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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Sehat Mandiri
Gubali, Derina Dwifrila Ridhani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Public Health

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ANTIBIOFILM ACTIVITY OF MANGOSTEEN (Garcinia mangostana L.) LEAF EXTRACT AGAINST COLLECTION OF BACTERIAL ISOLATES FROM DIABETIC ULCERS Gubali, Derina Dwifrila Ridhani; Rasdianah, Nur; Akuba, Juliyanty; Abdulkadir, Widy Susanti; Uno, Wiwit Zuriati
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 10 No. 2 (2024): February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v10i2.11185

Abstract

Mangosteen (Garcinia mangostana L.) is a plant that contains many benefits and has the potential to be a medicinal plant in treating various diseases. Mangosteen leaves contain flavonoids, saponins, tannins, alkaloids and terpenoids which are known to have antibacterial and antibiofilm properties. This anti-biofilm agent is an alternative treatment for diabetic wound infections where cases of antibiotic resistance have increased. One of the causes of resistance is the biofilm formed by infectious bacteria. This research is a type of laboratory experimental research which aims to determine the anti-biofilm activity of mangosteen leaf extract against biofilms formed by a collection of bacterial isolates from diabetic wounds. The antibiofilm activity test carried out consisted of a cell attachment prevention test, a biofilm formation inhibition test, and a biofilm destruction test using the crystal violet staining method using the tube method and measuring optical density values ​​on a UV-Vis spectrophotometer. The concentrations of mangosteen leaf extract used are 60%, 80% and 100% as well as control – and control +. The results of the antibiofilm test showed that mangosteen leaf extract had the best activity in inhibiting biofilm formation, preventing cell attachment, and destroying biofilm, respectively. The three most optimal activities were found at a concentration of 100%, with an inhibition percentage of 50.51%, prevention of 32.56%, and destruction of 5.63%.
Gambaran Frekuensi Penggunaan Antimikroba Oral pada Tatalaksana Terapi Pasien Acne Vulgaris di RSUD Toto Kabila Gorontalo Tuloli, Teti Sutriyati; Asriastuti, Andi Nabirah; Gubali, Derina Dwifrila Ridhani; Indriatawati, Jihan; Rombe, Nensy Toban; Kahar, Putri Kartika Adhilia; Tolulu, Sri Noviani
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1219

Abstract

Acne vulgaris is a chronic inflammatory disorder that occurs in the polysebaceous unit and is generally caused by infection with the bacterium Propionibacterium acnes. The role of these bacteria in the pathogenesis of acne is the basis for giving antimicrobials or antibiotics in the management of acne vulgaris therapy, both in topical and oral forms. This study aims to describe the frequency of use of oral antimicrobials in the treatment of acne vulgaris and to determine the accuracy of antibiotic selection based on the severity of acne at Toto Kabila General Hospital, Gorontalo. This type of research is an observational study with a descriptive design and data collection was carried out retrospectively using medical record sheets from patients diagnosed with acne vulgaris. The results showed that of the 6 cases, there were 3 types of oral antibiotics used in the management of acne vulgaris, namely clindamycin, doxycycline and amoxicillin. Oral antibiotic therapy was found to be used alone in 5 cases, consisting of clindamycin 33.3%, doxycycline 33.3%, and amoxicillin 16.7%. While the use of a combination of antibiotics was only found in 1 case, namely a combination of clindamycin and gentamicin cream of 16.7%. Based on these results, it concluded that antibiotic therapy given as monotherapy or a combination of antibiotics in this study is not appropriate because it has the potential for resistance and recommended that all health workers and families pay attention to the use of antibiotics.
Co-Authors Asriastuti, Andi Nabirah Indriatawati, Jihan Kahar, Putri Kartika Adhilia Nur Rasdianah Rombe, Nensy Toban Teti Sutriyati Tuloli Tolulu, Sri Noviani Widy Susanti Abdulkadir Wiwit Zuriati Uno