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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Pharmaceutical Science and Technology Majalah Kesehatan FKUB Jurnal Kesehatan Manarang Journal of Dedicators Community Journal of Midwifery Jurnal Kesehatan Islam : Islamic Health Journal Oksitosin : Jurnal Ilmiah Kebidanan Journal of Issues in Midwifery Science Midwifery Jurnal Kebidanan Malakbi Majalah Kesehatan Indonesia Jurnal Mandala Pengabdian Masyarakat Indonesian Journal of Pharmaceutical Education KESANS : International Journal of Health and Science
Ni Luh Putu Herli Mastuti
Fakultas Kedokteran Universitas Brawijaya Malang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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The Influence of Gestational Age on Neonatal Hypoglycemia Among Preterm Neonates in Secondary Hospital Setting Mastuti, Ni Luh Putu Herli
Majalah Kesehatan Indonesia Vol. 6 No. 2: 2025
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2025248

Abstract

Preterm neonates frequently encounter health challenges due to immaturity of organ systems, particularly metabolic complications such as hypoglycemia. This study aimed to analyze gestational age as a risk factor for neonatal hypoglycemia in a secondary hospital setting. An observational retrospective design was employed using medical records of preterm neonates born before 37 weeks gestation, admitted to Mitra Delima Hospital, Malang, Indonesia, between January and December 2023. Neonates with diabetic mothers or congenital anomalies were excluded. Hypoglycemia was defined as blood glucose levels below 60 mg/dL measured via heel puncture. Of 59 preterm neonates studied, 17 (29%) experienced hypoglycemia, while 42 (71%) maintained normoglycemia. Cesarean section deliveries accounted for 74.6% of the cases, with no significant differences in maternal age or neonatal complications between groups. Gestational age was significantly lower in hypoglycemic neonates compared to those normoglycemic (mean 24.18 vs. 33.93 weeks; p=0.045), although birth weight alone did not significantly correlate with hypoglycemia. These findings suggest that lower gestational age constitutes a primary risk factor for neonatal hypoglycemia. Thus, rigorous clinical monitoring and targeted screening protocols are strongly recommended, especially for neonates born prematurely, to mitigate hypoglycemia-related morbidity and long-term neurodevelopmental complications.
Effect of infused lemon water (citrus limon) on Newborn Baby Weight (BBL) in pregnant rats (rattus norvegicus) exposed to electric cigarette vapor Fadilah, Rahmawati Nurul; Nurdiana, Nurdiana; Mastuti, Ni Luh Putu Herli
Science Midwifery Vol 12 No 3 (2024): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i3.1637

Abstract

The electric cigarettes are said safe for health, in fact there are toxic substances, carcinogens, and unstable nicotine, it is suspected to cause low birth weight in pregnant women who are exposed to electric cigarette. Nicotine in electric cigarette is free radicals, so to ward off free radicals is required antioxidant. Infused lemon contains antioxidants that are higher than lime and are believed to resist free radicals from electric cigarettes. The purpose of research to determine the influence of infused lemon water in preventing low birth weight in pregnant rats (Rattus novergicus) exposed by electric cigarettes. The study used 30 pregnant rats, divided into 5 groups; Negative control (KN), positive control (KP), Treatment (P1), Treatment (P2), Treatment (P3). Using electric cigarette liquid 9 mg, and the difference in the weight of lemon in the making of infused water (P (1): 25g, P (2): 50g, P (3): 100g lemon + 100ml water). The treatment is given on day 1 ovulation to day 18, sacrificed on the 19th day ovulation then calculated the average weight of the baby. The average weight baby KN: 5.502g, KP: 2.821g, P (1): 4.301g, P (2): 4.888g, P (3): 5.435g. The result of One-way ANOVA indicates there is a significant difference in the treatment group with the value P=0,000 (P<0.05). The KP group differs significantly from KN. Group P (1,2,3) is significantly different from KP. The KN group is significantly different from P (1), but does not differ significantly from P (2, 3). The group P (1) differs significantly with P (3). Infused lemon juice can prevent the occurrence of low birth weight in the child of the pregnant rats that’s exposed by electric cigarettes especially in group P (3).
Paramedic Mental Workload in Pandemic Covid-19 Era Arifianto, Dedy; Fitriasari, Nikma; Mastuti, Ni Luh Putu Herli
Jurnal Kedokteran Brawijaya Vol. 33 Supplement 1 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.01.1s

