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All Journal Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Journal of Innovative and Creativity Jurnal Sains Farmasi dan Kesehatan
Erida Novriani
Universitas Prima Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Uji Aktivitas Sediaan Mikroenkapsulasi Ekstrak Etanol Daun Sukun (Artocarpus altilis L.) Sebagai Antidiabetes Terhadap Tikus Putih Jantan yang di Induksi Aloksan Razoki Lubis; Khansa Sabira; Erida Novriani
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.6975

Abstract

Diabetes Mellitus (DM) merupakan kelompok gangguan metabolik yang ditandai dengan kondisi hiperglikemia akibat kegagalan sekresi insulin, gangguan kerja insulin, maupun kombinasi keduanya. Penellitian ini bertujuan untuk mengevaluasi efek antidiabetes dari sediaan mikroenkapsulasi ekstrak etanol daun sukun (Artocarpus altilis L.) terhadap tikus putih jantan yang diinduksi aloksan & untuk menentukan konsentrasi sediaan mikroenkapsulasi ekstrak etanol daun sukun yang memberikan penurunan kadar glukosa darah paling optimal dibandingkan dengan kontrol positif (metformin). Hewan uji dibuat menjadi model tikus Diabetes Mellitus (DM tipe-2) dengan menggunakan induksi aloksan. Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan 30 ekor tikus wistar jantan yang telah diinduksi menjadi model tikus Diabetes Mellitus dengan KGDP > 126 mg/dL dibagi menjadi 6 kelompok perlakuan, yaitu terdiri dari kontrol negatif (aloksan), kontrol positif (metformin 45 mg/kgBB), perlakuan 1,2 dan 3 diberikan sediaan mikroenkapsulasi ekstrak etanol daun sukun (EEDS). Kemudian diberikan sediaan uji selama 14 hari. Pengukuran kadar gula darah menggunakan alat cek gula darah Autocheck. Hasil menunjukkan bahwa % penurunan kadar glukosa darah pada kontrol negatif 0%, kontrol positif 17%%, , EEDS 0,25% sebesar 24%, EEDS 0,5% sebesar 25%, dan EEDS 0,75% mencapai 20%. Hal ini menunjukkan bahwa perlakuan Ekstrak Etanol Daun Sukun dengan konsentrasi 0,75% menghasilkan penurunan kadar gula darah yang hampir sebanding dengan metformin. Sebaliknya, konsentrasi 0,25% hanya memberikan efek yang kurang optimal. Dengan demikian, mikroenkapsulasi ekstrak etanol daun sukun berpotensi sebagai agen alternatif dalam menurunkan kadar gula darah.
Uji Aktivitas Sediaan Mikroenkapsulasi Ekstrak Etanol Daun Sukun (Artocarpus Altilis L.) Sebagai Antidiabetes Terhadap Tikus Putih Jantan Yang Di Induksi Aloksan Khansa Sabira; Razoki Razoki; Erida Novriani
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7107

Abstract

Telah dilakukan penelitian tentang uji efek antidiabetes sediaan mikroenkapsulasi ekstrak etanol daun sukun (Artocarpus altilis L.) terhadap tikus putih jantan. Penellitian ini bertujuan untuk mengevaluasi efek antidiabetes dari sediaan mikroenkapsulasi ekstrak etanol daun sukun (Artocarpus altilis L.) terhadap tikus putih jantan yang diinduksi aloksan & untuk menentukan konsentrasi sediaan mikroenkapsulasi ekstrak etanol daun sukun yang memberikan penurunan kadar glukosa darah paling optimal dibandingkan dengan kontrol positif (metformin). Hewan uji dibuat menjadi model tikus Diabetes Mellitus (DM tipe-2) dengan menggunakan induksi aloksan. Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan 30 ekor tikus wistar jantan yang telah diinduksi menjadi model tikus Diabetes Mellitus dengan KGDP > 126 mg/dL dibagi menjadi 6 kelompok perlakuan, yaitu terdiri dari kontrol negatif (aloksan), kontrol positif (metformin 45 mg/kgBB), perlakuan 1,2 dan 3 diberikan sediaan mikroenkapsulasi ekstrak etanol daun sukun (EEDS). Kemudian diberikan sediaan uji selama 14 hari. Pengukuran kadar gula darah menggunakan alat cek gula darah Autocheck. Hasil menunjukkan bahwa % penurunan kadar glukosa darah pada kontrol negatif 0%, kontrol positif 17%%, , EEDS 0,25% sebesar 24%, EEDS 0,5% sebesar 25%, dan EEDS 0,75% mencapai 20%. Hal ini menunjukkan bahwa perlakuan Ekstrak Etanol Daun Sukun dengan konsentrasi 0,75% menghasilkan penurunan kadar gula darah yang hampir sebanding dengan metformin. Sebaliknya, konsentrasi 0,25% hanya memberikan efek yang kurang optimal. Dengan demikian, mikroenkapsulasi ekstrak etanol daun sukun berpotensi sebagai agen alternatif dalam menurunkan kadar gula darah
Uji Aktivitas Sediaan Mikroenkapsulasi Ekstrak Etanol Daun Sukun (Artocarpus altilis L.) Sebagai Antidiabetes Terhadap Tikus Putih Jantan yang di Induksi Aloksan Razoki Lubis; Khansa Sabira; Erida Novriani
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7108

