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All Journal Jambura Journal of Health Sciences and Research Jurnal Dunia Farmasi Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences.
Razoki Razoki
Program Studi Sarjana Farmasi Klinis Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Other

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Mikroenkapsulasi Bisoprolol dengan Penyalut Albumin Razoki Razoki
Jurnal Dunia Farmasi Vol 5, No 1 (2020): Edisi Desember
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v5i1.4762

Abstract

Sejalan dengan kemajuan teknologi di bidang farmasi, teknik mikroenkapsulasi telah digunakan untuk memperbaiki stabilitas zat aktif. Tujuan: Penelitian ini bertujuan untuk mengetahui apakah bisoprolol dapat di mikrokapsul mengggunakan albumin. Metode: Penelitian ini bersifat eksperimental dengan memformulasikan bisoprolol dengan albumin sebagai penyalut yang digunakan adalah 1:6, 1:4 dan 1:2 berturut-turut untuk Formula I, Formula II dan Formula III menggunakan metode penguapan pelarut. Hasil: Albumin dapat digunakan sebagai penyalut mikroenkapasulasi bisoprolol dan  distribusi ukuran partikel 209-1998 µm. Hasil penelitian menunjukkan bahwa mikrokapsul dengan perbandingan antara bisoprolol dengan albumin 1:6 memiliki pelepasan zat aktif yang paling baik dengan disolusi dari mikroenkapsulasi bisoprolol dengan penyalut albumin. Kesimpulan: Albumin dapat digunakan sebagai penyalut mikrokapsul bisoprolol dimana semakin besar konsentrasi albumin pelepasan zat aktif bahan aktif dari mikrokapsul akan semakin diperlambat.
THE EFFECT OF DRUG COUNSELING ON HYPERTENSION PATIENT'S COMPLIANCE IN A HOSPITAL IN MEDAN CITY etha tesalonika tamba; Reh Malem Br Karo; Razoki Razoki; Elfia Neswita; Erida Novriani
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.15100

Abstract

Pemahaman pasien terhadap pengobatan merupakan faktor kunci untuk terjadinya kepatuhan dalam pengobatan sehingga didapatkan terapi yang optimal dan efektif. Namun kenyataannya masih banyaknya pasien yang tidak patuh dalam pengobatan terutama pada penyakit hipertensi. Hipertensi dapat memicu penyakit lainnya / komplikasi sehingga dapat merusak organ-organ vital dan mengancam kualitas hidup seseorang. Untuk mencegah hal tersebut maka dibutuhkan kepatuhan pasien hipertensi dalam meminum obat dimana konseling menjadi sektor penerapan konsep asuhan kefarmasian dengan tujuan menambah ilmu perihal obat, penyakit serta harapannya mampu memahamkan penderita perihal peran obat untuk kesembuhan penyakit. Kebaruan penelitian ini karena meneliti tentang pengaruh konseling obat terhadap kepatuhan pasien  hipertensi di salah satu rumah sakit. Tujuan penelitian ini adalah untuk mengetahui apakah ada pengaruh konseling obat terhadap kepatuhan pasien hipertensi rawat jalan di salah satu rumah sakit di Kota Medan. Metode Penelitian dilakukan secara eksperimental dengan menggunakan pra- eksperimental (Pre-Experimental) dan rancangan The One Group Pretest – Posttest Design. Penelitian ini dilakukan di salah satu rumah sakit kota medan selama bulan April 2022. Populasi adalah Pasien di salah satu rumah sakit di Kota Medan yang memenuhi kriteria inklusi dan ekslusi. Sebanyak 39 pasien yang memenuhi kriteria diberikan kueisioner MMAS-8 lalu dilakukan analisa data menggunakan Uji Normalitas, Paired T-Test, Regresi Linear Sederhana dan Pengujian Hipotesis Parsial. Hasil penelitian ini didapatkan nilai Uji Normalitas, paired T-Test, Regresi linear dan pengujian hipotesis parsial secara berturut-turt adalah 0,05; 0,05; 0,01 dan 0,00. probability 0.05. Kesimpulan ada pengaruh konseling obat terhadap kepatuhan pasien hipertensi rawat jalan di salah satu rumah sakit di Kota Medan.Kata kunci: Konseling Obat; Kepatuhan; Hipertensi AbstractPatient understanding of treatment is a key factor for adherence to treatment so that optimal and effective therapy is obtained. However, in reality there are still many patients who do not comply with treatment, especially in hypertension. Hypertension is also a trigger for complications that can damage vital organs and threaten a person's quality of life. Therefore, patient compliance is needed in taking hypertension medication. Counseling is a sector of applying the concept of pharmaceutical care with the aim of increasing knowledge about drugs, diseases and the hope of being able to understand patients about the role of drugs for healing disease. The novelty of this study is because it examines the effect of drug counseling on the adherence of hypertensive patients in one of the hospitals. The purpose of this study was to determine whether there is an effect of drug counseling on the adherence of outpatient hypertension patients at a hospital in Medan City. Methods The research was conducted experimentally using a pre- experimental (Pre-Experimental) and The One Group Pretest – Posttest Design. This research was conducted at one Medan city hospital for 1 month in April 2022. The population was patients at one Medan city hospital who met the inclusion and exclusion criteria. A total of 39 patients who met the criteria were given a MMAS-8 questionnaire and then analyzed the data using the Normality Test, Paired T-Test, Simple Linear Regression and Partial Hypothesis Testing. The results of this study obtained a significant value of 0.000. The conclusion is that there is an effect of drug counseling on the compliance of outpatient hypertension patients in a hospital in Medan City.Keywords: Drug Counseling; Adherance; Hypertension
ADMINISTRATIVE, PHARMACEUTIC AND CLINICAL STUDY OF PRESCRIPTION ANTI-DIABETES DRUGS IN ONE OF MEDAN CITY PHARMACIES Yogi Andriansyah; Elfia Neswita; Razoki Razoki
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.14252

