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GAMBARAN DETEKSI MOLEKULER TUBERKULOSIS RESISTEN RIFAMPISIN MENGGUNAKAN NESTED REAL TIME POLYMERASE CHAIN REACTION DI RSUD INDRAMAYU Sari, Sania Putri Tresna; Reki, Winarto; Silvia, Indriani
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.46078

Abstract

Tuberkulosis (TB) diakibatkan oleh Mycobacterium tuberculosis yang menginfeksi paru-paru dan organ ekstra paru. Pemeriksaan tes cepat molekuler (TCM) merupakan metode deteksi molekuler berbasis nested real-time PCR untuk diagnosis TB. Jumlah TB pada laki-laki lebih banyak dibanding perempuan, dan persentase kejadian TB semakin besar seiring bertambahnya usia individu. Penelitian ini bertujuan untuk mengetahui gambaran hasil pemeriksaan MTB Rifampisin Sensitif (Rif Sen), Rifampisin Resisten (Rif Res), dan Rifampisin Indeterminate (Rif Indet) pada pasien suspek tuberkulosis menggunakan tes cepat molekuler di Rumah Sakit Umum Daerah Indramayu. Metode penelitian yang digunakan adalah deskriptif observasional dengan populasi berupa data pasien yang diuji menggunakan specimen sputum melalui TCM MTB, dengan sampel sebanyak 97 pasien. Hasil pemeriksaan menunjukkan bahwa jumlah pasien laki-laki sebanyak 41 pasien (42,3%) dan perempuan sebanyak 56 pasien (57,7%). Kelompok usia dengan jumlah MTB positif tertinggi adalah pasien berusia 21-30 dan 31-40 tahun, masing-masing delapan pasien (21,6%). Dari segi jenis kelamin, MTB positif lebih banyak ditemukan pada laki-laki (58,3%) dibanding perempuan (41,7%), dan kelompok usia dengan persentase tertinggi adalah 31-40 tahun (22,2%). Hasil pemeriksaan MTB didominasi oleh Rif Res dengan jumlah 34 pasien (91,9%).
PROFIL ESTIMASI LAJU FILTRASI GLOMERULUS MENURUT FORMULA MODIFICATION OF DIET IN RENAL DISEASE PADA PENDERITA DM TIPE 2 DI RSUD ARJAWINANGUN Hendrawan, Fahrizky Nugraha; Indriyati, Rose; Gunawan, Irene; Amaliyah, Nihayatul; Silvia, Indriani; Oktavrisa, Friska
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 11 No 1 (2025): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v11i1.10297

Abstract

ABSTRAK Nefropati Diabetik (ND) merupakan salah satu komplikasi mikrovaskular yang menyerang ginjal menyebabkan gagal ginjal kronis. Salah satu parameter yang digunakan untuk mengetahui terjadi kerusakan ginjal adalah dengan melihat nilai estimasi Laju Filtrasi Glomerulus (eLFG), dimana parameter yang digunakan adalah formula Modification of Diet in Renal Disease (MDRD), yang dapat mempertimbangkan luas permukaan tubuh, ras, jenis kelamin, dan usia. Untuk mendapatkan gambaran eLFG pada penderita DM tipe 2 di RSUD Arjawinangun. Penelitian ini merupakan penelitian deskriptif. Sampel penelitian sejumlah 393 orang menggunakan teknik total sampling. Data penelitian menggunakan data sekunder. Hasil Univariat didapatkan gambaran usia hasil penelitian ini yaitu penurunan eLFG MDRD banyak terjadi pada usia antara 44 + 64 tahun, jenis kelamin hasil terbanyak yang diperoleh adalah perempuan sebanyak 255 (65%), tingkat pendidikan terbanyak pada Sekolah Dasar sebanyak 286 (72,8%), tidak merokok sebanyak 273 (69,5%), IMT terbanyak terjadi pada kategori normal sebanyak 283 (72%), tanpa riwayat hipertensi sebanyak 242 (61,6%), tanpa riwayat dislipidemia sebanyak 331 (84,2%), nilai eLFG MDRD Grade 1 sebanyak 121 (30,8%), Grade 2 sebanyak 103 (26,2%), Grade 3a sebanyak 58 (14,8%), Grade 3b sebanyak 48 (12,2%), Grade 4 sebanyak 41 (10,4%), Grade 5 sebanyak 22 (5,6%). Kasus DM tipe 2 pada pasien perempuan lebih banyak 65%, Usia rerata dengan penurunan fungsi ginjal terjadi antara usia 45 – 64 tahun, Riwayat hipertensi pada pasien DM tipe 2 tanpa hipertensi 61,6%, Riwayat dislipidemia pada pasien DM tipe 2 tanpa dislipidemia 61,6%. Rata – rata eLFG MDRD pada penelitian ini antara 69,8 + 78,5ml/min/1,73m2. Kata kunci : diabetes melitus tipe 2, eLFG modification of diet in renal disease, penyakit ginjal kronis. ABSTRACT Diabetic Nephropathy (ND) is a microvascular complication that attacks the kidneys causing chronic kidney failure. One of the parameters used to determine kidney damage is by looking at the estimated value of the Glomerular Filtration Rate (eGFR), where the parameter used is the Modification of Diet in Renal Disease (MDRD) formula, which can take into account body surface area, race, sex, and age. To get an overview of eGFR in type 2 DM patients at Arjawinangun Hospital. This research is a descriptive research. The research sample was 393 people using total sampling technique. The research data uses secondary data. Univariate analysis test. Univariate results showed that the age picture of the results of this study was that the decline in MDRD eLFG mostly occurred between the ages of 44 + 64 years, the gender with the highest results obtained was female at 255 (65%), the highest level of education was at elementary school at 286 (72.8%). ), did not smoke as many as 273 (69.5%), most BMI occurred in the normal category as many as 283 (72%), without a history of hypertension as many as 242 (61.6%), without a history of dyslipidemia as many as 331 (84.2%), Grade 1 MDRD eLFG value was 121 (30.8%), Grade 2 was 103 (26.2%), Grade 3a was 58 (14.8%), Grade 3b was 48 (12.2%), Grade 4 was 41 (10.4%), Grade 5 was 22 (5.6%). Cases of type 2 DM in female patients were 65% more, The mean age with decreased kidney function occurred between the ages of 45-64 years, History of hypertension in DM patients without hypertension 61.6%, history of dyslipidemia in type 2 DM patients without dyslipidemia 61.6%. The average MDRD eGFR in this study was between 69.8 + 78.5ml/min/1.73m2.
Percentage of Neutrophyl Lymphocyte Ratio and Glycated Hemoglobin in Type 2 Diabetes Mellitus Patients at Waled Hospital Adilah, Zahra Ul; Silvia, Indriani; Amaliyah , Nihayatul
Journal Of Social Science (JoSS) Vol 4 No 7 (2025): JOSS: Journal of Social Science
Publisher : Al-Makki Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57185/joss.v4i7.494