Abstract

Telah dilakukan penelitian tentang uji efek antidiabetes sediaan mikroenkapsulasi ekstrak etanol daun sukun (Artocarpus altilis L.) terhadap tikus putih jantan. Penellitian ini bertujuan untuk mengevaluasi efek antidiabetes dari sediaan mikroenkapsulasi ekstrak etanol daun sukun (Artocarpus altilis L.) terhadap tikus putih jantan yang diinduksi aloksan & untuk menentukan konsentrasi sediaan mikroenkapsulasi ekstrak etanol daun sukun yang memberikan penurunan kadar glukosa darah paling optimal dibandingkan dengan kontrol positif (metformin). Hewan uji dibuat menjadi model tikus Diabetes Mellitus (DM tipe-2) dengan menggunakan induksi aloksan. Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan 30 ekor tikus wistar jantan yang telah diinduksi menjadi model tikus Diabetes Mellitus dengan KGDP > 126 mg/dL dibagi menjadi 6 kelompok perlakuan, yaitu terdiri dari kontrol negatif (aloksan), kontrol positif (metformin 45 mg/kgBB), perlakuan 1,2 dan 3 diberikan sediaan mikroenkapsulasi ekstrak etanol daun sukun (EEDS). Kemudian diberikan sediaan uji selama 14 hari. Pengukuran kadar gula darah menggunakan alat cek gula darah Autocheck. Hasil menunjukkan bahwa % penurunan kadar glukosa darah pada kontrol negatif 0%, kontrol positif 17%%, , EEDS 0,25% sebesar 24%, EEDS 0,5% sebesar 25%, dan EEDS 0,75% mencapai 20%. Hal ini menunjukkan bahwa perlakuan Ekstrak Etanol Daun Sukun dengan konsentrasi 0,75% menghasilkan penurunan kadar gula darah yang hampir sebanding dengan metformin. Sebaliknya, konsentrasi 0,25% hanya memberikan efek yang kurang optimal. Dengan demikian, mikroenkapsulasi ekstrak etanol daun sukun berpotensi sebagai agen alternatif dalam menurunkan kadar gula darah
Formulasi dan Evaluasi Sediaan Sabun Cair dari Umbi Porang (Amorphophallus muelleri Blume): Novia Agustini Irmasyari Siregar; Roy Indrianto Bangar; Erida Novriani
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7530

Abstract

Porang tuber (Amorphophallus muelleri Blume) is a potential natural resource that can be developed as an active ingredient in cosmetic preparations, particularly liquid soap. This study aimed to formulate and evaluate liquid soap containing porang tuber extract and to determine its physical quality characteristics. The tubers were extracted by maceration using 70% ethanol. Prior to extraction, simplicia characterization was performed, including determination of moisture content, water-soluble extractive, ethanol-soluble extractive, total ash, and acid-insoluble ash. Phytochemical screening was carried out to identify secondary metabolites. The extract was formulated into liquid soap preparations with concentrations of 3%, 5%, and 8%. The evaluation included organoleptic tests, pH measurement, foam height test, irritation test, and hedonic test. The results of simplicia characterization showed that all parameters met the requirements of the Herbal Pharmacopeia. Phytochemical screening indicated the presence of alkaloids, flavonoids, saponins, tannins, and triterpenoids. The formulated liquid soaps showed acceptable physical characteristics, pH values within the Indonesian National Standard range (8–11), adequate foam formation, and no skin irritation. Hedonic testing demonstrated that all formulations were acceptable to panelists. It can be concluded that porang tuber extract has potential as a natural active ingredient in liquid soap formulations.
Analisis Kandungan Total Lemak pada Food Replacement (X) dan Fermentasi Akar Teratai (Nelumbo nucifera) Cut Rahil Sofia; Roy Indrianto Bangar; Erida Novriani
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 2 (2026): April 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i2.7794

