Article Per Year (5 Year)
p-Index From 2020 - 2025
1.006
P-Index
This Author published in this journals
All Journal Jurnal Kimia Riset Public Health of Indonesia Media Ilmu Kesehatan Health Sciences and Pharmacy Journal Acta Chimica Asiana Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Al Madury, Shalahuddin
Unknown Affiliation
Chemistry Health Professions Medicine & Pharmacology Nursing Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
Molecular docking study of catharanthus roseus compounds as potential ABL1 inhibitors for leukemia treatment Farid, Muhammad; Al Madury, Shalahuddin; Muslim, Ahmad Suriyadi; ‘Aini, Zakiyyah Qurrotul
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.235

Abstract

Leukemia is one type of cancer with a high mortality rate, caused by the proliferation of abnormal white blood cells that disrupt hematopoiesis function. Conventional therapies, such as chemotherapy and targeted therapy, often face challenges in the form of side effects and drug resistance. This study aims to evaluate the potential of Catharanthus roseus as a leukemia therapeutic agent through in silico. The docking process uses autodock, and ADMET prediction uses SwissADME and PKCMS. The study used the ABL1 protein (PDB ID: 4TWP) as a target with active compounds of Catharanthus roseus. The validation process of the docking method showed an RMSD value of 0.705 Å, indicating that the method used was valid. The results of the docking simulation showed that vindoline had the best affinity after native ligands with a binding energy of -8.64 kcal/mol, followed by catharanthine -6.16 kcal/mol and tryptophan -3.87 kcal/mol. ADMET prediction analysis showed that vindoline and catharanthine had promising pharmacokinetic and toxicity profiles, such as good blood-brain barrier (BBB) permeability and did not inhibit the CYP3A4 enzyme. These results indicate that vindoline and catharanthine are potential alternative leukemia treatments with high efficacy and low risk of side effects. This study provides a basis for further exploration of Catharanthus roseus in the development of effective and safe leukemia therapies.
Hubungan Interaksi Obat Antidiabetik Dengan Luaran Klinik Pada Pasien DM Tipe 2 Rawat Inap di RS PKU Muhammadiyah Gamping Yogyakarta Sugiyono, Sugiyono; Padmasari, Siwi; Al Madury, Shalahuddin
MEDIA ILMU KESEHATAN Vol 14 No 1 (2025): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v14i1.1479

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a chronic disease that often requires combination therapy, increasing the risk of drug interactions due to polypharmacy, which can affect clinical outcomes. Objective: To examine the relationship between the potential for drug interactions and clinical outcomes in hospitalized T2DM patients at PKU Muhammadiyah Gamping Hospital, Yogyakarta, from January 2022 to August 2023. Methods: This study employed a non-experimental analytical method with a retrospective approach, involving 179 patients who met the inclusion criteria. Univariate analysis was used to describe patient characteristics, medication patterns, and Random Blood Glucose (RBG) levels, while bivariate analysis (Chi-Square test) assessed the relationship between the potential for drug interactions and clinical outcomes.Results: The majority of T2DM patients were aged 41-59 years (50.28%), female (54.75%), and had comorbidities (91.62%). The most common treatment regimen was monotherapy with metformin (46.37%). Most patients received ≥5 medications (88.27%), and 81.56% had potential drug interactions. The predominant interaction mechanism was pharmacodynamic (86.21%) with moderate severity (89.72%). Chi-Square analysis yielded a p-value of 0.082 (p>0.05).Conclusion: No significant relationship was found between the potential for antidiabetic drug interactions and clinical outcomes in patients
Profil penggunaan antibiotik pada pasien anak dengan pneumonia yang dirawat di RSUD Wonosari Al Madury, Shalahuddin; Sugiyono, Sugiyono; Fitrianti, Meidina; Kurniawati, Siska Putri
Health Sciences and Pharmacy Journal Vol. 8 No. 3 (2024)
Publisher : STIKes Surya Global Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32504/hspj.v8i3.1296

Abstract

Pneumonia merupakan peradangan pada parenkim paru yang disebabkan oleh mikroorganisme, telah menyebabkan kematian 808.694 anak pada tahun 2017, dengan total mortalitas meningkat 15% pada tahun 2015 dan 16% pada tahun 2016. Meningkatnya prevalensi pneumonia menyebabkan pemberian antibiotik sebagai terapi juga meningkat, sehingga pemberian antibiotik harus terus dipantau. Penelitian ini diharapkan dapat memberikan gambaran penggunaan antibiotik empiris pada pasien anak yang dirawat di rumah sakit dengan diagnosis pneumonia. Penelitian ini bersifat deskriptif. Pengumpulan data dilakukan secara retrospektif terhadap pasien pneumonia yang memenuhi kriteria inklusi, sebanyak 100 orang dengan time limited sampling. Pengambilan data dilakukan melalui rekam medis pasien anak yang dirawat di rumah sakit dengan diagnosis pneumonia pada bulan Januari-Desember 2023. Pasien pneumonia anak terbanyak yang dirawat di instalasi rawat inap berjenis kelamin laki-laki 52%, berusia <59 bulan 82%, pasien terbanyak mengalami leukositosis 51%, dan didukung dengan gambaran pneumonia rontgen toraks 94%. Lama rawat inap pasien terbanyak pada kategori 4-6 hari yaitu 52%. Penggunaan antibiotik monoterapi sebanyak 57,86%. Kelompok antibiotik yang paling sering digunakan adalah kelompok sefalosporin generasi ketiga yaitu seftriakson sebanyak 32,23%. Penggunaan antibiotik kombinasi pada pasien pneumonia sebanyak 42,14% dengan kelompok antibiotik kombinasi yang paling sering digunakan yaitu antibiotik penisilin-aminoglikosida dengan pilihan antibiotik ampisilin + gentamisin sebanyak 10,74%. Sebagian besar antibiotik berada pada kategori Watch yaitu 68,60%. Pasien mayoritas mendapatkan monoterapi dengan seftriakson sebagai antibiotik yang paling sering dipilih dan sebagian besar masuk dalam kategori Watch.
Empowerment Model on Adolescent Social Capital for Smoking Cessation Behavior in Sumenep, East Java Riyadi, Sujono; Utami, Khristina Dias; Al Madury, Shalahuddin; Farid, Muhammad
Public Health of Indonesia Vol. 11 No. 2 (2025): April - June
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i2.984

