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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Global Health Management Journal PREPOTIF : Jurnal Kesehatan Masyarakat Ophthalmologica Indonesiana Biosaintifika: Journal of Biology & Biology Education
Reki, Winarto
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Agriculture, Biological Sciences & Forestry Education Health Professions Medicine & Pharmacology Nursing Public Health

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Age Krisniawati, Nia; Ciptaningtyas, Vincentia Rizke; Reki, Winarto
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022): June 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.015 KB) | DOI: 10.30659/sainsmed.v13i1.8663

Abstract

Most blood culture contaminants are coagulase-negative staphylococci (CoNS), which are also the leading cause of nosocomial bloodstream infections. To date, no research in Indonesia has analyzed the potential causes of a CoNS infection in the bloodstream. The goal of this research was to better understand who is at risk for developing a CONS-related bloodstream infection while in a hospital setting. Secondary data from the CONS blood culture results at Dr. Kariadi Hospital Semarang were used in this retrospective cross-sectional study conducted between January 1 and December 31, 2016. The Vitek-2 Compact System (Biomerieux, USA) and the Kirby Bauer method (Clinical & Laboratory Standards Institute (CLSI) of the USA) were used for the antibiotic identification and sensitivity testing, respectively. Multivariate with multiple logistic regressions and the Chi-Square test for categorical variables were used in the analysis. Among the study's 272 participants, 158 (58.1%) developed CONS-related bloodstream infections. Risk factors for central nervous system (CNS) bloodstream infection in 18-year-olds include preterm birth, low birth weight (LBW), compromised immunity, malnutrition, immunosuppressive therapy, and peripheral intravenous use. Age >=18, malnutrition, and immunosuppression therapy all ranked high as risk factors in a multivariate analysis. Risk factors for CONS-causing bloodstream infections in people aged 18 include malnutrition and immunosuppressant therapy.
Dietary Steamed Tomato Inhibits Hyper-production of Inflammatory Markers and Enhance miR-29b-3p Expression in Atherosclerosis Rats Dafip, Muchamad; Iswari, Retno Sri; Kartika, Aprilia Indra; Reki, Winarto; Gasem, Muhammad Husein; Fitria, Meutia Srikandi
Biosaintifika: Journal of Biology & Biology Education Vol. 16 No. 1 (2024): April 2024
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v15i1.782

Abstract

Atherosclerosis is triggered by cholesterol accumulation in endothelial layers that induces the production of inflammatory cytokines, including TNF-α, IL-6, and IL-10. This condition disrupts microRNA homeostasis like miR-29b-3p, generally maintaining artery health. Steamed tomatoes contain higher antioxidant properties than raw, which might be better against atherosclerosis. However, its influence on inflammation and miR-29b-3p balance remains unclear. This study aims to elucidate the effect of steamed tomatoes on the TNF-α, IL-6, and IL-10 levels and miR-29b-3p expression under atherosclerosis conditions. Sprague Dawley male rats were equally divided into K1 group of healthy rats given a placebo; K2 group was atherosclerosis rats induced with 2 m of cholesterin/ 200 g/KgBW per day, then K3 and K4 groups were atherosclerosis rats supplemented with 20 mg/ 200 g/KgBW per day of atorvastatin and 16 mg/ 200 g/KgBW per day of steamed-tomato extract for 60 days. Steamed tomato decreases cytokine level in the K4 group and significantly differs from all groups (p < 0.050). This study showed that increased proinflammatory cytokine, including TNF-α and IL-6, is hypothetically involved in plaque formation and lamina layer destruction in endothelial. Steamed tomato supplementation also significantly increases miR-29b-3p expression to 0.98 ± 0.33 log10 fold change higher than K2 and K3 (p = 0.000). This study demonstrated the potential of steamed tomatoes to improve dyslipidemia, atherosclerosis-related inflammation, and miRNA homeostasis. This research provides additional knowledge regarding determining the expression of miR-29b-3p, which has the potential to be developed as a diagnostic or therapeutic target.
GAMBARAN DETEKSI MOLEKULER TUBERKULOSIS RESISTEN RIFAMPISIN MENGGUNAKAN NESTED REAL TIME POLYMERASE CHAIN REACTION DI RSUD INDRAMAYU Sari, Sania Putri Tresna; Reki, Winarto; Silvia, Indriani
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.46078