Abstract

This research relies on the analysis of fat content from the food replacement product (x) and lotus root (nelumbo nucifera) fermentation by utilizing the Soxhlet method. The experiment was conducted by extraction using n-hexane solvent for six hours. The fat content was determined based on the difference in weight after extraction. The findings showed that the fat content in the food replacement product (x) reached 63.60%, while in the lotus root fermentation it was 89.19%. These high numbers are influenced by the composition of the ingredients used, the effectiveness of nonpolar solvents, as well as changes in the matrix structure due to fermentation which increases lipid accessibility. The fermentation process, which lasted for 22 days, enhances enzymatic effectiveness that damages cell walls, thereby facilitating the extraction of lipophilic compounds. The results of this study indicate that fermentation can increase the measurement of fat in plant-based food materials, but the figures obtained reflect the fat that was successfully extracted, not pure fat. According to regulations in Indonesia, there is not yet a maximum limit for fat content in foods for special nutritional needs.
Description of Diabetes Mellitus Patients' Knowledge Regarding Type 2 Diabetes Mellitus Treatment at Royal Prima Hospital Medan Rachel Adriany Br Sinaga; Erida Novriani; Roy Indrianto Bangar S
JURNAL KESEHATAN STIKes MUHAMMADIYAH CIAMIS Vol. 13 No. 1 (2026): Jurnal Kesehatan
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/jurkes.v13i1.1000

Abstract

Management of Type 2 Diabetes Mellitus (T2DM) as a chronic pathology highly depends on the synergy between pharmacological interventions and lifestyle modifications. Patient health literacy plays a crucial role in determining the effectiveness of glycemic control and the prevention of long-term complications. This research aims to map the patient knowledge profile while identifying the determinant factors influencing it at Royal Prima Hospital, Medan. Utilizing a descriptive quantitative design with a cross-sectional approach, this study involved 100 respondents recruited through an accidental sampling technique. The research instrument employed an adapted version of the DKQ-24 questionnaire. Univariate analysis results confirmed that the majority of respondents (79%) possessed adequate understanding regarding their treatment regimen. Based on the Chi-Square test, a significant correlation was found in the gender variable ($p = 0.044$), while other demographic and clinical variables showed no meaningful association. Furthermore, binary logistic regression testing demonstrated a lack of simultaneous influence from all independent variables on the level of patient knowledge.
UJI AKTIVITAS ANTIOKSIDAN METODE DPPH DARI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis L.) MENGGUNAKAN METODE MASERASI Cindy Kurnia Sari; Razoki Razoki; Erida Novriani
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2193

Abstract

Breadfruit leaves (Artocarpus altilis L.) area plant with various health benefits due to their natural chemical compounds, one of which acts as an antioxidant. Antioxidants are compounds that can halt the oxidation process by donating electrons, there by protecting normal cells, fats, and proteins from damage caused by free radicals. The concentration of an antioxidant that causes a 50% reduction in DPPH activity is referred to as the IC50.  The objective of this study was to determine the effectiveness of ethanol extract from breadfruit leaves in combating oxidation using the DPPH method. The results showed an IC50 value of 6.66 ppm for the extract, indicating very strong antioxidant activity, although it was more effective compared to vitamin C, which served as a positive control with an IC50 value of 1.15 ppm. This difference in effectiveness is influenced by the amount of phenolic compounds present and the potential pro-oxidant effects at higher concentrations. In summary, breadfruit leaves have high potential as asource of natural antioxidants and can be used to develop pharmaceutical products to treat degenerative diseases.
EVALUASI FORMULASI SEDIAAN MIKROENKAPSULASI EKSTRAK ETANOL DAUN MINDI (Melia Azedarach L.) Casey Dola Rebeca br Pinem; Razoki Razoki; Erida Novriani
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2203