Abstract

Diabetes melitus adalah penyakit kronis yang diakibatkan oleh resistensi insulin ditandai dengan kadar gula darah semakin tinggi. Diabetes mellitus memiliki angka kejadian yang cukup tinggi hampir di setiap negara. Kebaruan penelitian ini karena meneliti tentang kajian administratif, farmasetis dan klinis resep obat anti diabetes di salah satu apotek. Penelitian ini bertujuan untuk melihat kesesuaian pelayanan resep antidiabetik di apotek pada aspek kesesuaian adminstratif,farmasetis dan klinis resep dengan PMK No. 35 tentang Standar Pelayanan Kefarmasian di Apotek Kebaruan penelitian ini meneliti kajian administratif, farmasetis dan klinis resep obat anti diabetes. Jenis penelitian yang digunakan ialah metode penelitian deskriptif dengan pendekatan cross sectional. Data diperoleh dari resep periode Oktober – Desember 2020. Peneliti melakukan pengecekan didalam resep adakah obat yang berinteraksi antara obat satu dengan obat lain sehingga tidak menghasilkan efek terapi yang maksimal. Hasil penelitian menunjukkan bahwa tidak satupun resep yang secara keseluruhan memenuhi Kriteria Aspek Administrasi, Farmasetis dan klinis, namun terdapat 38 resep dari 53 resep  memenuhi aspek Farmasetis, terdapat 15 resep yang tidak memenuhi Kriteria Aspek Administrasi, Farmasetis dan klinis. Kesimpulan bahwa tidak satupun resep memenuhi PMK No.35 tahun 2014.Kata kunci: Resep; Administratif;  Farmasetis; Klinis; Obat Anti Diabetes AbstractDiabetes mellitus is a chronic disease caused by insulin resistance which is characterized by increased blood sugar levels. Diabetes mellitus has a fairly high incidence rate in almost every country. The novelty of this study is due to researching about administrative, pharmaceutic and clinical studies of prescription anti-diabetic drugs in one of the pharmacies. This study aims to determine the suitability of antidiabetic prescription services in pharmacies on aspects of administrative, pharmaceutical and clinical compliance with prescriptions with PMK No. 35 concerning Standards of Pharmaceutical Services in Pharmacies. The novelty of this study examines administrative, pharmaceutical and clinical studies of antidiabetic drug prescriptions. The type of research used is descriptive research method with a cross sectional approach. The data was obtained from prescriptions for the period October – December 2020. Researchers checked in the prescription whether there were drugs that interacted with each other so that they did not produce a maximum therapeutic effect. The results showed that none of the prescriptions met the administrative, pharmaceutical and clinical criteria, but 38 of the 53 prescriptions met the pharmaceutical aspects, there were 15 prescriptions that did not meet the criteria for administrative, pharmaceutical and clinical aspects. The conclusion is that there is no prescription to fulfill PMK No. 35 of 2014.Keywords: Recipe; Administrative; Pharmacy; Clinic;  Anti-Diabetes Medicine
Antioxidant and Antibacterial Activities of Ethanol Extract of Matoa (Pometia pinnata) Leaves Razoki Razoki
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.057 KB) | DOI: 10.36490/journal-jps.com.v6i2.97

