of aloevera compresses is effective against changes in breast swelling in breastfeeding mothers in the work area of the Srengat Health Center Office. The decrease in breast swelling scale after buying aloevera compresses occurs due to the high content of amino acids, minerals, polysaccharides in aloevera which is believed to reduce breast swelling and inflammation. And serves as an anti-inflammatory that localizes both damaged agents and damaged tissues. By doing aloevera compresses on breast swelling, it can reduce swelling in the breast optimally.
EVALUASI PENGGUNAAN OBAT PADA PASIEN HIPERTENSI RAWAT JALAN DI PUSKESMAS “X” KOTA SOLO Octavian Ashido Nababan; Isma Oktadiana; Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati
Jurnal Media Akademik (JMA) Vol. 2 No. 2 (2024): JURNAL MEDIA AKADEMIK Edisi Februari
Publisher : PT. Media Akademik Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62281/v2i2.185

Abstract

Hipertensi atau dikenal dengan “Silent Killer” yang merupakan pengukuran tekanan darah yang melebihi normal (140/90mmHg). Obat hipertensi dapat memberikan efek pada saat penggunaannya yang dapat menunjukkan sejauh mana obat yang telah diberikan mencapai terapi yang diharapkan secara praktik klinis. Penelitian ini bertujuan untuk mengetahui bagaimana penggunaan obat antihipertensi, efektivitas penggunaan dan perbandingan efektivitas obat antihipertensi tiap kelompok pada pasien. Penelitian ini merupakan penelitian secara deskriptif retrospektif, artinya didasarkan pada informasi yang diperoleh dari rekam medis pasien dengan melihat kejadian di masa lalu. Pada rekam medis dimasukkan data pasien hipertensi rawat jalan Puskesmas "X" Kota Solo pada bulan September 2023. Berdasarkan temuan penelitian, 40,30% pasien adalah laki-laki dan 59,70% pasien adalah perempuan. Terdapat 46 orang yang berusia lebih dari 60 tahun dan 21 pasien berusia antara 20 dan 60 tahun. Penggunaan antihipertensi sebagai obat tunggal digambarkan sebesar 35,82%, dan sebagai kombinasi, sebesar 64,18%. Studi tersebut mengklasifikasikan kemanjuran obat menjadi dua kategori: obat tunggal dan obat kombinasi. Dua kelompok telah dibandingkan mengenai kemanjuran antihipertensi individu. Hasil penelitian menunjukkan penggunaan obat pada beberapa golongan obat seperti CCB 41,67%. Golongan obat kombinasi CCB+ARB 46,51%. Karena obat antihipertensi mencapai target terapeutik tekanan darah sistolik sekitar 7-13 mmHg dan tekanan darah diastolic sekitar 4-8 mmHg. Perbandingan efektivitas antihipertensi Tunggal golongan ACEI Captopril (5.028/6.677). Golongan ARB Valsartan (16.666/5.715).
Virtual Socialization about the Use of Family Medicinal Plants (TOGA) as an Alternative for Treatment Ratna Mildawati; Bandhi Prasetya Nugroho; Fendy Prasetyawan; Ary Kristijono; Yuneka Saristiana; Isma Oktadiana; Arlan K Imran
Assoeltan: Indonesian Journal of Community Research and Engagement Vol. 1 No. 2 (2023): Indonesian Journal of Community Research and Engagement
Publisher : Edujavare Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70610/assoeltan.v1i2.270

Abstract

The use of plants as a treatment solution, whether as preventive, promotive or curative therapy, is becoming popular again with the public due to the trend of back to nature medicine. Family Medicinal Plants (TOGA) are plants that have medicinal properties and grow around community yards which are managed by families and planted to meet the family's medicinal needs. The development and utilization of family medicinal plant cultivation is very necessary to support public health. This activity is carried out in an effort to provide knowledge to improve health. The target of this health education activity is housewives. The activity method carried out in this community service is outreach using the lecture method and using power point slides which contain explanations of several types of superior family medicinal plants and by inviting the public to plant TOGA. The success of this community service is assessed from the target number of participants of 75%, achievement of goals of 80%, achievement of material targets of 80% and success of planting TOGA at home 80%. The conclusion of this community service is that TOGA education increases people's knowledge and understanding of TOGA
Chronopharmacological Study Of Angiotensin-Converting Enzyme Inhibitor Ramipril In Hypertensive Patients In A Hospital: Analysis Of Efficacy And Tolerability Based On Administration Time Variations Fendy Prasetyawan; Faisal Akhmal Muslikh; Yuneka Saristiana; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Dewi Retno Puspitosari
Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID) Vol. 3 No. 02 (2024): Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID), July 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58471/esaprom.v3i02.4752

