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All Journal Proceedings of the International Conference on Applied Science and Health Tunas Medika Jurnal Kedokteran & Kesehatan
Indriyati, Rose
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health

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INHIBITORY TEST OF DAYAK ONION (ELEUTHERINE BULBOSA MILL.) ESSENTIAL OIL TO THE GROWTH OF MALASSEZIA FURFUR Hayati, Syahidatun; Amanah, Amanah; Indriyati, Rose
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.69 KB)

Abstract

Background: Certain fungi are normal flora on human mucosa and skin, and they require lipids for growth. One of them is Malassezia furfur, which can develop into an opportunistic infection and will take a long time to treat. The fungus may cause pityriasis versicolor, which cause scaly and discoloration of the skin. It is estimated that 40-50% from population in the tropical country is infected. Dayak onion (Eleutherine bulbosa Mill.) essential oil have the potential to treat fungal infections. This research aims to see the inhibitory potential of dayak onion essential oil (Eleutherine bulbosa Mill.) in inhibiting the growth of Malassezia furfur.Methods: This is an experimental study with a post-test control group design. The samples grouped into 7 groups. The first five treatment (P1 to P5) was given dayak onion (Eleutherine bulbosa Mill.) essential oil with a concentration of 3.125%,6.25%, 12.5%, 25%, and 50%, P6 (positive control) was given ketoconazole, and P7 (negative control) was given 10% DMSO. The inhibitory effect is measured from the diameter of the inhibitory zone, then analyzed using Kruskal-Wallis and Mann-Whitney tests.Result: The result showed that average diameter on 50% concentration is 9.25mm, 25% concentration is 7.5mm, 12.5% concentration have diameter of 4.5mm, 6.25% concentration have diameter of 3mm, 3.125% concentration with diameter of 1.75mm, positive control group with diameter of 20mm, and negative control group with diameter 0mm.Conclusions: Essential oil of dayak onion (Eleutherine bulbosa Mill.) shows inhibition of the growth of Malassezia furfur. The smallest inhibition zone diameter was 1.75 mm with concentration of 3.125%. The largest inhibition zone at a concentration of 50% with diameter of 9.25 mm. This finding showed potential effects towards antifungi treatment.
PROFIL ESTIMASI LAJU FILTRASI GLOMERULUS MENURUT FORMULA MODIFICATION OF DIET IN RENAL DISEASE PADA PENDERITA DM TIPE 2 DI RSUD ARJAWINANGUN Hendrawan, Fahrizky Nugraha; Indriyati, Rose; Gunawan, Irene; Amaliyah, Nihayatul; Silvia, Indriani; Oktavrisa, Friska
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 11 No 1 (2025): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v11i1.10297

