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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Farmasi Indonesia JURNAL FARMASIMED (JFM) Jurnal Farmasi dan Sains Indonesia (JFSI) Generics: Journal of Research in Pharmacy Jurnal Pharmacopoeia SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT Generics : Journal of Research in Pharmacy Jurnal Sains dan Kesehatan JPEMAS: Jurnal Pengabdian Kepada Masyarakat
Purwaningsih, Avianti Eka Dewi Aditya
Program Studi Profesi Apoteker, Fakultas Farmasi, Universitas Setiabudi, Surakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : JURNAL FARMASIMED (JFM)

 1 
Evaluation of Inpatient Antibiotic Use at Hospital X, Semarang Regency, in 2023 Using Quantitative Methods Ivana; Avianti Eka Dewi Aditya Purwaningsih; Fadhila Shaumi Chunaesiana
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/q734wz44

Abstract

Background: Antibiotic resistance is a critical global health problem resulting from the inappropriate use of antibiotics. Understanding the pattern of antibiotic utilization is necessary to support rational prescribing and reduce resistance.Objective: This study aimed to evaluate the pattern of antibiotic use among inpatients at Hospital X in Semarang Regency in 2023. Methods: A retrospective study was conducted among inpatients aged 19–59 years who received antibiotic therapy between January and December 2023. Data were analyzed using the Anatomical Therapeutic Chemical/Defined Daily Dose method and Drug Utilization 90% to assess consumption patterns. Results: A total of 1,402 patients were included, with most patients being female and within the 49–59 age group. The majority of hospital stays lasted 1–5 days. Ceftriaxone injection is the most frequently used antibiotic and records the highest defined daily dose, followed by levofloxacin and ampicillin sulbactam. Conclusion: The study shows that ceftriaxone injection dominates antibiotic utilization. Regular evaluation using standardized methods is essential to ensure appropriate use and prevent resistance. Antibiotic procurement policies should be guided by actual consumption data to improve efficiency in drug management.
Antibiotic Use in Inpatients with Diarrhea in Children: A Quantitative Evaluation at Hospital X, Semarang Regency, 2023 Widiastuti, Zulfia; Purwaningsih, Avianti Eka Dewi Aditya; Ulum, Amalia Nurul
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/s8qfqn40

Abstract

Background : Infection remain one of the leading causes of morbidity in tropical regions such as Indonesia, with Escherichia coli being one of the most freequently identified pathogens. The high incidence of Escherichia coli-related infections has led to increased antibiotics use, considering that this commensal gut bactericum can cause both asymptomatic infections and symtomatic diarrhe, either bloody or non-bloody. Objective : This study aimed to evaluate use in pediatric patiens with diarrea at Hospital X, Semarang Regency, in 2023. Methods: This was a retrospective study uutilizing medical records of 323 pediatric patiens who met the inclusion and exclusion criteria. Data analysis was performed using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) methodology. Result:The analysis revealed that Ceftriaxone injection was the most frequently used antibiotic (61.95%), followed by Ampicillin, Amikacin, Gentamicin, and Cefotaxime. Ceftriaxone was often prefered due to its efficacy against both gram-positive and gram-negative bacteria comonly associated with pediatric diarrhea, as well as the advantage of accurate dosing trough injectable formulations. Most diarrhea cases occurred in boys (62.54%) and in children under five years of age (65.63%). Conclusion:Injectable formulations were chosen to reduce the risk of vomiting and to facilitate precise and effective dosing. Evaluation using the ATX/DDD method highlighted the need for more rational antibiotic management to prevent bacterial resistance in the future. Optimizing antibiotic stewardship is crucial to ensure targeted in the future. Optimizing antibiotic stewardship is crucial to ensure targeted, effective use and to preserve therapeutic efficacy in the long term. 
Evaluation Of Antibiotic Use In Diabetic Ulcer Patients Based On The Defined Daily Dose Method (Ddd) Widi, As Syifa Roidhotul Jannah Putri; Purwaningsih, Avianti Eka Dewi Aditya; Sari, Novita
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/8nffcw16

Abstract

Diabetic ulcers are a complication of diabetes mellitus that manifest as open skin wounds on the feet due to blood vessel disorders and nerve damage. These ulcers are susceptible to infection because bacteria thrive in high glucose environments. Selecting the right antibiotic is crucial in treating these infections. This study aims to predict the pattern of antibiotic prescribing in patients with diabetic ulcer infection in Hospital X Semarang Regency in 2023 using the ATC (Anatomical Therapeutic Chemical) method and DDD (Defined Daily Dose) units. This study is a retrospective descriptive study that analyzes data on diabetic ulcer patients who received antibiotic therapy between January-December 2023. The data collection technique was carried out by purposive sampling, following the inclusion and exclusion criteria. The results of the study of 168 patients with Diabetic Ulcers were found to be more dominant in female patients 53.57% (90 patients) and male patients 46.43% (78 patients). The antibiotic research that was classified as having the highest DDD/100 patient-days value was Ceftriaxone 44.99 DDD, followed by Metronidazole 33.96 DDD and Levofloxacin 26.85 DDD. Meanwhile, antibiotics that were included in the DU 90% segment with the order of highest to lowest values ​​were Ceftriaxone (36.16%), Metronidazole (63.46%), and Levofloxacin (85.04%). The use of antibiotics in diabetic ulcer patients based on the ATC/DDD and DU 90% methods needs to be reviewed periodically because it has the potential to cause the risk of resistance in patients which will then prolong the healing process. Based on the evaluation of antibiotic consumption patterns in diabetic ulcer patients at Hospital X, Semarang Regency in 2023 using the ATC/DDD and DU 90% methods, the antibiotics with the highest DDD/100 patient-days were Ceftriaxone (44.99), followed by Metronidazole (33.96) and Levofloxacin (26.85). These three antibiotics are included in the DU 90% segment, therefore their use needs to be periodically evaluated to ensure the rationality of therapy and to prevent the occurrence of antibiotic resistance.
The Effect of Genjer Leaf Extract Ointment (Limnocharis flava) on Incision Wounds in Male New Zealand White rabbits Megawati, Sefi; Saru Noliqo Rangkuti; Ilmi Hidayat; Avianti Eka Dewi Aditya Purwaningsih
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tfpm7z77