Abstract

This research investigates the chronopharmacological effects of Ramipril administration on hypertensive patients, focusing on the timing of drug intake. Studies conducted by Firli Choerun Nisa and Siti Rohmiati in 2022 provide the basis for this analysis. Using observational-analytic methods with cross-sectional designs, data were collected prospectively from 23 patients in each study. Firli Choerun Nisa's study at RSUD Singaparna Medika Citrautama, Tasikmalaya Regency, involved 14 patients in the light zeitgeber group and 9 in the dark zeitgeber group. Results indicated significant reductions in both systolic and diastolic blood pressures, with the dark zeitgeber group experiencing more substantial decreases. The SPSS analysis showed a p-value of 0.062, indicating no statistically significant difference between the groups. Siti Rohmiati's study at RSUD Dr. Soekardjo Tasikmalaya found similar results. The light zeitgeber group showed a systolic decrease of 9.9 mmHg and a diastolic decrease of 5 mmHg, while the dark zeitgeber group had decreases of 16.66 mmHg and 10.56 mmHg, respectively. The SPSS analysis also yielded a p-value of 0.062, supporting the conclusion of no significant difference in Ramipril's efficacy based on administration timing. The comprehensive analyses revealed that Ramipril effectively reduces blood pressure regardless of the administration time. Significant reductions in both the daytime and nighttime groups were noted, with trends suggesting a more pronounced effect during nighttime administration. These findings emphasize the importance of flexibility in medication timing, enhancing patient adherence without compromising therapeutic outcomes. In conclusion, the timing of Ramipril administration, whether in the morning or evening, does not significantly impact its effectiveness in managing hypertension. This flexibility offers practical benefits for clinical practice, supporting better patient adherence and optimized hypertension management. These studies contribute to the broader understanding of chronopharmacology, providing insights for improved treatment strategies in hypertensive care.
Community Education on Hypertension in Batua Dua Village's Simalungun Regency Area Arsiaty Sumule; okta, isma; Maswan Daulay; Salim Efendy; Fendy Prasetyawan; Ratna Mildawati
Amaluna: Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2024)
Publisher : Institut Agama Islam Negeri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21154/amaluna.v3i1.3520

Abstract

According to the 2018 Indonesian Basic Health Research Statistics (Riskesdas), 34.11% of Indonesians aged 18 or older have hypertension, with 8.36% of those affected based on diagnosis. According to the American Heart Association, the number of individuals with hypertension rises annually, and the average death rate from the condition increased by almost 21% between 2000 and 2010. Additionally, the death rate significantly increases in at least 46% of individuals with hypertension. The purpose of this service is to educate clients both before and after counseling on lifestyle compliance. The strategy is to distribute information on hypertension, which can raise public awareness by demonstrating positive answers and accuracy in responding to the questions. There was a difference in knowledge between the 20 respondents who participated in the counseling before and after it was provided.
Optimizing COVID-19 Therapy: Analysis of Prescription Profiles in Non-Comorbid Inpatients to Enhance Treatment Strategies and Clinical Outcomes Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Ilhawa Zahra
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study explores the clinical characteristics, treatment patterns, and outcomes of COVID-19 inpatients without comorbidities, aiming to contribute valuable insights to the management of the disease. Through meticulous data collection from medical records of 468 confirmed COVID-19 patients admitted to Gambiran Regional General Hospital between April and June 2020, 36 patients meeting inclusion criteria were identified. The research findings reveal a higher incidence of COVID-19 among males and a prevalent age group of 31-40 years. Notably, elderly individuals and those with underlying health conditions face a greater risk of severe outcomes, underscoring the importance of tailored interventions for vulnerable populations. The study highlights a diverse treatment approach, with a significant proportion of patients receiving supplements to bolster immune function. Antiviral medications like Favipiravir are also utilized to inhibit viral replication, although definitive treatment for COVID-19 remains elusive. Antibiotics play a crucial role in preventing bacterial respiratory infections, while supportive medications help alleviate symptoms commonly associated with the disease. Importantly, the findings emphasize the multifaceted nature of COVID-19 management and the need for targeted interventions to optimize patient outcomes. By elucidating the therapeutic landscape and clinical course of COVID-19 inpatients without comorbidities, this study contributes to the growing body of knowledge surrounding the disease. These insights can inform clinical decision-making, resource allocation, and public health strategies aimed at combating the ongoing pandemic.
Assessment of the Effectiveness of Centella asiatica Ethanol Extract in Alleviating Diarrhea in Castor Oil-Induced White Mice: A Pharmacological Approach Yuneka Sarisitiana; Fendy Prasetyawan; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Ivan Junius Mesak
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study investigated the potential anti-diarrheal effects of ethanol extract from Centella asiatica leaves using a castor oil-induced diarrhea model in mice. The extract, obtained from Centella asiatica leaves, was administered orally to mice at various doses. Parameters including the frequency, duration, and onset of diarrhea were measured and compared with control groups. Results indicated a dose-dependent reduction in diarrhea frequency and duration in treated mice. Higher doses of Centella asiatica ethanol leaf extract demonstrated efficacy comparable to loperamide, a standard anti-diarrheal drug. Histopathological analysis further revealed protective effects on intestinal tissue integrity, suggesting a potential mechanism of action for the observed anti-diarrheal activity. These findings underscore the potential of Centella asiatica ethanol leaf extract as a natural alternative for managing diarrhea. The study contributes to the growing body of evidence supporting the traditional use of Centella asiatica in folk medicine for gastrointestinal ailments. However, further research is warranted to elucidate the underlying mechanisms of action responsible for its anti-diarrheal effects and to conduct clinical trials for human validation. In conclusion, this research highlights the significance of exploring natural remedies derived from medicinal plants like Centella asiatica for combating gastrointestinal disorders. The study underscores the potential of Centella asiatica ethanol leaf extract as a therapeutic agent for managing diarrhea and improving public health outcomes.
Chemical Structure Profile and Computational Descriptors of Fenbufen Butanamine by PubChem Yuneka Saristiana; Fendy Prasetyawan; Ratna Mildawati; Yogi Bhakti Marhenta; Eka Hayati Rhomah; Mujtahid Bin Abd Kadir
Jurnal Kajian dan Inovasi Ilmu (JKII) Vol. 1 No. 2 (2025): November
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/jkii.v1.i2.2

