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All Journal Indonesian Journal of Global Health research International Journal of Health and Pharmaceutical (IJHP) International Journal of Health, Engineering and Technology HelFin Journal
Frisca Angreni
Department Of Anatomy, Faculty Of Medicine, Universitas Kristen Indonesia
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Spastic Lower Paraparesis Due To Multiple Ossification of The Ligamentum Flavum of Fusion and Tuberous Type In The Thoracolumbar Region In A 42-Year-Old Woman Gregorius Septayudha Suryonegoro; Frisca Angreni
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.462

Abstract

Ossification of the ligamentum flavum (OLF) is characterized by the replacement of ligamentum flavum tissue with mature laminar bone accompanied by hypertrophy. Although rare, its highest prevalence is reported among East Asian populations, predominantly affecting males under 50 years old, and most commonly found in the lower thoracic region. Clinically, OLF presents as a slowly progressive myelopathy, yet its precise pathogenesis remains unclear. Diagnostic imaging modalities include radiography, computed tomography (CT), and magnetic resonance imaging (MRI). This case report describes a 42-year-old female diagnosed with thoracolumbar OLF based on MRI examination. The patient presented with spastic paraparesis and hypoesthesia from both feet to dermatomes Th10–11 following a history of trauma. Lumbar radiography showed only lumbal spondylosis, while thoracolumbar MRI revealed nodular thickening of the ligamentum flavum from Th6–7 to Th12–L1, resulting in spinal canal stenosis and compression of the spinal cord. Additional degenerative findings included superior endplate degeneration of L4 and multiple intervertebral disc bulging. Neurological deficits indicated myelopathy and radiculopathy due to compression of the lateral corticospinal and spinothalamic tracts. The absence of spinal cord edema on MRI suggested a chronic onset. OLF frequently coexists with vertebral degenerative abnormalities, as observed in this patient. Based on the radiologic characteristics, the lesion represented several morphological types including extended, enlarged, fused, and tuberous forms. Laminectomy performed in this case resulted in gradual neurological recovery. In conclusion, OLF is a rare but important cause of progressive thoracic myelopathy that may lead to irreversible neurological impairment. MRI evaluation plays a crucial role in preoperative assessment of spinal canal stenosis and spinal cord compression.
The Relationship Between Random Blood Glucose Levels and The Incidence of Diabetic Foot Ulcers Nur Nunu Prihantini; Fri Rahmawati; Zefeilyne Angelita Permata Sitorus; John Jackson Yang; Frisca Angreni
International Journal of Health and Pharmaceutical (IJHP) Vol. 6 No. 2 (2026): May 2026
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v6i2.615

Abstract

Diabetes mellitus is a global health challenge characterized by an ever-increasing number of cases annually. The most feared chronic complication of diabetes mellitus is diabetic foot ulcer (DFU), which significantly increases the risk of amputation and mortality rates. This study aims to analyze the relationship between random blood sugar (RBS) levels and the incidence of DFU in type 2 diabetes mellitus patients at Paragon Hospital, Citeureup 2026. The research method used is an analytical observational design with a cross-sectional approach. A total of 54 subjects meet the inclusion criteria out of 109 type 2 diabetes mellitus patients. Medical record data were statistically analyzed using the Chi-Square test. The results indicated that DFU patients were predominantly male (53.7%) and belonged to the 46-55 age group (38.9%). Clinical findings showed that the majority of research subjects (88.9%) had high random blood sugar levels (≥ 200 mg/dL). Statistical test results yielded a p-value of 0.000 (p < 0.05), indicating a significant relationship between high RBS levels and the incidence of DFU. Based on the result the concluded that uncontrolled RBS levels are a primary trigger for DFU. Chronic hyperglycemia triggers vascular and nerve damage, which inhibits the tissue healing process in the feet. Optimal control of RBS levels is essential as a preventive measure to avoid amputation complications in type 2 diabetes patients.
Morphology Profile and PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Patients Marliana Nurprilinda; Silphia Novelyn; Sonya Trinur Veronika Siahaan; Frisca Angreni
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6167