Abstract

A Plants used for traditional medicine are matoa (Pometia pinnata). This plant is spread in almost every area in the province of Papua. The use of plants as medicinal ingredients is closely related to the content of chemical compounds contained in these plants, especially related to the active compounds contained in plants. Based on previous research, matoa leaf extract contains alkaloids, flavonoids, steroids, tannins, glycosides, and saponins. This study aims to determine the antioxidant and antibacterial activity of Pometia pinnata leaf extract. In the early stages of this research, the extraction process was carried out using the reflux method using ethanol solvent, testing the antioxidant activity using the DPPH and ABTS methods, as well as total phenol and flavonoids. Meanwhile, testing the antibacterial activity with the Minimum Inhibitory Concentration method against Staphylococcus aureus and Pseudomonas aeruginosa. From the results of the antioxidant activity test, the IC50 value was obtained in the DPPH method of 41.83 ± 0.17 µg/mL and also in the antibacterial test, it could inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa bacteria
Skrining Resep Polifarmasi Secara Klinis Pada Pasien Hipertensi Di Rumah Sakit Advent Razoki Razoki; Rezki Sari Harahap; Novitaria Br Sembiring; Elfia Neswita
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.932 KB) | DOI: 10.36490/journal-jps.com.v6i2.155

Abstract

Introduction: The use of drugs in inappropriate amounts or doses is known as polypharmacy. The development of polypharmacy and the complexity of drugs currently used in medicine allowed a huge increase in drug interactions. Method: The method used in this study is a descriptive method and data collection is carried out retrospectively. This study was conducted with the aim of finding out more about the description of drug interaction events in patients diagnosed with hypertension. Results: The collected prescriptions were those received by IFRS Advent Medan in October-December 2022 as many as 500 prescriptions. The next step, prescriptions are screened and adjusted to the categories of inclusion and exclusion requirements. Prescriptions that meet the inclusion category are original prescriptions with a minimum of 3 drugs, a total of 132 prescriptions. So in this article, a completeness analysis of polypharmacy prescriptions was carried out based on clinical studies of 132 prescriptions. Conclusion: The accuracy of indications, drug dosage, rules, methods, and duration of use of the complete drug is 100%, The prescription contains 3 drugs, there are 7 interacting prescriptions (54%) out of a total of 13 prescriptions.
Skrining Resep Polifarmasi Secara Klinis Pada Pasien Diabetes Melitus Tipe II Di Rumah Sakit Advent Razoki; Nur Afni Br. Ritonga; Novitaria Br. Sembiring; Elfia Neswita
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.748 KB) | DOI: 10.36490/journal-jps.com.v6i2.154

Abstract

A few examples of clinical criteria include precise indications, duplication therapy, allergies, unexpected drug reactions (ROTD), contraindications, and drug interactions. Staff employees in the pharmaceutical industry screen prescriptions to prevent the occurrence (Medication errors). According to Hindratni et al. (2017), treatment errors occur when medical professionals handle patients while giving them potentially harmful medications. Research Objectives to comprehend the frequency and seriousness of drug interactions that arise when diabetes mellitus drugs are administered in Adventist hospitals. This study uses descriptive research methods and retrospective research designs, which means it looks at the material already gathered and generated from October and December 2022 recipe dataThe 500 or so prescriptions that IFRS Adventist Medan received between October and December 2022 are where the recipes were collected. Five hundred tablets were used as a sample, and 131 met the criteria for inclusion in the clinical screening of polypharmacy prescriptions in patients with type II diabetes mellitus at Adventist hospitals. 100 percent of the 131 prescriptions were correct regarding indications, drug doses, instructions, methods, and duration of use. Three different drugs, or 25% of all medications, have interactions. The drugs they interacted with were found in 4 prescriptions or 72%. The number of pills (65.21%) containing the drugs they interacted with was 5. Six medicines (60.71%) included medications that interacted with one another. There were seven prescriptions (52.94%) that had interactions with drugs.
Uji skrining fitokimia dan pengukuran kadar total flavonoid pada ekstrak paku (Nephrolepis biserrata) dengan fraksi n-heksana, etil asetat, dan air Razoki; Ruth Gaby Syahanaya Butar-Butar; Elfia Neswita; Novitaria Br Sembiring; Erida Novriani; Nerly Juli Pranita Simanjuntak; Enni Halimahtussa’diyah Pakpahan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.185