Abstract

Diabetes mellitus (DM) is one of the leading causes of death in the world. The number of DM patients is increasing every year so it is necessary to treat and prevent it with an HbA1c laboratory examination as an establishment of the diagnosis of DM and a supporting examination using neutrophil lymphocyte ratio (NLR) as a complications marker from hyperglycemia. This study was conducted to determine the percentage of neutrophil lymphocyte ratio and glycated haemoglobin in type-2 diabetes mellitus patients at Waled Regional General Hospital. This study is an observational descriptive study using total sampling. The population in this study is type-2 DM patients aged 19-65 years with 39 samples. Type-2 DM patients who underwent NLR and HbA1c examinations showed that 16 (41%) male and 23 (59%) female patients, the highest age group was 17 (43.6%) in the age group of 46-55 years. The percentage of NLR values in this study was the normal range: 1-2 (53.8%) and the percentage of HbA1c values in this study was poor: >8 mmol/mol (48.7%). The presentation of NLR values in this study was obtained to be normal and increase HbA1c levels percentage.
Hubungan antara Hasil Skor Salzburg dan Kadar C-Reactive Protein untuk Mendeteksi Penyakit Paru Obstruktif Kronis di Rumah Sakit Umum Daerah Waled Anjani, Faizah; Silvia, Indriani; Agustina, Dwi Rosa Eka; Octavrisa, Friska; Herdwiyanti, Menik
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 10 No 3 (2024): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v10i3.9615

Abstract

Latar Belakang: Penyakit Paru Obstruktif Kronis (PPOK) masih menjadi suatu penyakit ancaman bagi masyarakat di Indonesia maupun dunia. Penting bagi tenaga kesehatan untuk melakukan skrining PPOK menggunakan kuesioner. Kuesioner skrining Salzburg merupakan kuesioner skrining yang sederhana dan mudah diterapkan untuk pemilihan awal rujukan spirometri. CRP merupakan marker inflamasi yang akan meningkat pada penyakit kronis salah satunya pada PPOK. Tujuan: Mengetahui hubungan antara skor kuesioner Salzburg untuk mendeteksi PPOK dengan kadar CRP di RSUD Waled. Metode: Penelitian berupa penelitian observasional analitik, menggunakan desain penelitian cross sectional. Teknik pemilihan sample menggunakan total sampling, didapat 23 pasien. Hasil: Hasil deteksi PPOK menggunakan kuesioner skrining Salzburg di RSUD Waled, dari 23 responden, sebanyak 18 orang (78,3%) memperoleh hasil skor kuesioner skrining Salzburg ≥2. Ditemukan hubungan yang signifikan (p = 0,035) antara skor Salzburg untuk mendeteksi PPOK dengan kadar marker inflamasi CRP (r = 0,500) di RSUD Waled. Kesimpulan: Terdapat hubungan yang signifikan (p = 0,035) antara kuesioner skrining Salzburg untuk mendeteksi PPOK dengan kadar marker inflamasi CRP (r = 0,500) di RSUD Waled yang menunjukkan bahwa semakin tinggi risiko PPOK dengan hasil skor kuesioner skrining Salzburg ≥2, maka semakin tinggi kadar CRP. Kata kunci: CRP, PPOK, kuesioner skrining Salzburg. ABSTRACT Background: Chronic Obstructive Pulmonary Disease (COPD) is still a disease that threatens all people in Indonesia and in the world. It is important for health workers to screen for COPD using a questionnaire. The Salzburg screening questionnaire is a simple and easy-to-use screening questionnaire for the initial selection of spirometry referrals. CRP is an inflammatory marker that will increase in chronic diseases, one of which is COPD. Objective: To determine the relationship between the Salzburg questionnaire score for detecting COPD and CRP levels at Waled Regional Hospital. Methods: This research is an analytic observational study using a cross sectional research design. The sample used was 23 people using total sampling technique. Results: The results of COPD detection using the Salzburg screening questionnaire at Waled Hospital, out of 23 respondents, as many as 18 people (78.3%) obtained the results of the Salzburg screening questionnaire score ≥2. There was a significant relationship (p = 0.035) between the Salzburg score for detecting COPD and the levels of the inflammatory marker CRP (r = 0.500) at Waled Hospital. Conclusion: There is a significant relationship (p = 0.035) between the Salzburg screening questionnaire for COPD detection and levels of the inflammatory marker CRP (r = 0.500) at Waled Hospital which shows that the higher the risk of COPD with the results of the Salzburg screening questionnaire score ≥2, the higher CRP levels.