Abstract

Fenbufen Butanamine is a structural derivative of the non-steroidal anti-inflammatory drug (NSAID) Fenbufen, characterized by the addition of a butanamine group to its core structure. This modification is intended to improve the pharmacokinetic and pharmacodynamic properties of the parent compound, potentially enhancing its therapeutic efficacy. In this study, we conducted a detailed computational analysis of Fenbufen Butanamine’s chemical structure and molecular descriptors using data retrieved from the PubChem database. The chemical identity was confirmed by its IUPAC name, InChI, InChIKey, and SMILES notation, which provide precise molecular characterization essential for database referencing and further computational modeling. Key computational descriptors, such as molecular weight, logP, topological polar surface area (TPSA), and the count of hydrogen bond donors and acceptors, were analyzed to assess drug-likeness and predict pharmacokinetic behavior. Our findings indicate that Fenbufen Butanamine possesses a biphenyl core that contributes to hydrophobic interactions, while the butanamine side chain introduces hydrophilic properties. This amphiphilic nature is likely to influence the compound’s solubility, membrane permeability, and binding affinity to biological targets. The computed descriptors suggest favorable properties for oral bioavailability and potential interactions within biological systems. These results serve as a foundational step for in silico drug design and optimization of Fenbufen derivatives. Further experimental and pharmacological studies are warranted to validate these computational predictions and explore the therapeutic potential of Fenbufen Butanamine. 
Evaluasi Efektifitas Penggunaan Uterotonika Misoprostol pada Induksi Persalinan Kehamilan Postterm Eka Nur Fatmawati; Ratna Mildawati; Yuneka Saristiana; Fendy Prasetyawan; Faisal Akhmal Muslikh
Jurnal Informatika dan Kesehatan Vol. 1 No. 1 (2024): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v1i1.3023