Abstract

Microencapsulation is a technology used to protect active ingredients from environmental influences and enhance their stability. This study aimed to evaluate the formulation of microencapsulated ethanol extract of mindi leaves (Melia azedarach L.), which possesses pharmacological activities as an antioxidant, antibacterial, and antidiabetic agent. The extraction of mindi leaves was performed using the maceration method with 80% ethanol, yielding a 10.4% extract. Microencapsulation was prepared using sodium alginate and chitosan as coating materials, with three different extract concentrations (0.25%, 0.5%, and 0.75%). Formulation evaluation included moisture content testing, stability testing using cycling test, and floating test on rat gastric mucosa. The results showed that moisture content ranged from 0.37% to 0.63%, with the 0.75% formulation having the lowest moisture content (0.37%). Stability testing over six cycles demonstrated that all formulations remained stable without significant changes in color, texture, and shape. The floating test showed a lag time of less than 2 minutes for all formulations with floating time ranging from 3 to 6 hours, where the 0.25% concentration exhibited the longest floating time (6 hours). It can be concluded that microencapsulation technology successfully produced mindi leaf ethanol extract preparations with stable characteristics, low moisture content, and good floating capability, making it potential as an oral drug delivery system.
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN SELEDRI (Apium graveolens L) TERHADAP BAKTERI Pseudomonas aeruginosa Suci Della; Muhammad Yunus; Erida Novriani
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2228

Abstract

Formulation and Antibacterial Action Assessment of Celery Leaf Extract Gel (Apium graveolens L. ) Against Staphylococcus aureus and Pseudomonas aeruginosa Bacteria Celery (Apium graveolens L.) is a plant recognized for its ability to fight bacteria because of substances like flavonoids, saponins, and tannins, which offer promising natural antibacterial alternatives. This study aimed to create a gel from celery leaf extract and test its antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa. The celery leaves were extracted using the maceration method with 96% ethanol, achieving a yield of 17.25%. Four distinct gel formulations were produced with varying levels of extract: 0% (F0), 5% (F1), 10% (F2), and 15% (F3), utilizing HPMC as the gel base. Evaluations of the physical properties, which included sensory testing, uniformity, pH, spreadability, and viscosity, showed that all formulations met the quality criteria for gel products. The pH values ranged from 6. 63 to 6. 81, the spreadability was recorded between 5-6 cm, and the viscosity varied from 15,567 to 18,325 cPs. The antibacterial effectiveness test on Staphylococcus aureus, conducted through the disc diffusion method, revealed inhibition zones of 9.2 mm (moderate), 10.3 mm (moderate), and 11.48 mm (strong) at concentrations of 2.5%, 5%, and 10%, respectively. These results indicate that the gel made from celery leaf extract shows antibacterial effects against Staphylococcus aureus, with the highest efficacy observed at a concentration of 10%.
Uji Anti Hiperglikemik Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight.) Walp) Dan Daun Cepcepan (Castanopsis Costata (Blume) A. Dc.) Terhadap Tikus Putih Devortivo Hartono Putra; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3399

Abstract

Hyperglycemia, characterized by elevated blood glucose levels, is a key clinical feature of diabetes mellitus. In recent years, medicinal plants have gained attention as alternative therapies due to their relatively minimal side effects. This study aimed to explore the potential of acombined ethanol extract of bay leaf (Syzgium polyanthum) and cepcepan leaf (castanopsis costata) in lowering blood flucose leveles in white rats (Rattus norvegicus) induced with alloxan. The extraction process was carried out using the maceration methos with 96% ethanol. Phytochemical screening revealed the presence of active compounds such as flavonoids, alkoloids, tannins, saponins, and steroid. The rats were divided into six groups: a normal group. A negative control group (alloxan only), a positive control group (glibenclamide 0.45 mg/kgBB), and three treatment groups receiving the combined extract at doses of 120 mg/kgBW, 250mg/kgBW, and 500mg/kgBW. Blood glucose levels were monitored from day 0 to day 15. ANOVA analysis showed a reduction in glucose levels among the treatment groups, althought the results were not statistically significant (p > 0.05). nevertheless, a consistent downward trend was observed, particularyl in the group receiving 250mg/kgBW. These findings suggest that the ethanol extract combination of bay and cepcepan leaves holds promise as an antihyperlycemic agent. However, frurther research is necessary to confirm its efficacy and fully understand its mechanism of action.
Co-Authors Casey Dola Rebeca br Pinem Cindy Kurnia Sari Cut Rahil Sofia Devortivo Hartono Putra Khansa Sabira Muhammad Yunus Novia Agustini Irmasyari Siregar Rachel Adriany Br Sinaga Razoki Razoki Lubis Razoki Razoki Roy Indrianto Bangar S Suci Della