Abstract

Background: Smoking is one of the risk factors for increasing morbidity and premature mortality worldwide. The large number of teenagers who smoke makes smoking the second largest contributor to global disability adjusted for life years with 148 million cases each year. Objective: This study aims to test a social empowerment model for adolescents to quit smoking, by exploring the influence of variables related to smoking cessation behavior among adolescents. Method: This study used a descriptive analytical design with a cross-sectional approach, involving 200 adolescents aged 12-25 years in Sumenep Regency, Madura. The structured questionnaire used to collect data has been validated. The analysis was carried out with descriptive statistics and path analysis using the STATA 13 to evaluate the effect of variables on smoking cessation behavior. Results: The study showed that out of 200 adolescents, 66% had a strong intention to quit smoking. Positive attitudes, subjective norms, and perceived behavioral control significantly influenced the intention to quit smoking. Adolescents with high knowledge about the dangers of smoking and strong social capital from peers also showed higher intentions. Path analysis indicated that the intention to quit smoking was the main mediator by the influence of attitudes, norms, and knowledge on smoking cessation behavior, with a p-value <0.001 indicating high significance. Conclusion: The smoking cessation behavior adolescents is influenced by intention to quit smoking, positive attitudes, subjective norms, perceived control, and knowledge about the dangers of smoking. Social capital from peers plays an important role in increasing this intention. The implications of the results of this study emphasize the need for education-based interventions and social support to reduce smoking habits among adolescents. Keywords: Social capital; adolesent;  smoking cessation
Unraveling the Therapeutic Potential of Andrographis paniculata for Tuberculosis: Molecular Docking Study Farid, Muhammad; Al Madury, Shalahuddin; Muslim, Ahmad Suriyadi; ‘Aini, Zakiyyah Qurrotul
Jurnal Kimia Riset Vol. 10 No. 1 (2025): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v10i1.69932

Abstract

Tuberculosis (TB) remains a global health challenge with increasing drug resistance. This study aims to explore the potential of Andrographis paniculata as an alternative anti-TB therapy through an in silico approach. The study was conducted using the molecular docking method using Biovia Discovery Studio, AutoDock 1.5.7, and ChemDraw 3D software. The target proteins analyzed were 1TYP and 3R6C. which play a role in the biosynthesis of Mycobacterium tuberculosis cell walls. The docking results showed that dehydroandrographolide and neoandrographolide compounds have lower binding energies than ethambutol, with ΔG values of -9.54 kcal/mol and -9.04 kcal/mol at 3R6C, respectively. Stable hydrogen and non-hydrogen interactions indicate a stronger inhibitory potential against protein targets. Pharmacokinetic analysis through SwissADME and PKCMS confirmed that this compound meets Lipinski's Rule of 5 criteria, and has lower toxicity compared to conventional TB drugs. Thus, this study provides new insights into the development of natural compound-based TB therapy, which is potentially more effective and has minimal side effects. Further studies are needed to confirm the activity of this compound through in vitro and in vivo tests.
Smoking Cessation Behavior Among Madurese Adolescents: The Role of Social Capital and the Theory of Planned Behavior Riyadi, Sujono; Marmi , Marmi; Al Madury, Shalahuddin; Farid, Muhammad
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 9: SEPTEMBER 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i9.7883

Abstract

Introduction: The high prevalence of smoking among Madurese adolescents reflects a complex public health challenge. This study aims to analyze the influence of social capital and elements of the Theory of Planned Behavior on smoking cessation intentions among Madurese adolescents within their local cultural context. Methods: A cross-sectional path analysis was conducted with 200 adolescents aged 15–19 years in Sumenep, Madura, using a structured questionnaire to measure attitudes, subjective norms, perceived behavioral control, and smoking cessation intention. Social capital was assessed through three dimensions: trust, social networks, and reciprocity norms, within the context of adolescents' relationships with family, peers, and the broader community. Results: The findings reveal that strong social support from family and peers significantly influences adolescents' intentions to quit smoking, strengthening the effectiveness of Theory of Planned Behavior (TPB) factors in driving positive behavioral change. Path analysis showed that the intention to quit smoking had a direct and significant effect on actual smoking cessation behavior (? = 1.56; p < 0.001). Attitudes, subjective norms, and perceived behavioral control demonstrated indirect effects through intention. Adolescents with high perceived behavioral control and positive attitudes toward quitting were more likely to succeed in cessation efforts. Conclusion: These results emphasize the importance of social capital in anti-smoking interventions, especially in culturally cohesive societies such as Madura. Future interventions should leverage community and family-based support systems to enhance smoking cessation efforts among adolescents.
Co-Authors Ahmad Suriyadi Muslim Fitrianti, Meidina Khristina Dias Utami Kurniawati, Siska Putri Marmi Marmi Muhammad Farid Padmasari, Siwi Sugiyono Sugiyono Sujono Riyadi ‘Aini, Zakiyyah Qurrotul