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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Jurnal Sehat Mandiri
Tolulu, Sri Noviani
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Public Health

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SENSITIVITY OF BIOFILM-PRODUCING BACTERIA FROM NASOGASTRIC TUBES TO ANTIBIOTICS CEFTRIAXONE & CEFOBACTAM Tolulu, Sri Noviani; Rasdianah, Nur; Pakaya, Mahdalena Sy.; Madania; Uno, Wiwit Zuriati
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 11 No. 2 (2025): Biolink February
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v11i2.12880

Abstract

Nasogastric Tube (NGT) is a common practice in medical care, especially for the administration of nutrients or drugs directly into the digestive tract. The surface of the NGT is in direct contact with the respiratory tract and digestive tract providing ideal conditions for bacteria to form biofilms. Biofilms have the ability to provide a high level of resistance to antimicrobial action and body defenses. Biofilms provide a microenvironment that protects bacteria from direct exposure to antimicrobial agents, such as antibiotics. This study aims to determine the sensitivity of biofilm-producing bacteria from NGT to antibiotics. This study used an experimental method conducted in the Pharmaceutical Microbiology Laboratory using purposive sampling techniques, biofilm detection using the Congo Red Agar and tube methods, Ceftriaxone and Cefobactam antibiotic sensitivity tests using the disc diffusion method. The results obtained that the positive Nasogastric Tube device can produce biofilm bacteria and can affect bacteria to become more resistant to antibiotics for long-term use of the Nasogastric Tube device. It can be seen that the measurement of the inhibition zone shows that the Ceftriaxone antibiotic has an average inhibition zone of 2.32 mm and Cefobactam 7.42 mm.
Gambaran Frekuensi Penggunaan Antimikroba Oral pada Tatalaksana Terapi Pasien Acne Vulgaris di RSUD Toto Kabila Gorontalo Tuloli, Teti Sutriyati; Asriastuti, Andi Nabirah; Gubali, Derina Dwifrila Ridhani; Indriatawati, Jihan; Rombe, Nensy Toban; Kahar, Putri Kartika Adhilia; Tolulu, Sri Noviani
Jurnal Sehat Mandiri Vol 19 No 1 (2024): Jurnal Sehat Mandiri, Volume 19, No.1 Juni 2024
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v19i1.1219

Abstract

Acne vulgaris is a chronic inflammatory disorder that occurs in the polysebaceous unit and is generally caused by infection with the bacterium Propionibacterium acnes. The role of these bacteria in the pathogenesis of acne is the basis for giving antimicrobials or antibiotics in the management of acne vulgaris therapy, both in topical and oral forms. This study aims to describe the frequency of use of oral antimicrobials in the treatment of acne vulgaris and to determine the accuracy of antibiotic selection based on the severity of acne at Toto Kabila General Hospital, Gorontalo. This type of research is an observational study with a descriptive design and data collection was carried out retrospectively using medical record sheets from patients diagnosed with acne vulgaris. The results showed that of the 6 cases, there were 3 types of oral antibiotics used in the management of acne vulgaris, namely clindamycin, doxycycline and amoxicillin. Oral antibiotic therapy was found to be used alone in 5 cases, consisting of clindamycin 33.3%, doxycycline 33.3%, and amoxicillin 16.7%. While the use of a combination of antibiotics was only found in 1 case, namely a combination of clindamycin and gentamicin cream of 16.7%. Based on these results, it concluded that antibiotic therapy given as monotherapy or a combination of antibiotics in this study is not appropriate because it has the potential for resistance and recommended that all health workers and families pay attention to the use of antibiotics.
Co-Authors Asriastuti, Andi Nabirah Gubali, Derina Dwifrila Ridhani Indriatawati, Jihan Kahar, Putri Kartika Adhilia Madania Mahdalena Sy Pakaya Nur Rasdianah Rombe, Nensy Toban Teti Sutriyati Tuloli Wiwit Zuriati Uno