Abstract

The number of Covid-19 patients hospitalized continues to increase in line with the increase in Covid-19 cases in Indonesia. The increasing number of Covid-19 patients in hospitals is increasing the workload of paramedics. High workloads will cause saturation and fatigue. In addition, an increase in the number of Covid-19 patients increases anxiety and depression will be infected when treating patients. Paramedics should also use personal protective equipment during shift guards which causes dehydration and discomfort. This situation can degrade the quality of service to patients. The study aims to measure the mental workload of paramedics by NASA-TLX (National Aeronautics and Space Administration Task Load Index) method and find out the factors that affect mental workload levels. This research is a quantitative research with a cross sectional approach. The research was conducted at Hospital X type C in Malang Regency in October 2020. The samples used were all 100 Hospital X paramedics. Research instruments in the form of questionnaires shared through Google Form. Data analysis is done with descriptive analysis and Chi-Square analysis with p value <0.05. The results found paramedics had a low mental workload of 1%, a moderate mental load of 3%, a high mental workload of 47%, and a very high mental workload of 49%. The Chi-Square test results found that age factors had an effect on the mental workload level of paramedics.
Faktor-Faktor Penyebab Remaja Putus Sekolah Usia 12 - 18 Tahun di Polobangkeng Utara, Kabupaten Takalar Anwar, Yulianti; Hadju, Veni; Rambulangi, Samrichard; Mastuti, Nih Luh Putu Herli
Jurnal Kebidanan Malakbi Vol 3 No 2 (2022): Agustus 2022
Publisher : Jurusan Kebidanan Poltekkes Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/b.v3i2.690

Abstract

Dropout is a predicate given to former students who are unable to complete a level of education and unable to continue their studies to the next level of education. This study determines the factors that cause adolescents to drop out of school. This study is qualitative descriptive research with the type of field research. Data collection techniques are by conducting observations, interviews, and documentation. Meanwhile, to determine the informants using the purposive sampling technique, in this case, the researchers chose informants, namely teenagers who dropped out of school, aged 12-18 years, parents of teenagers, and the local government. The analysis used is an interactive model of data analysis technique that includes three paths specifically, data reduction, data presentation, and conclusion drawing. The results showed that the factors that caused teenagers to drop out of school were economic problems, low learning abilities, adolescent associations, and student attitudes towards teachers.
Efficacy and safety of Maternal voice for Preterm Neonatal Pain: a Systematic Literature Review Mastuti, Ni Luh Putu Herli
Journal of Midwifery Vol. 8 No. 2 (2023): Published on Desember 2023
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jom.8.2.1-14.2023

Abstract

Purpose: Pain in neonates, especially in preterm neonates has short effects and long effects. A mother’s voice can stabilize the physiological state, support feeding, reduce pain, and promote growth and development. aimed to analyze the effect and safety of maternal voice for preterm neonatal pain, to provide scientific evidence.Design : The research design used in this study is the systematic literature review. The identification of the study uses a PRISMA flow diagram, and quality assessment uses critical appraisal tools from the Centre for Evidence-Based Medicine. The analyzed data related to the population, intervention, and outcomes (PIO components).Findings: Ten studies were included in this study, ranging from 2018 to 2023. Seven studies showed the significant efficacy of maternal voice in reducing preterm neonatal pain, and three studies no significance. Five studies show maternal voice can reduce pain significantly more than routine care, and two studies use a combination of maternal voice and other non-pharmacological management, including breast milk, taste, Non-nutritive sucking, heartbeat sounds mother voice, and mother touch therapy. Pain parameters use the Pain Scale and serum and salivary cortisol level.Implications: Maternal voice; both live or recorded, voice or heartbeat, was effective and safe in reducing pain sensation in preterm neonates. 
Pelatihan Laktasi Multidisipliner: Kolaborasi Dosen Kebidanan dan Dokter Spesialis Anak Fakultas Kedokteran Universitas Brawijaya Mastuti, Ni Luh Putu Herli; Barlianto, Wisnu; Ulfah, Mega; Kusumaningtyas, Dian
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 2 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i2.934