Abstract

ABSTRAK Nefropati Diabetik (ND) merupakan salah satu komplikasi mikrovaskular yang menyerang ginjal menyebabkan gagal ginjal kronis. Salah satu parameter yang digunakan untuk mengetahui terjadi kerusakan ginjal adalah dengan melihat nilai estimasi Laju Filtrasi Glomerulus (eLFG), dimana parameter yang digunakan adalah formula Modification of Diet in Renal Disease (MDRD), yang dapat mempertimbangkan luas permukaan tubuh, ras, jenis kelamin, dan usia. Untuk mendapatkan gambaran eLFG pada penderita DM tipe 2 di RSUD Arjawinangun. Penelitian ini merupakan penelitian deskriptif. Sampel penelitian sejumlah 393 orang menggunakan teknik total sampling. Data penelitian menggunakan data sekunder. Hasil Univariat didapatkan gambaran usia hasil penelitian ini yaitu penurunan eLFG MDRD banyak terjadi pada usia antara 44 + 64 tahun, jenis kelamin hasil terbanyak yang diperoleh adalah perempuan sebanyak 255 (65%), tingkat pendidikan terbanyak pada Sekolah Dasar sebanyak 286 (72,8%), tidak merokok sebanyak 273 (69,5%), IMT terbanyak terjadi pada kategori normal sebanyak 283 (72%), tanpa riwayat hipertensi sebanyak 242 (61,6%), tanpa riwayat dislipidemia sebanyak 331 (84,2%), nilai eLFG MDRD Grade 1 sebanyak 121 (30,8%), Grade 2 sebanyak 103 (26,2%), Grade 3a sebanyak 58 (14,8%), Grade 3b sebanyak 48 (12,2%), Grade 4 sebanyak 41 (10,4%), Grade 5 sebanyak 22 (5,6%). Kasus DM tipe 2 pada pasien perempuan lebih banyak 65%, Usia rerata dengan penurunan fungsi ginjal terjadi antara usia 45 – 64 tahun, Riwayat hipertensi pada pasien DM tipe 2 tanpa hipertensi 61,6%, Riwayat dislipidemia pada pasien DM tipe 2 tanpa dislipidemia 61,6%. Rata – rata eLFG MDRD pada penelitian ini antara 69,8 + 78,5ml/min/1,73m2. Kata kunci : diabetes melitus tipe 2, eLFG modification of diet in renal disease, penyakit ginjal kronis. ABSTRACT Diabetic Nephropathy (ND) is a microvascular complication that attacks the kidneys causing chronic kidney failure. One of the parameters used to determine kidney damage is by looking at the estimated value of the Glomerular Filtration Rate (eGFR), where the parameter used is the Modification of Diet in Renal Disease (MDRD) formula, which can take into account body surface area, race, sex, and age. To get an overview of eGFR in type 2 DM patients at Arjawinangun Hospital. This research is a descriptive research. The research sample was 393 people using total sampling technique. The research data uses secondary data. Univariate analysis test. Univariate results showed that the age picture of the results of this study was that the decline in MDRD eLFG mostly occurred between the ages of 44 + 64 years, the gender with the highest results obtained was female at 255 (65%), the highest level of education was at elementary school at 286 (72.8%). ), did not smoke as many as 273 (69.5%), most BMI occurred in the normal category as many as 283 (72%), without a history of hypertension as many as 242 (61.6%), without a history of dyslipidemia as many as 331 (84.2%), Grade 1 MDRD eLFG value was 121 (30.8%), Grade 2 was 103 (26.2%), Grade 3a was 58 (14.8%), Grade 3b was 48 (12.2%), Grade 4 was 41 (10.4%), Grade 5 was 22 (5.6%). Cases of type 2 DM in female patients were 65% more, The mean age with decreased kidney function occurred between the ages of 45-64 years, History of hypertension in DM patients without hypertension 61.6%, history of dyslipidemia in type 2 DM patients without dyslipidemia 61.6%. The average MDRD eGFR in this study was between 69.8 + 78.5ml/min/1.73m2.
PROFIL LIPID PADA PENDERITA DIABETES MELLITUS TIPE 2 DI RSUD ARJAWINANGUN PERIODE 2022 Pamungkas, Nanda Dwi; Herdwiyanti, Menik; Indriyati, Rose; Wirandoko, Ignatius Hapsoro; Astuti, Widi; Canceryta, Sherly; Romdhoni, Mohamad
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 11 No 2 (2025): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v11i2.10951

Abstract

ABSTRAK LATAR BELAKANG Diabetes mellitus (DM) merupakan penyakit metabolik dengan karakteristikhiperglikemia yang terjadi karena kelainan sekresi insulin, resistensi insulin atau keduanya. Resistensi Insulindapat disebabkan oleh dislipidemia sehingga menyebabkan DM. Riset Kesehatan Dasar (2018) menunjukanadanya peningkatan yang cukup signifikan pada prevalensi diabetes mellitus dari 6,9% menjadi 8,5%. Dikabupaten Cirebon, kecamatan Arjawingun memiliki penderita DM sebanyak 699 orang di dua pelayanankesehatan data dinkes kabupaten Cirebon. TUJUAN Mengetahui gambaran karakteristik Profil Lipid PadaPenderita Diabetes Mellitus Tipe 2 di RSUD Arjawinangun. METODE Penelitian ini menggunakan metodedeskriptif observasional dengan teknik pengambilan data total sampling. Didapatkan 88 sampel dari data RekamMedik Bulan Januari sampai Desember tahun 2022 sudah memenuhi kriteria inklusi dan eklusi. Data diolahdengan analisis univariat. HASIL Hasil penelitian menunjukan penderita DMT2 di RSUD Arjawinangunmemiliki mayoritas berusia lansia akhir sebanyak 36 sampel (40,9%), lebih banyak Perempuan 64 sampel(72,7%), memiliki mayoritas BMI dengan kategori obesitas tipe 1 sebanyak 38 sampel (43,2%), kadar GDS≥300 sebanyak 71 sampel (80,7%), kadar HbA1c (>8%) 86 sampel (97,7%), kadar LDL (≥190 mg/dl) 23sampel (26,1%), kadar HDL (<40 mg/dl) 63 sampel (71,6%), Trigliserida (200-499 mg/dl) 55 sampel (62,5%),kadar Kolesterol total (≥240 mg/dl) 45 sampel (51,1%). SIMPULAN Penderita DMT2 di RSUD Arjawinangun,lebih banyak Perempuan, penderita mayoritas lansia akhir dan memiliki BMI dengan kategori obesitas. KadarGDS tidak terkontrol, kadar HbA1c mayoritas kendali buruk. Pada pemeriksaan profil lipid didapatkanmayoritas HDL kategori rendah, LDL sangat tinggi, Trigliserida tinggi, dan Kolesterol total tinggi.Kata Kunci : Profil lipid, Diabetes mellitus tipe 2, Dislipidemia, resistensi insulin. ABSTRACT BACKGROUND Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia that occursdue to abnormalities in insulin secretion, insulin resistance or both. Insulin resistance can be caused bydyslipidemia, leading to T2DM. Basic Health Research (2018) showed a significant increase in the prevalenceof diabetes mellitus from 6.9% to 8.5%. In Cirebon Regency, Arjawingun sub-district has 699 people with DM intwo health services. OBJECTIVE Determine characteristic of Lipid Profile in Patients with Type 2 DiabetesMellitus at Arjawingun hospital. METHODS This study used descriptive observational method with totalsampling data collection technique. From 239 samples 88 samples from medical record data from January toDecember 2022 with the inclusion and exclusion criteria. Data were processed with univariate analysis.RESULTS The results showed that patients with T2DM at Arjawinangun Hospital had a majority of late elderlyas many as 36 people (40.9%), more women 64 people (72.7%), had a majority of BMI with type 1 obesitycategory as many as 38 samples (43.2%), GDS levels ≥300 as many as 71 people (80.7%), HbA1c levels (>8%)86 people (97.7%), LDL levels (≥190 mg/dl) 23 people (26.1%), HDL levels (<40 mg/dl) 63 people (71.6%),Triglycerides (200-499 mg/dl) 55 people (62.5%), Total cholesterol levels (≥240 mg/dl) 45 people (51.1%).CONCLUSION Patients with T2DM at Arjawinangun Hospital, more women (72.7%) than men (27.3%), themajority of patients are elderly and have BMI in the obesity category. GDS levels are not controlled (≥300) asmuch as 80.7%, the majority of HbA1c levels are poorly controlled. In the lipid profile examination, the majorityof HDL was found to be low, LDL was very high, Triglycerides were high, and Total cholesterol was high.Keyword : Lipid profile, Diabetes mellitus, Dyslipidemia, insulin resistance.
POLA BAKTERI PENYEBAB SEPSIS DAN KEPEKAANNYA TERHADAP ANTIBIOTIK DI RUMAH SAKIT DAERAH GUNUNG JATI PERIODE 1 JANUARI-31 DESEMBER 2022 Ramadhani, Chandra Eka; Gasem, Muhammad Hussein; Indrakusuma, Mohammad Erwin; Amaliah, Nihayatul; Indriyati, Rose
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 10 No 3 (2024): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v10i3.9617