Abstract

Nephrolepis Biserrata, including ferns and lycophytes, are a group of plants that have been around for a long time on Earth, with more than 12,000 different species. Ferns have an important role in the ecosystem, such as helping to form humus, protect the soil from erosion, maintain soil moisture, and act as pioneer plants in the early stages of forest ecosystem succession. Phytochemical screening tests can identify bioactives that are not yet visible through bags or tests that can quickly separate natural ingredients that contain certain phytochemicals and those that do not. Extraction is the activity of withdrawing soluble chemical compounds so that they are separated from insoluble materials. Extraction can be done in various ways including n-hexane which aims to remove fat, ethyl acetate which can extract semi-polar compounds, and water which is a universal solvent.The methods used in this study include maceration, phytochemical screening, fractionation, and data analysis. The results of this research conclude that secondary metabolite compounds are present in the leaves of the Nephrolepis Biserrata fern, based on positive phytochemical tests for alkaloids, phenolics, flavonoids, tannins, and triterpenoids in the ethanol fraction. The n-hexane fraction contains alkaloids, phenolics, flavonoids, tannins, steroids, and triterpenoids. The ethyl acetate fraction contains alkaloids, phenolics, flavonoids, saponins, and tannins, while the water fraction contains alkaloids, phenolics, flavonoids, and tannins. The total flavonoid content is 17.615 mg QE/g of extract. UV-Vis spectroscopy identification results indicate the presence of ???? → ????* and n→ ????* transitions.
Uji Efek Antihiperglikimia Fraksi Aktif Ekstrak Etanol Daun Sirsak (Annona Muricata) dan Ekstrak Ikan Gabus (Channa Striata) pada Tikus Razoki Razoki; Cindy Ronaldo Munthe; Reh Malem Br Karo; Muhammad Yunus; Asyrun Alkhaira Lubis
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 6 No. 4 (2024): Ranah Research : Journal Of Multidisciplinary Research and Development (Mei 202
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/rrj.v6i4.919

Abstract

Tujuan penlitian ini adalah untuk mengetahui efektivitas antihiperglikemia pada tumbuhan daun sirsak (annona muricata) sebagai terapi diabetes mellitus. Ekstrak di maserasi menggunakan pelrut ethanol 96%. Hasil skrining fitokimia menunjukan bahwa pada daun sirsak (annona muricata) mengandung senyawa alkaloid, flavonoid, saponin, tanin dan steroid/triterpenoid. Kemudian di lanjutkan proses fraksinasi ekstrak daun sirsak (annona muricata) untuk memperoleh fraksi aktif ekstrak etanol daun sirsak (annona muricata) dengan partisi cair-cair menggunakan pelarut n-heksan:etanol 96% = 1:1. Pengujian antihiperglikemia menggunakan hewan percobaan tikus puith jantan galur wistar. Konsentrasi kelompok Pada perlaukan pertama tidak diberikan perlakuan atau sebagai kelompok kontrol negatif, kelompok kedua diberikan perlakuan berupa pemberian fraksi ethanol ekstrak daun sirsak dengan dosis 200 mg/kg BB, kelompok ketiga diberikan ekstrak ikan gabus dengan dosis 250 mg/kg BB, kelompok keempat yang diberikan kombinasi fraksi ethanol ekstrak sirsak 200 mg/kg BB dan ekstak ikan gabus 250 mg/kg BB. Kelompok kelima yang diberikan kombinasi fraksi ethanol ekstrak daun sirsak 400 mg/kg BB dengan ekstrak ikan gabus 250 mg/kg BB. Lalu pada kelompok keenam diberikan kombinasi fraksi ethanol ekstrak daun sirsak 800 mg/kg BB dengan eksrak ikan gabus 250 mg/kg BB. Hasil paling besar dalam menurunkan kadar gula darah tikus pada kelompok keenam diberikan kombinasi fraksi ethanol ekstrak daun sirsak 800 mg/kg BB dengan eksrak ikan gabus 250 mg/kg BB dengan nilai rerata penurunan -25,54 %, Kelompok kelima yang diberikan kombinasi fraksi ethanol ekstrak daun sirsak 400 mg/kg BB dengan ekstrak ikan gabus 250 mg/kg BB dengan nilai penurun -3,65%, kelompok kedua diberikan perlakuan berupa pemberian fraksi ethanol ekstrak daun sirsak dengan dosis 200 mg/kg BB dengan nilai rerata penurunan -2,96%. Dan menunjukan bahwa penurunan kadar gula darah terbesar pada tikus jantan galur wistar yang di induksi glukosa 40% yaitu pada pada kelompok keenam diberikan kombinasi fraksi ethanol ekstrak daun sirsak 800 mg/kg BB dengan eksrak ikan gabus 250 mg/kg BB dengan nilai rerata penurunan -25,54 %.
Co-Authors Asyrun Alkhaira Lubis Cindy Ronaldo Munthe Elfia Neswita Elfia Neswita Elfia Neswita Elfia Neswita Elfia Neswita Elfia Neswita Enni Halimahtussa’diyah Pakpahan Erida Novriani Erida Novriani etha tesalonika tamba Muhammad Yunus Nerly Juli Pranita Simanjuntak Novitaria Br Sembiring Novitaria Br Sembiring Novitaria Br. Sembiring Nur Afni Br. Ritonga Reh Malem br Karo Reh Malem Br Karo Rezki Sari Harahap Ruth Gaby Syahanaya Butar-Butar vira rusliza Yogi Andriansyah