Abstract

Tuberkulosis (TB) diakibatkan oleh Mycobacterium tuberculosis yang menginfeksi paru-paru dan organ ekstra paru. Pemeriksaan tes cepat molekuler (TCM) merupakan metode deteksi molekuler berbasis nested real-time PCR untuk diagnosis TB. Jumlah TB pada laki-laki lebih banyak dibanding perempuan, dan persentase kejadian TB semakin besar seiring bertambahnya usia individu. Penelitian ini bertujuan untuk mengetahui gambaran hasil pemeriksaan MTB Rifampisin Sensitif (Rif Sen), Rifampisin Resisten (Rif Res), dan Rifampisin Indeterminate (Rif Indet) pada pasien suspek tuberkulosis menggunakan tes cepat molekuler di Rumah Sakit Umum Daerah Indramayu. Metode penelitian yang digunakan adalah deskriptif observasional dengan populasi berupa data pasien yang diuji menggunakan specimen sputum melalui TCM MTB, dengan sampel sebanyak 97 pasien. Hasil pemeriksaan menunjukkan bahwa jumlah pasien laki-laki sebanyak 41 pasien (42,3%) dan perempuan sebanyak 56 pasien (57,7%). Kelompok usia dengan jumlah MTB positif tertinggi adalah pasien berusia 21-30 dan 31-40 tahun, masing-masing delapan pasien (21,6%). Dari segi jenis kelamin, MTB positif lebih banyak ditemukan pada laki-laki (58,3%) dibanding perempuan (41,7%), dan kelompok usia dengan persentase tertinggi adalah 31-40 tahun (22,2%). Hasil pemeriksaan MTB didominasi oleh Rif Res dengan jumlah 34 pasien (91,9%).
HUBUNGAN PENDAPATAN KELUARGA DENGAN PENGETAHUAN, SIKAP DAN PERILAKU PASIEN TB PARU Madani, Muhammad Hilman Al; Reki, Winarto; Khasanah, Uswatun
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.48472

Abstract

Penelitian ini bertujuan untuk memahami pengaruh pendapatan keluarga terhadap akses terhadap layanan kesehatan, pendidikan, dan lingkungan, serta bagaimana faktor-faktor tersebut memengaruhi pengetahuan, sikap, dan perilaku penderita tuberkulosis (TB) paru. Meskipun hubungan antara pendapatan keluarga dengan akses terhadap layanan dasar masih terbatas, studi ini memberikan wawasan mengenai peran faktor ekonomi dalam penyebaran informasi dan tindakan pencegahan TB. Penelitian ini dilakukan di Balai Kesehatan Paru Masyarakat (BKPM) Cirebon dengan pendekatan analitik observasional menggunakan desain potong lintang. Sebanyak 110 responden dipilih menggunakan metode consecutive sampling, dan data dianalisis menggunakan uji Spearman. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki pendapatan rendah (39,1%), pengetahuan kategori kurang (37,3%), sikap kategori kurang (52,7%), dan perilaku kategori kurang (58,2%). Terdapat hubungan yang signifikan dan korelasi yang kuat antara pendapatan keluarga dengan pengetahuan (p=0,001; r=0,675), sikap (p=0,001; r=0,485), dan perilaku terhadap TB (p=0,001; r=0,497). Pasien dengan pendapatan keluarga yang lebih tinggi cenderung memiliki pengetahuan yang lebih baik mengenai TB paru, sikap yang lebih positif terhadap pengobatan dan pencegahan, serta perilaku yang lebih baik dalam menjalani pengobatan. Dengan demikian, dapat disimpulkan bahwa terdapat hubungan antara tingkat pendidikan dan pendapatan keluarga dengan pengetahuan, sikap, dan perilaku penderita TB paru.
The Features of Children with Tuberculosis at Sidawangi Pulmonary Hospital in Indonesia: Interactions within the Home as a Potential Transmission Risk Pratiwi, Witri; Toipah, Iip; Rachmawan, Yogi Puji; Reki, Winarto
GHMJ (Global Health Management Journal) Vol. 8 No. 1 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-811203

Abstract

Background: Tuberculosis (TB) is an infectious disease that can infect children. The prevalence of pediatric TB in Indonesia has increased in recent years, causing a major burden on children's health. Aims: To determine the characteristics of pediatric TB patients at Sidawangi Pulmonary Hospital, West Java Province, Indonesia. Methods: A cross-sectional study was conducted at Sidawangi Pulmonary Hospital, West Java Province, Indonesia. The samples were new cases of pediatric TB from January 2020 to July 2023. Data were collected and analyzed from outpatient and inpatient medical records. Logistic regression was used to analyze the association between age and household contact. Results: There were 190 pediatric TB patients collected during the study period. Most of them were less than 5 years old (37.9%). The proportion of male and female was almost same. Most pediatric TB patients had household contacts (73.7%), especially those <1 year old. TB patients aged <1 year had an AOR of 31.94 (95%CI 3.8­­­–268.35) for household contact compared to those aged 10-17 years. Conclusion: Pediatric TB patients at Sidawangi Pulmonary Hospital are mostly less than 5 years old. Compared to older age groups, pediatric TB patients aged <1 year had the highest proportion of household contacts. The government needs to pay attention to the risk of TB transmission to children through household contact, especially in younger children. Received: 27 January 2025 | Reviewed: 11 February 2025 | Revised: 22 February 2025 | Accepted: 23 February 2025.
GAMBARAN UMUM TOKSOPLASMOSIS OKULER DI RUMAH SAKIT DR KARIADI SEMARANG: STUDI RETROSPEKTIF 5 TAHUN Ariska, Amalia Dwi; Reki, Winarto; Novita, Dina
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/qsgkaj50