Abstract

Postterm pregnancy, namely pregnancy that reaches 42 weeks or exceeds 294 days which requires appropriate treatment and there are indications of labor induction. The principle of labor management in postterm pregnancy is the fulfillment of the requirements for induction of labor. The pharmacological induction method uses the uterotonic drug misoprostol. This research aims to evaluate and analyze the cost effectiveness of using the uterotonic misoprostol in labor induction of postterm pregnancies. This research method is descriptive observation using a cross-sectional research design from a hospital perspective. Retrospective data collection method. Evaluation of the effectiveness of using the uterotonic misoprostol with percentages. The results of this study show the pattern of use of misoprostol uterotonics (73.5%), the use of uterotonics is in accordance with hospital guidelines (96%), the effectiveness of using uterotonics is successful in preventing bleeding (57.4%). And analysis of the cost effectiveness of using misoprostol and oxytocin in labor induction at RSUD dr. Sayidiman Magetan can conclude that misoprostol uterotonic is more effective with a percentage value of 60%. Abstrak Kehamilan postterm, yaitu kehamilan yang mencapai 42 minggu atau melewati 294 hari yang memerlukan penanganan tepat dan muncul indikasi dilaksanakan induksi persalinan. Prinsip penatalaksanaan persalinan pada kehamilan postterm adalah terpenuhinya syarat-syarat melakukan induksi persalinan. Metode induksi farmakologis menggunakan obat uterotonika misoprostol. Pelitian ini bertujuan untuk mengevaluasi dan analisis efektifitas biaya penggunaan uterotonika misoprostol pada induksi persalinan kehamilan postterm. Metode penelitian ini observasi deskriptif dengan menggunakan rancangan penelitian cross sectional menurut perspektif rumah sakit. Metode pengambilan data secara retrospektif. Evaluasi efektifitas penggunaan uterotonika misoprostol dengan persentase. Hasil penelitian ini menunjukkan pola penggunaan uterotonika misoprostol (73,5%), penggunaan uterotonika sudah sesuai dengan guideline rumah sakit (96%), efektifitas penggunaan uterotonika berhasil mencegah perdarahan (57,4%). Dan analisis efektifitas biaya penggunaan misoprostol dan oksitosin pada induksi persalinan di RSUD dr. Sayidiman Magetan dapat disimpulkan uterotonika misoprostol lebih effective dengan nilai persentase 60 %.
Studi Analisa Kronofarmakologi Penggunaan Obat Ibuprofen pada Pasien Covid-19 di Rawap Inap RSUD Dr. Soedomo Trenggalek Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Emma Jayanti Besan; Muhammad Nurul Fadel; Charliandri Saputra Wahab; Muhammad Alviyan Shutiawan
Jurnal Informatika dan Kesehatan Vol. 1 No. 1 (2024): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v1i1.3024

Abstract

The global COVID-19 pandemic has presented unprecedented challenges to global health. The Dr. Soedomo Regional General Hospital in Trenggalek has been at the forefront of managing COVID-19 patients, with a primary focus on the use of ibuprofen to alleviate symptoms such as fever and pain. Despite the widespread use of ibuprofen, knowledge regarding its interaction with the circadian rhythm, especially in COVID-19 patients, remains limited. This study employed an analytical observational approach with a Cross-Sectional design to analyze the use of ibuprofen in COVID-19 patients at Dr. Soedomo Regional General Hospital in Trenggalek. The study included 100 patients, emphasizing body temperature at three different times. Data analysis revealed a significant decrease in body temperature after therapy, particularly at 4:00 PM. These findings lay the foundation for the development of more targeted and personalized treatment strategies by understanding the body's response patterns to therapy at different times.   Abstrak Pandemi global COVID-19 telah menciptakan tantangan kesehatan global yang belum pernah terjadi sebelumnya. Rumah Sakit Umum Daerah Dr. Soedomo di Trenggalek telah menjadi pusat perhatian dalam menangani pasien COVID-19. Fokus utama adalah penggunaan ibuprofen untuk mengelola gejala, seperti demam dan nyeri. Meskipun ibuprofen umum digunakan, pengetahuan tentang interaksi dengan siklus sirkadian tubuh, terutama pada pasien COVID-19, masih terbatas. Penelitian ini menggunakan pendekatan observasional analitik dengan desain Cross Sectional untuk menganalisis penggunaan ibuprofen pada pasien COVID-19 di RSUD Dr. Soedomo Trenggalek. Hasil penelitian melibatkan 100 pasien, dengan fokus pada suhu tubuh pada tiga waktu berbeda. Analisis data menunjukkan penurunan suhu tubuh yang signifikan setelah terapi, terutama pada pukul 16.00 WIB. Hasil ini memberikan dasar untuk pengembangan strategi pengobatan yang lebih terarah dan personalisasi, dengan memahami pola respons tubuh terhadap terapi pada waktu yang berbeda.
Co-Authors Abd Rofiq Akhmal, Faisal Anis Akhwan Dhafin Arsiaty Sumule Ary Kristijono Asrizal Azis Bandhi Prasetya Nugroho Chandra Arifin Charliandri Saputra Wahab Dewi Retno Puspitosari Dwi Lukmawati Eka Hayati Rhomah Eka Nur Fatmawati Ema Tri Wulan Emma Jayanti Besan Faisal Akhmal Muslihk Faisal Akhmal Muslikh Fendy Prasetyawan Fransiska Septiana Ilhawa Zahra Imran, Arlan K Isma Oktadiana Ivan Junius Mesak Kristian Ubanayo Lusiana Aprillia maswan daulay Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Mujtahid Bin Abd Kadir Neta Ayu Andera Octavian Ashido Nababan okta, isma Salim Efendy Yogi Bhakti Marhenta Yuneka Sarisitiana Yuneka Saristiana