Abstract

Background: Incision wounds are a common type of open wound that require proper treatment to prevent infection and accelerate the healing process. The use of natural products as alternative wound therapy has been increasingly developed, one of which is yellow velvetleaf (Limnocharis flava), known to contain active compounds such as flavonoids, tannins, and saponins that have anti-inflammatory and wound healing properties. Objective: This study aimed to determine the effect of ethanol extract ointment of Limnocharis flava leaves on incision wound healing in male New Zealand White rabbits and to identify the most effective extract concentration. Methods: Limnocharis flava leaves were extracted using 70% ethanol by maceration with a ratio of 1:10, then formulated into ointments with concentrations of F1 (5%), F2 (7.5%), F3 (10%), F4 (negative control), and F5 (positive control using povidone-iodine). Results: The evaluation results showed that all ointment formulations met the physical requirements, including good homogeneity, stable form and color, pH compatible with skin pH, as well as optimal spreadability and adhesion. Observation of wound healing indicated an increase in the percentage of wound closure with higher extract concentrations and longer treatment duration. Statistical analysis using Two-Way ANOVA showed a p-value < 0.05, indicating a significant effect of extract concentration and duration of treatment on incision wound healing. Conclusion: Quantitatively, the 10% concentration group (F3) showed the highest percentage of wound closure and the fastest healing time compared to other groups, with effectiveness approaching the positive control. The 10% Limnocharis flava leaf extract ointment is the most effective formulation for accelerating incision wound healing.
Overview of Antiepileptic Drug (AED) Use in Outpatient Patients at UNS Hospital Maya Nur Ayu Fatdhillillah; Purwaningsih, Avianti Eka Dewi Aditya; E. Aprilia L. Tobing
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/5s852a48

Abstract

Epilepsy is a long-term disorder of the nervous system that requires long-term therapy using antiepileptic drugs (AEDs) to control seizures. The proper pattern of AED use plays a significant role in the effectiveness of treatment and patients’ overall well-being. This study aims to describe the use of antiepileptic drugs in outpatient patients at Universitas Sebelas Maret Hospital during the period of January-December 2024. This study used a non-experimental design with a descriptive approach, and data collection was conducted retrospectively through the review of medical records of epilepsy patients. From a total population of 1,236 medical record data, 303 samples were collected that satisfied the inclusion criteria. The analyzed data included patient characteristics based on gender and age, types of AED therapy, dosage, and usage rules. The study results show that outpatient epilepsy patients were predominantly female (53.14%) and the young adult age group 19-65 years (81.19%). The most commonly used therapy pattern was monotherapy, with Phenytoin 100 mg being the most frequently prescribed drug (28.38%), mainly at a dose of 1 tablet twice daily. Combination therapy was used in some patients with variations of two to four antiepileptic drugs. The conclusion of this study indicates that phenytoin is still the primary choice in the outpatient management of epilepsy at UNS Hospital, and reflects its role as a first-line drug effective in controlling various types of seizures. Predominated by females (53.14%) and the young adult age group aged 19-65 years (81.19%).
Co-Authors Abadi, Dzithauly Maulidiva Adhi Wardhana Amrullah Adhi Wardhana Amrullah Agnes Prawistya Sari Amrullah, Adhi Wardhana Atiek Murharyati Chandra, Sherley Widya Djoko Wahyono Djoko Wahyono E. Aprilia L. Tobing Eersta Zusvita Widyastuti Effendy, Aura Nurul Alfiah Endang Sri Rejeki Fadhila Shaumi Chunaesiana Fita Rahmawati Fita Rahmawati Harsono, Samuel Budi Ilmi Hidayat Ivana Marlina, Dian Maya Nur Ayu Fatdhillillah Megawati, Sefi Novita Sari Nur Anggreini Dwi Sasangka Rahardjoputro, Rolando Rolando Rahardjoputro Sari, Agnes Prawistya Saru Noliqo Rangkuti Ulum, Amalia Nurul Untsa, Farrohatul Widi, As Syifa Roidhotul Jannah Putri Widiastuti, Zulfia Widyaningrum, Riana Widyastuti, Eersta Zusvita