Abstract

Introduction: Ocular toxoplasmosis is the most common infectious etiology of posterior uveitis. The aim of this study is to describe the clinical characteristics of ocular toxoplasmosis in Dr. Kariadi Hospital, Semarang. Methods: A retrospective review of out-patient medical records of ocular toxoplasmosis at Dr. Kariadi Hospital Semarang from January 2018 to December 2022 was done. All toxoplasmic uveitis were included, whereas incomplete medical records and loss of follow-up were excluded.  The clinical characteristics of patients were recorded and analyzed. Results: During 5 years a total of 160 patients were recruited of which 123 fulfilled the criteria, consisting of 47 males (38.2%) and 76 females (61.8%), mostly were acquired infection (97.6%) with immunocompetent status (75.6%), and affected unilateral eye (65%). The predominant age was 26-45 years old (41.5%). Primary infection (70.7%) was greater than recurrent infection (8.9%) in which recurrence affects 46-65 years old (72.7%). Visual acuity at the initial presentation was <6/18-6/60 (26.2%), and the final follow-up increased to ?6/18 (33.1%). Posterior uveitis (35.1%) with posterior pole lesion (66%) was a common clinical sign found. Medications given were trimethoprim-sulfamethoxazole (51,3%), and corticosteroid (27.5%) as an adjuvant. The complication detected was cataract (13%). Conclusion: Ocular toxoplasmosis was mostly found in immunocompetent male patients, acquired, unilateral, and in the posterior pole.  A good response was found by trimethoprim-sulfamethoxazole and corticosteroid medications.
EFFECT OF “PERMATA-KU” EXERCISE ON THE AMPLITUDE OF ACCOMMODATION AND COMPUTER VISION SYNDROME SCORE IN COMPUTER USERS Azkadina, Amira; Nugroho, Trilaksana; Astuti, Fatimah Dyah Nur; Reki, Winarto; Dharma, Andhika Guna
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/e07wgj60

Abstract

Background and Objective: Intense and long-term computer users are at risk of suffering health problems known as computer vision syndrome (CVS) which can have an impact on physical, mental, and economic health. One of the alternative therapies developed is "PERMATA-KU" exercise to reduce complaints related to CVS. The aim of the study was to reveal the effect of "PERMATA-KU" exercise on amplitude of accommodation (AA) and Computer Vision Syndrome scores on computer users. Method: The study of a quasi-experimental with pre-post control design was done. The research subjects were divided into the “PERMATA-KU” exercise group (21 people) and the control group (19 people) with treatment for 4 weeks. CVS scores were measured using the CVS-Questionnaire and monocular AA scores were measured using the push-up method using a Berrens ruler. Mann-Whitney difference test analysis was performed. Results: The exercise group experienced a significant increase in monocular AA value (p=0.010) while the control group experienced a significant decrease in AA (p=0.025). The mean delta of monocular AA values between groups was significantly different after the intervention (p=0.001). There was a significant difference in CVS scores between the postintervention groups (p=0.006) with the mean delta CVS scores between groups being significantly different (p=0.002). There was no correlation between AA scores and CVS scores (p=0.126). Conclusion: "PERMATA-KU" exercise for 4 weeks was shown to significantly increase the value of amplitude of accommodation and decrease CVS scores, but the increase in accommodation amplitude did not correlate with a decrease in CVS scores.
Co-Authors Amira Azkadina Aprilia Indra Kartika, Aprilia Indra Ariska, Amalia Dwi Astuti, Fatimah Dyah Nur Dafip, Muchamad Dharma, Andhika Guna Dina Novita, Dina Fitria, Meutia Srikandi Gasem, Muhammad Husein Hery Widijanto Krisniawati, Nia Madani, Muhammad Hilman Al Nugroho, Trilaksana Rachmawan, Yogi Puji Retno Sri Iswari Sari, Sania Putri Tresna Silvia, Indriani Toipah, Iip V. Rizke Ciptaningtyas Witri Pratiwi