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All Journal Jurnal Sehat Mandiri Jurnal Kesehatan Farmasi
Kahar, Putri Kartika Adhilia
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Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Uji Aktivitas Antidiare Kombinasi Ekstrak Metanol Daun Jambu Biji (Psidium guajava) Dan Daun Sirih (Piper betle) Pada Mencit Jantan( Mus muscullus ) Kahar, Putri Kartika Adhilia; Abdulkadir, Widy Susanti; Hiola, Faramita
Jurnal Kesehatan Farmasi Vol 7 No 1 (2025): Jurnal Kesehatan Farmasi
Publisher : Jurusan Farmasi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkpharm.v7i1.2736

Abstract

Daun Jambu Biji (Psidium guajava L.) dan Daun Sirih (Piper betle L.) merupakan salah satu tanaman herbal atau obat tradisional yang digunakan untuk mengobati diare atau mencret, disentri dan kolesterol. Komponen aktif yang banyak terdapat pada kedua tanaman ini yang memiliki efek antidiare adalah tanin dan flavonoid dimana flavonoid dapat menghambat pengeluaran asetilkolin dan kontraksi usus, tanin memiliki efek mengurangi peristaltik usus. Penelitian ini bertujuan untuk mengetahui efektifitas daun jambu biji dan daun sirih terhadap antidiare pada mencit. Daun Jambu Bij dan daun Sirih diekstraksi dengan metode maserasi. Aktifitas antidiare menggunakan metode proteksi yaitu tikus diberi 1 ml oleum ricini secara oral, kemudian didiamkan selama 1 jam. Selanjutnya masing-masing kelompok diberi perlakuan, yaitu kelompok I diberi suspensi Na-CMC 1% sebagai kontrol negatif, kelompok II diberikan suspensi Loperamid HCl sebagai kontrol positif, Kelompok III mencit diberi kombinasi ekstrak metanol daun Jambu Biji : dan daun Sirih 1:1, kelompok IV mencit diberi kombinasi ekstrak metanol daun Jambu Biji : dan daun Sirih 1:2 dan kelompok V mencit diberi kombinasi ekstrak metanol daun Jambu Biji : dan daun Sirih 2:1. Berdasarkan hasil uji statistic One Way Anova diperoleh bahwa ekstrak yang memiliki aktifitas antidiare palin baik yaitu pada kombinasi ekstrak metanol daun Jambu Biji : dan daun Sirih 2:1.
Gambaran Frekuensi Penggunaan Antimikroba Oral pada Tatalaksana Terapi Pasien Acne Vulgaris di RSUD Toto Kabila Gorontalo Tuloli, Teti Sutriyati; Asriastuti, Andi Nabirah; Gubali, Derina Dwifrila Ridhani; Indriatawati, Jihan; Rombe, Nensy Toban; Kahar, Putri Kartika Adhilia; Tolulu, Sri Noviani
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1219

Abstract

Acne vulgaris is a chronic inflammatory disorder that occurs in the polysebaceous unit and is generally caused by infection with the bacterium Propionibacterium acnes. The role of these bacteria in the pathogenesis of acne is the basis for giving antimicrobials or antibiotics in the management of acne vulgaris therapy, both in topical and oral forms. This study aims to describe the frequency of use of oral antimicrobials in the treatment of acne vulgaris and to determine the accuracy of antibiotic selection based on the severity of acne at Toto Kabila General Hospital, Gorontalo. This type of research is an observational study with a descriptive design and data collection was carried out retrospectively using medical record sheets from patients diagnosed with acne vulgaris. The results showed that of the 6 cases, there were 3 types of oral antibiotics used in the management of acne vulgaris, namely clindamycin, doxycycline and amoxicillin. Oral antibiotic therapy was found to be used alone in 5 cases, consisting of clindamycin 33.3%, doxycycline 33.3%, and amoxicillin 16.7%. While the use of a combination of antibiotics was only found in 1 case, namely a combination of clindamycin and gentamicin cream of 16.7%. Based on these results, it concluded that antibiotic therapy given as monotherapy or a combination of antibiotics in this study is not appropriate because it has the potential for resistance and recommended that all health workers and families pay attention to the use of antibiotics.
Co-Authors Asriastuti, Andi Nabirah Gubali, Derina Dwifrila Ridhani Hiola, Faramita Indriatawati, Jihan Rombe, Nensy Toban Teti Sutriyati Tuloli Tolulu, Sri Noviani Widy Susanti Abdulkadir