Abstract

Kesadaran tentang pentingnya Air Susu ibu sebagai nutrisi terbaik untuk bayi masih sangat kurang, dengan keberhasilan ASI eksklusif tinggal nasional sebesar 73,97%.  Ibu memegang peranan penting untuk keberhasilan ASI Eksklusif, sehingga sangat diperlukan peningkatan pemahaman dan kesiapan ibu. Bidan merupakan salah satu tenaga kesehatan yang bersentuhan langsung dengan ibu, terutama selama menyusui. Sehingga sangat penting untuk meningkatkan kemampuan bidan, dengan melakukan kolaborasi antara Departemen Kebidanan dengan dokter spesialis anak Fakultas Kedokteran Universitas Brawijaya. Kegiatan ini dilakukan dengan memakai metode penyampaian materi, dengan judul Air Susu Ibu sebagai nutrisi penting untuk bayi, Manajemen Laktasi, Pentingnya kesehatan Mental ibu menyusui, serta ditutup oleh materi tentang Alergi susu sapi di bayi. Sasaran untuk mencapai tujuan kegiatan yaitu 40 tenaga bidan di wilayah kota Malang, baik yang bekerja di Rumah, Sakit, Rawat jalan maupun sebagai Bidan Praktek Mandiri. Setelah pemberian materi, dilanjutkan dengan diskusi interaktif, yang cukup memberikan peluang peserta untuk mendiskusikan materi yang diberikan yang akan diterapkan dalam pelayanan kepada pasien. Kegiatan ini cukup memberikan tingkat pemahaman bidan, terutama untuk keberhasilan menyusui disertai dengan persiapan ibu serta deteksi kemungkianan alergi protein susu sapi. Hasil menunjukkan peningkatan yang signifikan pada nilai rata-rata dari 17 menjadi 23 pada pre dan post-test. Kegiatan pelatihan dengan melibatkan fasilitator multidisipliner sangat penting untuk peningkatan kompetensi bidan dalam manajeman laktasi dengan mengedepankan bukti - bukti ilmiah.
Virgin Coconut Oil and Folic Acid Effects on mTOR and Growth in Rotenone-Induced Stunted Zebrafish Larvae Farica Emiliana; Hanida Aisyah Ardiana; Syahana Aini; Nurdiana Nurdiana; Ni Luh Putu Herli Mastuti; Ariani Ariani
Indonesian Journal of Pharmaceutical Education Vol 6, No 2 (2026): May–August 2026
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v6i2.37769

Abstract

Stunting is characterized by impaired linear growth and is associated with dysregulation of the mechanistic target of rapamycin (mTOR) pathway. Rotenone-induced mitochondrial dysfunction suppresses mTOR signaling through oxidative stress and ATP depletion. This study evaluated the effects of Virgin Coconut Oil (VCO), folic acid, and their combination on mTOR expression and body length in rotenone-induced stunted zebrafish larvae. Zebrafish were divided into five groups (n = 3 biological replicates per group, 30 larvae per replicate): negative control, positive control (rotenone 12.5 ppb), VCO (6.25%), folic acid (70 µM), and combination treatment. mTOR expression at 9 days post-fertilization was analyzed using RT-qPCR (ΔCt for statistical analysis; 2⁻ΔΔCt for fold change presentation), and body length was measured at 3, 6, and 9 dpf. Statistical analysis was performed using one-way ANOVA followed by Tukey’s HSD post hoc test. Rotenone significantly reduced mTOR expression and body length (p 0.001). VCO and folic acid alone significantly increased mTOR expression and improved linear growth, particularly at 6–9 dpf, whereas the combination did not produce a superior effect, suggesting a dose-ratio dependent response. In conclusion, VCO and folic acid individually increase mTOR expression and support growth in rotenone-induced stunted zebrafish, while their combination at the tested doses does not provide additional benefit beyond single treatment.
Four weeks Sustainable Montessori Program for Preschool Child Self-Reliant Attitude at Kindergarten school Ringinrejo District Kediri Zakiah Diah Zulfiani; Ni Luh Putu Herli Mastuti; Rahma Dian Hanifarizani
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 9 (2026): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i9.656

Abstract

Introduction: Early childhood education plays an important role in shaping character, one of which is preschool self-reliant Attitude children. However, the level still varies, and the inconsistent application of learning methods can hinder the development of it. Objective: This study aims to determine the effect of a Sustainable Montessori Program (4 weeks) on Preschool Children's Self-Reliant Attitude at Kindergarten School, Ringinrejo District, Kediri Regency. Method: The study used a quantitative approach with a quasi-experimental nonequivalent control group design, involving 30 children who were divided into a control group and an experimental group. Data were collected through pretests and posttests using observation sheets and then analyzed using the Wilcoxon Test at a significance level of 0.05. Result and Discussion: This study showed an increase in Self-Reliant Attitude in the experimental group (p-value of 0.001), Conclusions: The Sustainable Montessori Program (for 4 weeks) has a significant effect on improving Self-Reliant Attitude of preschool children
Minyak Kelapa Murni dan Asam Folat Secara Tunggal Maupun Kombinasi Memodulasi Ekspresi Growth Hormone pada Larva Zebrafish Model Stunting yang Diinduksi Rotenon Emiliana, Farica; Ardiana, Hanida Aisyah; Aini, Syahana; Nurdiana, Nurdiana; Mastuti, Ni Luh Putu Herli
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.70291