Abstract

Lung cancer cases in Indonesia became the second highest with the highest mortality rate in 2022. Various advanced examinations such as histopathology and immunohistochemistry are performed to identify the morphological types of lung cancer. Histopathologically, lung cancer classified into two types are Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC). After histopathological examination, further immunohistochemical testing is required to help classify the subtype and identify therapeutic markers. One of the markers is the expression of Programmed Death Ligand 1 (PD-L1). Patients with this marker can receive anti-PD-L1 immunotherapy according to the specified criteria. This study determined the morphological profile and PD-L1 expression in patients with Non-Small Cell Lung Cancer (NSCLC) at Siloam MRCCC Semanggi Hospital between 2020 and 2022. The method used was descriptive with a retrospective approach by collecting data from the archives of the Anatomical Pathology Laboratory at Siloam MRCCC Semanggi Hospital. The population in this study comprised all patients diagnosed with NSCLC who underwent PD-L1 IHC testing at Siloam MRCCC Semanggi Hospital between 2020 and 2022. Data collection was conducted using a total sampling method, including all individuals who met the predefined inclusion and exclusion criteria. The final sample consisted of 91 patients diagnosed with NSCLC who had undergone PD-L1 IHC examination during the 2020–2022 period. A total of 91 patients including the inclusion and exclusion criteria were included in the data and analyzed. The analysis revealed that the age group 60-69 years accounted for 39.5% of cases, 54.9% of cases were male, 73.6% of cases had an adenocarcinoma morphology, and 54.9% of cases had a negative PD-L1. The incidence of NSCLC patients who underwent PD-L1 IHK examination based on age was dominated by the 60-69 year age group, and most of them were male with the most common diagnosis being adenocarcinoma morphology type and PD-L1 expression with negative values.
Factors Associated With Pregnancy Outcomes After Intrauterine Insemination Batara Imanuel Sirait; Frisca Angreni; Indira Naomi Hutahaean
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.682

Abstract

Infertility is a reproductive disorder defined as the inability to achieve a clinical pregnancy after 12 months or more of regular unprotected intercourse. It may be caused by female and/or male factors. Intrauterine insemination (IUI) is a form of assisted reproduction commonly used to treat subfertility. In Indonesia, infertility affects an estimated 10–15% of couples, equivalent to 4–6 million out of 29.8 million couples of reproductive age. This study aimed to evaluate factors associated with pregnancy success following IUI at Morula IVF Clinic, Jakarta, during January - December 2023. An analytic descriptive design was applied, and associations were tested using the Chi-square method. A total of 199 patients were included, with an overall IUI pregnancy success rate of 8.5%. Successful pregnancies were most frequently observed among wives aged 25 - 35 years, those with a body mass index of 18.5–24.9 kg/m², and cycles with pre-wash semen volume of 2 - 5 mL, sperm concentration >16 million, and sperm motility >30%. Chi-square analysis demonstrated that only sperm motility was significantly associated with IUI success (p=0.029), while wife’s age, body mass index, pre-wash semen volume, and sperm concentration showed no significant association.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN STUNTING PADA BALITA DI DESA PANGADEGAN KABUPATEN SUMEDANG: FACTORS RELATED TO THE INCIDENT OF STUNTING IN TODDLERS IN PANGADEGAN VILLAGE, SUMEDANG REGENCY Andriyani Risma Sanggul; Frisca Angreni
HelFin Journal Vol. 3 No. 1 (2026): Januari
Publisher : Fakultas Vokasi Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/helfin.v3i1.6421

Abstract

Stunting merupakan gangguan pertumbuhan dan perkembangan pada anak yang terjadi akibat interaksi berbagai faktor. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang berkaitan dengan kejadian stunting pada balita yang berdomisili di Desa Pangadegan. Penelitian menggunakan desain analitik dengan pendekatan potong lintang (cross-sectional) dan dilaksanakan pada bulan Mei 2023. Pengumpulan data dilakukan melalui pengisian kuesioner oleh responden serta pemeriksaan antropometri pada balita, yang meliputi pengukuran tinggi dan berat badan. Responden dipilih menggunakan teknik purposive sampling dengan total sampel sebanyak 170 orang. Hasil uji statistik Chi-Square menunjukkan bahwa kualitas air minum (p = 0,002), ketersediaan fasilitas limbah (p = 0,003), kadar hemoglobin ibu saat hamil (p = 0,002), asupan nutrisi ibu selama kehamilan (p = 0,005), riwayat berat badan lahir rendah (BBLR) (p = 0,0001), pemberian ASI eksklusif (p = 0,0001), serta penyakit infeksi (p = 0,0001) memiliki hubungan yang signifikan dengan kejadian stunting. Faktor-faktor tersebut berpotensi menjadi determinan penting dalam upaya pencegahan stunting pada anak.
Co-Authors Batara Imanuel Sirait Fri Rahmawati Gregorius Septayudha Suryonegoro Indira Naomi Hutahaean John Jackson Yang Marliana Nurprilinda Nur Nunu Prihantini Sanggul Andriyani Risma Silphia Novelyn Sonya Trinur Veronika Siahaan Zefeilyne Angelita Permata Sitorus