Abstract

Latar Belakang: Prevalensi 2017 sepsis didunia 48,9 juta dengan mortalitas 11 juta kasus. Pola bakteri penyebabsepsis dan kepekaan antibiotik sangat penting mencegah resistensi dan meningkatnya mortalitas. Tujuan:Mempelajari pola persebaran bakteri dan kepekaannya terhadap antibiotik di Rumah Sakit Daerah (RSD) GunungJati. Metode: Data retrospektif berupa rekam medis, hasil pemeriksaan kultur darah dan uji kepekaan antibiotikdari pasien yang dicurigai sepsis di RSD Gunung Jati selama periode 1 Januari-31 Desember 2022. Penelitiandilaksanakan pada April-Juli tahun 2023. Analisis data dengan World Health Organization (WHO) Net versi 2023sesuai Pedoman Penyusunan Antibiogram Nasional tahun 2022. Hasil: Tiga bakteri terbanyak penyebab sepsisadalah bakteri Gram Negatif; Escherichia coli 26 (24,5%), Klebsiella pneumoniae 18 (17%) dan bakteri GramPositif; Staphylococcus auereus 20 (18,9%). Uji kepekaan antibiotik dengan tingkat Susceptible (≥75 %) padaGram Positif; Amikacin (100%), Linezolid (92%), Rifampicin (87,5%), Vancomycin (84,6%) danTrimethoprim/Sulfamethoxazol (76,2%) sedangkan pada Gram Negatif; Meropenem (96,1%), Ertapenem(89,8%), Amikacin (88,5%) dan Cefepime (76%). Simpulan: Bakteri penyebab sepsis terbanyak adalahEscherichia coli, Stapylococcus aureus dan Klebsiella pneumoniae. Profil kepekaan antibiotik yang baik (≥75 %)pada bakteri Gram Positif; Amikacin, Linezolid, Rifampicin, Vancomycin dan Trimethoprim/Sulfamethoxazolsedangkan pada bakteri Gram Negatif; Meropenem, Ertapenem, Amikacin dan Cefepime.Kata Kunci: Pola Bakteri, Kepekaan Antibiotik, Sepsis
Co-Authors Amaliah, Nihayatul Amaliyah, Nihayatul amanah amanah Canceryta, Sherly Gasem, Muhammad Hussein Gunawan, Irene Hayati, Syahidatun Hendrawan, Fahrizky Nugraha Herdwiyanti, Menik Ignatius Hapsoro Wirandoko Indrakusuma, Mohammad Erwin Oktavrisa, Friska pamungkas, Nanda dwi Ramadhani, Chandra Eka Romdhoni, Mohamad Silvia, Indriani Widi Astuti