Abstract

Stunting merupakan masalah kesehatan global yang berkaitan dengan gangguan pertumbuhan linier yang berhubungan dengan penurunan ekspresi growth hormone (GH) dan sering dikaitkan dengan stres oksidatif.  Virgin Coconut Oil dan asam folat memiliki sifat antioksidan yang berpotensi memulihkan jalur pertumbuhan. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian VCO dan asam folat, baik secara tunggal maupun kombinasi, terhadap ekspresi GH pada model stunting larva zebrafish yang diinduksi rotenon. Penelitian eksperimental laboratorik dengan desain post-test only controlled group dilakukan menggunakan larva zebrafish (Danio rerio). Sampel dibagi menjadi lima kelompok, yaitu kontrol negatif, kontrol positif, perlakuan VCO (6,25%), perlakuan asam folat (70 μM), dan kombinasi keduanya. Ekspresi GH diukur pada hari ke-9 pasca fertilisasi menggunakan RT-qPCR. Analisis data dilakukan menggunakan uji one-way ANOVA yang dilanjutkan dengan uji Tukey’s HSD. Terdapat perbedaan yang signifikan pada ekspresi GH antar kelompok (p < 0,001). Kelompok kontrol positif menunjukkan ekspresi terendah. Di antara kelompok perlakuan, VCO menunjukkan peningkatan ekspresi GH tertinggi (0,9122 ± 0,09704), diikuti oleh asam folat (0,5186 ± 0,24155), sedangkan kombinasi keduanya menunjukkan peningkatan yang minimal (0,0563 ± 0,01577). VCO dan asam folat secara tunggal meningkatkan ekspresi GH. Namun, kombinasi keduanya tidak memberikan manfaat tambahan, yang mengindikasikan kemungkinan tidak adanya efek sinergis dan berkaitan dengan interaksi yang bergantung pada dosis dalam regulasi GH.
Effects of Virgin Coconut Oil and Folic Acid on Glutathione Peroxidase and Locomotor Performance in a Zebrafish Model of Stunting Hanida Aisyah Ardiana; Farica Emiliana; Syahana Aini; Nurdiana Nurdiana; Brigitta Ida Resita Vebrianti Corebima; Ni Luh Putu Herli Mastuti
Indonesian Journal of Pharmaceutical Education Vol 6, No 2 (2026): May–August 2026
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v6i2.38432

Abstract

Stunting is a global health problem with multidimensional consequences, not only limited to impaired physical growth but also affecting cognitive development. One of the key mechanisms underlying stunting pathology is oxidative stress, which disrupts cellular homeostasis and developmental processes. The primary antioxidant defense system, such as glutathione peroxidase (GPx), plays a crucial role in neutralizing free radicals and protecting cells from oxidative damage. Virgin coconut oil is known to contain medium-chain fatty acids and bioactive compounds with antioxidant and anti-inflammatory properties. Meanwhile, folic acid plays an essential role in cellular metabolism, DNA synthesis, and maintaining redox balance. This study aimed to investigate the effect of VCO and folic acid on GPx gene expression and locomotor activity in zebrafish larvae using a rotenone-induced stunting model. Each group consisted of 30 larvae, divided into five groups; negative control (CN), positive control exposed to 12.5 ppb rotenone (PC), rotenone + VCO 6.25% (P1), rotenone + 70 µM folic acid (P2), and a combination of both (P3). Locomotor activity was assessed at 3, 6, and 9 dpf using EthoVision software, while GPx expression was analyzed at 9 dpf using the RT-qPCR method. The results showed that group P1 (6.25% VCO) exhibited the highest GPx expression, with a fold change of 10.41 ± 0.35 and significantly increased compared with the negative control (p 0.05), followed by the group P2 (70 µM folic acid) and P3 (combination). The highest locomotor activity was also observed in group P1, with an average total distance traveled of 85.9 ± 2.7 cm over a 10-minute observation period. These findings suggest that VCO has the potential to enhance antioxidant enzyme capacity (GPx) and improve locomotor performance in zebrafish larvae, though further studies are needed to confirm its underlying mechanisms and clinical applicability.
Co-Authors Adityas Ramadhani Aini, Syahana Andi Alimuddin Unde Andi Nilawati Usman Anwar, Yulianti Ardiana, Hanida Aisyah Ariani Ariani Ariani Arifianto, Dedy Astri Proborini Brigitta Ida Resita Vebrianti Corebima Bukhari, Agussalim Burhanuddin Bahar Chusyairi, Onnitia Dwi Putri Dewi Ariani Dian Kusumaningtyas Emiliana, Farica Fadilah, Rahmawati Nurul Farica Emiliana Farica Emiliana Fitriasari, Nikma Hajeng Wulandari Hanida Aisyah Ardiana Hanida Aisyah Ardiana Healthy Hidayanty Lilik Zuhriyah Lovita, Agnestia Naning Dian Mega Ulfah Nur Aini Retno Hastuti Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Nurdiana Nurpudji A. Taslim Pradipta, Dea Putri Fathma, Putri Rahma Dian Hanifarizani Ratnaeni Samrichar R Samrichard Rambulangi sholihatul amaliya Syahana Aini Syahana Aini Veni Hadju Veni Hadju Wisnu Barlianto Yulianti Anwar Yuseva Sariati Yuseva Sariati, Yuseva Zakiah Diah Zulfiani